Xuemei Huang, MD, PhD

    • 5482 Citations
    • 39 h-Index
    1974 …2022
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    Research Output 1990 2019

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    Article

    Evaluating the cost-effectiveness of an early detection of Parkinson's disease through innovative technology

    Muñoz, D. A., Kilinc, M. S., Nembhard, H. B., Tucker, C. & Huang, X., Apr 3 2017, In : Engineering Economist. 62, 2, p. 180-196 17 p.

    Research output: Contribution to journalArticle

    Cost effectiveness
    Disease
    costs
    Health
    Costs
    54 Citations (Scopus)

    Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease

    Robak, L. A., Jansen, I. E., Rooij, J. V., Uitterlinden, A. G., Kraaij, R., Jankovic, J., Heutink, P., Shulman, J. M., Nalls, M. A., Plagnol, V., Hernandez, D. G., Sharma, M., Sheerin, U. M., Saad, M., Simón-Sánchez, J., Schulte, C., Lesage, S., Sveinbjörnsdóttir, S., Arepalli, S., Barker, R. & 120 others, Ben, Y., Berendse, H. W., Berg, D., Bhatia, K., de Bie, R. M. A., Biffi, A., Bloem, B., Bochdanovits, Z., Bonin, M., Bras, J. M., Brockmann, K., Brooks, J., Burn, D. J., Majounie, E., Charlesworth, G., Lungu, C., Chen, H., Chinnery, P. F., Chong, S., Clarke, C. E., Cookson, M. R., Cooper, J. M., Corvol, J. C., Counsell, C., Damier, P., Dartigues, J. F., Deloukas, P., Deuschl, G., Dexter, D. T., van Dijk, K. D., Dillman, A., Durif, F., Dürr, A., Edkins, S., Evans, J. R., Foltynie, T., Dong, J., Gardner, M., Gibbs, J. R., Goate, A., Gray, E., Guerreiro, R., Harris, C., van Hilten, J. J., Hofman, A., Hollenbeck, A., Holton, J., Hu, M., Huang, X., Wurster, I., Mätzler, W., Hudson, G., Hunt, S. E., Huttenlocher, J., Illig, T., Jónsson, P. V., Lambert, J. C., Langford, C., Lees, A., Lichtner, P., Limousin, P., Lopez, G., Lorenz, D., Lungu, C., McNeill, A., Moorby, C., Moore, M., Morris, H. R., Morrison, K. E., Escott-Price, V., Mudanohwo, E., O’sullivan, S. S., Pearson, J., Perlmutter, J. S., Pétursson, H., Pollak, P., Post, B., Potter, S., Ravina, B., Revesz, T., Riess, O., Rivadeneira, F., Rizzu, P., Ryten, M., Sawcer, S., Schapira, A., Scheffer, H., Shaw, K., Shoulson, I., Shulman, J., Sidransky, E., Smith, C., Spencer, C. C. A., Stefánsson, H., Bettella, F., Stockton, J. D., Strange, A., Talbot, K., Tanner, C. M., Tashakkori-Ghanbaria, A., Tison, F., Trabzuni, D., Traynor, B. J., Uitterlinden, A. G., Velseboer, D., Vidailhet, M., Walker, R., Warrenburg, B. V. D., Wickremaratchi, M., Williams, N., Williams-Gray, C. H., Winder-Rhodes, S., Stefánsson, K., Martinez, M., Wood, N. W., Hardy, J., Heutink, P., Brice, A., Gasser, T. & Singleton, A. B., Dec 1 2017, In : Brain. 140, 12, p. 3191-3203 13 p.

    Research output: Contribution to journalArticle

    Open Access
    Parkinson Disease
    Glucosylceramidase
    Genes
    Exome
    Disease Susceptibility
    23 Citations (Scopus)

    Female reproductive factors, menopausal hormone use, and Parkinson's disease

    Liu, R., Baird, D., Park, Y., Freedman, N. D., Huang, X., Hollenbeck, A., Blair, A. & Chen, H., Jan 1 2014, In : Movement Disorders. 29, 7, p. 889-896 8 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Hormones
    Confidence Intervals
    Odds Ratio
    Menopause
    14 Citations (Scopus)

    Finger force changes in the absence of visual feedback in patients with Parkinson's disease

    Jo, H. J., Ambike, S., Lewis, M., Huang, X. & Latash, M., Jan 1 2016, In : Clinical Neurophysiology. 127, 1, p. 684-692 9 p.

