Xuemei Huang, MD, PhD

    • 5744 Citations
    • 39 h-Index
    1974 …2024

    Research output per year

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    Research Output

    2020

    Non-motor symptoms and striatal dopamine transporter binding in early Parkinson's disease

    Liu, R., Umbach, D. M., Tröster, A. I., Huang, X. & Chen, H., Mar 2020, In : Parkinsonism and Related Disorders. 72, p. 23-30 8 p.

    Research output: Contribution to journalArticle

    Synergic control of action in levodopa-naïve Parkinson’s disease patients: I. Multi-finger interaction and coordination

    de Freitas, P. B., Freitas, S. M. S. F., Reschechtko, S., Corson, T., Lewis, M. M., Huang, X. & Latash, M. L., Jan 1 2020, In : Experimental Brain Research. 238, 1, p. 229-245 17 p.

    Research output: Contribution to journalArticle

    Understanding the links between cardiovascular disease and Parkinson's disease

    Potashkin, J., Huang, X., Becker, C., Chen, H., Foltynie, T. & Marras, C., Jan 1 2020, In : Movement Disorders. 35, 1, p. 55-74 20 p.

    Research output: Contribution to journalReview article

    1 Scopus citations

    α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson's disease patients

    Manne, S., Kondru, N., Jin, H., Anantharam, V., Huang, X., Kanthasamy, A. & Kanthasamy, A. G., Feb 1 2020, In : Movement Disorders. 35, 2, p. 268-278 11 p.

    Research output: Contribution to journalArticle

    1 Scopus citations
    2019
    Open Access
    1 Scopus citations

    Brain cholesterol metabolism and Parkinson's disease

    Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M. M., Chen, H., Hohl, R. J. & Mailman, R. B., Mar 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

    Research output: Contribution to journalArticle

    5 Scopus citations

    Characterization of Parkinson's disease using blood-based biomarkers: A multicohort proteomic analysis

    Posavi, M., Diaz-Ortiz, M., Liu, B., Swanson, C. R., Skrinak, R. T., Hernandez-Con, P., Amado, D. A., Fullard, M., Rick, J., Siderowf, A., Weintraub, D., McCluskey, L., Trojanowski, J. Q., Dewey, R. B., Huang, X. & Chen-Plotkin, A. S., Jan 1 2019, In : PLoS medicine. 16, 10, e1002931.

    Research output: Contribution to journalArticle

    Open Access

    Development and validation of the automated imaging differentiation in parkinsonism (AID-P): a multicentre machine learning study

    Archer, D. B., Bricker, J. T., Chu, W. T., Burciu, R. G., McCracken, J. L., Lai, S., Coombes, S. A., Fang, R., Barmpoutis, A., Corcos, D. M., Kurani, A. S., Mitchell, T., Black, M. L., Herschel, E., Simuni, T., Parrish, T. B., Comella, C., Xie, T., Seppi, K., Bohnen, N. I. & 11 others, Müller, M. LTM., Albin, R. L., Krismer, F., Du, G., Lewis, M. M., Huang, X., Li, H., Pasternak, O., McFarland, N. R., Okun, M. S. & Vaillancourt, D. E., Sep 2019, In : The Lancet Digital Health. 1, 5, p. e222-e231

    Research output: Contribution to journalArticle

    Open Access
    1 Scopus citations

    Higher Hippocampal Mean Diffusivity Values in Asymptomatic Welders

    Lee, E. Y., Flynn, M. R., Du, G., Lewis, M. M., Kong, L., Yanosky, J. D., Mailman, R. B. & Huang, X., Apr 1 2019, In : Toxicological Sciences. 168, 2, p. 486-496 11 p.

    Research output: Contribution to journalArticle

    1 Scopus citations

    Individual preferences in motor coordination seen across the two hands: relations to movement stability and optimality

    de Freitas, P. B., Freitas, S. M. S. F., Lewis, M. M., Huang, X. & Latash, M. L., Jan 31 2019, In : Experimental Brain Research. 237, 1

    Research output: Contribution to journalArticle

    Magnetic resonance T1w/T2w ratio: A parsimonious marker for Parkinson disease

    Du, G., Lewis, M. M., Sica, C., Kong, L. & Huang, X., Jan 2019, In : Annals of Neurology. 85, 1, p. 96-104 9 p.

    Research output: Contribution to journalArticle

    6 Scopus citations

    Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells

    Sarkar, S., Rokad, D., Malovic, E., Luo, J., Harischandra, D. S., Jin, H., Anantharam, V., Huang, X., Lewis, M., Kanthasamy, A. & Kanthasamy, A. G., Jan 8 2019, In : Science signaling. 12, 563, aat9900.

