• 1194 Citations
  • 21 h-Index
1991 …2020

Research output per year

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Research Output

2020

Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis

Li, Y., Liao, Z., Luo, H., Benyoucef, A., Kang, Y., Lai, Q., Dovat, S., Miller, B., Chepelev, I., Li, Y., Zhao, K., Brand, M. & Huang, S., Apr 6 2020, In : Nucleic acids research. 48, 6, p. 3119-3133 15 p.

Research output: Contribution to journalArticle

Open Access

Cellular signaling and epigenetic regulation of gene expression in leukemia

Gowda, C., Song, C., Ding, Y., Iyer, S., Dhanyamraju, P. K., McGrath, M., Bamme, Y., Soliman, M., Kane, S., Payne, J. L. & Dovat, S., Jan 2020, In : Advances in Biological Regulation. 75, 100665.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Regulation of small GTPase Rab20 by ikaros in B-cell acute lymphoblastic leukemia

Payne, J. L., Song, C., Ding, Y., Dhanyamraju, P. K., Bamme, Y., Schramm, J. W., Desai, D., Sharma, A., Gowda, C. & Dovat, S., Mar 1 2020, In : International journal of molecular sciences. 21, 5, 1718.

Research output: Contribution to journalArticle

Open Access

RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1

Elcheva, I. A., Wood, T., Chiarolanzio, K., Chim, B., Wong, M., Singh, V., Gowda, C. P., Lu, Q., Hafner, M., Dovat, S., Liu, Z., Muljo, S. A. & Spiegelman, V. S., May 1 2020, In : Leukemia. 34, 5, p. 1354-1363 10 p.

Research output: Contribution to journalArticle

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia

Annageldiyev, C., Gowda, K., Patel, T., Bhattacharya, P., Tan, S. F., Iyer, S., Desai, D., Dovat, S., Feith, D. J., Loughran, T. P., Amin, S., Claxton, D. & Sharma, A., Mar 1 2020, In : Haematologica. 105, 3, p. 687-696 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Luo, H., Sobh, A., Vulpe, C. D., Brewer, E., Dovat, S., Qiu, Y. & Huang, S., Mar 31 2019, In : Journal of visualized experiments : JoVE. 145

Research output: Contribution to journalArticle

Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity

Ding, Y., Zhang, B., Payne, J. L., Song, C., Ge, Z., Gowda, C., Iyer, S., Dhanyamraju, P. K., Dorsam, G., Reeves, M. E., Desai, D., Huang, S., Payne, K. J., Yue, F. & Dovat, S., Nov 1 2019, In : Leukemia. 33, 11, p. 2720-2731 12 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells

Nicolae, C. M., O’Connor, M. J., Schleicher, E. M., Song, C., Gowda, R., Robertson, G., Dovat, S. & Moldovan, G. L., Jul 4 2019, In : Oncogene. 38, 27, p. 5530-5540 11 p.

Research output: Contribution to journalArticle

RAG1 high expression associated with IKZF1 dysfunction in adult B-cell acute lymphoblastic leukemia

Han, Q., Ma, J., Gu, Y., Song, H., Kapadia, M., Kawasawa, Y. I., Dovat, S., Song, C. & Ge, Z., Jan 1 2019, In : Journal of Cancer. 10, 16, p. 3842-3850 9 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia

Cury, N. M., Mühlethaler, T., Laranjeira, A. B. A., Canevarolo, R. R., Zenatti, P. P., Lucena-Agell, D., Barasoain, I., Song, C., Sun, D., Dovat, S., Yunes, R. A., Prota, A. E., Steinmetz, M. O., Díaz, J. F. & Yunes, J. A., Nov 22 2019, In : iScience. 21, p. 95-109 15 p.

Research output: Contribution to journalArticle

Open Access
2018

Aberrant ARID5B expression and its association with Ikaros dysfunction in acute lymphoblastic leukemia

Ge, Z., Han, Q., Gu, Y., Ge, Q., Ma, J., Sloane, J., Gao, G., Payne, K. J., Szekely, L., Song, C. & Dovat, S., Nov 1 2018, In : Oncogenesis. 7, 11, 84.

