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Research Output 1993 2019

2019
7 Citations (Scopus)

Direct observation of individual tubulin dimers binding to growing microtubules

Mickolajczyk, K. J., Geyer, E. A., Kim, T., Rice, L. M. & Hancock, W. O., Apr 9 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 15, p. 7314-7322 9 p.

Research output: Contribution to journalArticle

Tubulin
Microtubules
Observation
Cell Division
Microscopy
2 Citations (Scopus)

Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes

Dumas, M. E., Chen, G. Y., Kendrick, N. D., Xu, G., Larsen, S. D., Jana, S., Waterson, A. G., Bauer, J. A., Hancock, W., Sulikowski, G. A. & Ohi, R., Jan 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 2, p. 148-154 7 p.

Research output: Contribution to journalArticle

Quinazolinones
Kinesin
Microtubules
Spindle Apparatus
Chromosomes
1 Citation (Scopus)

Insights into Kinesin-1 Stepping from Simulations and Tracking of Gold Nanoparticle-Labeled Motors

Mickolajczyk, K. J., Cook, A. S. I., Jevtha, J. P., Fricks, J. & Hancock, W. O., Jul 23 2019, In : Biophysical journal. 117, 2, p. 331-345 15 p.

Research output: Contribution to journalArticle

Kinesin
Gold
Nanoparticles
Adenosine Triphosphate
Proteins

Kinesin-5 Promotes Microtubule Nucleation and Assembly by Stabilizing a Lattice-Competent Conformation of Tubulin

Chen, G. Y., Cleary, J. M., Asenjo, A. B., Chen, Y., Mascaro, J. A., Arginteanu, D. F. J., Sosa, H. & Hancock, W. O., Jul 22 2019, In : Current Biology. 29, 14, p. 2259-2269.e4

Research output: Contribution to journalArticle

Kinesin
kinesin
Tubulin
tubulin
Microtubules
1 Citation (Scopus)

Load-dependent detachment kinetics plays a key role in bidirectional cargo transport by kinesin and dynein

Ohashi, K. G., Han, L., Mentley, B., Wang, J., Fricks, J. & Hancock, W. O., Apr 2019, In : Traffic. 20, 4, p. 284-294 11 p.

Research output: Contribution to journalArticle

Dyneins
Kinesin
Kinetics
Cytoplasmic Dyneins
Optical Tweezers
2 Citations (Scopus)

Motor Dynamics Underlying Cargo Transport by Pairs of Kinesin-1 and Kinesin-3 Motors

Arpağ, G., Norris, S. R., Mousavi, S. I., Soppina, V., Verhey, K. J., Hancock, W. O. & Tüzel, E., Mar 19 2019, In : Biophysical journal. 116, 6, p. 1115-1126 12 p.

Research output: Contribution to journalArticle

Kinesin
Microtubules
Transport Vesicles
Dendrites
Axons
1 Citation (Scopus)

The Orphan Kinesin PAKRP2 Achieves Processive Motility via a Noncanonical Stepping Mechanism

Gicking, A. M., Wang, P., Liu, C., Mickolajczyk, K. J., Guo, L., Hancock, W. O. & Qiu, W., Apr 2 2019, In : Biophysical journal. 116, 7, p. 1270-1281 12 p.

Research output: Contribution to journalArticle

Kinesin
Proteins
Neck
Hydrolysis
Adenosine Triphosphate
2018
1 Citation (Scopus)

High-resolution single-molecule kinesin assays at kHz frame rates

Mickolajczyk, K. J. & Hancock, W. O., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 123-138 16 p. (Methods in Molecular Biology; vol. 1805).

Research output: Chapter in Book/Report/Conference proceedingChapter

Adenylyl Imidodiphosphate
Kinesin
Gold
Nanoparticles
In Vitro Techniques
1 Citation (Scopus)

Mechanics of bidirectional cargo transport

Hancock, W. O., Jan 1 2018, Dyneins: Dynein Mechanics, Dysfunction, and Disease: Second Edition. Elsevier, Vol. 2. p. 152-171 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dyneins
Kinesin
Mechanics
Microtubules
Membrane Fluidity

Mitotic kinesins in action: diffusive searching, directional switching, and ensemble coordination

Gicking, A. M., Qiu, W. & Hancock, W. O., May 15 2018, In : Molecular biology of the cell. 29, 10, p. 1153-1156 4 p.

