• 2845 Citations
  • 28 h-Index
1978 …2023
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Research Output 1982 2019

  • 2845 Citations
  • 28 h-Index
  • 55 Article
  • 5 Review article
  • 2 Comment/debate
  • 1 Editorial
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Article
2019

Repository corticotropin injection reverses critical elements of the TLR9/B cell receptor activation response in human B cells in vitro

Olsen, N. J., Benko, A. L., McAloose, C. A., Becker, P. M., Wright, D., Sunyer, T., Kawasawa, Y. I. & Kovacs, W. J., Apr 2019, In : Clinical Immunology. 201, p. 70-78 9 p.

Research output: Contribution to journalArticle

Adrenocorticotropic Hormone
B-Lymphocytes
Messenger RNA
Injections
Immunoglobulin M
2018
1 Citation (Scopus)

Repository corticotrophin injection exerts direct acute effects on human B cell gene expression distinct from the actions of glucocorticoids

Benko, A. L., McAloose, C. A., Becker, P. M., Wright, D., Sunyer, T., Kawasawa, Y. I., Olsen, N. J. & Kovacs, W. J., Apr 2018, In : Clinical and Experimental Immunology. 192, 1, p. 68-81 14 p.

Research output: Contribution to journalArticle

Adrenocorticotropic Hormone
Glucocorticoids
B-Lymphocytes
Gene Expression
Messenger RNA
2015
6 Citations (Scopus)

Direct effects of HP Acthar Gel® on human B lymphocyte activation in vitro

Olsen, N. J., Decker, D. A., Higgins, P., Becker, P. M., McAloose, C. A., Benko, A. L. & Kovacs, W. J., Oct 27 2015, In : Arthritis Research and Therapy. 17, 1, 300.

Research output: Contribution to journalArticle

Lymphocyte Activation
Adrenocorticotropic Hormone
B-Lymphocytes
Gels
CD40 Ligand
2014
8 Citations (Scopus)

Glucocorticoid inhibition of activation-induced cytidine deaminase expression in human B lymphocytes

Benko, A. L., Olsen, N. J. & Kovacs, W. J., Feb 15 2014, In : Molecular and Cellular Endocrinology. 382, 2, p. 881-887 7 p.

Research output: Contribution to journalArticle

Lymphocytes
Glucocorticoids
B-Lymphocytes
Glucocorticoid Receptors
Immunoglobulin Somatic Hypermutation
2012
11 Citations (Scopus)

Estrogen and telomerase in human peripheral blood mononuclear cells

Benko, A. L., Olsen, N. J. & Kovacs, W. J., Nov 25 2012, In : Molecular and Cellular Endocrinology. 364, 1-2, p. 83-88 6 p.

Research output: Contribution to journalArticle

Telomerase
Blood Cells
Estrogens
Blood
T-cells
2011
29 Citations (Scopus)

Evidence that androgens modulate human thymic T cell output

Olsen, N. & Kovacs, W., Jan 1 2011, In : Journal of Investigative Medicine. 59, 1, p. 32-35 4 p.

Research output: Contribution to journalArticle

T-cells
Androgens
T-Lymphocytes
Blood
T-Cell Antigen Receptor
6 Citations (Scopus)
Androgen Receptors
Autoimmunity
Systemic Lupus Erythematosus
Autoantibodies
Androgens

Short stature in a patient with familial glucocorticoid deficiency

Mathew, R. P. & Kovacs, W. J., Aug 1 2011, In : Journal of Pediatric Endocrinology and Metabolism. 24, 7-8, p. 569-571 3 p.

Research output: Contribution to journalArticle

Glucocorticoids
Corticotropin Receptors
Mutation
Hypothyroidism
Thyroxine
2007
55 Citations (Scopus)

Macrophage expression of peroxisome proliferator-activated receptor-α reduces atherosclerosis in low-density lipoprotein receptor-deficient mice

Babaev, V. R., Ishiguro, H., Ding, L., Yancey, P. G., Dove, D. E., Kovacs, W. J., Semenkovich, C. F., Fazio, S. & Linton, M. F., Sep 1 2007, In : Circulation. 116, 12, p. 1404-1412 9 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
LDL Receptors
Atherosclerosis
Macrophages
Scavenger Receptors
2006
10 Citations (Scopus)

Quantitation and cellular localization of 11β-HSD1 expression in murine thymus

Nuotio-Antar, A. M., Hasty, A. H. & Kovacs, W. J., May 1 2006, In : Journal of Steroid Biochemistry and Molecular Biology. 99, 2-3, p. 93-99 7 p.