Research output: Contribution to journalArticle

7 Scopus citations

New rapid method to detect BCR-ABL fusion genes with multiplex RT-qPCR in one-tube at a time

Tong, Y. Q., Zhao, Z. J., Liu, B., Bao, A. Y., Zheng, H. Y., Gu, J., Xia, Y., McGrath, M., Dovat, S., Song, C. & Li, Y., Jun 2018, In : Leukemia Research. 69, p. 47-53 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia

Ge, Z., Gu, Y., Han, Q., Sloane, J., Ge, Q., Gao, G., Ma, J., Song, H., Hu, J., Chen, B., Dovat, S. & Song, C., Jan 2018, In : Epigenomics. 10, 1, p. 59-69 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

A novel dual inhibitor of microtubule and Bruton's tyrosine kinase inhibits survival of multiple myeloma and osteoclastogenesis

Pandey, M. K., Gowda, K., Sung, S. S., Abraham, T., Budak-Alpdogan, T., Talamo, G., Dovat, S. & Amin, S., Sep 2017, In : Experimental Hematology. 53, p. 31-42 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia

Gowda, C., Soliman, M., Kapadia, M., Ding, Y., Payne, K. & Dovat, S., Aug 2017, In : Advances in Biological Regulation. 65, p. 16-25 10 p.

Research output: Contribution to journalReview article

15 Scopus citations

Casein kinase II (CK2) as a therapeutic target for hematological malignancies

Gowda, C., Sachdev, M., Muthusami, S., Kapadia, M., Petrovic-Dovat, L., Hartman, M., Ding, Y., Song, C., Payne, J. L., Tan, B. H. & Dovat, S., Jan 1 2017, In : Current Pharmaceutical Design. 23, 1, p. 95-107 13 p.

Research output: Contribution to journalReview article

11 Scopus citations

Corrigendum: Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia

Ge, Z., Gu, Y., Han, Q., Zhao, G., Li, M., Li, J., Chen, B., Sun, T., Dovat, S., Gale, R. P. & Song, C., Jan 11 2017, In : Scientific reports. 7, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Germline IKAROS mutation associated with primary immunodeficiency that progressed to T-cell acute lymphoblastic leukemia

Yoshida, N., Sakaguchi, H., Muramatsu, H., Okuno, Y., Song, C., Dovat, S., Shimada, A., Ozeki, M., Ohnishi, H., Teramoto, T., Fukao, T., Kondo, N., Takahashi, Y., Matsumoto, K., Kato, K. & Kojima, S., May 1 2017, In : Leukemia. 31, 5, p. 1221-1223 3 p.

Research output: Contribution to journalLetter

11 Scopus citations

Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia

Ge, Z., Zhou, X., Gu, Y., Han, Q., Li, J., Chen, B., Ge, Q., Dovat, E., Payne, J. L., Sun, T., Song, C. & Dovat, S., Jan 1 2017, In : Oncotarget. 8, 5, p. 8022-8034 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Regulation of cellular proliferation in acute lymphoblastic leukemia by Casein Kinase II (CK2) and Ikaros

Gowda, C., Song, C., Kapadia, M., Payne, J. L., Hu, T., Ding, Y. & Dovat, S., Jan 1 2017, In : Advances in Biological Regulation. 63, p. 71-80 10 p.

Research output: Contribution to journalReview article

19 Scopus citations

STAT5 alters the state of transcriptional networks, driving aggressive leukemia

Dovat, S. & Payne, K. J., May 18 2017, In : Nature Immunology. 18, 6, p. 597-598 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
2016

Amplexicaule A exerts anti-tumor effects by inducing apoptosis in human breast cancer

Xiang, M., Su, H., Shu, G., Wan, D., He, F., Loaec, M., Ding, Y., Li, J., Dovat, S., Yang, G. & Song, C., Jan 1 2016, In : Oncotarget. 7, 14, p. 18521-18530 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis

Francis, O. L., Milford, T. A. M., Martinez, S. R., Baez, I., Coats, J. S., Mayagoitia, K., Concepcion, K. R., Ginelli, E., Beldiman, C., Benitez, A., Weldon, A. J., Arogyaswamy, K., Shiraz, P., Fisher, R., Morris, C. L., Zhang, X. B., Filippov, V., van Handel, B., Ge, Z., Song, C. & 3 others, Dovat, S., Su, R. J. & Payne, K. J., Mar 31 2016, In : Haematologica. 101, 4, p. 417-426 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Co-existence of IL7R high and SH2B3 low expression distinguishes a novel high-risk acute lymphoblastic leukemia with Ikaros dysfunction

Ge, Z., Gu, Y., Xiao, L., Han, Q., Li, J., Chen, B., Yu, J., Kawasawa, Y. I., Payne, K. J., Dovat, S. & Song, C., Jan 1 2016, In : Oncotarget. 7, 29, p. 46014-46027 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics

Bao, L., Chen, S. J., Conrad, K., Keefer, K., Abraham, T., Lee, J. P., Wang, J. F., Zhang, X. Q., Hirschler-Laszkiewicz, I., Wang, H. G., Dovat, S., Gans, B., Madesh, M., Cheung, J. Y. & Miller, B. A., Nov 18 2016, In : Journal of Biological Chemistry. 291, 47, p. 24449-24464 16 p.

