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Spencer Szczesny, PhD

    • 533 Citations
    • 15 h-Index
    20042019

    Research output per year

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    Personal profile

    Research interests

    Dr. Spencer Szczesny heads the Multiscale Biomechanics and Mechanobiology Lab, which is part of the departments of Biomedical Engineering and Orthopaedics and Rehabilitation at Penn State. His research investigates the interplay between tendon multiscale mechanics and mechanobiology in the context of tissue remodeling (e.g., degeneration, repair and development). The ultimate goals of his work are to identify the causes of tendon pathology, discover novel therapeutic options and direct the design of biomaterials that can recapitulate the behavior of native tissue. This multidisciplinary research involves the use of multiscale mechanical testing, computational modeling, cell and tissue culture and biomaterial fabrication.

    Education/Academic qualification

    PhD, University of Pennsylvania

    … → May 2015

    MS, Massachusetts Institute of Technology

    … → May 2005

    BS, University of Pennsylvania

    … → May 2003

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    Projects

    Studying Mechanotransduction in Late Embryonic Development to Inform Tendon Tissue Engineering

    Szczesny, S.

    National Institute of Arthritis and Musculoskeletal and Skin Diseases

    7/1/19 → 6/30/20

    Project: Research project

    Role of Mechanical Loading and Stem Cell Mechanotransduction in Tendon Degeneration

    Szczesny, S.

    National Institute of Arthritis and Musculoskeletal and Skin Diseases

    7/1/16 → 6/30/17

    Project: Research project

    • Research Output

    • 533 Citations
    • 15 h-Index
    • 22 Article
    • 8 Conference contribution
    • 3 Review article
    • 1 Paper

    Macroporous hydrogels for stable sequestration and sustained release of vascular endothelial growth factor and basic fibroblast growth factor using nucleic acid aptamers

    Abune, L., Zhao, N., Lai, J., Peterson, B., Szczesny, S. & Wang, Y., Jan 1 2019, In : ACS Biomaterials Science and Engineering.

    Research output: Contribution to journal › Article

    • 4 Scopus citations

    Expansion of mesenchymal stem cells on electrospun scaffolds maintains stemness, mechano-responsivity, and differentiation potential

    Heo, S. J., Szczesny, S. E., Kim, D. H., Saleh, K. S. & Mauck, R. L., Feb 1 2018, In : Journal of Orthopaedic Research. 36, 2, p. 808-815 8 p.

    Research output: Contribution to journal › Article

    • 13 Scopus citations

    Fatigue loading of tendon results in collagen kinking and denaturation but does not change local tissue mechanics

    Szczesny, S. E., Aeppli, C., David, A. & Mauck, R. L., Apr 11 2018, In : Journal of Biomechanics. 71, p. 251-256 6 p.

    Research output: Contribution to journal › Article

    • 8 Scopus citations

    Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates

    Gong, Z., Szczesny, S. E., Caliari, S. R., Charrier, E. E., Chaudhuri, O., Cao, X., Lin, Y., Mauck, R. L., Janmey, P. A., Burdick, J. A. & Shenoy, V. B., Mar 20 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 12, p. E2686-E2695

    Research output: Contribution to journal › Article

    • 38 Scopus citations

    Crimped Nanofibrous Biomaterials Mimic Microstructure and Mechanics of Native Tissue and Alter Strain Transfer to Cells

    Szczesny, S. E., Driscoll, T. P., Tseng, H. Y., Liu, P. C., Heo, S. J., Mauck, R. L. & Chao, P. H. G., Nov 13 2017, In : ACS Biomaterials Science and Engineering. 3, 11, p. 2869-2876 8 p.

    Research output: Contribution to journal › Article

    • 13 Scopus citations