Research output: Contribution to journalArticle

Thymus
Thymus Gland
Glucocorticoids
Thymocytes
Metabolites
2004
17 Citations (Scopus)

A novel mutation in the preprovasopressin gene identified in a kindred with autosomal dominant neurohypophyseal diabetes insipidus

Wahlstrom, J. T., Fowler, M. J., Nicholson, W. E. & Kovacs, W. J., Apr 1 2004, In : Journal of Clinical Endocrinology and Metabolism. 89, 4, p. 1963-1968 6 p.

Research output: Contribution to journalArticle

Neurogenic Diabetes Insipidus
Medical problems
Vasopressins
Genes
Arginine
4 Citations (Scopus)

Gene expression phenotyping of an ACTH-producing small cell lung cancer line

Turney, M. K., Nicholson, W. E. & Kovacs, W., Apr 30 2004, In : Molecular and Cellular Endocrinology. 219, 1-2, p. 105-113 9 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Gene expression
Adrenocorticotropic Hormone
Cells
Gene Expression
2003
13 Citations (Scopus)

Epidermal growth factor increases cortisol production and type II 3β-hydroxysteroid dehydrogenase/Δ 54 -isomerase expression in human adrenocortical carcinoma cells: Evidence for a stat5-dependent mechanism

Feltus, F. A., Kovacs, W., Nicholson, W., Silva, C. M., Nagdas, S. K., Ducharme, N. A. & Melner, M. H., May 1 2003, In : Endocrinology. 144, 5, p. 1847-1853 7 p.

Research output: Contribution to journalArticle

3-Hydroxysteroid Dehydrogenases
Adrenocortical Carcinoma
Isomerases
Epidermal Growth Factor
Hydrocortisone
2002
26 Citations (Scopus)

Glucocorticoids enhance activation of the human type II 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase gene

Feltus, F. A., Cote, S., Simard, J., Gingras, S., Kovacs, W. J., Nicholson, W. E., Clark, B. J. & Melner, M. H., Sep 2002, In : Journal of Steroid Biochemistry and Molecular Biology. 82, 1, p. 55-63 9 p.

Research output: Contribution to journalArticle

3-Hydroxysteroid Dehydrogenases
Isomerases
Glucocorticoids
Genes
Chemical activation
2001
201 Citations (Scopus)

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension

Holla, V. R., Adas, F., Imig, J. D., Zhao, X., Price, E., Olsen, N., Kovacs, W. J., Magnuson, M. A., Keeney, D. S., Breyer, M. D., Falck, J. R., Waterman, M. R. & Capdevila, J. H., Apr 24 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 9, p. 5211-5216 6 p.

Research output: Contribution to journalArticle

Mixed Function Oxygenases
Androgens
Hypertension
Blood Pressure
Kidney
152 Citations (Scopus)

Androgen receptors in thymic epithelium modulate thymus size and thymocyte development

Olsen, N., Olson, G., Viselli, S. M., Gu, X. & Kovacs, W., Jan 1 2001, In : Endocrinology. 142, 3, p. 1278-1283 6 p.

Research output: Contribution to journalArticle

Androgen Receptors
Thymocytes
Thymus Gland
Epithelium
Androgens
50 Citations (Scopus)

Bone marrow stromal cells mediate androgenic suppression of B lymphocyte development

Olsen, N., Gu, X. & Kovacs, W., Dec 29 2001, In : Journal of Clinical Investigation. 108, 11, p. 1697-1704 8 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Androgens
B-Lymphocytes
Stromal Cells
Bone Marrow
100 Citations (Scopus)

Effects of androgens on T and B lymphocyte development

Olsen, N. & Kovacs, W., Jan 1 2001, In : Immunologic Research. 23, 2-3, p. 281-288 8 p.

