Thomas Ma

2019

Intestinal epithelial tight junction barrier regulation by autophagy-related protein ATG6/beclin 1

Wong, M., Ganapathy, A. S., Suchanec, E., Laidler, L., Ma, T. & Nighot, P., May 2019, In : American Journal of Physiology - Cell Physiology. 316, 5, p. C753-C765

Research output: Contribution to journal › Article

2 Scopus citations

Investigating intestinal permeability and gut microbiota roles in acute coronary syndrome patients

Alhmoud, T., Kumar, A., Lo, C. C., Al-Sadi, R., Clegg, S., Alomari, I., Zmeili, T., Gleasne, C. D., Mcmurry, K., Dichosa, A. E. K., Vuyisich, M., Chain, P. S. G., Mishra, S. & Ma, T., Aug 2019, In : Human Microbiome Journal. 13, 100059.

Research output: Contribution to journal › Article

Open Access

Lipopolysaccharide-Induced Increase in Intestinal Permeability Is Mediated by TAK-1 Activation of IKK and MLCK/MYLK Gene

Nighot, M., Rawat, M., Al-Sadi, R., Castillo, E. F., Nighot, P. & Ma, T. Y., Apr 2019, In : American Journal of Pathology. 189, 4, p. 797-812 16 p.

Research output: Contribution to journal › Article

5 Scopus citations

MMP-9-induced increase in intestinal epithelial tight permeability is mediated by p38 kinase signaling pathway activation of MLCK gene

Al-Sadi, R., Youssef, M., Rawat, M., Guo, S., Dokladny, K., Haque, M., Watterson, M. D. & Ma, T. Y., Feb 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 316, 2, p. G278-G290

Research output: Contribution to journal › Article

2 Scopus citations

2018

Expression of programmed death-ligand 1 by human colonic CD90⁺ stromal cells differs between ulcerative colitis and Crohn's disease and determines their capacity to suppress Th1 cells

Beswick, E. J., Grim, C., Singh, A., Aguirre, J. E., Tafoya, M., Qiu, S., Rogler, G., McKee, R., Samedi, V., Ma, T. Y., Reyes, V. E., Powell, D. W. & Pinchuk, I. V., May 30 2018, In : Frontiers in immunology. 9, MAY, 1125.

Research output: Contribution to journal › Article

11 Scopus citations

2017

Chloride channel ClC- 2 enhances intestinal epithelial tight junction barrier function via regulation of caveolin-1 and caveolar trafficking of occludin

Nighot, P. K., Leung, L. & Ma, T. Y., Mar 1 2017, In : Experimental Cell Research. 352, 1, p. 113-122 10 p.

Research output: Contribution to journal › Article

11 Scopus citations

Lipopolysaccharide-Induced Increase in Intestinal Epithelial Tight Permeability Is Mediated by Toll-Like Receptor 4/Myeloid Differentiation Primary Response 88 (MyD88) Activation of Myosin Light Chain Kinase Expression

Nighot, M., Al-Sadi, R., Guo, S., Rawat, M., Nighot, P., Watterson, M. D. & Ma, T. Y., Dec 2017, In : American Journal of Pathology. 187, 12, p. 2698-2710 13 p.

Research output: Contribution to journal › Article

29 Scopus citations

2016

Intestinal barrier dysfunction in human necrotizing enterocolitis

Moore, S. A., Nighot, P., Reyes, C., Rawat, M., McKee, J., Lemon, D., Hanson, J. & Ma, T. Y., Dec 1 2016, In : Journal of pediatric surgery. 51, 12, p. 1907-1913 7 p.

Research output: Contribution to journal › Article

21 Scopus citations

TNF-α Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-α Axis Activation of the Canonical NF-κB Pathway

Al-Sadi, R., Guo, S., Ye, D., Rawat, M. & Ma, T. Y., May 1 2016, In : American Journal of Pathology. 186, 5, p. 1151-1165 15 p.

Research output: Contribution to journal › Article

63 Scopus citations

2015

Autophagy enhances intestinal epithelial tight junction barrier function by targeting claudin-2 protein degradation

Nighot, P. K., Hu, C. A. A. & Ma, T. Y., Mar 13 2015, In : Journal of Biological Chemistry. 290, 11, p. 7234-7246 13 p.

Research output: Contribution to journal › Article

63 Scopus citations

Genetic Ablation of the ClC-2 Cl-Channel disrupts mouse gastric parietal cell acid secretion

Nighot, M. P., Nighot, P. K., Ma, T. Y., Malinowska, D. H., Shull, G. E., Cuppoletti, J. & Blikslager, A. T., Sep 17 2015, In : PloS one. 10, 9, A1344.

Research output: Contribution to journal › Article

12 Scopus citations

Lipopolysaccharide regulation of intestinal tight junction permeability is mediated by TLR4 signal transduction pathway activation of FAK and MyD88

Guo, S., Nighot, M., Al-Sadi, R., Alhmoud, T., Nighot, P. & Ma, T., Nov 15 2015, In : Journal of Immunology. 195, 10, p. 4999-5010 12 p.

Research output: Contribution to journal › Article

88 Scopus citations

Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis

Nighot, P., Al-Sadi, R., Rawat, M., Guo, S., Watterson, D. M. & Ma, T., Jan 1 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 12, p. G988-G997

Research output: Contribution to journal › Article

42 Scopus citations

2014

Acute Fatty Liver of Pregnancy Treated with Plasma Exchange

Hartwell, L. & Ma, T., Sep 1 2014, In : Digestive Diseases and Sciences. 59, 9, p. 2076-2080 5 p.

Research output: Contribution to journal › Article

5 Scopus citations

Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway

Al-Sadi, R., Ye, D., Boivin, M., Guo, S., Hashimi, M., Ereifej, L. & Ma, T. Y., Mar 24 2014, In : PloS one. 9, 3, e85345.

Research output: Contribution to journal › Article

97 Scopus citations

Pericardial Effusion of Obscure Origin

Muralimohan, R., Delu, A. & Ma, T., Nov 19 2014, In : Digestive Diseases and Sciences. 59, 12, p. 2909-2912 4 p.

Research output: Contribution to journal › Article

2013

Chloride channel ClC-2 is a key factor in the development of DSS-induced murine colitis

Nighot, P., Young, K., Nighot, M., Rawat, M., Sung, E. J., Maharshak, N., Plevy, S. E., Ma, T. & Blikslager, A., Dec 1 2013, In : Inflammatory bowel diseases. 19, 13, p. 2867-2877 11 p.

Research output: Contribution to journal › Article

20 Scopus citations

Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14

Guo, S., Al-Sadi, R., Said, H. M. & Ma, T., Feb 1 2013, In : American Journal of Pathology. 182, 2, p. 375-387 13 p.

Research output: Contribution to journal › Article

214 Scopus citations

Mechanism of IL-1β modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation

Al-Sadi, R., Guo, S., Ye, D., Dokladny, K., Alhmoud, T., Ereifej, L., Said, H. M. & Ma, T., Jun 15 2013, In : Journal of Immunology. 190, 12, p. 6596-6606 11 p.

Research output: Contribution to journal › Article

65 Scopus citations

Stromal Cells Induce Th17 during Helicobacter pylori Infection and in the Gastric Tumor Microenvironment

Pinchuk, I. V., Morris, K. T., Nofchissey, R. A., Earley, R. B., Wu, J. Y., Ma, T. Y. & Beswick, E. J., Jan 30 2013, In : PloS one. 8, 1, e53798.

Research output: Contribution to journal › Article

35 Scopus citations

TNF-α modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1

Al-Sadi, R., Guo, S., Ye, D. & Ma, T. Y., Dec 1 2013, In : American Journal of Pathology. 183, 6, p. 1871-1884 14 p.

Research output: Contribution to journal › Article

94 Scopus citations

2012

Mechanism of Interleukin-1β induced-increase in mouse intestinal permeability in vivo

Al-Sadi, R., Guo, S., Dokladny, K., Smith, M. A., Ye, D., Kaza, A., Watterson, D. M. & Ma, T., Oct 1 2012, In : Journal of Interferon and Cytokine Research. 32, 10, p. 474-484 11 p.

Research output: Contribution to journal › Article

50 Scopus citations

2011

Cellular and molecular mechanism of interleukin-1β modulation of Caco-2 intestinal epithelial tight junction barrier

Al-Sadi, R., Ye, D., Said, H. M. & Ma, T. Y., Apr 1 2011, In : Journal of Cellular and Molecular Medicine. 15, 4, p. 970-982 13 p.

