Shen-shu Sung, PhD

    • 1249 Citations
    • 18 h-Index
    1985 …2017

    Research output per year

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    Research Output

    • 1249 Citations
    • 18 h-Index
    • 30 Article
    • 1 Review article
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    Article
    2017

    A novel dual inhibitor of microtubule and Bruton's tyrosine kinase inhibits survival of multiple myeloma and osteoclastogenesis

    Pandey, M. K., Gowda, K., Sung, S. S., Abraham, T., Budak-Alpdogan, T., Talamo, G., Dovat, S. & Amin, S., Sep 2017, In : Experimental Hematology. 53, p. 31-42 12 p.

    Research output: Contribution to journalArticle

    6 Scopus citations

    Dielectric screening effect of electronic polarization and intramolecular hydrogen bonding

    Sung, S. S., Oct 2017, In : Protein Science. 26, 10, p. 2003-2009 7 p.

    Research output: Contribution to journalArticle

    1 Scopus citations
    2016

    Targeting of Chk2 as a countermeasure to dose-limiting toxicity triggered by topoisomerase-II (TOP2) poisons

    Gokare, P., Navaraj, A., Zhang, S., Motoyama, N., Sung, S. S. & Finnberg, N. K., May 17 2016, In : Oncotarget. 7, 20, p. 29520-29530 11 p.

    Research output: Contribution to journalArticle

    4 Scopus citations
    2015

    Peptide folding driven by Van der Waals interactions

    Sung, S. S., Sep 2015, In : Protein Science. 24, 9, p. 1383-1388 6 p.

    Research output: Contribution to journalArticle

    3 Scopus citations

    The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines

    Dick, T. E., Hengst, J. A., Fox, T. E., Colledge, A. L., Kale, V. P., Sung, S. S., Sharma, A., Amin, S., Loughran, T. P., Kester, M., Wang, H. G. & Yun, J. K., Mar 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 352, 3, p. 494-508 15 p.

    Research output: Contribution to journalArticle

    22 Scopus citations
    2014

    A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion

    Kale, V. P., Hengst, J. A., Desai, D. H., Dick, T. E., Choe, K. N., Colledge, A. L., Takahashi, Y., Sung, S. S., Amin, S. G. & Yun, J. K., Nov 28 2014, In : Cancer Letters. 354, 2, p. 299-310 12 p.

    Research output: Contribution to journalArticle

    13 Scopus citations

    Characterization of a novel anti-cancer compound for astrocytomas

    Lee, S. Y., Slagle-Webb, B., Rizk, E., Patel, A., Miller, P. A., Sung, S. S. & Connor, J. R., Sep 25 2014, In : PloS one. 9, 9, e108166.

    Research output: Contribution to journalArticle

    5 Scopus citations

    Gambogic acid inhibits multiple myeloma mediated osteoclastogenesis through suppression of chemokine receptor CXCR4 signaling pathways

    Pandey, M. K., Kale, V. P., Song, C., Sung, S. S., Sharma, A. K., Talamo, G., Dovat, S. & Amin, S. G., Oct 1 2014, In : Experimental Hematology. 42, 10, p. 883-896 14 p.

    Research output: Contribution to journalArticle

    26 Scopus citations

    Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells

    Doi, K., Gowda, K., Liu, Q., Lin, J. M., Sung, S., Dower, C., Claxton, D., Loughran, T. P., Amin, S. & Wang, H-G., Dec 1 2014, In : Cancer Biology and Therapy. 15, 12, p. 1688-1699 12 p.

    Research output: Contribution to journalArticle

    6 Scopus citations
    2012

    Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

    Doi, K., Li, R., Sung, S. S., Wu, H., Liu, Y., Manieri, W., Krishnegowda, G., Awwad, A., Dewey, A., Liu, X., Amin, S., Cheng, C., Qin, Y., Schonbrunn, E., Daughdrill, G., Loughran, T. P., Sebti, S. & Wang, H. G., Mar 23 2012, In : Journal of Biological Chemistry. 287, 13, p. 10224-10235 12 p.

    Research output: Contribution to journalArticle

    106 Scopus citations

    Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors

    Li, R., Martin, M. P., Liu, Y., Wang, B., Patel, R. A., Zhu, J. Y., Sun, N., Pireddu, R., Lawrence, N. J., Li, J., Haura, E. B., Sung, S. S., Guida, W. C., Schonbrunn, E. & Sebti, S. M., Mar 8 2012, In : Journal of Medicinal Chemistry. 55, 5, p. 2474-2478 5 p.

    Research output: Contribution to journalArticle

    34 Scopus citations

    Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)

    Pireddu, R., Forinash, K. D., Sun, N. N., Martin, M. P., Sung, S. S., Alexander, B., Zhu, J. Y., Guida, W. C., Schönbrunn, E., Sebti, S. M. & Lawrence, N. J., Jun 2012, In : MedChemComm. 3, 6, p. 699-709 11 p.

    Research output: Contribution to journalArticle

    33 Scopus citations

    Virtual target screening: Validation using kinase inhibitors

    Santiago, D. N., Pevzner, Y., Durand, A. A., Tran, M., Scheerer, R. R., Daniel, K., Sung, S. S., Lee Woodcock, H., Guida, W. C. & Brooks, W. H., Aug 27 2012, In : Journal of Chemical Information and Modeling. 52, 8, p. 2192-2203 12 p.