    Research output: Contribution to journalArticle

    Sensory Feedback
    Fingers
    Parkinson Disease
    Advisory Committees
    5 Citations (Scopus)

    Folded concave penalized learning in identifying multimodal MRI marker for Parkinson's disease

    Liu, H., Du, G., Zhang, L., Lewis, M., Wang, X., Yao, T., Li, R. & Huang, X., Aug 1 2016, In : Journal of Neuroscience Methods. 268, p. 1-6 6 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Learning
    Biomarkers
    Passive Cutaneous Anaphylaxis
    Logistic Models
    13 Citations (Scopus)

    Free water improves detection of changes in the substantia nigra in parkinsonism: A multisite study

    Ofori, E., Krismer, F., Burciu, R. G., Pasternak, O., McCracken, J. L., Lewis, M. M., Du, G., McFarland, N. R., Okun, M. S., Poewe, W., Mueller, C., Gizewski, E. R., Schocke, M., Kremser, C., Li, H., Huang, X., Seppi, K. & Vaillancourt, D. E., Oct 2017, In : Movement Disorders. 32, 10, p. 1457-1464 8 p.

    Research output: Contribution to journalArticle

    Parkinsonian Disorders
    Substantia Nigra
    Water
    Anisotropy
    Diffusion Magnetic Resonance Imaging
    3 Citations (Scopus)

    Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans

    Dong, J., Wyss, A., Yang, J., Price, T. R., Nicolas, A., Nalls, M., Tranah, G., Franceschini, N., Xu, Z., Schulte, C., Alonso, A., Cummings, S. R., Fornage, M., Zaykin, D., Li, L., Huang, X., Kritchevsky, S., Liu, Y., Gasser, T., Wilson, R. S. & 9 others, De Jager, P. L., Singleton, A. B., Pinto, J. M., Harris, T., Mosley, T. H., Bennett, D. A., London, S., Yu, L. & Chen, H., Dec 1 2017, In : Molecular Neurobiology. 54, 10, p. 8021-8032 12 p.

    Research output: Contribution to journalArticle

    Smell
    Genome-Wide Association Study
    African Americans
    Neurodegenerative Diseases
    Prodromal Symptoms
    1150 Citations (Scopus)

    Genome-wide association study reveals genetic risk underlying Parkinson's disease

    Simón-Sánchez, J., Schulte, C., Bras, J. M., Sharma, M., Gibbs, J. R., Berg, D., Paisan-Ruiz, C., Lichtner, P., Scholz, S. W., Hernandez, D. G., Krüger, R., Federoff, M., Klein, C., Goate, A., Perlmutter, J., Bonin, M., Nalls, M. A., Illig, T., Gieger, C., Houlden, H. & 27 others, Steffens, M., Okun, M. S., Racette, B. A., Cookson, M. R., Foote, K. D., Fernandez, H. H., Traynor, B. J., Schreiber, S., Arepalli, S., Zonozi, R., Gwinn, K., Van Der Brug, M., Lopez, G., Chanock, S. J., Schatzkin, A., Park, Y., Hollenbeck, A., Gao, J., Huang, X., Wood, N. W., Lorenz, D., Deuschl, G., Chen, H., Riess, O., Hardy, J. A., Singleton, A. B. & Gasser, T., Dec 2009, In : Nature Genetics. 41, 12, p. 1308-1312 5 p.