    Research output: Contribution to journalArticle

    9 Scopus citations

    Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

    Harischandra, D. S., Rokad, D., Neal, M. L., Ghaisas, S., Manne, S., Sarkar, S., Panicker, N., Zenitsky, G., Jin, H., Lewis, M., Huang, X., Anantharam, V., Kanthasamy, A. & Kanthasamy, A. G., Jan 1 2019, In : Science signaling. 12, 572, eaau4543.

    Research output: Contribution to journalArticle

    12 Scopus citations

    Multimodal MRI evaluation of parkinsonian limbic pathologies

    Wang, E. W., Du, G., Lewis, M. M., Lee, E. Y., De Jesus, S., Kanekar, S., Kong, L. & Huang, X., Apr 2019, In : Neurobiology of Aging. 76, p. 194-200 7 p.

    Research output: Contribution to journalArticle

    Quantitative analysis of multi-element synergy stabilizing performance: comparison of three methods with respect to their use in clinical studies

    Freitas, S. M. S. F., de Freitas, P. B., Lewis, M. M., Huang, X. & Latash, M. L., Feb 4 2019, In : Experimental Brain Research. 237, 2, p. 453-465 13 p.

    Research output: Contribution to journalArticle

    2 Scopus citations

    Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders

    Manne, S., Kondru, N., Hepker, M., Jin, H., Anantharam, V., Lewis, M., Huang, X., Kanthasamy, A. & Kanthasamy, A. G., Sep 15 2019, In : Journal of Neuroimmune Pharmacology. 14, 3, p. 423-435 13 p.

    Research output: Contribution to journalArticle

    5 Scopus citations
    2018

    Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients

    Du, G., Lewis, M., Sica, C., He, L., Connor, J., Kong, L., Mailman, R. & Huang, X., Sep 2018, In : Movement Disorders. 33, 9, p. 1423-1431 9 p.

    Research output: Contribution to journalArticle

    14 Scopus citations

    HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity

    Nixon, A. M., Meadowcroft, M. D., Neely, E. B., Snyder, A. M., Purnell, C. J., Wright, J., Lamendella, R., Nandar, W., Huang, X. & Connor, J. R., May 2018, In : Journal of neurochemistry. 145, 4, p. 299-311 13 p.

    Research output: Contribution to journalArticle

    1 Scopus citations
    Open Access
    2 Scopus citations

    Projection of the prevalence of Parkinson's disease in the coming decades: Revisited

    Rossi, A., Berger, K., Chen, H., Leslie, D., Mailman, R. & Huang, X., Jan 2018, In : Movement Disorders. 33, 1, p. 156-159 4 p.

    Research output: Contribution to journalArticle

    21 Scopus citations

    Stability of steady hand force production explored across spaces and methods of analysis

    de Freitas, P. B., Freitas, S. M. S. F., Lewis, M. M., Huang, X. & Latash, M. L., Jun 1 2018, In : Experimental Brain Research. 236, 6, p. 1545-1562 18 p.

    Research output: Contribution to journalArticle

    5 Scopus citations

    Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes

    Lewis, M., Du, G., Baccon, J., Snyder, A., Murie, B., Cooper, F., Stetter, C., Kong, L., Sica, C., Mailman, R., Connor, J. & Huang, X., Sep 2018, In : Movement Disorders. 33, 9, p. 1432-1439 8 p.

    Research output: Contribution to journalArticle

    13 Scopus citations

    Systemic effects of deep brain stimulation on synergic control in Parkinson's disease

    Falaki, A., Jo, H. J., Lewis, M. M., O'Connell, B., De Jesus, S., McInerney, J., Huang, X. & Latash, M. L., Jun 2018, In : Clinical Neurophysiology. 129, 6, p. 1320-1332 13 p.

    Research output: Contribution to journalArticle

    5 Scopus citations

    Welding-related brain and functional changes in welders with chronic and low-level exposure

    Lee, E. Y., Flynn, M. R., Lewis, M. M., Mailman, R. B. & Huang, X., Jan 2018, In : NeuroToxicology. 64, p. 50-59 10 p.

    Research output: Contribution to journalArticle

    4 Scopus citations
    2017

    Association of neurobehavioral performance with R2* in the caudate nucleus of asymptomatic welders

    Lee, E. Y., Eslinger, P. J., Flynn, M. R., Wagner, D., Du, G., Lewis, M. M., Kong, L., Mailman, R. B. & Huang, X., Jan 1 2017, In : NeuroToxicology. 58, p. 66-74 9 p.