    Research output: Contribution to journalArticle

    15 Scopus citations
    2011

    The BH3 α-helical mimic BH3-M6 disrupts Bcl-XL, Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner

    Kazi, A., Sun, J., Doi, K., Sung, S. S., Takahashi, Y., Yin, H., Rodriguez, J. M., Becerril, J., Berndt, N., Hamilton, A. D., Wang, H. G. & Sebti, S. M., Mar 18 2011, In : Journal of Biological Chemistry. 286, 11, p. 9382-9392 11 p.

    Research output: Contribution to journalArticle

    90 Scopus citations
    2010

    Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112

    Chen, L., Pernazza, D., Scott, L. M., Lawrence, H. R., Ren, Y., Luo, Y., Wu, X., Sung, S., Guida, W. C., Sebti, S. M., Lawrence, N. J. & Wu, J., Sep 1 2010, In : Biochemical Pharmacology. 80, 6, p. 801-810 10 p.

    Research output: Contribution to journalArticle

    27 Scopus citations
    2009

    Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking

    Lawrence, H. R., Li, Z., Richard Yip, M. L., Sung, S. S., Lawrence, N. J., McLaughlin, M. L., McManus, G. J., Zaworotko, M. J., Sebti, S. M., Chen, J. & Guida, W. C., Jul 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 14, p. 3756-3759 4 p.

    Research output: Contribution to journalArticle

    29 Scopus citations
    2008

    A small-molecule E2F inhibitor blocks growth in a melanoma culture model

    Ma, Y., Kurtyka, C. A., Boyapalle, S., Sung, S. S., Lawrence, H., Guida, W. & Cress, W. D., Aug 1 2008, In : Cancer Research. 68, 15, p. 6292-6299 8 p.

    Research output: Contribution to journalArticle

    54 Scopus citations

    Computational validation of the importance of absolute stereochemistry in virtual screening

    Brooks, W. H., Daniel, K. G., Sung, S. & Guida, W. C., Mar 1 2008, In : Journal of Chemical Information and Modeling. 48, 3, p. 639-645 7 p.

    Research output: Contribution to journalArticle

    34 Scopus citations

    Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds

    Lawrence, H. R., Pireddu, R., Chen, L., Luo, Y., Sung, S., Szymanski, A. M., Yip, M. L. R., Guida, W. C., Sebti, S. M., Wu, J. & Lawrence, N. J., Aug 28 2008, In : Journal of Medicinal Chemistry. 51, 16, p. 4948-4956 9 p.

    Research output: Contribution to journalArticle

    58 Scopus citations
    2006

    Discovery of a novel Shp2 protein tyrosine phosphatase inhibitor

    Chen, L., Sung, S. S., Yip, M. L. R., Lawrence, H. R., Ren, Y., Guida, W. C., Sebti, S. M., Lawrence, N. J. & Wu, J., 2006, In : Molecular pharmacology. 70, 2, p. 562-570 9 p.

    Research output: Contribution to journalArticle

    183 Scopus citations
    1989

    The channel properties of possible gramicidin dimers

    Sung, S. S. & Jordan, P. C., Oct 9 1989, In : Journal of Theoretical Biology. 140, 3, p. 369-380 12 p.

    Research output: Contribution to journalArticle

    9 Scopus citations
    1988

    Theoretical study of double ion occupancy in a gramicidin-like channel

    Sung, S. S. & Jordan, P. C., 1988, In : Journal of physical chemistry. 92, 8, p. 2362-2366 5 p.

    Research output: Contribution to journalArticle

    3 Scopus citations

    Theoretical study of the antiparallel double-stranded helical dimer of gramicidin as an ion channel

    Sung, S. S. & Jordan, P. C., Jan 1 1988, In : Biophysical journal. 54, 3, p. 519-526 8 p.

    Research output: Contribution to journalArticle

    15 Scopus citations
    1987

    The interaction of Cl- with a gramicidin-like channel

    Sung, S. S. & Jordan, P. C., Jul 1987, In : Biophysical Chemistry. 27, 1, p. 1-6 6 p.

    Research output: Contribution to journalArticle

    9 Scopus citations

    Why is gramicidin valence selective? A theoretical study

    Sung, S. S. & Jordan, P. C., 1987, In : Biophysical journal. 51, 4, p. 661-672 12 p.

    Research output: Contribution to journalArticle

    32 Scopus citations
    1986

    NO chemisorption on Ni(111): Coverage effects, site preferences, and adsorption geometry

    Sung, S., Hoffmann, R. & Thiel, P. A., Dec 1 1986, In : Journal of physical chemistry. 90, 7, p. 1380-1388 9 p.

    Research output: Contribution to journalArticle

    30 Scopus citations

    Structures and energetics of monovalent ion-water microclusters

    Sung, S. & Jordan, P. C., Jan 1 1986, In : The Journal of Chemical Physics. 85, 7, p. 4045-4051 7 p.

    Research output: Contribution to journalArticle

    63 Scopus citations

    The close ties between organometallic chemistry, surface science, and the solid state

    Hoffmann, R., Wijeyesekera, S. D. & Sung, S. S., Jan 1 1986, In : Pure and Applied Chemistry. 58, 4, p. 481-494 14 p.

    Research output: Contribution to journalArticle

    11 Scopus citations
    1985

    Bonding in Nitrosylated Iron-Sulfur Clusters

    Sung, S. S., Butler, A. R., Glidewell, C. & Hoffmann, R., Nov 1 1985, In : Inorganic chemistry. 24, 23, p. 3856-3859 4 p.

    Research output: Contribution to journalArticle

    41 Scopus citations

    How Carbon Monoxide Bonds to Metal Surfaces

    Sung, S. S. & Hoffmann, R., Feb 1985, In : Journal of the American Chemical Society. 107, 3, p. 578-584 7 p.

    Research output: Contribution to journalArticle

    266 Scopus citations