Spencer Szczesny, PhD

    • 432 Citations
    • 14 h-Index
    20042019
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    Personal profile

    Research interests

    Dr. Spencer Szczesny heads the Multiscale Biomechanics and Mechanobiology Lab, which is part of the departments of Biomedical Engineering and Orthopaedics and Rehabilitation at Penn State. His research investigates the interplay between tendon multiscale mechanics and mechanobiology in the context of tissue remodeling (e.g., degeneration, repair and development). The ultimate goals of his work are to identify the causes of tendon pathology, discover novel therapeutic options and direct the design of biomaterials that can recapitulate the behavior of native tissue. This multidisciplinary research involves the use of multiscale mechanical testing, computational modeling, cell and tissue culture and biomaterial fabrication.

    Education/Academic qualification

    PhD, University of Pennsylvania

    … → May 2015

    MS, Massachusetts Institute of Technology

    … → May 2005

    BS, University of Pennsylvania

    … → May 2003

    Fingerprint Dive into the research topics where Spencer Szczesny is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

    • 5 Similar Profiles
    Tendons Engineering & Materials Science
    Mechanics Medicine & Life Sciences
    Hydrogels Engineering & Materials Science
    Tissue Engineering & Materials Science
    Collagen Medicine & Life Sciences
    Fibers Engineering & Materials Science
    Compliant mechanisms Engineering & Materials Science
    Rotator Cuff Medicine & Life Sciences

    Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Projects 2016 2018

    Tendons
    Stem Cells
    Fatigue
    Cell Differentiation
    Tendinopathy

    Research Output 2004 2019

    • 432 Citations
    • 14 h-Index
    • 22 Article
    • 9 Conference contribution
    • 3 Review article
    Hydrogels
    Nucleic acids
    Fibroblast Growth Factor 2
    Fibroblasts
    Nucleic Acids
    9 Citations (Scopus)

    Expansion of mesenchymal stem cells on electrospun scaffolds maintains stemness, mechano-responsivity, and differentiation potential

    Heo, S. J., Szczesny, S., Kim, D. H., Saleh, K. S. & Mauck, R. L., Feb 1 2018, In : Journal of Orthopaedic Research. 36, 2, p. 808-815 8 p.

    Research output: Contribution to journalArticle

    Mesenchymal Stromal Cells
    Plastics
    Tissue Engineering
    Tissue Scaffolds
    Phenotype
    5 Citations (Scopus)

    Fatigue loading of tendon results in collagen kinking and denaturation but does not change local tissue mechanics

    Szczesny, S., Aeppli, C., David, A. & Mauck, R. L., Apr 11 2018, In : Journal of Biomechanics. 71, p. 251-256 6 p.

    Research output: Contribution to journalArticle

    Denaturation
    Tendons
    Mechanics
    Collagen
    Fatigue
    22 Citations (Scopus)

    Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates

    Gong, Z., Szczesny, S. E., Caliari, S. R., Charrier, E. E., Chaudhuri, O., Cao, X., Lin, Y., Mauck, R. L., Janmey, P. A., Burdick, J. A. & Shenoy, V. B., Mar 20 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 12, p. E2686-E2695

    Research output: Contribution to journalArticle

    Viscosity
    Extracellular Matrix
    Cell-Matrix Junctions
    Monte Carlo Method
    Focal Adhesions
    8 Citations (Scopus)

    Crimped Nanofibrous Biomaterials Mimic Microstructure and Mechanics of Native Tissue and Alter Strain Transfer to Cells

    Szczesny, S., Driscoll, T. P., Tseng, H. Y., Liu, P. C., Heo, S. J., Mauck, R. L. & Chao, P. H. G., Nov 13 2017, In : ACS Biomaterials Science and Engineering. 3, 11, p. 2869-2876 8 p.

    Research output: Contribution to journalArticle

    Biocompatible Materials
    Biomaterials
    Mechanics
    Tissue
    Microstructure