    Research output: Contribution to journalArticle

    6 Scopus citations

    Changes in Multidigit Synergies and Their Feed-Forward Adjustments in Multiple Sclerosis

    Jo, H. J., Mattos, D., Lucassen, E. B., Huang, X. & Latash, M. L., Mar 4 2017, In : Journal of motor behavior. 49, 2, p. 218-228 11 p.

    Research output: Contribution to journalArticle

    9 Scopus citations

    Circulating cholesterol levels may link to the factors influencing Parkinson's Risk

    Zhang, L., Wang, X., Wang, M., Sterling, N. W., Du, G., Lewis, M. M., Yao, T., Mailman, R. B., Li, R. & Huang, X., Sep 27 2017, In : Frontiers in Neurology. 8, SEP, 501.

    Research output: Contribution to journalArticle

    3 Scopus citations

    Clinical quantitative susceptibility mapping (QSM): Biometal imaging and its emerging roles in patient care

    Wang, Y., Spincemaille, P., Liu, Z., Dimov, A., Deh, K., Li, J., Zhang, Y., Yao, Y., Gillen, K. M., Wilman, A. H., Gupta, A., Tsiouris, A. J., Kovanlikaya, I., Chiang, G. C. Y., Weinsaft, J. W., Tanenbaum, L., Chen, W., Zhu, W., Chang, S., Lou, M. & 14 others, Kopell, B. H., Kaplitt, M. G., Devos, D., Hirai, T., Huang, X., Korogi, Y., Shtilbans, A., Jahng, G. H., Pelletier, D., Gauthier, S. A., Pitt, D., Bush, A. I., Brittenham, G. M. & Prince, M. R., Oct 2017, In : Journal of Magnetic Resonance Imaging. 46, 4, p. 951-971 21 p.

    Research output: Contribution to journalReview article

    53 Scopus citations
    6 Scopus citations

    Cortical gray and subcortical white matter associations in Parkinson's disease

    Sterling, N. W., Du, G., Lewis, M. M., Swavely, S., Kong, L., Styner, M. & Huang, X., Jan 1 2017, In : Neurobiology of Aging. 49, p. 100-108 9 p.

    Research output: Contribution to journalArticle

    4 Scopus citations

    Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing

    International Parkinson's Disease Genetics Consortium (IPGDC), Jan 30 2017, In : Genome biology. 18, 1, 22.

    Research output: Contribution to journalArticle

    29 Scopus citations
    9 Scopus citations

    Evaluating the cost-effectiveness of an early detection of Parkinson's disease through innovative technology

    Muñoz, D. A., Kilinc, M. S., Nembhard, H. B., Tucker, C. & Huang, X., Apr 3 2017, In : Engineering Economist. 62, 2, p. 180-196 17 p.