Research output: Contribution to journalReview article

Kinesin
Microtubules
Spindle Apparatus
Cell Division
Cell Biology
11 Citations (Scopus)

Motor Reattachment Kinetics Play a Dominant Role in Multimotor-Driven Cargo Transport

Feng, Q., Mickolajczyk, K. J., Chen, G. Y. & Hancock, W. O., Jan 23 2018, In : Biophysical journal. 114, 2, p. 400-409 10 p.

Research output: Contribution to journalArticle

Kinesin
Microtubules
1 Citation (Scopus)

The S6 gate in regulatory Kv6 subunits restricts heteromeric K+ channel stoichiometry

Pisupati, A., Mickolajczyk, K. J., Horton, W., van Rossum, D. B., Anishkin, A., Chintapalli, S. V., Li, X., Chu-Luo, J., Busey, G., Hancock, W. O. & Jegla, T., Dec 1 2018, In : Journal of General Physiology. 150, 12, p. 1702-1721 20 p.

Research output: Contribution to journalArticle

S 6
Consensus Sequence
Cnidaria
Phenotype
Voltage-Gated Potassium Channels
2017
18 Citations (Scopus)

A Tubulin Binding Switch Underlies Kip3/Kinesin-8 Depolymerase Activity

Arellano-Santoyo, H., Geyer, E. A., Stokasimov, E., Chen, G. Y., Su, X., Hancock, W., Rice, L. M. & Pellman, D., Jul 10 2017, In : Developmental Cell. 42, 1, p. 37-51.e8

Research output: Contribution to journalArticle

Kinesin
Tubulin
Microtubules
Switches
Depolymerization
7 Citations (Scopus)

Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin

Guan, R., Zhang, L., Su, Q. P., Mickolajczyk, K. J., Chen, G. Y., Hancock, W. O., Sun, Y., Zhao, Y. & Chen, Z., Apr 10 2017, In : Nature communications. 8, 14951.

Research output: Contribution to journalArticle

Kinesin
Conformations
Crystal structure
crystal structure
Neck
9 Citations (Scopus)

Eg5 Inhibitors Have Contrasting Effects on Microtubule Stability and Metaphase Spindle Integrity

Chen, G. Y., Kang, Y. J., Gayek, A. S., Youyen, W., Tüzel, E., Ohi, R. & Hancock, W. O., Apr 21 2017, In : ACS chemical biology. 12, 4, p. 1038-1046 9 p.

Research output: Contribution to journalArticle

Kinesin
Metaphase
Microtubules
Assays
Antimitotic Agents
15 Citations (Scopus)

Kinesin Processivity Is Determined by a Kinetic Race from a Vulnerable One-Head-Bound State

Mickolajczyk, K. J. & Hancock, W. O., Jun 20 2017, In : Biophysical journal. 112, 12, p. 2615-2623 9 p.

Research output: Contribution to journalArticle

Kinesin
Head
Microtubules
Static Electricity
Adenosine Triphosphatases
12 Citations (Scopus)

The axonal transport motor kinesin-2 navigates microtubule obstacles via protofilament switching

Hoeprich, G. J., Mickolajczyk, K. J., Nelson, S. R., Hancock, W. O. & Berger, C. L., May 1 2017, In : Traffic. 18, 5, p. 304-314 11 p.

Research output: Contribution to journalArticle

Kinesin
Axonal Transport
Microtubules
Microtubule-Associated Proteins
Switching frequency
2016
8 Citations (Scopus)

Engineered kinesin motor proteins amenable to small-molecule inhibition

Engelke, M. F., Winding, M., Yue, Y., Shastry, S., Teloni, F., Reddy, S., Blasius, T. L., Soppina, P., Hancock, W. O., Gelfand, V. I. & Verhey, K. J., Apr 5 2016, In : Nature communications. 7, 11159.