    Research output: Contribution to journalArticle

    Genome-Wide Association Study
    Parkinson Disease
    Synucleins
    Genetic Heterogeneity
    Population Genetics
    5 Citations (Scopus)

    Genome-wide meta-analysis on the sense of smell among US older adults

    Dong, J., Yang, J., Tranah, G., Franceschini, N., Parimi, N., Alkorta-Aranburu, G., Xu, Z., Alonso, A., Cummings, S. R., Fornage, M., Huang, X., Kritchevsky, S., Liu, Y., London, S., Niu, L., Wilson, R. S., De Jager, P. L., Yu, L., Singleton, A. B., Harris, T. & 4 others, Mosley, T. H., Pinto, J. M., Bennett, D. A. & Chen, H., Nov 1 2015, In : Medicine (United States). 94, 47, p. e1892

    Research output: Contribution to journalArticle

    Smell
    Meta-Analysis
    Genome
    Parkinson Disease
    Genome-Wide Association Study
    43 Citations (Scopus)

    Genome-wide pleiotropy between Parkinson disease and autoimmune diseases

    for the International Parkinson's Disease Genomics Consortium (IPDGC), United Kingdom Brain Expression Consortium (UKBEC) Investigators, North American Brain Expression Consortium (NABEC), Jul 2017, In : JAMA neurology. 74, 7, p. 780-792 13 p.

    Research output: Contribution to journalArticle

    Autoimmune Diseases
    Parkinson Disease
    Genome
    Genome-Wide Association Study
    Phenotype
    10 Citations (Scopus)

    Head injury, potential interaction with genes, and risk for Parkinson's disease

    Gao, J., Liu, R., Zhao, E., Huang, X., Nalls, M. A., Singleton, A. B. & Chen, H., Mar 1 2015, In : Parkinsonism and Related Disorders. 21, 3, p. 292-296 5 p.

    Research output: Contribution to journalArticle

    Craniocerebral Trauma
    Parkinson Disease
    Genes
    Confidence Intervals
    Genome-Wide Association Study
    35 Citations (Scopus)

    Heart rate variability and the risk of Parkinson disease: The Atherosclerosis Risk in Communities study

    Alonso, A., Huang, X., Mosley, T. H., Heiss, G. & Chen, H., May 1 2015, In : Annals of Neurology. 77, 5, p. 877-883 7 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Atherosclerosis
    Heart Rate
    Proportional Hazards Models
    Confidence Intervals
    1 Citation (Scopus)

    HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity

    Nixon, A. M., Meadowcroft, M. D., Neely, E. B., Snyder, A. M., Purnell, C. J., Wright, J., Lamendella, R., Nandar, W., Huang, X. & Connor, J. R., May 2018, In : Journal of neurochemistry. 145, 4, p. 299-311 13 p.

    Research output: Contribution to journalArticle

    Paraquat
    Genotype
    Substantia Nigra
    Tyrosine 3-Monooxygenase
    Iron
    1 Citation (Scopus)

    Higher Hippocampal Mean Diffusivity Values in Asymptomatic Welders

    Lee, E. Y., Flynn, M. R., Du, G., Lewis, M., Kong, L., Yanosky, J., Mailman, R. & Huang, X., Apr 1 2019, In : Toxicological Sciences. 168, 2, p. 486-496 11 p.

    Research output: Contribution to journalArticle

    Manganese
    Alzheimer Disease
    Hippocampus
    Brain
    Diffusion tensor imaging
    28 Citations (Scopus)

    Higher iron in the red nucleus marks Parkinson's dyskinesia

    Lewis, M., Du, G., Kidacki, M., Patel, N., Shaffer, M. L., Mailman, R. & Huang, X., May 1 2013, In : Neurobiology of Aging. 34, 5, p. 1497-1503 7 p.

    Research output: Contribution to journalArticle

    Red Nucleus
    Dyskinesias
    Parkinson Disease
    Iron
    Levodopa
    7 Citations (Scopus)

    Higher plasma LDL-cholesterol is associated with preserved executive and fine motor functions in Parkinson’s disease

    Sterling, N. W., Lichtenstein, M., Lee, E. Y., Lewis, M. M., Evans, A., Eslinger, P. J., Du, G., Gao, X., Chen, H., Kong, L. & Huang, X., Jan 1 2016, In : Aging and Disease. 7, 3, p. 237-245 9 p.

    Research output: Contribution to journalArticle

    Open Access
    LDL Cholesterol
    Parkinson Disease
    Cholesterol
    Executive Function
    Cognition
    12 Citations (Scopus)

    History of smoking and olfaction in Parkinson's disease

    Lucassen, E., Sterling, N. W., Lee, E. Y., Chen, H., Lewis, M., Kong, L. & Huang, X., Jan 1 2014, In : Movement Disorders. 29, 8, p. 1069-1074 6 p.

    Research output: Contribution to journalArticle

    Smell
    Parkinson Disease
    Smoking
    Monoamine Oxidase Inhibitors
    Monoamine Oxidase
    1 Citation (Scopus)
    Open Access
    Inflammatory Bowel Diseases
    Phenotype
    Voltage-Gated Sodium Channels
    Abdominal Pain
    Single Nucleotide Polymorphism
    68 Citations (Scopus)

    Imaging nigral pathology and clinical progression in Parkinson's disease

    Du, G., Lewis, M. M., Sen, S., Wang, J., Shaffer, M. L., Styner, M., Yang, Q. X. & Huang, X., Nov 1 2012, In : Movement Disorders. 27, 13, p. 1636-1643 8 p.

    Research output: Contribution to journalArticle

    Clinical Pathology
    Substantia Nigra
    Parkinson Disease
    Anisotropy
    Diffusion Tensor Imaging
    20 Citations (Scopus)

    Impaired synergic control of posture in Parkinson's patients without postural instability

    Falaki, A., Huang, X., Lewis, M. M. & Latash, M. L., Feb 1 2016, In : Gait and Posture. 44, p. 209-215 7 p.

    Research output: Contribution to journalArticle

    Posture
    Parkinson Disease
    Muscles
    Electromyography
    Biomarkers
    10 Citations (Scopus)

    Increased R2* in the caudate nucleus of asymptomatic welders

    Lee, E. Y., Flynn, M. R., Du, G., Li, Y., Lewis, M. M., Herring, A. H., Buren, E. V., Buren, S. V., Kong, L., Fry, R. C., Snyder, A. M., Connor, J. R., Yang, Q. X., Mailman, R. B. & Huang, X., Apr 1 2016, In : Toxicological Sciences. 150, 2, p. 369-377 9 p., kfv331.

    Research output: Contribution to journalArticle

    Welding
    Caudate Nucleus
    Manganese
    Basal Ganglia
    Blood
    13 Citations (Scopus)

    Indan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential

    Cozzi, N. V., Frescas, S., Marona-Lewicka, D., Huang, X. & Nichols, D. E., Mar 1 1998, In : Pharmacology Biochemistry and Behavior. 59, 3, p. 709-715 7 p.

    Research output: Contribution to journalArticle

    Norfenfluramine
    Fenfluramine
    Serotonin
    Pharmaceutical Preparations
    indan
    19 Citations (Scopus)

    Independent component analysis involving autocorrelated sources with an application to functional magnetic resonance imaging

    Lee, S., Shen, H., Truong, Y., Lewis, M. & Huang, X., Oct 21 2011, In : Journal of the American Statistical Association. 106, 495, p. 1009-1024 16 p.

    Research output: Contribution to journalArticle

    Functional Magnetic Resonance Imaging
    Independent Component Analysis
    Spectral Density Function
    Marginal Function
    Correlation Structure
    11 Citations (Scopus)

    Individual and joint prevalence of three nonmotor symptoms of PD in the US general population

    Chen, H., Huang, X., Guo, X. & Peddada, S., Jan 1 2014, In : Movement Disorders. 29, 10, p. 1316-1319 4 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Joints
    Population
    Nutrition Surveys

    Individual preferences in motor coordination seen across the two hands: relations to movement stability and optimality

    de Freitas, P. B., Freitas, S. M. S. F., Lewis, M., Huang, X. & Latash, M., Jan 31 2019, In : Experimental Brain Research. 237, 1

