Research output per year
Research output per year
Personal profile
Research interests
The long-term research interest in Dr. Shengyu Yang’s lab is to understand the mechanisms underlying cancer metastasis and developing novel therapeutic strategies in the prevention and treatment of cancer metastasis.
The research in the lab currently focus on two areas related to mitochondrial signaling and metabolism in cancer metastasis.
The first area of research effort is to understand how the actin cytoskeleton remodeling in lung adenocarcinoma promotes metastatic colonization by controlling mitochondrial DNA homeostasis and augmenting mitochondrial oxidative phosphorylation. The second area of research effort is to understand the role of mitochondrial calcium signaling in the control of metabolic stress resistance by activating the Keap1-Nrf2 antioxidant response program in metastatic pancreatic cancer.
Teaching and educational interests
Dr. Shengyu Yang is co-directing a new course for medical students at Penn State College of Medicine, Mitochondria in Physiology and Diseases, with Dr. Katherine Aird.
Dr. Yang also lectures on receptor tyrosine kinase signaling, cancer metastasis and mitochondrial dynamics to graduate students.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Postdoctoral Fellowship, Weill Cornell Medical College
… → 2010
Biophysics, PhD, Chinese Academy of Science
… → 2001
BS, Xiamen University
… → 1996
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BZW1 Facilitates Glycolysis and Promotes Tumor Growth in Pancreatic Ductal Adenocarcinoma Through Potentiating eIF2α Phosphorylation
Li, Z., Ge, Y., Dong, J., Wang, H., Zhao, T., Wang, X., Liu, J., Gao, S., Shi, L., Yang, S., Huang, C. & Hao, J., Apr 2022, In: Gastroenterology. 162, 4, p. 1256-1271.e14Research output: Contribution to journal › Article › peer-review
8 Citations (SciVal) -
ESE3/EHF, a promising target of rosiglitazone, suppresses pancreatic cancer stemness by downregulating CXCR4
Zhou, T., Liu, J., Xie, Y., Yuan, S., Guo, Y., Bai, W., Zhao, K., Jiang, W., Wang, H., Wang, H., Zhao, T., Huang, C., Gao, S., Wang, X., Yang, S. & Hao, J., Feb 1 2022, In: Gut. 71, 2, p. 357-371 15 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
ESE3-positive PSCs drive pancreatic cancer fibrosis, chemoresistance and poor prognosis via tumour–stromal IL-1β/NF–κB/ESE3 signalling axis
Zhao, T., Xiao, D., Jin, F., Sun, X., Yu, J., Wang, H., Liu, J., Cai, W., Huang, C., Wang, X., Gao, S., Liu, Z., Yang, S., Gao, C. & Hao, J., Nov 1 2022, In: British Journal of Cancer. 127, 8, p. 1461-1472 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer
Wang, X., Li, Y., Li, Z., Lin, S., Wang, H., Sun, J., Lan, C., Wu, L., Sun, D., Huang, C., Singh, P. K., Hempel, N., Trebak, M., DeNicola, G. M., Hao, J. & Yang, S., Jun 15 2022, In: Cancer Research. 82, 12, p. 2254-2268 15 p.Research output: Contribution to journal › Article › peer-review
14 Citations (SciVal) -
Recent advances in small-molecule fluorescent probes for studying ferroptosis
Qi, Y. L., Wang, H. R., Chen, L. L., Duan, Y. T., Yang, S. Y. & Zhu, H. L., Sep 2 2022, In: Chemical Society Reviews. 51, 18, p. 7752-7778 27 p.Research output: Contribution to journal › Review article › peer-review
6 Scopus citations