Research output: Contribution to journalArticle

Kinesin
proteins
Molecules
molecules
Proteins
9 Citations (Scopus)

Interferometric Scattering Microscopy for the Study of Molecular Motors

Andrecka, J., Takagi, Y., Mickolajczyk, K. J., Lippert, L. G., Sellers, J. R., Hancock, W. O., Goldman, Y. E. & Kukura, P., Jan 1 2016, Methods in Enzymology. Academic Press Inc., p. 517-539 23 p. (Methods in Enzymology; vol. 581).

Research output: Chapter in Book/Report/Conference proceedingChapter

Microscopy
Microscopic examination
Scattering
Metal Nanoparticles
Dyneins
7 Citations (Scopus)

Kinesin-2 and Apc function at dendrite branch points to resolve microtubule collisions

Weiner, A. T., Lanz, M. C., Goetschius, D. J., Hancock, W. O. & Rolls, M. M., Jan 1 2016, In : Cytoskeleton. 73, 1, p. 35-44 10 p.

Research output: Contribution to journalArticle

Kinesin
Dendrites
Microtubules
Neurons
7 Citations (Scopus)

Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel

Upadhyay, A., Pisupati, A., Jegla, T., Crook, M., Mickolajczyk, K. J., Shorey, M., Rohan, L. E., Billings, K. A., Rolls, M. M., Hancock, W. O. & Hanna-Rose, W., Oct 12 2016, In : Nature communications. 7, 13135.

Research output: Contribution to journalArticle

nicotinamide
Optical character recognition
Niacinamide
Drosophila
Caenorhabditis elegans
24 Citations (Scopus)

The Kinesin-1 Chemomechanical Cycle: Stepping Toward a Consensus

Hancock, W. O., Mar 29 2016, In : Biophysical journal. 110, 6, p. 1216-1225 10 p.

Research output: Contribution to journalReview article

Kinesin
Head
Tubulin
Microtubules
Binding Sites
15 Citations (Scopus)

The kinesin-5 chemomechanical cycle is dominated by a two-heads-bound state

Chen, G. Y., Mickolajczyk, K. J. & Hancock, W. O., Sep 23 2016, In : Journal of Biological Chemistry. 291, 39, p. 20283-20294 12 p.

Research output: Contribution to journalArticle

Kinesin
Adenosine Triphosphate
Head
Adenosine Diphosphate
Microtubules
2015

Aging Gracefully: A New Model of Microtubule Growth and Catastrophe

Hancock, W. O., Dec 15 2015, In : Biophysical journal. 109, 12, p. 2449-2451 3 p.

Research output: Contribution to journalShort survey

Tubulin
Microtubules
Growth
66 Citations (Scopus)

Examining kinesin processivity within a general gating framework

Andreasson, J. O. L., Milic, B., Chen, G. Y., Guydosh, N. R., Hancock, W. O. & Block, S. M., Apr 22 2015, In : eLife. 2015, 4, p. 1-44 44 p.

Research output: Contribution to journalArticle

Kinesin
Head
Neck
Cysteine
Hydrolysis
31 Citations (Scopus)

Kinesin-5 is a microtubule polymerase

Chen, Y. & Hancock, W. O., Oct 6 2015, In : Nature communications. 6, 8160.

Research output: Contribution to journalArticle

Kinesin
chutes
Microtubules
polymerization
axons
46 Citations (Scopus)

Kinetics of nucleotide-dependent structural transitions in the kinesin-1 hydrolysis cycle

Mickolajczyk, K. J., Deffenbaugh, N. C., Arroyo, J. O., Andrecka, J., Kukura, P. & Hancock, W. O., Dec 29 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 52, p. E7186-E7193

Research output: Contribution to journalArticle

Kinesin
Hydrolysis
Nucleotides
Adenosine Triphosphate
Head
21 Citations (Scopus)

Processivity of the Kinesin-2 KIF3A results from rear head gating and not front head gating

Chen, G. Y., Arginteanu, D. F. J. & Hancock, W. O., Apr 17 2015, In : Journal of Biological Chemistry. 290, 16, p. 10274-10294 21 p.