Research output: Contribution to journalArticle

Androgens
B-Lymphocytes
Lymphocytes
T-Lymphocytes
Mesenchymal Stromal Cells
9 Citations (Scopus)
Pro-Opiomelanocortin
Glucocorticoid Receptors
Response Elements
Glucocorticoids
Genes
1998
13 Citations (Scopus)

An ACTH-producing small cell lung cancer expresses aberrant glucocorticoid receptor transcripts from a normal gene

Parks, L. L., Turney, M. K., Detera-Wadleigh, S. & Kovacs, W., Jul 25 1998, In : Molecular and Cellular Endocrinology. 142, 1-2, p. 175-181 7 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Small Cell Lung Carcinoma
Adrenocorticotropic Hormone
Genes
Cells
102 Citations (Scopus)

Androgens accelerate thymocyte apoptosis

Olsen, N. J., Viselli, S. M., Fan, J. & Kovacs, W. J., Jan 1 1998, In : Endocrinology. 139, 2, p. 748-752 5 p.

Research output: Contribution to journalArticle

Thymocytes
Androgens
Apoptosis
Thymus Gland
Androgen-Insensitivity Syndrome
10 Citations (Scopus)

Expression of 11β-hydroxysteroid dehydrogenase type 2 in an ACTH- producing small cell lung cancer

Parks, L. L., Turney, M. K., Gaitan, D. & Kovacs, W., Nov 1 1998, In : Journal of Steroid Biochemistry and Molecular Biology. 67, 4, p. 341-346 6 p.

Research output: Contribution to journalArticle

11-beta-Hydroxysteroid Dehydrogenases
Small Cell Lung Carcinoma
Adrenocorticotropic Hormone
Glucocorticoids
Cells
1997
76 Citations (Scopus)

Androgens alter B cell development in normal male mice

Viselli, S. M., Reese, K. R., Fan, J., Kovacs, W. & Olsen, N., Dec 15 1997, In : Cellular Immunology. 182, 2, p. 99-104 6 p.

Research output: Contribution to journalArticle

Androgens
B-Lymphocytes
Androgen Receptors
Bone Marrow
Orchiectomy
54 Citations (Scopus)

Schistosoma mansoni: Susceptibility differences between male and female mice can be mediated by testosterone during early infection

Nakazawa, M., Fantappie, M. R., Freeman, G. L., Eloi-Santos, S., Olsen, N., Kovacs, W., Secor, W. E. & Colley, D. G., Jan 1 1997, In : Experimental Parasitology. 85, 3, p. 233-240 8 p.

Research output: Contribution to journalArticle

Schistosoma mansoni
Testosterone
Infection
Schistosomiasis mansoni
Sexism
1996

An ACTH-producing small cell lung cancer expresses an aberrant glucocorticoid receptor (GR) transcript from a normal GR gene

Parks, L. L., Tumey, M. K. & Kovacs, W. J., Jan 1 1996, In : Journal of Investigative Medicine. 44, 1, p. 30A

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Small Cell Lung Carcinoma
Adrenocorticotropic Hormone
Genes
Cells
2 Citations (Scopus)

Castration of normal male mice results in B cell expansion which is reversible with androgen replacement

Olsen, N., Viselli, S., Reese, K., Fan, J. & Kovacs, W., Jan 1 1996, In : Journal of Investigative Medicine. 44, 1, p. 38A

Research output: Contribution to journalArticle

Orchiectomy
Castration
Androgens
B-Lymphocytes
Cells
1995
56 Citations (Scopus)
Klinefelter Syndrome
Systemic Lupus Erythematosus
Testosterone
Hormones
Antinuclear Antibodies
114 Citations (Scopus)

Castration alters peripheral immune function in normal male mice

Viselli, S. M., Stanziale, S., Shults, K., Kovacs, W. & Olsen, N., Jan 1 1995, In : Immunology. 84, 2, p. 337-342 6 p.

Research output: Contribution to journalArticle

Castration
Spleen
T-Lymphocytes
Interferons
Androgens
54 Citations (Scopus)

Glucocorticoid receptor structure and function in an adrenocorticotropin-secreting small cell lung cancer

Gaitan, D., DeBold, C. R., Turney, M. K., Zhou, P., Orth, D. N. & Kovacs, W. J., Sep 1 1995, In : Molecular Endocrinology. 9, 9, p. 1193-1201 9 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Small Cell Lung Carcinoma
Adrenocorticotropic Hormone
Transfection
Complementary DNA
79 Citations (Scopus)

Immunochemical and flow cytometric analysis of androgen receptor expression in thymocytes

Viselli, S. M., Olsen, N. J., Shults, K., Steizer, G. & Kovacs, W. J., Mar 1995, In : Molecular and Cellular Endocrinology. 109, 1, p. 19-26 8 p.