Research output: Contribution to journalArticle

23 Scopus citations

Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia

Song, C., Pan, X., Ge, Z., Gowda, C., Ding, Y., Li, H., Li, Z., Yochum, G., Muschen, M., Li, Q., Payne, K. J. & Dovat, S., Jun 1 2016, In : Leukemia. 30, 6, p. 1436-1440 5 p.

Research output: Contribution to journalLetter

19 Scopus citations

High CRLF2 expression associates with IKZF1 dysfunction in adult acute lymphoblastic leukemia without CRLF2 rearrangement

Ge, Z., Gu, Y., Zhao, G., Li, J., Chen, B., Han, Q., Guo, X., Liu, J., Li, H., Yu, M. D., Olson, J., Steffens, S., Payne, K. J., Song, C. & Dovat, S., Jan 1 2016, In : Oncotarget. 7, 31, p. 49722-49732 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia

Ge, Z., Li, M., Zhao, G., Xiao, L., Gu, Y., Zhou, X., Yu, M. D., Li, J., Dovat, S. & Song, C., Oct 2016, In : Oncology Letters. 12, 4, p. 2746-2751 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Protein signaling and regulation of gene transcription in leukemia: Role of the Casein Kinase II-Ikaros axis

Gowda, C., Song, C., Ding, Y., Kapadia, M. & Dovat, S., Jan 1 2016, In : Journal of Investigative Medicine. 64, 3, p. 735-739 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Targeting high dynamin-2 (DNM2) expression by restoring ikaros function in acute lymphoblastic leukemia

Ge, Z., Gu, Y., Han, Q., Zhao, G., Li, M., Li, J., Chen, B., Sun, T., Dovat, S., Gale, R. P. & Song, C., Nov 25 2016, In : Scientific reports. 6, 38004.

Research output: Contribution to journalArticle

13 Scopus citations

Transcriptional regulation of JARID1B/KDM5B histone demethylase by ikaros, histone deacetylase 1 (HDAC1), and casein kinase 2 (CK2) in B-cell acute lymphoblastic leukemia

Wang, H., Song, C., Ding, Y., Pan, X., Ge, Z., Tan, B. H., Gowda, C., Sachdev, M., Muthusami, S., Ouyang, H., Lai, L., Francis, O. L., Morris, C. L., Abdel-Azim, H., Dorsam, G., Xiang, M., Payne, K. J. & Dovat, S., Feb 19 2016, In : Journal of Biological Chemistry. 291, 8, p. 4004-4018 15 p.

Research output: Contribution to journalArticle

26 Scopus citations

TSLP or IL-7 provide an IL-7Rα signal that is critical for human B lymphopoiesis

Milford, T. A. M., Su, R. J., Francis, O. L., Baez, I., Martinez, S. R., Coats, J. S., Weldon, A. J., Calderon, M. N., Nwosu, M. C., Botimer, A. R., Suterwala, B. T., Zhang, X. B., Morris, C. L., Weldon, D. J., Dovat, S. & Payne, K. J., Sep 1 2016, In : European Journal of Immunology. 46, 9, p. 2155-2161 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

WDR5 high expression and its effect on tumorigenesis in leukemia

Ge, Z., Song, E. J., Kawasawa, Y. I., Li, J., Dovat, S. & Song, C., Jan 1 2016, In : Oncotarget. 7, 25, p. 37740-37754 15 p.

Research output: Contribution to journalArticle

21 Scopus citations
2015

Arrhythmogenic biophysical phenotype for SCN5A mutation S1787N depends upon splice variant background and intracellular acidosis

Hu, R. M., Tan, B. H., Tester, D. J., Song, C., He, Y., Dovat, S., Peterson, B. Z., Ackerman, M. J. & Makielski, J. C., Apr 29 2015, In : PloS one. 10, 4, e0124921.

Research output: Contribution to journalArticle

11 Scopus citations

Characterization of LEF1 high expression and novel mutations in adult acute lymphoblastic leukemia

Guo, X., Zhang, R., Liu, J., Li, M., Song, C., Dovat, S., Li, J. & Ge, Z., May 5 2015, In : PloS one. 10, 5, e0125429.