Research output: Contribution to journalArticle

Kinesin
Head
Assays
Adenosine Diphosphate
Kinetics
32 Citations (Scopus)

The mechanochemical cycle of mammalian kinesin-2 KIF3A/B under load

Andreasson, J. O. L., Shastry, S., Hancock, W. O. & Block, S. M., May 4 2015, In : Current Biology. 25, 9, p. 1166-1175 10 p.

Research output: Contribution to journalArticle

Kinesin
kinesin
Dyneins
Optical Tweezers
Transport Vesicles
2014
20 Citations (Scopus)

An EB1-kinesin complex is sufficient to steer microtubule growth in vitro

Chen, Y., Rolls, M. & Hancock, W. O., Feb 3 2014, In : Current Biology. 24, 3, p. 316-321 6 p.

Research output: Contribution to journalArticle

Kinesin
kinesin
Microtubules
microtubules
Growth
166 Citations (Scopus)

Bidirectional cargo transport: Moving beyond tug of war

Hancock, W. O., Sep 2014, In : Nature Reviews Molecular Cell Biology. 15, 9, p. 615-628 14 p.

Research output: Contribution to journalReview article

Microtubules
Dyneins
Kinesin
Organelles
Direction compound
57 Citations (Scopus)

Kinesin processivity is gated by phosphate release

Milic, B., Andreasson, J. O. L., Hancock, W. O. & Block, S. M., Sep 30 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 39, p. 14136-14140 5 p.

Research output: Contribution to journalArticle

Kinesin
Adenosine Triphosphate
Phosphates
Hydrolysis
Microtubules
44 Citations (Scopus)

Kinesin's neck-linker determines its ability to navigate obstacles on the microtubule surface

Hoeprich, G. J., Thompson, A. R., McVicker, D. P., Hancock, W. O. & Berger, C. L., Apr 15 2014, In : Biophysical journal. 106, 8, p. 1691-1700 10 p.

Research output: Contribution to journalArticle

Kinesin
Microtubules
Neck
Microtubule-Associated Proteins
Protein Isoforms
6 Citations (Scopus)

Mitotic kinesins: A reason to delve into kinesin-12

Hancock, W. O., Oct 6 2014, In : Current Biology. 24, 19, p. R968-R970

Research output: Contribution to journalShort survey

Kinesin
kinesin
Kinetochores
kinetochores
Drug Delivery Systems
28 Citations (Scopus)
Photobleaching
Practice Guidelines
Cellulose
Biopolymers
Plant Cells
46 Citations (Scopus)

Transport by populations of fast and slow kinesins uncovers novel family-dependent motor characteristics important for in vivo function

Arpaʇ, G., Shastry, S., Hancock, W. O. & Tüzel, E., Oct 21 2014, In : Biophysical journal. 107, 8, p. 1896-1904 9 p.

Research output: Contribution to journalArticle

Kinesin
Microtubules
Population
Compliance
2013
5 Citations (Scopus)

Estimating Velocity for Processive Motor Proteins with Random Detachment

Hughes, J., Shastry, S., Hancock, W. O. & Fricks, J., Jun 1 2013, In : Journal of Agricultural, Biological, and Environmental Statistics. 18, 2, p. 204-217 14 p.

Research output: Contribution to journalArticle

Students
Proteins
Protein
protein
Infinite Variance
2012
1 Citation (Scopus)

Cytoskeletal organization: Whirling to the beat

Hancock, W. O., Jun 19 2012, In : Current Biology. 22, 12, p. R493-R495

Research output: Contribution to journalShort survey

Axonemal Dyneins
schools of fish
Birds
Microtubules
Fish
10 Citations (Scopus)

Kinesins with Extended Neck Linkers: A Chemomechanical Model for Variable-Length Stepping

Hughes, J., Hancock, W. O. & Fricks, J., May 1 2012, In : Bulletin of Mathematical Biology. 74, 5, p. 1066-1097 32 p.

