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Personal profile

Research interests

The long-term research interest in Dr. Shengyu Yang’s lab is to understand the mechanisms underlying cancer metastasis and developing novel therapeutic strategies in the prevention and treatment of cancer metastasis.

The research in the lab currently focus on two areas related to mitochondrial signaling and metabolism in cancer metastasis.

The first area of research effort is to understand how the actin cytoskeleton remodeling in lung adenocarcinoma promotes metastatic colonization by controlling mitochondrial DNA homeostasis and augmenting mitochondrial oxidative phosphorylation. The second area of research effort is to understand the role of mitochondrial calcium signaling in the control of metabolic stress resistance by activating the Keap1-Nrf2 antioxidant response program in metastatic pancreatic cancer.

Teaching and educational interests

Dr. Shengyu Yang is co-directing a new course for medical students at Penn State College of Medicine, Mitochondria in Physiology and Diseases, with Dr. Katherine Aird.

Dr. Yang also lectures on receptor tyrosine kinase signaling, cancer metastasis and mitochondrial dynamics to graduate students.

Education/Academic qualification

Postdoctoral Fellowship, Weill Medical College

… → 2010

Biophysics, PhD, Chinese Academy of Science

… → 2001

BS, Xiamen University

… → 1996

Fingerprint Dive into the research topics where Shengyu Yang is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Neoplasm Metastasis Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Adenocarcinoma Medicine & Life Sciences
Cell Movement Medicine & Life Sciences
Pancreatic Neoplasms Medicine & Life Sciences
Cells Chemical Compounds
Actins Medicine & Life Sciences
Melanoma Medicine & Life Sciences

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Projects 2013 2023

Neoplasm Metastasis
Actin Cytoskeleton
Neoplasms
AMP-Activated Protein Kinases
fascin
Melanoma
Neoplasm Metastasis
Calcium
Neoplasms
Basement Membrane

Research Output 2000 2019

  • 1315 Citations
  • 15 h-Index
  • 40 Article
  • 3 Chapter
  • 1 Comment/debate

Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments

Lin, S., Huang, C., Gunda, V., Sun, J., Chellappan, S. P., Li, Z., Izumi, V., Fang, B., Koomen, J., Singh, P. K., Hao, J. & Yang, S., Sep 10 2019, In : Cell Reports. 28, 11, p. 2824-2836.e8

Research output: Contribution to journalArticle

Open Access
Oxidative Phosphorylation
Actin Cytoskeleton
Actins
Lung Neoplasms
Physiological Stress

Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC

Alhothali, M., Mathew, M., Iyer, G., Lawrence, H. R., Yang, S., Chellappan, S. & Padmanabhan, J., May 16 2019, In : International journal of molecular sciences. 20, 10

Research output: Contribution to journalArticle

Open Access
Fendiline
combat
Therapeutic Uses
Tumors
tumors
1 Citation (Scopus)

Imaging elemental events of store-operated Ca2+ entry in invading cancer cells with plasmalemmal targeted sensors

Lu, F., Sun, J., Zheng, Q., Li, J., Hu, Y., Yu, P., He, H., Zhao, Y., Wang, X., Yang, S. & Cheng, H., Mar 1 2019, In : Journal of Cell Science. 132, 6, 224923.

Research output: Contribution to journalArticle

Open Access
Neoplasms
Biosensing Techniques
Calmodulin
Melanoma
Interviews

LIMS1 promotes pancreatic cancer cell survival under oxygen-glucose deprivation conditions by enhancing HIF1A protein translation

Huang, C., Li, Y., Li, Z., Xu, Y., Li, N., Ge, Y., Dong, J., Chang, A., Zhao, T., Wang, X., Wang, H., Yang, S., Xie, K., Hao, J. & Ren, H., Jan 1 2019, In : Clinical Cancer Research. 25, 13, p. 4091-4103 13 p.

Research output: Contribution to journalArticle

Protein Biosynthesis
Pancreatic Neoplasms
Cell Survival
Oxygen
Glucose

The diverse contributions of fucose linkages in cancer

Keeley, T. S., Yang, S. & Lau, E., Sep 1 2019, In : Cancers. 11, 9, 1241.

Research output: Contribution to journalArticle

Open Access
Fucose
Polysaccharides
Biological Phenomena
Post Translational Protein Processing
Neoplasms