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Personal profile

Research interests

Dr. Vonn Walter's primary research field is cancer genomics, particularly gene expression profiling, DNA copy number analysis and integrated analysis of multiple genomic data types. He is interested in all aspects of RNA sequencing data analysis, including pre-processing, normalization, differential expression analysis, unsupervised clustering, development of gene expression classifiers, pathway analysis, and network analysis. His PhD thesis led to the development of the DiNAMIC algorithm for assessing the statistical significance of recurrent genomic aberrations, such as regions of the genome where DNA copy number gains or losses are observed across multiple subjects. He also created the mVisAGe R package for computing and visualizing bivariate correlations that can be used to perform exploratory analyses for identifying regions of the genome where underling genomic aberrations affect the expression of regional genes.

Dr. Walter enjoys team science, and plays a variety of roles in ongoing collaborations with researchers at Penn State College of Medicine and elsewhere. He is a member of the Biostatistics/Bioinformatics Shared Resource of Penn State Cancer Institute.

Education/Academic qualification

Postdoctoral Fellow, Lineberger Comprehensive Cancer Center

Aug 2010Apr 2013

Biostatistics, PhD, University of North Carolina Chapel Hill

Aug 2005Jul 2010

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 3 Similar Profiles
Neoplasms Medicine & Life Sciences
Tumors Chemical Compounds
Mutation Medicine & Life Sciences
Genes Chemical Compounds
DNA Medicine & Life Sciences
Squamous Cell Carcinoma Medicine & Life Sciences
RNA Sequence Analysis Medicine & Life Sciences
Gene Expression Medicine & Life Sciences

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Research Output 2011 2019

  • 4790 Citations
  • 16 h-Index
  • 33 Article
  • 3 Comment/debate
  • 1 Chapter

Gene Expression Subtype Predicts Nodal Metastasis and Survival in Human Papillomavirus–Negative Head and Neck Cancer

Zevallos, J. P., Mazul, A. L., Walter, V. & Hayes, D. N., Jan 1 2019, In : Laryngoscope. 129, 1, p. 154-161 8 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Squamous Cell Carcinoma
Neoplasm Metastasis
Gene Expression
Survival
1 Citations
Urinary Bladder Neoplasms
Neoplasms
Histology
Selection Bias
Carcinoma
1 Citations
Manuscripts
Neoplasms
Chromosomes
Uveal melanoma
Malpractice
Climate
Thyroid Neoplasms
climate
incidence

Frequent HPV-independent p16/INK4A overexpression in head and neck cancer

Lechner, M., Chakravarthy, A. R., Walter, V., Masterson, L., Feber, A., Jay, A., Weinberger, P. M., McIndoe, R. A., Forde, C. T., Chester, K., Kalavrezos, N., O'Flynn, P., Forster, M., Jones, T. M., Vaz, F. M., Hayes, D. N. & Fenton, T. R., Aug 1 2018, In : Oral Oncology. 83, p. 32-37 6 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Squamous Cell Neoplasms
Protein Array Analysis
Head
Mutation