Projects per year
Personal profile
Research interests
The long-term research interest in Dr. Shengyu Yang’s lab is to understand the mechanisms underlying cancer metastasis and developing novel therapeutic strategies in the prevention and treatment of cancer metastasis.
The research in the lab currently focus on two areas related to mitochondrial signaling and metabolism in cancer metastasis.
The first area of research effort is to understand how the actin cytoskeleton remodeling in lung adenocarcinoma promotes metastatic colonization by controlling mitochondrial DNA homeostasis and augmenting mitochondrial oxidative phosphorylation. The second area of research effort is to understand the role of mitochondrial calcium signaling in the control of metabolic stress resistance by activating the Keap1-Nrf2 antioxidant response program in metastatic pancreatic cancer.
Teaching and educational interests
Dr. Shengyu Yang is co-directing a new course for medical students at Penn State College of Medicine, Mitochondria in Physiology and Diseases, with Dr. Katherine Aird.
Dr. Yang also lectures on receptor tyrosine kinase signaling, cancer metastasis and mitochondrial dynamics to graduate students.
Education/Academic qualification
Postdoctoral Fellowship, Weill Cornell Medical College
… → 2010
Biophysics, PhD, Chinese Academy of Science
… → 2001
BS, Xiamen University
… → 1996
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Mitochondrial calcium signaling in pancreatic cancer metastasis and progression
Singh, P. & Yang, S.
3/1/22 → 2/28/23
Project: Research project
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Store-operated calcium entry in tumor invasion and metastasis
12/3/13 → 11/30/19
Project: Research project
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BZW1 Facilitates Glycolysis and Promotes Tumor Growth in Pancreatic Ductal Adenocarcinoma Through Potentiating eIF2α Phosphorylation
Li, Z., Ge, Y., Dong, J., Wang, H., Zhao, T., Wang, X., Liu, J., Gao, S., Shi, L., Yang, S., Huang, C. & Hao, J., Apr 2022, In: Gastroenterology. 162, 4, p. 1256-1271.e14Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
ESE3/EHF, a promising target of rosiglitazone, suppresses pancreatic cancer stemness by downregulating CXCR4
Zhou, T., Liu, J., Xie, Y., Yuan, S., Guo, Y., Bai, W., Zhao, K., Jiang, W., Wang, H., Wang, H., Zhao, T., Huang, C., Gao, S., Wang, X., Yang, S. & Hao, J., Feb 1 2022, In: Gut. 71, 2, p. 357-371 15 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
SOX8 Affects Tumoral SPARC Expression by Regulating EZH2 to Attenuate Effectiveness of albumin-bound paclitaxel in PDAC
Gao, S., Hao, J., Yuan, S., Xu, J., Zhou, B., Zhou, Y., Lang, M., Cao, J., Liu, Z. & Yang, S., 2022, In: International Journal of Biological Sciences. 18, 3, p. 911-922 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
CD73 induces gemcitabine resistance in pancreatic ductal adenocarcinoma: A promising target with non-canonical mechanisms
Yu, X., Liu, W., Wang, Z., Wang, H., Liu, J., Huang, C., Zhao, T., Wang, X., Gao, S., Ma, Y., Wu, L., Li, X., Yang, S. & Hao, J., Oct 28 2021, In: Cancer Letters. 519, p. 289-303 15 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression
Lin, S., Li, Y., Wang, D., Huang, C., Marino, D., Bollt, O., Wu, C., Taylor, M. D., Li, W., DeNicola, G. M., Hao, J., Singh, P. K. & Yang, S., Oct 10 2021, In: Cancer Letters. 518, p. 230-242 13 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations