• 5329 Citations
  • 40 h-Index
1989 …2023
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Research Output 1989 2019

  • 5329 Citations
  • 40 h-Index
  • 85 Article
  • 3 Chapter
  • 3 Letter
  • 3 Review article
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Article
2019

Intestinal epithelial tight junction barrier regulation by autophagy-related protein ATG6/beclin 1

Wong, M., Ganapathy, A. S., Suchanec, E., Laidler, L., Ma, T. & Nighot, P., May 1 2019, In : American Journal of Physiology - Cell Physiology. 316, 5, p. C753-C765

Research output: Contribution to journalArticle

Tight Junctions
Occludin
Autophagy
Caco-2 Cells
Endocytosis

Investigating intestinal permeability and gut microbiota roles in acute coronary syndrome patients

Alhmoud, T., Kumar, A., Lo, C. C., Al-Sadi, R., Clegg, S., Alomari, I., Zmeili, T., Gleasne, C. D., Mcmurry, K., Dichosa, A. E. K., Vuyisich, M., Chain, P. S. G., Mishra, S. & Ma, T., Aug 1 2019, In : Human Microbiome Journal. 13, 100059.

Research output: Contribution to journalArticle

Open Access
Acute Coronary Syndrome
Permeability
Proteobacteria
Lipopolysaccharides
Dysbiosis
2 Citations (Scopus)

Lipopolysaccharide-Induced Increase in Intestinal Permeability Is Mediated by TAK-1 Activation of IKK and MLCK/MYLK Gene

Nighot, M., Rawat, M., Al-Sadi, R., Castillo, E. F., Nighot, P. & Ma, T., Apr 1 2019, In : American Journal of Pathology. 189, 4, p. 797-812 16 p.

Research output: Contribution to journalArticle

Myosin-Light-Chain Kinase
Tight Junctions
Lipopolysaccharides
Permeability
Genes
1 Citation (Scopus)

MMP-9-induced increase in intestinal epithelial tight permeability is mediated by p38 kinase signaling pathway activation of MLCK gene

Al-Sadi, R., Youssef, M., Rawat, M., Guo, S., Dokladny, K., Haque, M., Watterson, M. D. & Ma, T., Feb 1 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 316, 2, p. G278-G290

Research output: Contribution to journalArticle

Myosin-Light-Chain Kinase
MAP Kinase Signaling System
Matrix Metalloproteinase 9
Permeability
Tight Junctions
2018
9 Citations (Scopus)

Expression of programmed death-ligand 1 by human colonic CD90+ stromal cells differs between ulcerative colitis and Crohn's disease and determines their capacity to suppress Th1 cells

Beswick, E. J., Grim, C., Singh, A., Aguirre, J. E., Tafoya, M., Qiu, S., Rogler, G., McKee, R., Samedi, V., Ma, T. Y., Reyes, V. E., Powell, D. W. & Pinchuk, I. V., May 30 2018, In : Frontiers in immunology. 9, MAY, 1125.

Research output: Contribution to journalArticle

Th1 Cells
Stromal Cells
Ulcerative Colitis
Crohn Disease
Fibroblasts
2017
9 Citations (Scopus)
Occludin
Caveolin 1
Tight Junctions
Caveolae
Caveolins
19 Citations (Scopus)
Myosin-Light-Chain Kinase
Toll-Like Receptor 4
Lipopolysaccharides
Permeability
Tight Junctions
2016
15 Citations (Scopus)

Intestinal barrier dysfunction in human necrotizing enterocolitis

Moore, S. A., Nighot, P., Reyes, C., Rawat, M., McKee, J., Lemon, D., Hanson, J. & Ma, T., Dec 1 2016, In : Journal of pediatric surgery. 51, 12, p. 1907-1913 7 p.

