• 1273 Citations
  • 22 h-Index
20062020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 1273 Citations
  • 22 h-Index
  • 38 Article
  • 4 Chapter
  • 1 Review article
Filter
Article
2020

Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity

Kouba, S., Braire, J., Félix, R., Chantôme, A., Jaffrès, P. A., Lebreton, J., Dubreuil, D., Pipelier, M., Zhang, X., Trebak, M., Vandier, C., Mathé-Allainmat, M. & Potier-Cartereau, M., Jan 15 2020, In : European Journal of Medicinal Chemistry. 186, 111854.

Research output: Contribution to journalArticle

The native ORAI channel trio underlies the diversity of Ca2+ signaling events

Yoast, R. E., Emrich, S. M., Zhang, X., Xin, P., Johnson, M. T., Fike, A. J., Walter, V., Hempel, N., Yule, D. I., Sneyd, J., Gill, D. L. & Trebak, M., May 15 2020, In : Nature communications. 11, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
2019

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. L. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity

Emrich, S. M., Yoast, R. E., Xin, P., Zhang, X., Pathak, T., Nwokonko, R., Gueguinou, M. F., Subedi, K. P., Zhou, Y., Ambudkar, I. S., Hempel, N., Machaca, K., Gill, D. L. & Trebak, M., Apr 19 2019, In : Journal of Biological Chemistry. 294, 16, p. 6318-6332 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ

Liu, Z., Wei, Y., Zhang, L., Yee, P. P., Johnson, M., Zhang, X., Gulley, M., Atkinson, J. M., Trebak, M., Wang, H-G. & Li, W., Jan 3 2019, In : Oncogene. 38, 1, p. 120-139 20 p.

Research output: Contribution to journalArticle

10 Scopus citations
2018

Oncogenic KRAS suppresses store-operated Ca2+ entry and ICRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines

Pierro, C., Zhang, X., Kankeu, C., Trebak, M., Bootman, M. D. & Roderick, H. L., Jun 2018, In : Cell Calcium. 72, p. 70-80 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Golgi-associated protein kinase C-ϵ is delivered to phagocytic cups: Role of phosphatidylinositol 4-phosphate

Hanes, C. M., D'Amico, A. E., Ueyama, T., Wong, A. C., Zhang, X., Hynes, W. F., Barroso, M. M., Cady, N. C., Trebak, M., Saito, N. & Lennartz, M. R., Jul 1 2017, In : Journal of Immunology. 199, 1, p. 271-277 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mitochondria control store-operated Ca2+ entry through Na+ and redox signals

Ben-Kasus Nissim, T., Zhang, X., Elazar, A., Roy, S., Stolwijk, J. A., Zhou, Y., Motiani, R. K., Gueguinou, M., Hempel, N., Hershfinkel, M., Gill, D. L., Trebak, M. & Sekler, I., Mar 15 2017, In : EMBO Journal. 36, 6, p. 797-815 19 p.

Research output: Contribution to journalArticle

24 Scopus citations
2016

Calcium signaling is dispensable for receptor regulation of endothelial barrier function

Stolwijk, J. A., Zhang, X., Gueguinou, M., Zhang, W., Matrougui, K., Renken, C. & Trebak, M., Oct 28 2016, In : Journal of Biological Chemistry. 291, 44, p. 22894-22912 19 p.

Research output: Contribution to journalArticle

25 Scopus citations

Low-Voltage-Activated CaV3.1 Calcium Channels Shape T Helper Cell Cytokine Profiles

Wang, H., Zhang, X., Xue, L., Xing, J., Jouvin, M. H., Putney, J. W., Anderson, M. P., Trebak, M. & Kinet, J. P., Apr 19 2016, In : Immunity. 44, 4, p. 782-794 13 p.

Research output: Contribution to journalArticle

14 Scopus citations
2015

Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia

Zhang, W., Zhang, X., González-Cobos, J. C., Stolwijk, J. A., Matrougui, K. & Trebak, M., Feb 20 2015, In : Journal of Biological Chemistry. 290, 8, p. 5015-5027 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Multiple types of calcium channels arising from alternative translation initiation of the Orai1 message

Desai, P. N., Zhang, X., Wu, S., Janoshazi, A., Bolimuntha, S., Putney, J. W. & Trebak, M., Jul 28 2015, In : Science signaling. 8, 387, ra74.

Research output: Contribution to journalArticle

59 Scopus citations

Novel protein kinase C-mediated control of orai1 function in invasive melanoma

Hooper, R., Zhang, X., Webster, M., Go, C., Kedra, J., Marchbank, K., Gill, D. L., Weeraratna, A. T., Trebak, M. & Soboloff, J., Jan 1 2015, In : Molecular and cellular biology. 35, 16, p. 2790-2798 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
2014

Complex role of STIM1 in the activation of store-independent Orai1/3 channels

Zhang, X., Zhang, W., González-Cobos, J. C., Jardin, I., Romanin, C., Matrougui, K. & Trebak, M., Mar 2014, In : Journal of General Physiology. 143, 3, p. 3450-3359 92 p.