    Research output: Contribution to journalArticle

    Hand
    Fingers
    Sensory Feedback
    Social Adjustment
    Task Performance and Analysis
    2 Citations (Scopus)

    Lateralized basal ganglia vulnerability to pesticide exposure in asymptomatic agricultural workers

    Lewis, M., Sterling, N. W., Du, G., Lee, E. Y., Shyu, G., Goldenberg, M., Allen, T., Stetter, C., Kong, L., Snipes, S. A., Jones, B. C., Chen, H., Mailman, R. & Huang, X., Jan 1 2017, In : Toxicological Sciences. 159, 1, p. 170-178 9 p.

    Research output: Contribution to journalArticle

    Diffusion tensor imaging
    Basal Ganglia
    Pesticides
    Corpus Striatum
    Globus Pallidus
    14 Citations (Scopus)

    Local Linear Discriminant Analysis (LLDA) for group and region of interest (ROI)-based fMRI analysis

    McKeown, M. J., Li, J., Huang, X., Lewis, M., Rhee, S., Young Truong, K. N. & Wang, Z. J., Sep 1 2007, In : NeuroImage. 37, 3, p. 855-865 11 p.

    Research output: Contribution to journalArticle

    Public Opinion
    Discriminant Analysis
    Magnetic Resonance Imaging
    Population
    6 Citations (Scopus)

    Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders

    Lewis, M. M., Flynn, M. R., Lee, E. Y., Van Buren, S., Van Buren, E., Du, G., Fry, R. C., Herring, A. H., Kong, L., Mailman, R. B. & Huang, X., Dec 1 2016, In : NeuroToxicology. 57, p. 39-44 6 p.

    Research output: Contribution to journalArticle

    Welding
    Blood
    Globus Pallidus
    Biomarkers
    Brain
    94 Citations (Scopus)

    Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

    Lesage, S., Drouet, V., Majounie, E., Deramecourt, V., Jacoupy, M., Nicolas, A., Cormier-Dequaire, F., Hassoun, S. M., Pujol, C., Ciura, S., Erpapazoglou, Z., Usenko, T., Maurage, C. A., Sahbatou, M., Liebau, S., Ding, J., Bilgic, B., Emre, M., Erginel-Unaltuna, N., Guven, G. & 177 others, Tison, F., Tranchant, C., Vidailhet, M., Corvol, J. C., Krack, P., Leutenegger, A. L., Nalls, M. A., Hernandez, D. G., Heutink, P., Gibbs, J. R., Hardy, J., Wood, N. W., Gasser, T., Durr, A., Deleuze, J. F., Tazir, M., Destée, A., Lohmann, E., Kabashi, E., Singleton, A., Corti, O., Brice, A., Tison, F., Vidailhet, M., Corvol, J. C., Agid, Y., Anheim, M., Bonnet, A. M., Borg, M., Broussolle, E., Damier, P., Destée, A., Dürr, A., Durif, F., Krack, P., Klebe, S., Lohmann, E., Martinez, M., Pollak, P., Rascol, O., Tranchant, C., Vérin, M., Viallet, F., Lesage, S., Majounie, E., Tison, F., Vidailhet, M., Corvol, J. C., Nalls, M. A., Hernandez, D. G., Gibbs, J. R., Dürr, A., Arepalli, S., Barker, R. A., Ben-Shlomo, Y., Berg, D., Bettella, F., Bhatia, K., de Bie, R. M. A., Biffi, A., Bloem, B. R., Bochdanovits, Z., Bonin, M., Bras, J. M., Brockmann, K., Brooks, J., Burn, D. J., Charlesworth, G., Chen, H., Chinnery, P. F., Chong, S., Clarke, C. E., Cookson, M. R., Counsell, C., Damier, P., Dartigues, J. F., Deloukas, P., Deuschl, G., Dexter, D. T., van Dijk, K. D., Dillman, A., Dong, J., Durif, F., Edkins, S., Escott-Price, V., Evans, J. R., Foltynie, T., Gao, J., Gardner, M., Goate, A., Gray, E., Guerreiro, R., Harris, C., van Hilten, J. J., Hofman, A., Hollenbeck, A., Holmans, P., Holton, J., Hu, M., Huang, X., Huber, H., Hudson, G., Hunt, S. E., Huttenlocher, J., Illig, T., Jónsson, P. V., Kilarski, L. L., Jansen, I. E., Lambert, J. C., Langford, C., Lees, A., Lichtner, P., Limousin, P., Lopez, G., Lorenz, D., Lubbe, S., Lungu, C., Martinez, M., Mätzler, W., McNeill, A., Moorby, C., Moore, M., Morrison, K. E., Mudanohwo, E., O’sullivan, S. S., Owen, M. J., Pearson, J., Perlmutter, J. S., Pétursson, H., Plagnol, V., Pollak, P., Post, B., Potter, S., Ravina, B., Revesz, T., Riess, O., Rivadeneira, F., Rizzu, P., Ryten, M., Saad, M., Simón-Sánchez, J., Sawcer, S., Schapira, A., Scheffer, H., Schulte, C., Sharma, M., Shaw, K., Sheerin, U. M., Shoulson, I., Shulman, J., Sidransky, E., Spencer, C. C. A., Stefánsson, H., Stefánsson, K., Stockton, J. D., Strange, A., Talbot, K., Tanner, C. M., Tashakkori-Ghanbaria, A., Trabzuni, D., Traynor, B. J., Uitterlinden, A. G., Velseboer, D., Walker, R., Warrenburg, B. V. D., Wickremaratchi, M., Williams-Gray, C. H., Winder-Rhodes, S., Wurster, I., Williams, N., Morris, H. R., Heutink, P., Hardy, J., Wood, N. W., Gasser, T., Singleton, A. B. & Brice, A., Mar 3 2016, In : American Journal of Human Genetics. 98, 3, p. 500-513 14 p.

    Research output: Contribution to journalArticle

    Open Access
    Mitochondrial Degradation
    Parkinsonian Disorders
    Protein Transport
    Exome
    Consanguinity
    7 Citations (Scopus)

    Lower fractional anisotropy in the globus pallidus of asymptomatic welders, a marker for long-term welding exposure

    Lee, E. Y., Flynn, M. R., Du, G., Lewis, M., Herring, A. H., Van Buren, E., Van Buren, S., Kong, L., Mailman, R. & Huang, X., Sep 1 2016, In : Toxicological Sciences. 153, 1, p. 165-173 9 p., kfw116.

    Research output: Contribution to journalArticle

    Welding
    Globus Pallidus
    Anisotropy
    Manganese
    Basal Ganglia
    115 Citations (Scopus)

    Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease

    Huang, X., Chen, H., Miller, W. C., Mailman, R., Woodard, J. L., Chen, P. C., Xiang, D., Murrow, R. W., Wang, Y. Z. & Poole, C., Feb 15 2007, In : Movement Disorders. 22, 3, p. 377-381 5 p.

    Research output: Contribution to journalArticle

    LDL Cholesterol
    Parkinson Disease
    Confidence Intervals
    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Odds Ratio
    71 Citations (Scopus)

    Low LDL cholesterol and increased risk of Parkinson's disease: Prospective results from Honolulu-Asia aging study

    Huang, X., Abbott, R. D., Petrovitch, H., Mailman, R. & Ross, G. W., May 15 2008, In : Movement Disorders. 23, 7, p. 1013-1018 6 p.

    Research output: Contribution to journalArticle

    LDL Cholesterol
    Parkinson Disease
    Coffee
    Fasting
    Smoking
    17 Citations (Scopus)

    Machine learning classification of medication adherence in patients with movement disorders using non-wearable sensors

    Tucker, C. S., Behoora, I., Nembhard, H. B., Lewis, M., Sterling, N. W. & Huang, X., Nov 1 2015, In : Computers in Biology and Medicine. 66, p. 120-134 15 p.

