Xuemei Huang, MD, PhD

    • 5482 Citations
    • 39 h-Index
    1974 …2022
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    Research Output 1990 2019

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    49 Citations (Scopus)

    1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: A Potent Serotonin 5-HT2A/2C Agonist

    Nichols, D. E., Frescas, S., Marona-Lewicka, D., Huang, X., Roth, B. L., Gudelsky, G. A. & Nash, J. F., Dec 1 1994, In : Journal of Medicinal Chemistry. 37, 25, p. 4346-4351 6 p.

    Research output: Contribution to journalArticle

    Serotonin 5-HT2 Receptor Agonists
    Receptor, Serotonin, 5-HT2A
    Receptor, Serotonin, 5-HT2C
    Serotonin
    Inositol
    35 Citations (Scopus)

    2, 3-Dihydrobenzofuran Analogues of Hallucinogenic Phenethylamines

    Nichols, D. E., Snyder, S. E., Oberlender, R., Johnson, M. P. & Huang, X., Jan 1 1991, In : Journal of Medicinal Chemistry. 34, 1, p. 276-281 6 p.

    Research output: Contribution to journalArticle

    Phenethylamines
    Bromine
    Amphetamines
    Lysergic Acid Diethylamide
    Hydrophobic and Hydrophilic Interactions
    39 Citations (Scopus)

    5-HT2 receptor-mediated potentiation of dopamine synthesis and central serotonergic deficits

    Huang, X. & Nichols, D. E., Jul 20 1993, In : European Journal of Pharmacology. 238, 2-3, p. 291-296 6 p.

    Research output: Contribution to journalArticle

    Amphetamine
    Dopamine
    N-Methyl-3,4-methylenedioxyamphetamine
    Dihydroxyphenylalanine
    Serotonin
    7 Citations (Scopus)

    A data mining methodology for predicting early stage Parkinson's disease using non-invasive, high-dimensional gait sensor data

    Tucker, C., Han, Y., Black Nembhard, H., Lee, W. C., Lewis, M., Sterling, N. & Huang, X., Oct 2 2015, In : IIE Transactions on Healthcare Systems Engineering. 5, 4, p. 238-254 17 p.

    Research output: Contribution to journalArticle

    Data Mining
    Gait
    Parkinson Disease
    Data mining
    Disease
    20 Citations (Scopus)

    Alcohol Consumption, Types of Alcohol, and Parkinson's Disease

    Liu, R., Guo, X., Park, Y., Wang, J., Huang, X., Hollenbeck, A., Blair, A. & Chen, H., Jun 19 2013, In : PloS one. 8, 6, e66452.

    Research output: Contribution to journalArticle

    Parkinson disease
    Alcohol Drinking
    Parkinson Disease
    alcohols
    Alcohols
    19 Citations (Scopus)

    An exploratory analysis on gene-environment interactions for Parkinson disease

    Gao, J., Nalls, M. A., Shi, M., Joubert, B. R., Hernandez, D. G., Huang, X., Hollenbeck, A., Singleton, A. B. & Chen, H., Jan 1 2012, In : Neurobiology of Aging. 33, 10, p. 2528.e1-2528.e6

    Research output: Contribution to journalArticle

    Gene-Environment Interaction
    Parkinson Disease
    Caffeine
    Single Nucleotide Polymorphism
    Smoking

    An exploratory analysis on gene-environment interactions for Parkinson disease.

    Gao, J., Nalls, M. A., Shi, M., Joubert, B. R., Hernandez, D. G., Huang, X., Hollenbeck, A., Singleton, A. B. & Chen, H., Oct 1 2012, In : Neurobiology of Aging. 33, 10

    Research output: Contribution to journalArticle

    Gene-Environment Interaction
    Parkinson Disease
    Caffeine
    Single Nucleotide Polymorphism
    Smoking
    24 Citations (Scopus)

    An exploratory study on CLU, CR1 and PICALM and Parkinson disease

    Gao, J., Huang, X., Park, Y. Y., Hollenbeck, A. & Chen, H., Sep 6 2011, In : PLoS One. 6, 8, e24211.

    Research output: Contribution to journalArticle

    Parkinson disease
    Parkinson Disease
    odds ratio
    dementia
    confidence interval
    6 Citations (Scopus)

    An exploratory study on the CHRNA3-CHRNA5-CHRNB4 cluster, smoking, and Parkinson's disease

    Gao, J., Xu, H., Weinberg, C., Huang, X., Park, Y., Hollenbeck, A., Blair, A., Schatzkin, A., Burch, L. & Chen, H., Jun 1 2011, In : Neurodegenerative Diseases. 8, 5, p. 296-299 4 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Single Nucleotide Polymorphism
    Smoking
    Genome-Wide Association Study
    Tobacco Use Disorder
    116 Citations (Scopus)

    APOE-ε2 allele associated with higher pevalence of sporadic Parkinson disease

    Huang, X., Chen, P. C. & Poole, C., Jun 22 2004, In : Neurology. 62, 12, p. 2198-2202 5 p.

    Research output: Contribution to journalArticle

    Apolipoproteins
    Parkinson Disease
    Alleles
    Genotype
    Alzheimer Disease
    25 Citations (Scopus)

    Apolipoprotein E genotypes and the risk of Parkinson disease

    Gao, J., Huang, X., Park, Y., Liu, R., Hollenbeck, A., Schatzkin, A., Mailman, R. & Chen, H., Jan 1 2011, In : Neurobiology of Aging. 32, 11, p. 2106.e1-2106.e6

    Research output: Contribution to journalArticle

    Apolipoproteins E
    Parkinson Disease
    Odds Ratio
    Genotype
    Confidence Intervals
    95 Citations (Scopus)

    Arm swing magnitude and asymmetry during gait in the early stages of Parkinson's disease

    Lewek, M. D., Poole, R., Johnson, J., Halawa, O. & Huang, X., Feb 1 2010, In : Gait and Posture. 31, 2, p. 256-260 5 p.

    Research output: Contribution to journalArticle

    Gait
    Parkinson Disease
    Arm
    Heel
    Wrist
    72 Citations (Scopus)

    A single 20 mg dose of dihydrexidine (DAR-0100), a full dopamine D1 agonist, is safe and tolerated in patients with schizophrenia

    George, M. S., Molnar, C. E., Grenesko, E. L., Anderson, B., Mu, Q., Johnson, K., Nahas, Z., Knable, M., Fernandes, P., Juncos, J., Huang, X., Nichols, D. E. & Mailman, R., Jul 1 2007, In : Schizophrenia Research. 93, 1-3, p. 42-50 9 p.

    Research output: Contribution to journalArticle

    Dopamine Agonists
    Schizophrenia
    Short-Term Memory
    Perfusion
    Magnetic Resonance Imaging
    1 Citation (Scopus)
    Open Access
    dopamine beta-monooxygenase
    Dopamine beta-Hydroxylase
    inflammatory bowel disease
    Polymorphism
    Inflammatory Bowel Diseases
    6 Citations (Scopus)

    Association of neurobehavioral performance with R2* in the caudate nucleus of asymptomatic welders

    Lee, E. Y., Eslinger, P., Flynn, M. R., Wagner, D., Du, G., Lewis, M., Kong, L., Mailman, R. & Huang, X., Jan 1 2017, In : NeuroToxicology. 58, p. 66-74 9 p.

    Research output: Contribution to journalArticle

    Welding
    Caudate Nucleus
    Manganese
    Brain
    Neuropsychological Tests
    12 Citations (Scopus)

    A supervised singular value decomposition for independent component analysis of fMRI

    Bai, P., Shen, H., Huang, X. & Truong, Y., Oct 1 2008, In : Statistica Sinica. 18, 4, p. 1233-1252 20 p.

    Research output: Contribution to journalArticle

    Functional Magnetic Resonance Imaging
    Independent Component Analysis
    Singular value decomposition
    Spike
    Data Reduction
    32 Citations (Scopus)

    Asymmetrical lateral ventricular enlargement in Parkinson's disease

    Lewis, M. M., Smith, A. B., Styner, M., Gu, H., Poole, R., Zhu, H., Li, Y., Barbero, X., Gouttard, S., McKeown, M. J., Mailman, R. B. & Huang, X., Apr 1 2009, In : European Journal of Neurology. 16, 4, p. 475-481 7 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Lateral Ventricles
    Disease Progression
    Healthy Volunteers
    Hand
    9 Citations (Scopus)

    Asymmetrical ventricular enlargement in Parkinson's disease

    Huang, X., Lee, Y. Z., McKeown, M., Gerig, G., Gu, H., Weill Lin, P., Lewis, M. M., Ford, S., Tröster, A. I., Weinberger, D. R. & Styner, M., Aug 15 2007, In : Movement Disorders. 22, 11, p. 1657-1660 4 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Monozygotic Twins
    Lateral Ventricles
    Atrophy
    Magnetic Resonance Spectroscopy
    22 Citations (Scopus)

    Attenuation of 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity with the serotonin precursors tryptophan and 5-hydroxytryptophan

    Sprague, J. E., Huang, X., Kanthasamy, A. & Nichols, D. E., Jan 1 1994, In : Life Sciences. 55, 15, p. 1193-1198 6 p.