Research output: Contribution to journalArticle

Necrotizing Enterocolitis
Permeability
Occludin
Tight Junction Proteins
Myosin-Light-Chain Kinase
47 Citations (Scopus)

TNF-α Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-α Axis Activation of the Canonical NF-κB Pathway

Al-Sadi, R., Guo, S., Ye, D., Rawat, M. & Ma, T. Y., May 1 2016, In : American Journal of Pathology. 186, 5, p. 1151-1165 15 p.

Research output: Contribution to journalArticle

Tight Junctions
Permeability
Phosphotransferases
Tumor Necrosis Factor-alpha
MAP Kinase Kinase Kinase 1
2015
51 Citations (Scopus)

Autophagy enhances intestinal epithelial tight junction barrier function by targeting claudin-2 protein degradation

Nighot, P., Hu, C. A. A. & Ma, T., Mar 13 2015, In : Journal of Biological Chemistry. 290, 11, p. 7234-7246 13 p.

Research output: Contribution to journalArticle

Claudin-2
Claudins
Tight Junctions
Autophagy
Proteolysis
9 Citations (Scopus)

Genetic Ablation of the ClC-2 Cl-Channel disrupts mouse gastric parietal cell acid secretion

Nighot, M. P., Nighot, P. K., Ma, T. Y., Malinowska, D. H., Shull, G. E., Cuppoletti, J. & Blikslager, A. T., Sep 17 2015, In : PloS one. 10, 9, A1344.

Research output: Contribution to journalArticle

Gastric Parietal Cells
Proton-Translocating ATPases
Ablation
stomach
Gastric Mucosa
70 Citations (Scopus)
Focal Adhesion Protein-Tyrosine Kinases
Tight Junctions
Lipopolysaccharides
Permeability
Signal Transduction
35 Citations (Scopus)
Dextran Sulfate
Tight Junctions
Matrix Metalloproteinase 9
Colitis
Permeability
2014
5 Citations (Scopus)

Acute Fatty Liver of Pregnancy Treated with Plasma Exchange

Hartwell, L. & Ma, T., Sep 1 2014, In : Digestive Diseases and Sciences. 59, 9, p. 2076-2080 5 p.

Research output: Contribution to journalArticle

Plasma Exchange
Fetal Death
International Normalized Ratio
Pregnancy Complications
Acute Disease
82 Citations (Scopus)

Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway

Al-Sadi, R., Ye, D., Boivin, M., Guo, S., Hashimi, M., Ereifej, L. & Ma, T. Y., Mar 24 2014, In : PloS one. 9, 3, e85345.

Research output: Contribution to journalArticle

tight junctions
Claudin-2
MAP Kinase Signaling System
Tight Junctions
interleukin-6

Pericardial Effusion of Obscure Origin

Muralimohan, R., Delu, A. & Ma, T., Nov 19 2014, In : Digestive Diseases and Sciences. 59, 12, p. 2909-2912 4 p.

Research output: Contribution to journalArticle

Peritoneal Diseases
Transjugular Intrahepatic Portasystemic Shunt
Alcoholic Liver Cirrhosis
Pericardial Effusion
Ascites
2013
18 Citations (Scopus)

Chloride channel ClC-2 is a key factor in the development of DSS-induced murine colitis

Nighot, P., Young, K., Nighot, M., Rawat, M., Sung, E. J., Maharshak, N., Plevy, S. E., Ma, T. & Blikslager, A., Dec 1 2013, In : Inflammatory bowel diseases. 19, 13, p. 2867-2877 11 p.

Research output: Contribution to journalArticle

Dextran Sulfate
Colitis
Occludin
Caco-2 Cells
Tight Junctions
174 Citations (Scopus)
Enterocytes
Tight Junctions
Lipopolysaccharides
Permeability
Membranes
59 Citations (Scopus)

Mechanism of IL-1β modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation

Al-Sadi, R., Guo, S., Ye, D., Dokladny, K., Alhmoud, T., Ereifej, L., Said, H. M. & Ma, T., Jun 15 2013, In : Journal of Immunology. 190, 12, p. 6596-6606 11 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 2
Interleukin-1
Phosphotransferases
Myosins
Tight Junctions
33 Citations (Scopus)

Stromal Cells Induce Th17 during Helicobacter pylori Infection and in the Gastric Tumor Microenvironment

Pinchuk, I. V., Morris, K. T., Nofchissey, R. A., Earley, R. B., Wu, J. Y., Ma, T. Y. & Beswick, E. J., Jan 30 2013, In : PloS one. 8, 1, e53798.

Research output: Contribution to journalArticle

Tumor Microenvironment
stomach neoplasms
Helicobacter pylori
stromal cells
Helicobacter Infections
84 Citations (Scopus)

TNF-α modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1

Al-Sadi, R., Guo, S., Ye, D. & Ma, T., Dec 1 2013, In : American Journal of Pathology. 183, 6, p. 1871-1884 14 p.

Research output: Contribution to journalArticle

Tight Junctions
MAP Kinase Signaling System
Tumor Necrosis Factor-alpha
Permeability
Myosin-Light-Chain Kinase
2012
45 Citations (Scopus)

Mechanism of Interleukin-1β induced-increase in mouse intestinal permeability in vivo

Al-Sadi, R., Guo, S., Dokladny, K., Smith, M. A., Ye, D., Kaza, A., Watterson, D. M. & Ma, T., Oct 1 2012, In : Journal of Interferon and Cytokine Research. 32, 10, p. 474-484 11 p.

Research output: Contribution to journalArticle

Interleukin-1
Permeability
Myosin-Light-Chain Kinase
Dextrans
Enterocytes
2011
41 Citations (Scopus)

Cellular and molecular mechanism of interleukin-1β modulation of Caco-2 intestinal epithelial tight junction barrier

Al-Sadi, R., Ye, D., Said, H. M. & Ma, T., Apr 1 2011, In : Journal of Cellular and Molecular Medicine. 15, 4, p. 970-982 13 p.

Research output: Contribution to journalArticle

Tight Junctions
Interleukin-1
Myosin-Light-Chain Kinase
Permeability
Mitogen-Activated Protein Kinase 3
37 Citations (Scopus)

Differential expression of human riboflavin transporters -1, -2, and -3 in polarized epithelia: A key role for hRFT-2 in intestinal riboflavin uptake

Subramanian, V. S., Subramanya, S. B., Rapp, L., Marchant, J. S., Ma, T. & Said, H. M., Dec 1 2011, In : Biochimica et Biophysica Acta - Biomembranes. 1808, 12, p. 3016-3021 6 p.

Research output: Contribution to journalArticle

Riboflavin
Epithelium
Membranes
Intestines
human SLC52A3 protein
148 Citations (Scopus)

MicroRNA regulation of intestinal epithelial tight junction permeability

Ye, D., Guo, S., Al-Sadi, R. & Ma, T., Jan 1 2011, In : Gastroenterology. 141, 4, p. 1323-1333 11 p.

Research output: Contribution to journalArticle

Occludin
Tight Junctions
MicroRNAs
Permeability
Enterocytes
181 Citations (Scopus)

Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier

Al-Sadi, R., Khatib, K., Guo, S., Ye, D., Youssef, M. & Ma, T., Jun 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 6, p. G1054-G1064

Research output: Contribution to journalArticle

Occludin
Tight Junctions
Permeability
Dextrans
Small Interfering RNA
2010
21 Citations (Scopus)

Activation of caspase-3 in the skeletal muscle during haemodialysis

Boivin, M. A., Battah, S. I., Dominic, E. A., Kalantar-Zadeh, K., Ferrando, A., Tzamaloukas, A. H., Dwivedi, R., Ma, T. A., Moseley, P. & Raj, D. S. C., Oct 1 2010, In : European Journal of Clinical Investigation. 40, 10, p. 903-910 8 p.

