• 1962 Citations
  • 19 h-Index
1979 …2019
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Fingerprint Dive into the research topics where Shu-jen Chen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Transforming Growth Factors Medicine & Life Sciences
Fibroblasts Medicine & Life Sciences
Transient Receptor Potential Channels Medicine & Life Sciences
Procollagen Medicine & Life Sciences
Skin Medicine & Life Sciences
Ion Channels Medicine & Life Sciences
Neuroblastoma Medicine & Life Sciences
Binding Sites Medicine & Life Sciences

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Research Output 1979 2019

  • 1962 Citations
  • 19 h-Index
  • 32 Article

The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2

Bao, L., Festa, F., Freet, C. S., Lee, J. P., Hirschler-Laszkiewicz, I. M., Chen, S. J., Keefer, K. A., Wang, H. G., Patterson, A. D., Cheung, J. Y. & Miller, B. A., Dec 1 2019, In : Scientific reports. 9, 1, 14132.

Research output: Contribution to journalArticle

Open Access
Transient Receptor Potential Channels
Ion Channels
Cell Survival
NADP
NAD
6 Citations (Scopus)

The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation

Hirschler-Laszkiewicz, I., Chen, S., Bao, L., Wang, J., Zhang, X. Q., Santhanam, S., Keefer, K., Madesh, M., Cheung, J. Y. & Miller, B., Oct 6 2018, In : American Journal of Physiology - Cell Physiology. 315, 4, p. C571-C586

Research output: Contribution to journalArticle

Focal Adhesion Kinase 2
Transient Receptor Potential Channels
Neuroblastoma
Ion Channels
Cell Survival
20 Citations (Scopus)

Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics

Bao, L., Chen, S., Conrad, K., Keefer, K., Abraham, T., Lee, J. P., Wang, J. F., Zhang, X. Q., Hirschler-Laszkiewicz, I., Wang, H-G., Dovat, S., Gans, B., Madesh, M., Cheung, J. Y. & Miller, B., Nov 18 2016, In : Journal of Biological Chemistry. 291, 47, p. 24449-24464 16 p.

Research output: Contribution to journalArticle

Neuroblastoma
Ion Channels
Energy Metabolism
Reactive Oxygen Species
Cell Survival
42 Citations (Scopus)

A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α

Chen, S., Hoffman, N. E., Shanmughapriy, S., Bao, L., Keefer, K., Conrad, K., Merali, S., Takahashi, Y., Abraham, T., Hirschler-Laszkiewicz, I., Wang, J. F., Zhang, X. Q., Song, J., Barrero, C., Shi, Y., Imamura, Y., Bayerl, M., Sun, T., Barbour, M., Wang, H-G. & 3 others, Madesh, M., Cheung, J. Y. & Miller, B., Jan 1 2014, In : Journal of Biological Chemistry. 289, 52, p. 36284-36302 19 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Neuroblastoma
Ion Channels
Tumors
Growth
25 Citations (Scopus)

Role of TRPM2 in cell proliferation and susceptibility to oxidative stress

Chen, S. J., Zhang, W., Tong, Q., Conrad, K., Hirschler-Laszkiewicz, I., Bayerl, M., Kim, J. K., Cheung, J. Y. & Miller, B. A., Jun 10 2013, In : American Journal of Physiology - Cell Physiology. 304, 6, p. C548-C560

Research output: Contribution to journalArticle

Oxidative Stress
Cell Proliferation
Phosphatidylinositol 3-Kinase
Cell Survival
Facilitative Glucose Transport Proteins