    Research output: Contribution to journalArticle

    N-Methyl-3,4-methylenedioxyamphetamine
    5-Hydroxytryptophan
    Tryptophan
    Serotonin
    Rats
    30 Citations (Scopus)

    Behavioral, biochemical and neurotoxicological actions of the α-ethyl homologue of p-chloroamphetamine

    Johnson, M. P., Huang, X., Oberlender, R., Nash, J. F. & Nichols, D. E., Nov 20 1990, In : European Journal of Pharmacology. 191, 1, p. 1-10 10 p.

    Research output: Contribution to journalArticle

    p-Chloroamphetamine
    Amphetamine
    Serotonin
    N-Methyl-3,4-methylenedioxyamphetamine
    3,4-Dihydroxyphenylacetic Acid
    39 Citations (Scopus)

    Benzofuran Bioisosteres of Hallucinogenic Tryptamines

    Tomaszewski, Z., Johnson, M. P., Huang, X. & Nichols, D. E., May 1 1992, In : Journal of Medicinal Chemistry. 35, 11, p. 2061-2064 4 p.

    Research output: Contribution to journalArticle

    Benzofurans
    Tryptamines
    Receptor, Serotonin, 5-HT1A
    Amines
    Methoxydimethyltryptamines
    52 Citations (Scopus)

    Both coordination and symmetry of arm swing are reduced in Parkinson's disease

    Huang, X., Mahoney, J. M., Lewis, M. M., Guangwei Du, D., Piazza, S. J. & Cusumano, J. P., Mar 1 2012, In : Gait and Posture. 35, 3, p. 373-377 5 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Arm
    Gait
    Tremor
    Forearm
    2 Citations (Scopus)

    Brain cholesterol metabolism and Parkinson's disease

    Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M., Chen, H., Hohl, R. & Mailman, R., Mar 1 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Cholesterol
    Brain
    Odds Ratio
    Logistic Models
    77 Citations (Scopus)

    Caffeine intake, smoking, and risk of parkinson disease in men and women

    Liu, R., Guo, X., Park, Y., Huang, X., Sinha, R., Freedman, N. D., Hollenbeck, A. R., Blair, A. & Chen, H., Jun 1 2012, In : American journal of epidemiology. 175, 11, p. 1200-1207 8 p.

    Research output: Contribution to journalArticle

    Caffeine
    Parkinson Disease
    Smoking
    Confidence Intervals
    Logistic Models
    9 Citations (Scopus)

    Changes in Multidigit Synergies and Their Feed-Forward Adjustments in Multiple Sclerosis

    Jo, H. J., Mattos, D., Lucassen, E., Huang, X. & Latash, M., Mar 4 2017, In : Journal of motor behavior. 49, 2, p. 218-228 11 p.

    Research output: Contribution to journalArticle

    Multiple Sclerosis
    Fingers
    Advisory Committees
    72 Citations (Scopus)

    Changes in multifinger interaction and coordination in Parkinson's disease

    Park, J., Wu, Y. H., Lewis, M. M., Huang, X. & Latash, M. L., Aug 1 2012, In : Journal of neurophysiology. 108, 3, p. 915-924 10 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Fingers
    Social Adjustment
    Hand
    Advisory Committees

    Characterization of Parkinson's disease using blood-based biomarkers: A multicohort proteomic analysis

    Posavi, M., Diaz-Ortiz, M., Liu, B., Swanson, C. R., Skrinak, R. T., Hernandez-Con, P., Amado, D. A., Fullard, M., Rick, J., Siderowf, A., Weintraub, D., McCluskey, L., Trojanowski, J. Q., Dewey, R. B., Huang, X. & Chen-Plotkin, A. S., Jan 1 2019, In : PLoS medicine. 16, 10, e1002931.

    Research output: Contribution to journalArticle

    Open Access
    Proteomics
    Parkinson Disease
    Biomarkers
    Proteins
    Blood Proteins
    3 Citations (Scopus)

    Circulating cholesterol levels may link to the factors influencing Parkinson's Risk

    Zhang, L., Wang, X., Wang, M., Sterling, N. W., Du, G., Lewis, M., Yao, T., Mailman, R., Li, R. & Huang, X., Sep 27 2017, In : Frontiers in Neurology. 8, SEP, 501.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Cholesterol
    LDL Cholesterol
    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Propensity Score
    6 Citations (Scopus)
    Progressive Supranuclear Palsy
    Multiple System Atrophy
    Diffusion Tensor Imaging
    Parkinsonian Disorders
    Parkinson Disease
    109 Citations (Scopus)

    Combined R2* and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease

    Du, G., Lewis, M. M., Styner, M., Shaffer, M. L., Sen, S., Yang, Q. X. & Huang, X., Aug 1 2011, In : Movement Disorders. 26, 9, p. 1627-1632 6 p.

