Projects per year
Personal profile
Research interests
Dr. Spencer Szczesny heads the Multiscale Biomechanics and Mechanobiology Lab, which is part of the departments of Biomedical Engineering and Orthopaedics and Rehabilitation at Penn State. His research investigates the interplay between tendon multiscale mechanics and mechanobiology in the context of tissue remodeling (e.g., degeneration, repair and development). The ultimate goals of his work are to identify the causes of tendon pathology, discover novel therapeutic options and direct the design of biomaterials that can recapitulate the behavior of native tissue. This multidisciplinary research involves the use of multiscale mechanical testing, computational modeling, cell and tissue culture and biomaterial fabrication.
Education/Academic qualification
PhD, University of Pennsylvania
… → May 2015
MS, Massachusetts Institute of Technology
… → May 2005
BS, University of Pennsylvania
… → May 2003
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Projects
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Role of Mechanical Loading and Stem Cell Mechanotransduction in Tendon Degeneration
Szczesny, S. & SZCZESNY, S.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
7/1/16 → 8/14/17
Project: Research project
Research Output
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Dependence of tendon multiscale mechanics on sample gauge length is consistent with discontinuous collagen fibrils
Peterson, B. E. & Szczesny, S. E., Nov 2020, In: Acta Biomaterialia. 117, p. 302-309 8 p.Research output: Contribution to journal › Article › peer-review
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Ex vivo models of musculoskeletal tissues
Szczesny, S. E., Jul 3 2020, In: Connective Tissue Research. 61, 3-4, p. 245-247 3 p.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Macroporous hydrogels for stable sequestration and sustained release of vascular endothelial growth factor and basic fibroblast growth factor using nucleic acid aptamers
Abune, L., Zhao, N., Lai, J., Peterson, B., Szczesny, S. & Wang, Y., Jan 1 2019, In: ACS Biomaterials Science and Engineering.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Expansion of mesenchymal stem cells on electrospun scaffolds maintains stemness, mechano-responsivity, and differentiation potential
Heo, S. J., Szczesny, S. E., Kim, D. H., Saleh, K. S. & Mauck, R. L., Feb 1 2018, In: Journal of Orthopaedic Research. 36, 2, p. 808-815 8 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Fatigue loading of tendon results in collagen kinking and denaturation but does not change local tissue mechanics
Szczesny, S. E., Aeppli, C., David, A. & Mauck, R. L., Apr 11 2018, In: Journal of Biomechanics. 71, p. 251-256 6 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations