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Personal profile

Research interests

Dr. Vonn Walter's primary research field is cancer genomics, particularly gene expression profiling, DNA copy number analysis and integrated analysis of multiple genomic data types. He is interested in all aspects of RNA sequencing data analysis, including pre-processing, normalization, differential expression analysis, unsupervised clustering, development of gene expression classifiers, pathway analysis, and network analysis. His PhD thesis led to the development of the DiNAMIC algorithm for assessing the statistical significance of recurrent genomic aberrations, such as regions of the genome where DNA copy number gains or losses are observed across multiple subjects. He also created the mVisAGe R package for computing and visualizing bivariate correlations that can be used to perform exploratory analyses for identifying regions of the genome where underling genomic aberrations affect the expression of regional genes.

Dr. Walter enjoys team science, and plays a variety of roles in ongoing collaborations with researchers at Penn State College of Medicine and elsewhere. He is a member of the Biostatistics/Bioinformatics Shared Resource of Penn State Cancer Institute.

Education/Academic qualification

Postdoctoral Fellow, Lineberger Comprehensive Cancer Center

Aug 2010Apr 2013

Biostatistics, PhD, University of North Carolina Chapel Hill

Aug 2005Jul 2010

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Research Output

  • 6740 Citations
  • 22 h-Index
  • 46 Article
  • 3 Comment/debate
  • 1 Chapter

Gastrointestinal hypoalgesia in inflammatory bowel disease

Coates, M. D., Soriano, C., Dalessio, S., Stuart, A., Walter, V., Koltun, W., Bernasko, N., Tinsley, A., Clarke, K. & Williams, E. D., Jan 1 2020, In : Annals of Gastroenterology. 33, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

Open Access
  • Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer

    Osei-Amponsa, V., Buckwalter, J. M., Shuman, L., Zheng, Z., Yamashita, H., Walter, V., Wildermuth, T., Ellis-Mohl, J., Liu, C., Warrick, J. I., Shantz, L. M., Feehan, R. P., Al-Ahmadie, H., Mendelsohn, C., Raman, J. D., Kaestner, K. H., Wu, X. R. & DeGraff, D. J., Feb 6 2020, In : Oncogene. 39, 6, p. 1302-1317 16 p.

    Research output: Contribution to journalArticle

  • Characterization of histone deacetylase expression within in vitro and in vivo bladder cancer model systems

    Buckwalter, J. M., Chan, W., Shuman, L., Wildermuth, T., Ellis-Mohl, J., Walter, V., Warrick, J. I., Wu, X. R., Kaag, M., Raman, J. D. & Degraff, D. J., May 2 2019, In : International journal of molecular sciences. 20, 10, 2599.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Circulating microRNAs in plasma among men with low-grade and high-grade prostate cancer at prostate biopsy

    McDonald, A. C., Vira, M., Walter, V., Shen, J., Raman, J. D., Sanda, M. G., Patil, D. & Taioli, E., Jun 15 2019, In : Prostate. 79, 9, p. 961-968 8 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations
    Open Access
  • 1 Scopus citations