Research output: Contribution to journalArticle

Caspase 3
Renal Dialysis
Muscle
Skeletal Muscle
Chemical activation
91 Citations (Scopus)
MAP Kinase Kinase Kinases
Tight Junctions
Interleukin-1
Permeability
Myosin-Light-Chain Kinase
71 Citations (Scopus)

LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: Possible role of NF-κB

Dokladny, K., Lobb, R., Wharton, W., Ma, T. & Moseley, P. L., Mar 1 2010, In : Cell Stress and Chaperones. 15, 2, p. 153-163 11 p.

Research output: Contribution to journalArticle

NF-kappa B
Lipopolysaccharides
Rats
Cytokines
Animals
2009
16 Citations (Scopus)
Reduced Folate Carrier Protein
Dyneins
Folic Acid
Cell Biology
Proteins
208 Citations (Scopus)

Mechanism of cytokine modulation of epithelial tight junction barrier

Al-Sadi, R., Boivin, M. & Ma, T., Jan 1 2009, In : Frontiers in Bioscience. 14, 7, p. 2765-2778 14 p.

Research output: Contribution to journalArticle

Tight Junctions
Modulation
Cytokines
Anti-Inflammatory Agents
Transforming Growth Factors
41 Citations (Scopus)

Mechanism of interferon-γ-induced increase in T84 intestinal epithelial tight junction

Boivin, M. A., Roy, P. K., Bradley, A., Kennedy, J. C., Rihani, T. & Ma, T., Jan 1 2009, In : Journal of Interferon and Cytokine Research. 29, 1, p. 45-54 10 p.

Research output: Contribution to journalArticle

Tight Junctions
Interferons
Phosphatidylinositol 3-Kinase
Occludin
Permeability
24 Citations (Scopus)

Membrane targeting and intracellular trafficking of the human sodium-dependent multivitamin transporter in polarized epithelial cells

Subramanian, V. S., Marchant, J. S., Boulware, M. J., Ma, T. & Said, H. M., Apr 1 2009, In : American Journal of Physiology - Cell Physiology. 296, 4

Research output: Contribution to journalArticle

Intracellular Membranes
Epithelial Cells
Biotin
Kidney
Amino Acids
2008
36 Citations (Scopus)

Cellular and molecular mechanisms of heat stress-induced up-regulation of occludin protein expression: Regulatory role of heat shock factor-1

Dokladny, K., Ye, D., Kennedy, J. C., Moseley, P. L. & Ma, T., Jan 1 2008, In : American Journal of Pathology. 172, 3, p. 659-670 12 p.

Research output: Contribution to journalArticle

Occludin
Shock
Up-Regulation
Hot Temperature
Proteins
64 Citations (Scopus)
Myosin-Light-Chain Kinase
Tumor Necrosis Factor-alpha
Genes
Tight Junctions
Dimers
13 Citations (Scopus)

Expression of the p16(INK4a) gene product in premalignant and malignant epithelial lesions of the gallbladder

Lynch, B. C., Lathrop, S. L., Ye, D., Ma, T. Y. & Cerilli, L. A., Jun 1 2008, In : Annals of Diagnostic Pathology. 12, 3, p. 161-164 4 p.

Research output: Contribution to journalArticle

p16 Genes
Gallbladder
Epithelium
Adenocarcinoma
Staining and Labeling
8 Citations (Scopus)

Lack of cross-tolerance following heat and cadmium exposure in functional MDCK monolayers

Dokladny, K., Wharton, W., Ma, T. & Moseley, P. L., Oct 1 2008, In : Journal of Applied Toxicology. 28, 7, p. 885-894 10 p.

Research output: Contribution to journalArticle

Cadmium
Madin Darby Canine Kidney Cells
Canidae
Monolayers
Occludin
209 Citations (Scopus)

Mechanism of IL-lβ-induced increase in intestinal epithelial tight junction permeability

Al-Sadi, R., Ye, D., Dokladny, K. & Ma, T., Apr 15 2008, In : Journal of Immunology. 180, 8, p. 5653-5661 9 p.

