Projects per year
Personal profile
Research interests
The long-term research interest in Dr. Shengyu Yang’s lab is to understand the mechanisms underlying cancer metastasis and developing novel therapeutic strategies in the prevention and treatment of cancer metastasis.
The research in the lab currently focus on two areas related to mitochondrial signaling and metabolism in cancer metastasis.
The first area of research effort is to understand how the actin cytoskeleton remodeling in lung adenocarcinoma promotes metastatic colonization by controlling mitochondrial DNA homeostasis and augmenting mitochondrial oxidative phosphorylation. The second area of research effort is to understand the role of mitochondrial calcium signaling in the control of metabolic stress resistance by activating the Keap1-Nrf2 antioxidant response program in metastatic pancreatic cancer.
Teaching and educational interests
Dr. Shengyu Yang is co-directing a new course for medical students at Penn State College of Medicine, Mitochondria in Physiology and Diseases, with Dr. Katherine Aird.
Dr. Yang also lectures on receptor tyrosine kinase signaling, cancer metastasis and mitochondrial dynamics to graduate students.
Education/Academic qualification
Postdoctoral Fellowship, Weill Cornell Medical College
… → 2010
Biophysics, PhD, Chinese Academy of Science
… → 2001
BS, Xiamen University
… → 1996
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
- 1 Finished
Store-Operated Calcium Entry in Tumor Invasion and Metastasis
12/1/14 → 11/30/15
Project: Research project
Research Output
IL-37/ STAT3/ HIF-1α negative feedback signaling drives gemcitabine resistance in pancreatic cancer
Zhao, T., Jin, F., Xiao, D., Wang, H., Huang, C., Wang, X., Gao, S., Liu, J., Yang, S. & Hao, J., Jan 1 2020, In : Theranostics. 10, 9, p. 4088-4100 13 p.Research output: Contribution to journal › Article
Open Access
PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma (PDAC), and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC
Wang, X., Li, X., Wei, X., Jiang, H., Lan, C., Yang, S., Wang, H., Yang, Y., Tian, C., Xu, Z., Zhang, J., Hao, J. & Ren, H., Dec 1 2020, In : Signal Transduction and Targeted Therapy. 5, 1, 38.Research output: Contribution to journal › Article
Open Access
Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments
Lin, S., Huang, C., Gunda, V., Sun, J., Chellappan, S. P., Li, Z., Izumi, V., Fang, B., Koomen, J., Singh, P. K., Hao, J. & Yang, S., Sep 10 2019, In : Cell Reports. 28, 11, p. 2824-2836.e8Research output: Contribution to journal › Article
Open Access
3
Scopus
citations
Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC
Alhothali, M., Mathew, M., Iyer, G., Lawrence, H. R., Yang, S., Chellappan, S. & Padmanabhan, J., May 16 2019, In : International journal of molecular sciences. 20, 10Research output: Contribution to journal › Article
Open Access
1
Scopus
citations
Imaging elemental events of store-operated Ca2+ entry in invading cancer cells with plasmalemmal targeted sensors
Lu, F., Sun, J., Zheng, Q., Li, J., Hu, Y., Yu, P., He, H., Zhao, Y., Wang, X., Yang, S. & Cheng, H., Mar 1 2019, In : Journal of Cell Science. 132, 6, 224923.Research output: Contribution to journal › Article
Open Access
2
Scopus
citations