    Research output: Contribution to journalArticle

    Diffusion Tensor Imaging
    Anisotropy
    Substantia Nigra
    Parkinson Disease
    Magnetic Resonance Imaging
    4 Citations (Scopus)

    Cortical gray and subcortical white matter associations in Parkinson's disease

    Sterling, N. W., Du, G., Lewis, M., Swavely, S., Kong, L., Styner, M. & Huang, X., Jan 1 2017, In : Neurobiology of Aging. 49, p. 100-108 9 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Anisotropy
    Atrophy
    White Matter
    34 Citations (Scopus)

    D1 dopamine receptors

    Huang, X., Lawler, C. P., Lewis, M., Nichols, D. E. & Mailman, R., Jan 1 2001, In : International Review of Neurobiology. 48, p. 65-139 75 p.

    Research output: Contribution to journalArticle

    Brain Chemistry
    Dopamine D1 Receptors
    55 Citations (Scopus)

    Daytime napping, nighttime sleeping, and parkinson disease

    Gao, J., Huang, X., Park, Y., Hollenbeck, A., Blair, A., Schatzkin, A. & Chen, H., May 1 2011, In : American journal of epidemiology. 173, 9, p. 1032-1038 7 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Confidence Intervals
    Logistic Models
    Odds Ratio
    Prednisolone
    23 Citations (Scopus)

    Default mode network differences between rigidity- and tremor-predominant Parkinson's disease

    Karunanayaka, P., Lee, E. Y., Lewis, M., Sen, S., Eslinger, P., Yang, Q. & Huang, X., Aug 1 2016, In : Cortex. 81, p. 239-250 12 p.

    Research output: Contribution to journalArticle

    Tremor
    Parkinson Disease
    Parietal Lobe
    Gyrus Cinguli
    Hypokinesia
    52 Citations (Scopus)

    Depression and the subsequent risk of Parkinson's disease in the NIH-AARP diet and health study

    Fang, F., Xu, Q., Park, Y., Huang, X., Hollenbeck, A., Blair, A., Schatzkin, A., Kamel, F. & Chen, H., Jul 15 2010, In : Movement Disorders. 25, 9, p. 1157-1162 6 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Depression
    Diet
    Health
    Odds Ratio
    115 Citations (Scopus)

    Diabetes and risk of Parkinson's disease

    Xu, Q., Park, Y., Huang, X., Hollenbeck, A., Blair, A., Schatzkin, A. & Chen, H., Apr 1 2011, In : Diabetes care. 34, 4, p. 910-915 6 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Logistic Models
    Odds Ratio
    Heart Neoplasms
    Coffee
    15 Citations (Scopus)

    Dietary fat intake and risk for Parkinson's disease

    Dong, J., Beard, J. D., Umbach, D. M., Park, Y., Huang, X., Blair, A., Kamel, F. & Chen, H., Nov 1 2014, In : Movement Disorders. 29, 13, p. 1623-1630 8 p.

    Research output: Contribution to journalArticle

    Dietary Fats
    Parkinson Disease
    Unsaturated Fatty Acids
    Fats
    Confidence Intervals
    80 Citations (Scopus)

    Differential involvement of striato- and cerebello-thalamo-cortical pathways in tremor- and akinetic/rigid-predominant Parkinson's disease

    Lewis, M., Du, G., Sen, S., Kawaguchi, A., Truong, Y., Lee, S., Mailman, R. & Huang, X., Mar 17 2011, In : Neuroscience. 177, p. 230-239 10 p.

    Research output: Contribution to journalArticle

    Tremor
    Parkinson Disease
    Corpus Striatum
    Hypokinesia
    Basal Ganglia Diseases
    26 Citations (Scopus)

    Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing

    International Parkinson's Disease Genetics Consortium (IPGDC), Jan 30 2017, In : Genome biology. 18, 1, 22.

    Research output: Contribution to journalArticle

    Exome
    prioritization
    Parkinson disease
    Parkinson Disease
    gene
    13 Citations (Scopus)

    Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients

    Du, G., Lewis, M., Sica, C., He, L., Connor, J., Kong, L., Mailman, R. & Huang, X., Sep 1 2018, In : Movement Disorders. 33, 9, p. 1423-1431 9 p.

