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William O. Hancock

    • 2893 Citations
    • 31 h-Index
    1993 …2021
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    • 1 Similar Profiles
    Kinesin Medicine & Life Sciences
    Microtubules Medicine & Life Sciences
    Head Medicine & Life Sciences
    Neck Medicine & Life Sciences
    Tubulin Medicine & Life Sciences
    Proteins Medicine & Life Sciences
    Adenosine Triphosphate Medicine & Life Sciences
    Dyneins Medicine & Life Sciences

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    Projects 2006 2021

    Multimotor Mechanisms in Microtubule-based Transport

    Hancock, W. O.

    National Institutes of Health

    4/1/17 → 1/31/21

    Project: Research project

    Kinesin
    Microtubules
    Dyneins
    Cytoplasmic Dyneins
    Axonal Transport

    Molecular mechanism of Kinesin-2 motility

    Hancock, W. O.

    National Institutes of Health

    5/1/06 → 5/31/20

    Project: Research project

    Kinesin
    Microtubules
    Head
    Neck
    Flagella

    Kinesin and +TIP-based microtubule steering

    Hancock, W. O.

    National Institutes of Health

    9/21/12 → 8/31/17

    Project: Research project

    Kinesin
    Microtubules
    Neurons
    Dendrites
    Cytoskeleton

    Directed assembly of artificial mitotic spindles

    Hancock, W. O.

    National Institutes of Health

    6/1/08 → 5/31/11

    Project: Research project

    Spindle Apparatus
    Microtubules
    Mitosis
    Cell Division
    Microtubule Proteins

    Research Output 1993 2019

    7 Citations (Scopus)

    Direct observation of individual tubulin dimers binding to growing microtubules

    Mickolajczyk, K. J., Geyer, E. A., Kim, T., Rice, L. M. & Hancock, W. O., Apr 9 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 15, p. 7314-7322 9 p.

    Research output: Contribution to journal › Article

    Tubulin
    Microtubules
    Observation
    Cell Division
    Microscopy
    1 Citation (Scopus)

    Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes

    Dumas, M. E., Chen, G. Y., Kendrick, N. D., Xu, G., Larsen, S. D., Jana, S., Waterson, A. G., Bauer, J. A., Hancock, W., Sulikowski, G. A. & Ohi, R., Jan 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 2, p. 148-154 7 p.

    Research output: Contribution to journal › Article

    Quinazolinones
    Kinesin
    Microtubules
    Spindle Apparatus
    Chromosomes
    1 Citation (Scopus)

    Insights into Kinesin-1 Stepping from Simulations and Tracking of Gold Nanoparticle-Labeled Motors

    Mickolajczyk, K. J., Cook, A. S. I., Jevtha, J. P., Fricks, J. & Hancock, W. O., Jul 23 2019, In : Biophysical journal. 117, 2, p. 331-345 15 p.

    Research output: Contribution to journal › Article

    Kinesin
    Gold
    Nanoparticles
    Adenosine Triphosphate
    Proteins

    Kinesin-5 Promotes Microtubule Nucleation and Assembly by Stabilizing a Lattice-Competent Conformation of Tubulin

    Chen, G. Y., Cleary, J. M., Asenjo, A. B., Chen, Y., Mascaro, J. A., Arginteanu, D. F. J., Sosa, H. & Hancock, W. O., Jul 22 2019, In : Current Biology. 29, 14, p. 2259-2269.e4

    Research output: Contribution to journal › Article

    Kinesin
    kinesin
    Tubulin
    tubulin
    Microtubules

    Load-dependent detachment kinetics plays a key role in bidirectional cargo transport by kinesin and dynein

    Ohashi, K. G., Han, L., Mentley, B., Wang, J., Fricks, J. & Hancock, W. O., Apr 2019, In : Traffic. 20, 4, p. 284-294 11 p.

    Research output: Contribution to journal › Article

    Dyneins
    Kinesin
    Kinetics
    Cytoplasmic Dyneins
    Optical Tweezers