    Research output: Contribution to journalArticle

    Medication Adherence
    Movement Disorders
    Learning systems
    Sensors
    Data mining
    5 Citations (Scopus)

    Magnetic resonance T1w/T2w ratio: A parsimonious marker for Parkinson disease

    Du, G., Lewis, M., Sica, C., Kong, L. & Huang, X., Jan 1 2019, In : Annals of Neurology. 85, 1, p. 96-104 9 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Magnetic Resonance Spectroscopy
    Sensitivity and Specificity
    Area Under Curve
    Magnetic Resonance Imaging
    36 Citations (Scopus)

    Manganese accumulation in the olfactory bulbs and other brain regions of "asymptomatic" welders

    Sen, S., Flynn, M. R., Du, G., Tröster, A. I., An, H. & Huang, X., May 2 2011, In : Toxicological Sciences. 121, 1, p. 160-167 8 p.

    Research output: Contribution to journalArticle

    Olfactory Bulb
    Manganese
    Brain
    Magnetic resonance
    Hand
    4 Citations (Scopus)

    Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells

    Sarkar, S., Rokad, D., Malovic, E., Luo, J., Harischandra, D. S., Jin, H., Anantharam, V., Huang, X., Lewis, M., Kanthasamy, A. & Kanthasamy, A. G., Jan 8 2019, In : Science Signaling. 12, 563, aat9900.

    Research output: Contribution to journalArticle

    Inflammasomes
    Manganese
    Exosomes
    Interleukin-1
    Neurodegenerative diseases
    8 Citations (Scopus)

    Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

    Harischandra, D. S., Rokad, D., Neal, M. L., Ghaisas, S., Manne, S., Sarkar, S., Panicker, N., Zenitsky, G., Jin, H., Lewis, M., Huang, X., Anantharam, V., Kanthasamy, A. & Kanthasamy, A. G., Jan 1 2019, In : Science signaling. 12, 572, eaau4543.

    Research output: Contribution to journalArticle

    Synucleins
    Prions
    Manganese
    Agglomeration
    Exosomes
    45 Citations (Scopus)

    Meta-analyses on prevalence of selected Parkinson's nonmotor symptoms before and after diagnosis

    Chen, H., Zhao, E. J., Zhang, W., Lu, Y., Liu, R., Huang, X., Ciesielski-Jones, A. J., Justice, M. A., Cousins, D. S. & Peddada, S., Jan 8 2015, In : Translational Neurodegeneration. 4, 1, 1.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Meta-Analysis
    REM Sleep Behavior Disorder
    Constipation
    Publications
    13 Citations (Scopus)

    Microstructural changes in the substantia nigra of asymptomatic agricultural workers

    Du, G., Lewis, M., Sterling, N. W., Kong, L., Chen, H., Mailman, R. & Huang, X., Jan 1 2014, In : Neurotoxicology and Teratology. 41, p. 60-64 5 p.

    Research output: Contribution to journalArticle

    Substantia Nigra
    Pesticides
    Parkinson Disease
    Anisotropy
    Magnetic resonance
    9 Citations (Scopus)

    Motor equivalence and structure of variance: multi-muscle postural synergies in Parkinson’s disease

    Falaki, A., Huang, X., Lewis, M. & Latash, M., Jul 1 2017, In : Experimental Brain Research. 235, 7, p. 2243-2258 16 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Muscles
    Analysis of Variance
    Posture
    Pharmaceutical Preparations
    39 Citations (Scopus)

    Multi-atlas segmentation of subcortical brain structures via the AutoSeg software pipeline

    Wang, J., Vachet, C., Rumple, A., Gouttard, S., Ouziel, C., Perrot, E., Du, G., Huang, X., Gerig, G. & Styner, M., Feb 6 2014, In : Frontiers in Neuroinformatics. 8, FEB, 7.

    Research output: Contribution to journalArticle

    Atlases
    Brain
    Software
    Pipelines
    Tissue

    Multimodal MRI evaluation of parkinsonian limbic pathologies

    Wang, E. W., Du, G., Lewis, M., Lee, E. Y., De Jesus, S., Kanekar, S., Kong, L. & Huang, X., Apr 1 2019, In : Neurobiology of Aging. 76, p. 194-200 7 p.