Research output: Contribution to journal › Article

44 Scopus citations

Differential expression of human riboflavin transporters -1, -2, and -3 in polarized epithelia: A key role for hRFT-2 in intestinal riboflavin uptake

Subramanian, V. S., Subramanya, S. B., Rapp, L., Marchant, J. S., Ma, T. Y. & Said, H. M., Dec 1 2011, In : Biochimica et Biophysica Acta - Biomembranes. 1808, 12, p. 3016-3021 6 p.

Research output: Contribution to journal › Article

38 Scopus citations

MicroRNA regulation of intestinal epithelial tight junction permeability

Ye, D., Guo, S., Al-Sadi, R. & Ma, T., Jan 1 2011, In : Gastroenterology. 141, 4, p. 1323-1333 11 p.

Research output: Contribution to journal › Article

159 Scopus citations

Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier

Al-Sadi, R., Khatib, K., Guo, S., Ye, D., Youssef, M. & Ma, T., Jun 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 6, p. G1054-G1064

Research output: Contribution to journal › Article

200 Scopus citations

2010

Activation of caspase-3 in the skeletal muscle during haemodialysis

Boivin, M. A., Battah, S. I., Dominic, E. A., Kalantar-Zadeh, K., Ferrando, A., Tzamaloukas, A. H., Dwivedi, R., Ma, T. A., Moseley, P. & Raj, D. S. C., Oct 1 2010, In : European Journal of Clinical Investigation. 40, 10, p. 903-910 8 p.

Research output: Contribution to journal › Article

24 Scopus citations

IL-1β-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-κB pathway

Al-Sadi, R., Ye, D., Said, H. M. & Ma, T. Y., Nov 2010, In : American Journal of Pathology. 177, 5, p. 2310-2322 13 p.

Research output: Contribution to journal › Article

99 Scopus citations

LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: Possible role of NF-κB

Dokladny, K., Lobb, R., Wharton, W., Ma, T. Y. & Moseley, P. L., Mar 1 2010, In : Cell Stress and Chaperones. 15, 2, p. 153-163 11 p.

Research output: Contribution to journal › Article

76 Scopus citations

2009

Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier

Ashokkumar, B., Nabokina, S. M., Ma, T. Y. & Said, H. M., Sep 1 2009, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 297, 3, p. G480-G487

Research output: Contribution to journal › Article

16 Scopus citations

Mechanism of cytokine modulation of epithelial tight junction barrier

Al-Sadi, R., Boivin, M. & Ma, T., Jan 1 2009, In : Frontiers in Bioscience. 14, 7, p. 2765-2778 14 p.

Research output: Contribution to journal › Article

235 Scopus citations

Mechanism of interferon-γ-induced increase in T84 intestinal epithelial tight junction

Boivin, M. A., Roy, P. K., Bradley, A., Kennedy, J. C., Rihani, T. & Ma, T. Y., Jan 1 2009, In : Journal of Interferon and Cytokine Research. 29, 1, p. 45-54 10 p.

Research output: Contribution to journal › Article

41 Scopus citations

Membrane targeting and intracellular trafficking of the human sodium-dependent multivitamin transporter in polarized epithelial cells

Subramanian, V. S., Marchant, J. S., Boulware, M. J., Ma, T. Y. & Said, H. M., Apr 1 2009, In : American Journal of Physiology - Cell Physiology. 296, 4, p. C663-C671

Research output: Contribution to journal › Article

24 Scopus citations

2008

Cellular and molecular mechanisms of heat stress-induced up-regulation of occludin protein expression: Regulatory role of heat shock factor-1

Dokladny, K., Ye, D., Kennedy, J. C., Moseley, P. L. & Ma, T. Y., Mar 2008, In : American Journal of Pathology. 172, 3, p. 659-670 12 p.

Research output: Contribution to journal › Article

40 Scopus citations

Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-α-induced regulation of myosin light chain kinase gene activity

Ye, D. & Ma, T. Y., Aug 1 2008, In : Journal of Cellular and Molecular Medicine. 12, 4, p. 1331-1346 16 p.

Research output: Contribution to journal › Article

69 Scopus citations

Expression of the p16(INK4a) gene product in premalignant and malignant epithelial lesions of the gallbladder

Lynch, B. C., Lathrop, S. L., Ye, D., Ma, T. Y. & Cerilli, L. A., Jun 1 2008, In : Annals of Diagnostic Pathology. 12, 3, p. 161-164 4 p.

Research output: Contribution to journal › Article

13 Scopus citations

Lack of cross-tolerance following heat and cadmium exposure in functional MDCK monolayers

Dokladny, K., Wharton, W., Ma, T. & Moseley, P. L., Oct 1 2008, In : Journal of Applied Toxicology. 28, 7, p. 885-894 10 p.

