• Source: Scopus
  • Calculated based on no. of publications stored in Pure and citations from Scopus
1995 …2021

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Personal profile

Research interests

Dr. Thyagarajan Subramanian has been involved in numerous experimental therapeutics, epidemiological natural progression, and pathophysiological studies of Parkinson’s disease (PD). As such, he is intimately aware of the clinical problems faced by PD patients and their risk for disease-related complications. He has specific interest, experience and expertise in basal ganglia neurophysiology, how this is altered in disease and can be rectified by restorative therapies. He is a long-standing member of the national consortium Parkinson Study Group and has contributed to the development of several anti-PD medications. He is the director of the APDA Central PA Movement Disorders Informational and Referral Center at Penn State University, a center that treats more than 1,000 PD patients each year and he has personally recruited well over 2,000 PD patients into various research studies. His lead contributions to the field has been to demonstrate the usefulness of animal models of PD for experimental therapeutics, use of cell transplants that provide dopamine replacement into the striatum along with delivery of growth factors to correct basal ganglia pathophysiology. He discovered that continuous dopaminergic delivery into the striatum via cell transplants corrects electrophysiological deficits that are not corrected by pharmacological methods. In addition, he has contributed to the discovery of novel disease progression biomarkers in PD. His research uses detailed behavioral studies using both rodent and non-human primate models of PD, immunohistochemical assessments of substantia nigra neurons using unbiased stereology, electrophysiology from the basal ganglia and cerebral cortex at the single cell level as well as local field measurements, neurochemical measurements, stereotactic surgery, sleep studies, measurement and quantitation of drug induced dyskinesias, optogenetic and chemogenetic deconstruction of circuits involved in PD and directed translational research efforts for both motor and nonmotor features of PD.

Clinical interests

Dr. Thyagarajan Subramanian is a neurologist with fellowship training in movement disorders. Dr. Subramanian cares for an array of neurologic conditions, including Parkinson’s disease (PD), Lewy-body dementia, Parkinson-plus disorders, Huntington’s disease (HD), dystonia, tics and Tourette’s syndrome, tardive dyskinesias, unusual movement disorders, post-polio syndrome and interventional therapies in neurology. He performs botulinum toxin injections with and without EMG and ultrasound guidance, baclofen pump management, deep brain stimulation assessments and programming, intra-operative neurophysiological monitoring and adjustments, intrajejunal levodopa infusion pump assessments and adjustments, apomorphine injection initiation and a wide array of other neurological interventions. He is an advocate for expanding telehealth and for the use of remote clinical assessments in movement disorders. Dr. Subramanian has a special interest in caring for early onset PD (EOPD) patients. He has the largest number of EOPD patients in the world under the case of a single physician. He is an outstanding clinical teacher for the next generation of doctors and an exceptional public educator having established partnerships with patient support groups for PD and HD all over central Pennsylvania. He has created as series of widely acclaimed archived podcasts on all aspects of PD, and he is the creator of a series of popular educational YouTube videos on the impact of COVID-19 on PD patients.

Professional information

Licensed physician, Pennsylvania State Board of Medicine, 2005

Board-certified neurologist, American Board of Psychiatry and Neurology, 1996, 2016

Permanent certification, Educational Council for Foreign Medical Graduates (ECFMG), 1989

Education/Academic qualification

Neurology, Postdoctoral clinical and research fellowship, Emory University School of Medicine

19941997

Neurology, Residency and teaching fellowship, University of Pittsburgh School of Medicine

19911994

Internal medicine, Internship, UPMC Presbyterian Shadyside

19901991

Graduate research fellowship, University of Pittsburgh

19881990

Internship and general surgery residency, Calicut Medical College

19861988

MD, Calicut Medical College

… → 1985

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