Projects per year
Personal profile
Research interests
The long-term research interest in Dr. Shengyu Yang’s lab is to understand the mechanisms underlying cancer metastasis and developing novel therapeutic strategies in the prevention and treatment of cancer metastasis.
The research in the lab currently focus on two areas related to mitochondrial signaling and metabolism in cancer metastasis.
The first area of research effort is to understand how the actin cytoskeleton remodeling in lung adenocarcinoma promotes metastatic colonization by controlling mitochondrial DNA homeostasis and augmenting mitochondrial oxidative phosphorylation. The second area of research effort is to understand the role of mitochondrial calcium signaling in the control of metabolic stress resistance by activating the Keap1-Nrf2 antioxidant response program in metastatic pancreatic cancer.
Teaching and educational interests
Dr. Shengyu Yang is co-directing a new course for medical students at Penn State College of Medicine, Mitochondria in Physiology and Diseases, with Dr. Katherine Aird.
Dr. Yang also lectures on receptor tyrosine kinase signaling, cancer metastasis and mitochondrial dynamics to graduate students.
Education/Academic qualification
Postdoctoral Fellowship, Weill Cornell Medical College
… → 2010
Biophysics, PhD, Chinese Academy of Science
… → 2001
BS, Xiamen University
… → 1996
Fingerprint Dive into the research topics where Shengyu Yang is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Neoplasm Metastasis
Medicine & Life Sciences
Neoplasms
Medicine & Life Sciences
Adenocarcinoma
Medicine & Life Sciences
Cell Movement
Medicine & Life Sciences
Pancreatic Neoplasms
Medicine & Life Sciences
Cells
Chemical Compounds
Actins
Medicine & Life Sciences
Melanoma
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2013 2023
Neoplasm Metastasis
Neoplasms
Actin Cytoskeleton
fascin
AMP-Activated Protein Kinases
Store-Operated Calcium Entry in Tumor Invasion and Metastasis
12/3/13 → 11/30/19
Project: Research project
Melanoma
Neoplasm Metastasis
Calcium
Neoplasms
Basement Membrane
Research Output 2000 2019
2
Citations
(Scopus)
Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments
Lin, S., Huang, C., Gunda, V., Sun, J., Chellappan, S. P., Li, Z., Izumi, V., Fang, B., Koomen, J., Singh, P. K., Hao, J. & Yang, S., Sep 10 2019, In : Cell Reports. 28, 11, p. 2824-2836.e8Research output: Contribution to journal › Article
Open Access
Oxidative Phosphorylation
Actin Cytoskeleton
Actins
Lung Neoplasms
Physiological Stress
Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC
Alhothali, M., Mathew, M., Iyer, G., Lawrence, H. R., Yang, S., Chellappan, S. & Padmanabhan, J., May 16 2019, In : International journal of molecular sciences. 20, 10Research output: Contribution to journal › Article
Open Access
Fendiline
combat
Therapeutic Uses
Tumors
tumors
2
Citations
(Scopus)
Imaging elemental events of store-operated Ca2+ entry in invading cancer cells with plasmalemmal targeted sensors
Lu, F., Sun, J., Zheng, Q., Li, J., Hu, Y., Yu, P., He, H., Zhao, Y., Wang, X., Yang, S. & Cheng, H., Mar 1 2019, In : Journal of Cell Science. 132, 6, 224923.Research output: Contribution to journal › Article
Open Access
Neoplasms
Biosensing Techniques
Calmodulin
Melanoma
Interviews
LIMS1 promotes pancreatic cancer cell survival under oxygen-glucose deprivation conditions by enhancing HIF1A protein translation
Huang, C., Li, Y., Li, Z., Xu, Y., Li, N., Ge, Y., Dong, J., Chang, A., Zhao, T., Wang, X., Wang, H., Yang, S., Xie, K., Hao, J. & Ren, H., Jan 1 2019, In : Clinical Cancer Research. 25, 13, p. 4091-4103 13 p.Research output: Contribution to journal › Article
Protein Biosynthesis
Pancreatic Neoplasms
Cell Survival
Oxygen
Glucose
1
Citation
(Scopus)
The diverse contributions of fucose linkages in cancer
Keeley, T. S., Yang, S. & Lau, E., Sep 2019, In : Cancers. 11, 9, 1241.Research output: Contribution to journal › Article
Open Access
Fucose
Polysaccharides
Biological Phenomena
Post Translational Protein Processing
Neoplasms