    Research output: Contribution to journalArticle

    Substantia Nigra
    Control Groups
    Parkinson Disease
    Longitudinal Studies
    Pars Reticulata
    11 Citations (Scopus)

    Dopaminergic modulation of arm swing during gait among Parkinson's disease patients

    Sterling, N. W., Cusumano, J. P., Shaham, N., Piazza, S. J., Liu, G., Kong, L., Du, G., Lewis, M. & Huang, X., Jan 1 2015, In : Journal of Parkinson's Disease. 5, 1, p. 141-150 10 p.

    Research output: Contribution to journalArticle

    Gait
    Parkinson Disease
    Arm
    Dopamine Agents
    Forearm
    22 Citations (Scopus)

    Dopaminergic modulation of motor coordinaton in Parkinson's disease

    Park, J., Lewis, M., Huang, X. & Latash, M., Jan 1 2014, In : Parkinsonism and Related Disorders. 20, 1, p. 64-68 5 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Fingers
    Pharmaceutical Preparations
    Social Adjustment
    Hand
    9 Citations (Scopus)
    Parkinson Disease
    Muscles
    Dopamine Agents
    Pressure
    Pharmaceutical Preparations
    12 Citations (Scopus)

    Drug discrimination and receptor binding studies of N-isopropyl lysergamide derivatives

    Huang, X., Marona-Lewicka, D., Pfaff, R. C. & Nichols, D. E., Jan 1 1994, In : Pharmacology, Biochemistry and Behavior. 47, 3, p. 667-673 7 p.

    Research output: Contribution to journalArticle

    Drug Receptors
    Lysergic Acid Diethylamide
    Derivatives
    Rats
    8-Hydroxy-2-(di-n-propylamino)tetralin
    60 Citations (Scopus)

    Dynamic changes in cerebello-thalamo-cortical motor circuitry during progression of Parkinson's disease

    Sen, S., Kawaguchi, A., Truong, Y., Lewis, M. & Huang, X., Mar 17 2010, In : Neuroscience. 166, 2, p. 712-719 8 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Magnetic Resonance Imaging
    Hand
    Disease Progression
    Motor Cortex
    36 Citations (Scopus)

    Early cortical gray matter loss and cognitive correlates in non-demented Parkinson's patients

    Lee, E. Y., Sen, S., Eslinger, P., Wagner, D., Shaffer, M. L., Kong, L., Lewis, M., Du, G. & Huang, X., Dec 1 2013, In : Parkinsonism and Related Disorders. 19, 12, p. 1088-1093 6 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Occipital Lobe
    Frontal Lobe
    Gray Matter
    Corpus Striatum
    7 Citations (Scopus)

    Effect of a Chiral 4-Alkyl Substituent in Hallucinogenic Amphetamines

    Oberlender, R., Ramachandran, P. V., Johnson, M. P., Huang, X. & Nichols, D. E., Sep 1 1995, In : Journal of Medicinal Chemistry. 38, 18, p. 3593-3601 9 p.

    Research output: Contribution to journalArticle

    Amphetamines
    Lysergic Acid Diethylamide
    Amphetamine
    Serotonin
    Binding Sites
    35 Citations (Scopus)

    Effects of olivo-ponto-cerebellar atrophy (OPCA) on finger interaction and coordination

    Park, J., Lewis, M., Huang, X. & Latash, M., May 1 2013, In : Clinical Neurophysiology. 124, 5, p. 991-998 8 p.

    Research output: Contribution to journalArticle

    Olivopontocerebellar Atrophies
    Fingers
    Advisory Committees
    Ataxia
    Cerebellum
    21 Citations (Scopus)

    Effects of Parkinson's disease on optimization and structure of variance in multi-finger tasks

    Park, J., Jo, H. J., Lewis, M., Huang, X. & Latash, M., Nov 1 2013, In : Experimental Brain Research. 231, 1, p. 51-63 13 p.

    Research output: Contribution to journalArticle

    Fingers
    Parkinson Disease
    Basal Ganglia
    Control Groups
    19 Citations (Scopus)

    Effects of unilateral stroke on multi-finger synergies and their feed-forward adjustments

    Jo, H. J., Maenza, C., Good, D., Huang, X., Park, J., Sainburg, R. L. & Latash, M., Apr 5 2016, In : Neuroscience. 319, p. 194-205 12 p.

    Research output: Contribution to journalArticle

    Fingers
    Stroke
    Advisory Committees
    Hand