Research output: Contribution to journalArticle

Kinesin
kinesin
neck
Neck
Microtubules
6 Citations (Scopus)

Microtubule asters as templates for nanomaterials assembly

Verma, V., Catchmark, J. M., Brown, N. & Hancock, W. O., Dec 27 2012, In : Journal of Biological Engineering. 6, 23.

Research output: Contribution to journalArticle

Nanowhiskers
Nanostructures
Nanostructured materials
Cellulose
Microtubules
2011
8 Citations (Scopus)

A matrix computational approach to kinesin neck linker extension

Hughes, J., Hancock, W. O. & Fricks, J., Jan 21 2011, In : Journal of Theoretical Biology. 269, 1, p. 181-194 14 p.

Research output: Contribution to journalArticle

Kinesin
kinesin
neck
Neck
Renewal Theory
10 Citations (Scopus)

"Artificial mitotic spindle" generated by dielectrophoresis and protein micropatterning supports bidirectional transport of kinesin-coated beads

Uppalapati, M., Huang, Y. M., Aravamuthan, V., Jackson, T. N. & Hancock, W. O., Jan 1 2011, In : Integrative Biology. 3, 1, p. 57-64 8 p.

Research output: Contribution to journalArticle

Kinesin
Spindle Apparatus
Chromosomes
Electrophoresis
Microtubules
20 Citations (Scopus)

Engineering tubulin: Microtubule functionalization approaches for nanoscale device applications

Malcos, J. L. & Hancock, W. O., Apr 1 2011, In : Applied Microbiology and Biotechnology. 90, 1, p. 1-10 10 p.

Research output: Contribution to journalReview article

Tubulin
Microtubules
Equipment and Supplies
Kinesin
Biological Transport
55 Citations (Scopus)

Interhead tension determines processivity across diverse N-terminal kinesins

Shastry, S. & Hancock, W. O., Sep 27 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 39, p. 16253-16258 6 p.

Research output: Contribution to journalArticle

Kinesin
Neck
Head
Mechanics
Biochemistry
2010
7 Citations (Scopus)

Likelihood inference for particle location in fluorescence microscopy

Hughes, J., Fricks, J. & Hancock, W., Jun 1 2010, In : Annals of Applied Statistics. 4, 2, p. 830-848 19 p.

Research output: Contribution to journalArticle

Fluorescence Microscopy
Likelihood Inference
Fluorescence microscopy
Stochastic models
Standard error
20 Citations (Scopus)

Monte carlo analysis of neck linker extension in kinesin molecular motors

Kutys, M. L., Fricks, J. & Hancock, W. O., Nov 1 2010, In : PLoS computational biology. 6, 11, e1000980.

Research output: Contribution to journalArticle

Molecular Motor
Monte Carlo analysis
Kinesin
kinesin
neck
68 Citations (Scopus)

Neck Linker Length Determines the Degree of Processivity in Kinesin-1 and Kinesin-2 Motors

Shastry, S. & Hancock, W. O., May 25 2010, In : Current Biology. 20, 10, p. 939-943 5 p.

Research output: Contribution to journalArticle

Kinesin
kinesin
neck
Neck
Head
2009
58 Citations (Scopus)

Anterograde microtubule transport drives microtubule bending in LLC-PK1 epithelial cells

Bicek, A. D., Tüzel, E., Demtchouk, A., Uppalapati, M., Hancock, W. O., Kroll, D. M. & Odde, D. J., Jun 15 2009, In : Molecular biology of the cell. 20, 12, p. 2943-2953 11 p.

Research output: Contribution to journalArticle

LLC-PK1 Cells
Microtubules
Epithelial Cells
Polymerization
Actomyosin
49 Citations (Scopus)
Kinesin
Sequence Analysis
Molecular Dynamics Simulation
Mechanical Properties
Molecular dynamics
7 Citations (Scopus)

Nanoscale patterning of kinesin motor proteins and its role in guiding microtubule motility

Verma, V., Hancock, W. O. & Catchmark, J. M., Jan 1 2009, In : Biomedical Microdevices. 11, 2, p. 313-322 10 p.

Research output: Contribution to journalArticle

Kinesin
Microtubules
NEMS
Proteins
Nanolithography