Research output: Contribution to journalArticle

Androgen Receptors
Thymocytes
Androgens
Thymus
Thymus Gland
1994
57 Citations (Scopus)

Induction of immature thymocyte proliferation after castration of normal male mice

Olsen, N., Viselli, S. M., Shults, K., Stelzer, G. & Kovacs, W., Jan 1 1994, In : Endocrinology. 134, 1, p. 107-113 7 p.

Research output: Contribution to journalArticle

Orchiectomy
Thymocytes
Castration
Thymus Gland
Cell Cycle
1993
7 Citations (Scopus)

An androgenic affinity ligand covalently binds to cytosolic aldehyde dehydrogenase from human genital skin fibroblasts

McCammon, D. K., Zhou, P., Turney, M. K., McPhaul, M. J. & Kovacs, W., Jan 1 1993, In : Molecular and Cellular Endocrinology. 91, 1-2, p. 177-183 7 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Fibroblasts
Skin
Ligands
Complementary DNA
10 Citations (Scopus)

Determination of the lethal dose of dexamethasone for early passage in vitro human glioblastoma cell cultures

Maciunas, R. J., Mericle, R. A., Sneed, C. L., Hefner, D. J., Commers, P. A. & Kovacs, W. J., Sep 1993, In : Neurosurgery. 33, 3, p. 485-488 4 p.

Research output: Contribution to journalArticle

Glioblastoma
Dexamethasone
Cell Culture Techniques
Thymidine
Cell Line
54 Citations (Scopus)

Testosterone induces expression of transforming growth factor-beta1 in the murine thymus

Olsen, N. J., Zhou, P., Ong, H. & Kovacs, W. J., May 1993, In : Journal of Steroid Biochemistry and Molecular Biology. 45, 5, p. 327-332 6 p.

Research output: Contribution to journalArticle

Transforming Growth Factor beta1
Thymus
Thymus Gland
Androgens
Testosterone
1991
100 Citations (Scopus)

Androgen deprivation induces phenotypic and functional changes in the thymus of adult male mice

Olsen, N., Watson, M. B., Henderson, G. S. & Kovacs, W., Jan 1 1991, In : Endocrinology. 129, 5, p. 2471-2476 6 p.

Research output: Contribution to journalArticle

Thymocytes
Thymus Gland
Androgens
Phenotype
Thymidine
33 Citations (Scopus)
Androgens
Thymocytes
Thymus Gland
Androgen Receptors
Interleukin-4
1990
8 Citations (Scopus)

Estrogen and androgen production rates in two brothers with reifenstein syndrome

Guerami, A., Griffin, J. E., Kovacs, W. J., Grinof, P. B., Macdonald, P. C. & Wilson, J. D., Jul 1990, In : Journal of Clinical Endocrinology and Metabolism. 71, 1, p. 247-251 5 p.

Research output: Contribution to journalArticle

Androgen-Insensitivity Syndrome
Feminization
Androgens
Gynecomastia
Siblings
1989
41 Citations (Scopus)

Analysis of the androgen receptor in isolated testicular cell types with a microassay that uses an affinity ligand

Anthony, C. T., Kovacs, W. J. & Skinner, M. K., Nov 1989, In : Endocrinology. 125, 5, p. 2628-2635 8 p.

Research output: Contribution to journalArticle

Androgen Receptors
Ligands
Sertoli Cells
Leydig Cells
Androgens
8 Citations (Scopus)

Biochemical characterization of the protein affinity labeled by dihydrotestosterone 17β-bromoacetate: Comparison with the human androgen receptor

Kovacs, W., Turney, M. K. & Skinner, M. K., Jan 1 1989, In : Endocrinology. 124, 3, p. 1270-1277 8 p.

Research output: Contribution to journalArticle

Ligands
Proteins
Hydrophobic and Hydrophilic Interactions
Sucrose
Protein Isoforms
26 Citations (Scopus)

Increased Thymic Size and Thymocyte Interleukin 2 Production in Androgen‐Resistant Mice

Olsen, N. & Kovacs, W., Jan 1 1989, In : Scandinavian Journal of Immunology. 29, 6, p. 733-738 6 p.