Research output: Contribution to journalArticle

23 Scopus citations

Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia

Ge, Z., Guo, X., Li, J., Hartman, M., Kawasawa, Y. I., Dovat, S. & Song, C., Jan 1 2015, In : Oncotarget. 6, 39, p. 42300-42311 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia

Song, C., Gowda, C., Pan, X., Ding, Y., Tong, Y., Tan, B. H., Wang, H., Muthusami, S., Ge, Z., Sachdev, M., Amin, S. G., Desai, D., Gowda, K., Gowda, R., Robertson, G. P., Schjerven, H., Muschen, M., Payne, K. J. & Dovat, S., Oct 8 2015, In : Blood. 126, 15, p. 1813-1822 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Translating basic science discoveries to clinical practice-Let us not repeat the naiveté of the pre-omics era

Payne, K. J., Benitez, A. & Dovat, S., Mar 2015, In : Annals of Translational Medicine. 3, 4, 46.

Research output: Contribution to journalEditorial

2014

Epstein-Barr virus utilizes ikaros in regulating its latent-lytic switch in B cells

Iempridee, T., Reusch, J. A., Riching, A., Johannsen, E. C., Dovat, S., Kenney, S. C. & Mertz, J. E., May 2014, In : Journal of virology. 88, 9, p. 4811-4827 17 p.

Research output: Contribution to journalArticle

13 Scopus citations

G0S2-A new player in leukemia

Payne, K. J. & Dovat, S., Feb 1 2014, In : Leukemia Research. 38, 2, p. 147-148 2 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Gambogic acid inhibits multiple myeloma mediated osteoclastogenesis through suppression of chemokine receptor CXCR4 signaling pathways

Pandey, M. K., Kale, V. P., Song, C., Sung, S. S., Sharma, A. K., Talamo, G., Dovat, S. & Amin, S. G., Oct 1 2014, In : Experimental Hematology. 42, 10, p. 883-896 14 p.

Research output: Contribution to journalArticle

26 Scopus citations

Pathogenesis and regulation of cellular proliferation in acute lymphoblastic leukemia - The role of Ikaros

Wang, H., Ouyang, H., Lai, L., Petrovic-Dovat, L., Stankov, K., Bogdanovic, G. & Dovat, S., Jan 1 2014, In : Journal of B.U.ON.. 19, 1, p. 22-28 7 p.

Research output: Contribution to journalReview article

9 Scopus citations

Protein Phosphatase 1 (PP1) and Casein Kinase II (CK2) regulate Ikaros-mediated repression of TdT in thymocytes and T-cell leukemia

Wang, H., Song, C., Gurel, Z., Song, N., Ma, J., Ouyang, H., Lai, L., Payne, K. J. & Dovat, S., Dec 1 2014, In : Pediatric Blood and Cancer. 61, 12, p. 2230-2235 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Genetic targets in pediatric acute lymphoblastic leukemia

Gowda, C. & Dovat, S., Feb 15 2013, Impact of Genetic Targets on Cancer Therapy. El-Deiry, W. (ed.). p. 327-340 14 p. (Advances in Experimental Medicine and Biology; vol. 779).

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations

Ikaros: The enhancer makes the difference

Dovat, S., Oct 31 2013, In : Blood. 122, 18, p. 3091-3092 2 p.

Research output: Contribution to journalReview article

2 Scopus citations

Induction of senescence by adenosine suppressing the growth of lung cancer cells

Yang, D., Song, J., Wu, L., Ma, Y., Song, C., Dovat, S., Nishizaki, T. & Liu, J., Oct 11 2013, In : Biochemical and Biophysical Research Communications. 440, 1, p. 62-67 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
2012

Angiogenesis and survival in patients with myelodysplastic syndrome

Savic, A., Cemerikic-Martinovic, V., Dovat, S., Rajic, N., Urosevic, I., Sekulic, B., Kvrgic, V. & Popovic, S., Jul 1 2012, In : Pathology and Oncology Research. 18, 3, p. 681-690 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Cell cycle-specific function of Ikaros in human leukemia

Li, Z., Song, C., Ouyang, H., Lai, L., Payne, K. J. & Dovat, S., Jul 15 2012, In : Pediatric Blood and Cancer. 59, 1, p. 69-76 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the ikaros gene

Goldman, F. D., Gurel, Z., Al-Zubeidi, D., Fried, A. J., Icardi, M., Song, C. & Dovat, S., Apr 1 2012, In : Pediatric Blood and Cancer. 58, 4, p. 591-597 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros

Uckun, F. M., Ma, H., Zhang, J., Ozer, Z., Dovat, S., Mao, C., Ishkhanian, R., Goodman, P. & Qazi, S., Oct 30 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 44, p. 18072-18077 6 p.

Research output: Contribution to journalArticle

31 Scopus citations