    Research output: Contribution to journalArticle

    Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease

    Robak, L. A., Jansen, I. E., Rooij, J. V., Uitterlinden, A. G., Kraaij, R., Jankovic, J., Heutink, P., Shulman, J. M., Nalls, M. A., Plagnol, V., Hernandez, D. G., Sharma, M., Sheerin, U. M., Saad, M., Simón-Sánchez, J., Schulte, C., Lesage, S., Sveinbjörnsdóttir, S., Arepalli, S., Barker, R. & 120 others, Ben, Y., Berendse, H. W., Berg, D., Bhatia, K., de Bie, R. M. A., Biffi, A., Bloem, B., Bochdanovits, Z., Bonin, M., Bras, J. M., Brockmann, K., Brooks, J., Burn, D. J., Majounie, E., Charlesworth, G., Lungu, C., Chen, H., Chinnery, P. F., Chong, S., Clarke, C. E., Cookson, M. R., Cooper, J. M., Corvol, J. C., Counsell, C., Damier, P., Dartigues, J. F., Deloukas, P., Deuschl, G., Dexter, D. T., van Dijk, K. D., Dillman, A., Durif, F., Dürr, A., Edkins, S., Evans, J. R., Foltynie, T., Dong, J., Gardner, M., Gibbs, J. R., Goate, A., Gray, E., Guerreiro, R., Harris, C., van Hilten, J. J., Hofman, A., Hollenbeck, A., Holton, J., Hu, M., Huang, X., Wurster, I., Mätzler, W., Hudson, G., Hunt, S. E., Huttenlocher, J., Illig, T., Jónsson, P. V., Lambert, J. C., Langford, C., Lees, A., Lichtner, P., Limousin, P., Lopez, G., Lorenz, D., Lungu, C., McNeill, A., Moorby, C., Moore, M., Morris, H. R., Morrison, K. E., Escott-Price, V., Mudanohwo, E., O’sullivan, S. S., Pearson, J., Perlmutter, J. S., Pétursson, H., Pollak, P., Post, B., Potter, S., Ravina, B., Revesz, T., Riess, O., Rivadeneira, F., Rizzu, P., Ryten, M., Sawcer, S., Schapira, A., Scheffer, H., Shaw, K., Shoulson, I., Shulman, J., Sidransky, E., Smith, C., Spencer, C. C. A., Stefánsson, H., Bettella, F., Stockton, J. D., Strange, A., Talbot, K., Tanner, C. M., Tashakkori-Ghanbaria, A., Tison, F., Trabzuni, D., Traynor, B. J., Uitterlinden, A. G., Velseboer, D., Vidailhet, M., Walker, R., Warrenburg, B. V. D., Wickremaratchi, M., Williams, N., Williams-Gray, C. H., Winder-Rhodes, S., Stefánsson, K., Martinez, M., Wood, N. W., Hardy, J., Heutink, P., Brice, A., Gasser, T. & Singleton, A. B., Dec 1 2017, In : Brain. 140, 12, p. 3191-3203 13 p.

    Research output: Contribution to journalArticle

    Open Access
    70 Scopus citations

    Free water improves detection of changes in the substantia nigra in parkinsonism: A multisite study

    Ofori, E., Krismer, F., Burciu, R. G., Pasternak, O., McCracken, J. L., Lewis, M. M., Du, G., McFarland, N. R., Okun, M. S., Poewe, W., Mueller, C., Gizewski, E. R., Schocke, M., Kremser, C., Li, H., Huang, X., Seppi, K. & Vaillancourt, D. E., Oct 2017, In : Movement Disorders. 32, 10, p. 1457-1464 8 p.

    Research output: Contribution to journalArticle

    15 Scopus citations

    Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans

    Dong, J., Wyss, A., Yang, J., Price, T. R., Nicolas, A., Nalls, M., Tranah, G., Franceschini, N., Xu, Z., Schulte, C., Alonso, A., Cummings, S. R., Fornage, M., Zaykin, D., Li, L., Huang, X., Kritchevsky, S., Liu, Y., Gasser, T., Wilson, R. S. & 9 others, De Jager, P. L., Singleton, A. B., Pinto, J. M., Harris, T., Mosley, T. H., Bennett, D. A., London, S., Yu, L. & Chen, H., Dec 1 2017, In : Molecular Neurobiology. 54, 10, p. 8021-8032 12 p.

    Research output: Contribution to journalArticle

    3 Scopus citations

    Genome-wide pleiotropy between Parkinson disease and autoimmune diseases

    for the International Parkinson's Disease Genomics Consortium (IPDGC), United Kingdom Brain Expression Consortium (UKBEC) Investigators, North American Brain Expression Consortium (NABEC), Jul 2017, In : JAMA neurology. 74, 7, p. 780-792 13 p.

    Research output: Contribution to journalArticle

    51 Scopus citations

    Lateralized basal ganglia vulnerability to pesticide exposure in asymptomatic agricultural workers

    Lewis, M., Sterling, N. W., Du, G., Lee, E. Y., Shyu, G., Goldenberg, M., Allen, T., Stetter, C., Kong, L., Snipes, S. A., Jones, B. C., Chen, H., Mailman, R. & Huang, X., Jan 1 2017, In : Toxicological Sciences. 159, 1, p. 170-178 9 p.

    Research output: Contribution to journalArticle

    2 Scopus citations

    Motor equivalence and structure of variance: multi-muscle postural synergies in Parkinson’s disease

    Falaki, A., Huang, X., Lewis, M. M. & Latash, M. L., Jul 1 2017, In : Experimental Brain Research. 235, 7, p. 2243-2258 16 p.

    Research output: Contribution to journalArticle

    9 Scopus citations

    No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson’s disease in nine ADHD candidate SNPs

    International Parkinson Disease Genomics Consortium members, Jun 1 2017, In : ADHD Attention Deficit and Hyperactivity Disorders. 9, 2, p. 121-127 7 p.