Research output: Contribution to journalArticle

Tight Junctions
Myosins
Permeability
Protein Kinases
Phosphotransferases
2007
292 Citations (Scopus)

IL-1β causes an increase in intestinal epithelial tight junction permeability

Al-Sadi, R. & Ma, T., Apr 1 2007, In : Journal of Immunology. 178, 7, p. 4641-4649 9 p.

Research output: Contribution to journalArticle

Tight Junctions
Interleukin-1
Permeability
Inflammation
Apoptosis
77 Citations (Scopus)

Mechanism of glucocorticoid regulation of the intestinal tight junction barrier

Boivin, M. A., Ye, D., Kennedy, J. C., Al-Sadi, R., Shepela, C. & Ma, T. Y., Feb 1 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 292, 2, p. G590-G598

Research output: Contribution to journalArticle

Tight Junctions
Glucocorticoids
Myosin-Light-Chain Kinase
Glucocorticoid Receptors
Permeability
23 Citations (Scopus)

Tight junction targeting and intracellular trafficking of occludin in polarized epithelial cells

Subramanian, V. S., Marchant, J. S., Ye, D., Ma, T. & Said, H. M., Nov 1 2007, In : American Journal of Physiology - Cell Physiology. 293, 5

Research output: Contribution to journalArticle

Occludin
Tight Junctions
Epithelial Cells
Microtubules
Peptides
2006
27 Citations (Scopus)

Changing patterns of gallbladder carcinoma in New Mexico

Barakat, J., Dunkelberg, J. C. & Ma, T., Jan 15 2006, In : Cancer. 106, 2, p. 434-440 7 p.

Research output: Contribution to journalArticle

Gallbladder
North American Indians
Carcinoma
Incidence
Hispanic Americans
13 Citations (Scopus)

Induction of physiological thermotolerance in MDCK monolayers: Contribution of heat shock protein 70

Dokladny, K., Wharton, W., Lobb, R., Ma, T. & Moseley, P. L., Sep 13 2006, In : Cell Stress and Chaperones. 11, 3, p. 268-275 8 p.

Research output: Contribution to journalArticle

HSP70 Heat-Shock Proteins
Monolayers
Hot Temperature
Heat-Shock Proteins
Thermal stress
243 Citations (Scopus)
Myosin-Light-Chain Kinase
Tight Junctions
Tumor Necrosis Factor-alpha
Permeability
Genetic Promoter Regions
123 Citations (Scopus)
Tight Junctions
Permeability
Hot Temperature
Heat-Shock Proteins
Temperature
2005
21 Citations (Scopus)
Retinal Pigments
Riboflavin
Calmodulin
Retinal Pigment Epithelium
4-Chloromercuribenzenesulfonate
289 Citations (Scopus)
Myosin-Light-Chain Kinase
Tight Junctions
Proteins
Permeability
Messenger RNA
2004
16 Citations (Scopus)

Mechanism and regulation of folate uptake by human pancreatic epithelial MIA PaCa-2 cells

Nabokina, S. M., Ma, T. Y. & Said, H. M., Jul 1 2004, In : American Journal of Physiology - Cell Physiology. 287, 1 56-1, p. C142-C148

Research output: Contribution to journalArticle

Folic Acid
Reduced Folate Carrier Protein
Protein-Tyrosine Kinases
Gene Silencing
Small Interfering RNA
473 Citations (Scopus)

TNF-α-induced increase in intestinal epithelial tight junction permeability requires NF-κB activation

Ma, T., Iwamoto, G. K., Hoa, N. T., Akotia, V., Pedram, A., Boivin, M. A. & Said, H. M., Mar 1 2004, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 286, 3 49-3

Research output: Contribution to journalArticle

Tight Junctions
Permeability
Zonula Occludens-1 Protein
Crohn Disease
Down-Regulation
2003
49 Citations (Scopus)
Pyridoxine
Caco-2 Cells
Epithelial Cells
Vitamin B 6
Amiloride