Research output: Contribution to journal › Article

8 Scopus citations

Mechanism of IL-lβ-induced increase in intestinal epithelial tight junction permeability

Al-Sadi, R., Ye, D., Dokladny, K. & Ma, T., Apr 15 2008, In : Journal of Immunology. 180, 8, p. 5653-5661 9 p.

Research output: Contribution to journal › Article

220 Scopus citations

2007

IL-1β causes an increase in intestinal epithelial tight junction permeability

Al-Sadi, R. M. & Ma, T. Y., Apr 1 2007, In : Journal of Immunology. 178, 7, p. 4641-4649 9 p.

Research output: Contribution to journal › Article

Open Access

313 Scopus citations

Mechanism of glucocorticoid regulation of the intestinal tight junction barrier

Boivin, M. A., Ye, D., Kennedy, J. C., Al-Sadi, R., Shepela, C. & Ma, T. Y., Feb 1 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 292, 2, p. G590-G598

Research output: Contribution to journal › Article

81 Scopus citations

Tight junction targeting and intracellular trafficking of occludin in polarized epithelial cells

Subramanian, V. S., Marchant, J. S., Ye, D., Ma, T. Y. & Said, H. M., Nov 1 2007, In : American Journal of Physiology - Cell Physiology. 293, 5, p. C1717-C1726

Research output: Contribution to journal › Article

26 Scopus citations

2006

Changing patterns of gallbladder carcinoma in New Mexico

Barakat, J., Dunkelberg, J. C. & Ma, T., Jan 15 2006, In : Cancer. 106, 2, p. 434-440 7 p.

Research output: Contribution to journal › Article

29 Scopus citations

Induction of physiological thermotolerance in MDCK monolayers: Contribution of heat shock protein 70

Dokladny, K., Wharton, W., Lobb, R., Ma, T. Y. & Moseley, P. L., Sep 13 2006, In : Cell Stress and Chaperones. 11, 3, p. 268-275 8 p.

Research output: Contribution to journal › Article

15 Scopus citations

Molecular mechanism of tumor necrosis factor-α modulation of intestinal epithelial tight junction barrier

Ye, D., Ma, I. & Ma, T. Y., Mar 1 2006, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 290, 3, p. G496-G504

Research output: Contribution to journal › Article

253 Scopus citations

Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability

Dokladny, K., Moseley, P. L. & Ma, T. Y., Feb 1 2006, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 290, 2, p. G204-G212

Research output: Contribution to journal › Article

129 Scopus citations

2005

Mechanism of riboflavin uptake by cultured human retinal pigment epithelial ARPE-19 cells: Possible regulation by an intracellular Ca²⁺-calmodulin-mediated pathway

Said, H. M., Wang, S. & Ma, T. Y., Jul 15 2005, In : Journal of Physiology. 566, 2, p. 369-377 9 p.

Research output: Contribution to journal › Article

22 Scopus citations

Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: Role of myosin light-chain kinase protein expression

Ma, T. Y., Boivin, M. A., Ye, D., Pedram, A. & Said, H. M., Mar 1 2005, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 288, 3 51-3, p. G422-G430

Research output: Contribution to journal › Article

303 Scopus citations

2004

Mechanism and regulation of folate uptake by human pancreatic epithelial MIA PaCa-2 cells

Nabokina, S. M., Ma, T. Y. & Said, H. M., Jul 1 2004, In : American Journal of Physiology - Cell Physiology. 287, 1 56-1, p. C142-C148

Research output: Contribution to journal › Article

16 Scopus citations

TNF-α-induced increase in intestinal epithelial tight junction permeability requires NF-κB activation

Ma, T., Iwamoto, G. K., Hoa, N. T., Akotia, V., Pedram, A., Boivin, M. A. & Said, H. M., Mar 2004, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 286, 3 49-3, p. G367-G376

Research output: Contribution to journal › Article

500 Scopus citations

2003

A carrier-mediated mechanism for pyridoxine uptake by human intestinal epithelial Caco-2 cells: Regulation by a PKA-mediated pathway

Said, H. M., Ortiz, A. & Ma, T., Nov 2003, In : American Journal of Physiology - Cell Physiology. 285, 5 54-5, p. C1219-C1225

Research output: Contribution to journal › Article

51 Scopus citations

Thomas Ma, MD, PhD