Research output: Contribution to journalArticle

Thymocytes
Interleukin-2
Androgen-Insensitivity Syndrome
Androgen Receptors
Androgens
4 Citations (Scopus)

The 56 kDa protein of human genital skin fibroblasts is identical to that radiolabelled by [3H]dihydrotestosterone 17β-bromoacetate

Belsham, D. D., Rosenmann, E., Pereira, F. A., Williams, S. G., Turney, M. K., Kovacs, W., Faber, L. E. & Wrogemann, K., Jan 1 1989, In : Journal of Steroid Biochemistry. 33, 3, p. 389-394 6 p.

Research output: Contribution to journalArticle

Fibroblasts
Skin
Proteins
Electrophoresis, Gel, Two-Dimensional
Electrophoresis
1988
14 Citations (Scopus)
Fibroblasts
Ligands
Androgen Receptors
Proteins
Cultured Cells
12 Citations (Scopus)

Monoclonal antibodies to rat androgen-binding protein recognize both of its subunits and cross-react with rabbit and human testosterone-binding globulin

Kovacs, W., Bell, B. W., Turney, M. K. & Danzo, B. J., Jan 1 1988, In : Endocrinology. 122, 6, p. 2639-2647 9 p.

Research output: Contribution to journalArticle

Androgen-Binding Protein
Globulins
Testosterone
Monoclonal Antibodies
Rabbits
1987
104 Citations (Scopus)

Androgen receptors in human thymocytes

Kovacs, W. & Olsen, N., 1987, In : Journal of Immunology. 139, 2, p. 490-493 4 p.

Research output: Contribution to journalArticle

Thymocytes
Androgen Receptors
Thymus Gland
Thymus Extracts
Metribolone

Androgen Receptors in Human Thymocytes

KOVACS, W. J. & OLSEN, N. J., Dec 1987, In : Annals of the New York Academy of Sciences. 513, 1, p. 509-510 2 p.

Research output: Contribution to journalArticle

Androgen Receptors
Thymocytes
human AR protein
15 Citations (Scopus)

Gonadotropins and testosterone escape from suppression during prolonged luteinizing hormone-releasing hormone antagonist administration in normal men

Pavlou, S. N., Interlandi, J. W., Wakefield, G., Island, D. P., Rivier, J., Vale, W. & Kovacs, W. J., May 1987, In : Journal of Clinical Endocrinology and Metabolism. 64, 5, p. 1070-1074 5 p.

Research output: Contribution to journalArticle

Hormone Antagonists
Gonadotropins
Gonadotropin-Releasing Hormone
Testosterone
Serum

Regulation of Steroidogenic Responsiveness and Cyclic Nucleotide Levels by Atrial Natriuretic Factor in Isolated Mouse Leydig Cells

PANDEY, KAILASH. N., PAVLOU, SPYROS. N., KOVACS, WILLIAM. J. & INAGAMI, TADASHI., Dec 1987, In : Annals of the New York Academy of Sciences. 513, 1, p. 398-400 3 p.

Research output: Contribution to journalArticle

Leydig Cells
Cyclic Nucleotides
Atrial Natriuretic Factor
Cells
Mouse
48 Citations (Scopus)

Suppression of pituitary-gonadal function by a potent new luteinizing hormone-releasing hormone antagonist in normal men

Pavlou, S. N., Wakefield, G. B., Island, D. P., Hoffman, P. G., Lepage, M. E., Chan, R. L., Nerenberg, C. A. & Kovacs, W. J., May 1987, In : Journal of Clinical Endocrinology and Metabolism. 64, 5, p. 931-936 6 p.

Research output: Contribution to journalArticle

Hormone Antagonists
Gonadotropin-Releasing Hormone
Testosterone
Serum
Gonadotrophs
1986
67 Citations (Scopus)

Atrial natriuretic factor regulates steroidogenic responsiveness and cyclic nucleotide levels in mouse leydig cells in vitro

Pandey, K. N., Paylou, S. N., Kovacs, W. & Inagami, T., Jul 16 1986, In : Biochemical and Biophysical Research Communications. 138, 1, p. 399-404 6 p.

Research output: Contribution to journalArticle

Leydig Cells
Cyclic Nucleotides
Atrial Natriuretic Factor
Testosterone
Luteinizing Hormone
70 Citations (Scopus)
Hormone Antagonists
Follicle Stimulating Hormone
Gonadotropin-Releasing Hormone
Aromatase
Granulosa Cells