    Research output: Contribution to journalArticle

    Hippocampus
    Nucleus Accumbens
    Amygdala
    Magnetic Resonance Imaging
    Pathology
    5 Citations (Scopus)

    No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson’s disease in nine ADHD candidate SNPs

    International Parkinson Disease Genomics Consortium members, Jun 1 2017, In : ADHD Attention Deficit and Hyperactivity Disorders. 9, 2, p. 121-127 7 p.

    Research output: Contribution to journalArticle

    Attention Deficit Disorder with Hyperactivity
    Single Nucleotide Polymorphism
    Parkinson Disease
    Norepinephrine Plasma Membrane Transport Proteins
    Receptor, Serotonin, 5-HT1B
    19 Citations (Scopus)

    Novel serotonergic agents

    Nichols, D. E., Marona-Lewicka, D., Huang, X. & Johnson, M. P., 1993, In : Drug Design and Discovery. 9, 3-4, p. 299-312 14 p.

    Research output: Contribution to journalArticle

    Serotonin Agents
    Phenethylamines
    Serotonin Receptor Agonists
    Serotonin Antagonists
    Serotonin Uptake Inhibitors
    13 Citations (Scopus)

    Olfaction and incident Parkinson disease in US white and black older adults

    Chen, H., Shrestha, S., Huang, X., Jain, S., Guo, X., Tranah, G. J., Garcia, M. E., Satterfield, S., Phillips, C. & Harris, T. B., Oct 3 2017, In : Neurology. 89, 14, p. 1441-1447 7 p.

    Research output: Contribution to journalArticle

    Smell
    Parkinson Disease
    Confidence Intervals
    hydroquinone
    Information Storage and Retrieval
    24 Citations (Scopus)

    Olfactory-related cortical atrophy is associated with olfactory dysfunction in Parkinson's disease

    Lee, E. Y., Eslinger, P., Du, G., Kong, L., Lewis, M. & Huang, X., Jan 1 2014, In : Movement Disorders. 29, 9, p. 1205-1208 4 p.

    Research output: Contribution to journalArticle

    Atrophy
    Parkinson Disease
    Prefrontal Cortex
    Brain
    Smell
    6 Citations (Scopus)

    Parkinson's disease biomarkers program brain imaging repository

    Ofori, E., Du, G., Babcock, D., Huang, X. & Vaillancourt, D. E., Jan 1 2016, In : NeuroImage. 124, p. 1120-1124 5 p.

    Research output: Contribution to journalArticle

    Neuroimaging
    Parkinson Disease
    Biomarkers
    Essential Tremor
    Information Dissemination
    134 Citations (Scopus)

    Physical activities and future risk of Parkinson disease

    Xu, Q., Park, Y., Huang, X., Hollenbeck, A., Blair, A., Schatzkin, A. & Chen, H., Jul 27 2010, In : Neurology. 75, 4, p. 341-348 8 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Exercise
    Confidence Intervals
    Cohort Studies
    Odds Ratio
    100 Citations (Scopus)

    Plasma urate and Parkinson's disease in the atherosclerosis risk in communities (ARIC) study

    Chen, H., Mosley, T. H., Alonso, A. & Huang, X., May 1 2009, In : American journal of epidemiology. 169, 9, p. 1064-1069 6 p.

    Research output: Contribution to journalArticle

    Uric Acid
    Parkinson Disease
    Atherosclerosis
    Confidence Intervals
    African Americans
    60 Citations (Scopus)

    p-Methylthioamphetamine is a potent new non-neurotoxic serotonin-releasing agent

    Huang, X., Marona-Lewicka, D. & Nichols, D. E., Dec 8 1992, In : European Journal of Pharmacology. 229, 1, p. 31-38 8 p.

    Research output: Contribution to journalArticle

    p-Chloroamphetamine
    Serotonin Agents
    Serotonin
    Corpus Striatum
    N-Methyl-3,4-methylenedioxyamphetamine