    Research output: Contribution to journalArticle

    5 Scopus citations

    Olfaction and incident Parkinson disease in US white and black older adults

    Chen, H., Shrestha, S., Huang, X., Jain, S., Guo, X., Tranah, G. J., Garcia, M. E., Satterfield, S., Phillips, C. & Harris, T. B., Oct 3 2017, In : Neurology. 89, 14, p. 1441-1447 7 p.

    Research output: Contribution to journalArticle

    16 Scopus citations

    Parkinson's disease biomarkers: Perspective from the NINDS Parkinson's Disease Biomarkers Program

    Gwinn, K., David, K. K., Swanson-Fischer, C., Albin, R., Hillaire-Clarke, C. S., Sieber, B. A., Lungu, C., Bowman, F. D., Alcalay, R. N., Babcock, D., Dawson, T. M., Dewey, R. B., Foroud, T., German, D., Huang, X., Petyuk, V., Potashkin, J. A., Saunders-Pullman, R., Sutherland, M., Walt, D. R. & 6 others, West, A. B., Zhang, J., Chen-Plotkin, A., Scherzer, C. R., Vaillancourt, D. E. & Rosenthal, L. S., Jun 2017, In : Biomarkers in Medicine. 11, 6, p. 451-473 23 p.

    Research output: Contribution to journalReview article

    16 Scopus citations

    Positive association between Toxoplasma gondii IgG serointensity and current dysphoria/hopelessness scores in the Old Order Amish: A preliminary study

    Wadhawan, A., Dagdag, A., Duffy, A., Daue, M. L., Ryan, K. A., Brenner, L. A., Stiller, J. W., Pollin, T. I., Groer, M. W., Huang, X., Lowry, C. A., Mitchell, B. D. & Postolache, T. T., Dec 20 2017, In : Pteridines. 28, 3-4, p. 185-194 10 p.

    Research output: Contribution to journalArticle

    4 Scopus citations

    Predicting the multi-domain progression of Parkinson's disease: A Bayesian multivariate generalized linear mixed-effect model

    Wang, M., Li, Z., Lee, E. Y., Lewis, M. M., Zhang, L., Sterling, N. W., Wagner, D., Eslinger, P., Du, G. & Huang, X., Sep 25 2017, In : BMC Medical Research Methodology. 17, 1, 147.

    Research output: Contribution to journalArticle

    Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database

    Liu, G., Sterling, N. W., Kong, L., Lewis, M. M., Mailman, R. B., Chen, H., Leslie, D. & Huang, X., Jun 2017, In : Movement Disorders. 32, 6, p. 913-917 5 p.

    Research output: Contribution to journalArticle

    22 Scopus citations

    The Prevalence of Anosmia and Associated Factors among U.S. Black and White Older Adults

    Dong, J., Pinto, J. M., Guo, X., Alonso, A., Tranah, G., Cauley, J. A., Garcia, M., Satterfield, S., Huang, X., Harris, T., Mosley, T. H. & Chen, H., Aug 1 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 8, p. 1080-1086 7 p.

    Research output: Contribution to journalArticle

    12 Scopus citations
    2016

    Default mode network differences between rigidity- and tremor-predominant Parkinson's disease

    Karunanayaka, P. R., Lee, E. Y., Lewis, M. M., Sen, S., Eslinger, P. J., Yang, Q. X. & Huang, X., Aug 1 2016, In : Cortex. 81, p. 239-250 12 p.

    Research output: Contribution to journalArticle

    24 Scopus citations

    Effects of unilateral stroke on multi-finger synergies and their feed-forward adjustments

    Jo, H. J., Maenza, C., Good, D., Huang, X., Park, J., Sainburg, R. L. & Latash, M., Apr 5 2016, In : Neuroscience. 319, p. 194-205 12 p.

    Research output: Contribution to journalArticle

    20 Scopus citations

    Finger force changes in the absence of visual feedback in patients with Parkinson's disease

    Jo, H. J., Ambike, S., Lewis, M., Huang, X. & Latash, M., Jan 1 2016, In : Clinical Neurophysiology. 127, 1, p. 684-692 9 p.

    Research output: Contribution to journalArticle

    14 Scopus citations

    Folded concave penalized learning in identifying multimodal MRI marker for Parkinson's disease

    Liu, H., Du, G., Zhang, L., Lewis, M., Wang, X., Yao, T., Li, R. & Huang, X., Aug 1 2016, In : Journal of Neuroscience Methods. 268, p. 1-6 6 p.

    Research output: Contribution to journalArticle

    5 Scopus citations