Research output: Contribution to journalArticle

46 Scopus citations
9 Scopus citations
2013

Emerging roles of Orai3 in pathophysiology

Motiani, R. K., Stolwijk, J. A., Newton, R. L., Zhang, X. & Trebak, M., Sep 1 2013, In : Channels. 7, 5, p. 392-401 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Mechanisms of STIM1 Activation of Store-Independent Leukotriene C4-Regulated Ca2+ Channels

Zhang, X., González-Cobos, J. C., Schindl, R., Muik, M., Ruhle, B., Motiani, R. K., Bisaillon, J. M., Zhang, W., Fahrner, M., Barroso, M., Matrougui, K., Romanin, C. & Trebak, M., Sep 11 2013, In : Molecular and cellular biology. 33, 18, p. 3715-3723 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Orai3 is an estrogen receptor α-regulated Ca2+ channel that promotes tumorigenesis

Motiani, R. K., Zhang, X., Harmon, K. E., Keller, R. S., Matrougui, K., Bennett, J. A. & Trebak, M., Jan 1 2013, In : FASEB Journal. 27, 1, p. 63-75 13 p.

Research output: Contribution to journalArticle

98 Scopus citations

PKC-ε pseudosubstrate and catalytic activity are necessary for membrane delivery during IgG-mediated phagocytosis

Wood, T. R., Chow, R. Y., Hanes, C. M., Zhang, X., Kashiwagi, K., Shirai, Y., Trebak, M., Loegering, D. J., Saito, N. & Lennartz, M. R., Jul 1 2013, In : Journal of Leukocyte Biology. 94, 1, p. 109-122 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion

Motiani, R. K., Hyzinski-García, M. C., Zhang, X., Henkel, M. M., Abdullaev, I. F., Kuo, Y. H., Matrougui, K., Mongin, A. A. & Trebak, M., Sep 1 2013, In : Pflugers Archiv European Journal of Physiology. 465, 9, p. 1249-1260 12 p.

Research output: Contribution to journalArticle

112 Scopus citations

STIM1 controls endothelial barrier function independently of Orai1 and Ca2+ entry

Shinde, A. V., Motiani, R. K., Zhang, X., Abdullaev, I. F., Adam, A. P., González-Cobos, J. C., Zhang, W., Matrougui, K., Vincent, P. A. & Trebak, M., Mar 19 2013, In : Science signaling. 6, 267, p. ra18

Research output: Contribution to journalArticle

62 Scopus citations

Store-independent Orai1/3 channels activated by intracrine leukotrienec4: Role in neointimal hyperplasia

González-Cobos, J. C., Zhang, X., Zhang, W., Ruhle, B., Motiani, R. K., Schindl, R., Muik, M., Spinelli, A. M., Bisaillon, J. M., Shinde, A. V., Fahrner, M., Singer, H. A., Matrougui, K., Barroso, M., Romanin, C. & Trebak, M., Mar 29 2013, In : Circulation research. 112, 7, p. 1013-1025 13 p.

Research output: Contribution to journalArticle

76 Scopus citations

Urotensin-II promotes vascular smooth muscle cell proliferation through store-operated calcium entry and EGFR transactivation

Rodríguez-Moyano, M., Díaz, I., Dionisio, N., Zhang, X., Ávila-Medina, J., Calderón-Sánchez, E., Trebak, M., Rosado, J. A., Ordóñez, A. & Smani, T., Nov 1 2013, In : Cardiovascular Research. 100, 2, p. 297-306 10 p.

Research output: Contribution to journalArticle

47 Scopus citations
2012

Acid-sensitive TWIK and TASK two-pore domain potassium channels change ion selectivity and become permeable to sodium in extracellular acidification

Ma, L., Zhang, X., Zhou, M. & Chen, H., Oct 26 2012, In : Journal of Biological Chemistry. 287, 44, p. 37145-37153 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Airway smooth muscle STIM1 and Orai1 are upregulated in asthmatic mice and mediate PDGF-activated SOCE, CRAC currents, proliferation, and migration

Spinelli, A. M., González-Cobos, J. C., Zhang, X., Motiani, R. K., Rowan, S., Zhang, W., Garrett, J., Vincent, P. A., Matrougui, K., Singer, H. A. & Trebak, M., Nov 1 2012, In : Pflugers Archiv European Journal of Physiology. 464, 5, p. 481-492 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of alzheimer disease

Oulès, B., Del Prete, D., Greco, B., Zhang, X., Lauritzen, I., Sevalle, J., Moreno, S., Paterlini-Bréchot, P., Trebak, M., Checler, F., Benfenati, F. & Chami, M., Aug 22 2012, In : Journal of Neuroscience. 32, 34, p. 11820-11834 15 p.

Research output: Contribution to journalArticle

107 Scopus citations
2011

Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways

Balghi, H., Robert, R., Rappaz, B., Zhang, X., Wohlhuter-Haddad, A., Evagelidis, A., Luo, Y., Goepp, J., Ferraro, P., Roméo, P., Trebak, M., Wiseman, P. W., Thomas, D. Y. & Hanrahan, J. W., Dec 2011, In : FASEB Journal. 25, 12, p. 4274-4291 18 p.

Research output: Contribution to journalArticle

41 Scopus citations

Orai1-mediated ICRAC is essential for neointima formation after vascular injury

Zhang, W., Halligan, K. E., Zhang, X., Bisaillon, J. M., Gonzalez-Cobos, J. C., Motiani, R. K., Hu, G., Vincent, P. A., Zhou, J., Barroso, M., Singer, H. A., Matrougui, K. & Trebak, M., Aug 19 2011, In : Circulation research. 109, 5, p. 534-542 9 p.

Research output: Contribution to journalArticle

95 Scopus citations

TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemia

Ma, L., Zhang, X. & Chen, H., Jun 7 2011, In : Science Signaling. 4, 176, ra37.

Research output: Contribution to journalArticle

44 Scopus citations
2009

Protective effect of total aralosides of Aralia elata (Miq) Seem (TASAES) against diabetic cardiomyopathy in rats during the early stage, and possible mechanisms

Xi, S., Zhou, G., Zhang, X., