Projects per year
Personal profile
Research interests
Dr. Susan Hafenstein's research focuses on understanding the structure and functions of viruses, specifically host-virus interactions that facilitate viral entry into cells. She is an expert in cryoEM, utilizing local reconstruction approaches to solve atomic resolution maps of viruses like HPV, murine papillomavirus, polyomavirus and Zika virus.
Teaching and educational interests
Dr. Hafenstein is committed to mentoring undergraduate, graduate, and post-degree students in cryoEM, structural biology and infectious diseases. She mentors students within her research lab, prioritizing trainee projects, grant pursuit and publications. Dr. Hafenstein also developed and teaches the Department of Biochemistry & Molecular Biology's cryoEM class and leads a weekly structural biology journal club that is open to all Penn State researchers interested in learning more about cryoEM.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Postdoctoral Fellowship, Purdue University
… → 2007
Pathobiology, PhD, University of Arizona
… → 2003
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Projects
- 2 Finished
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Development of Cryo-EM/TEM Technologies for Small Protein and RNA Systems
Lindner, S. E., Hafenstein, S. & Lindner, S. E.
1/1/18 → 12/31/21
Project: Research project
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Structural Controls of Functional Receptor and Antibody Binding to Viral Capsids.
Parrish, C. R. & Hafenstein, S.
National Institute of Allergy and Infectious Diseases
12/1/10 → 11/30/14
Project: Research project
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Accurate virus identification with interpretable Raman signatures by machine learning
Ye, J., Yeh, Y. T., Xue, Y., Wang, Z., Zhang, N., Liu, H., Zhang, K., Ricker, R. A., Yu, Z., Roder, A., Lopez, N. P., Organtini, L., Greene, W., Hafenstein, S., Lu, H., Ghedin, E., Terrones, M., Huang, S. & Huang, S. X., Jun 7 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 23, e2118836119.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Asymmetry in icosahedral viruses
Jose, J. & Hafenstein, S. L., Jun 2022, In: Current Opinion in Virology. 54, 101230.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
Characterization of Mayaro virus (strain BeAn343102) biology in vertebrate and invertebrate cellular backgrounds
Pujhari, S., Brustolin, M., Heu, C. C., Smithwick, R., Larrosa, M., Hafenstein, S. & Rasgon, J. L., Oct 1 2022, In: Journal of General Virology. 103, 10Research output: Contribution to journal › Article › peer-review
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Cryo-EM Structure of Gokushovirus UEC6098 Reveals a Novel Capsid Architecture for a Single-Scaffolding Protein, Microvirus Assembly System
Lee, H., Baxter, A. J., Bator, C. M., Fane, B. A. & Hafenstein, S. L., Nov 2022, In: Journal of virology. 96, 21Research output: Contribution to journal › Article › peer-review
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Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis
Chen, Y. C., Dinavahi, S. S., Feng, Q., Gowda, R., Ramisetti, S., Xia, X., LaPenna, K. B., Chirasani, V. R., Cho, S. H., Hafenstein, S. L., Battu, M. B., Berg, A., Sharma, A. K., Kirchhausen, T., Dokholyan, N. V., Amin, S., He, P. & Robertson, G. P., May 28 2021, In: Cancer Letters. 506, p. 107-119 13 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations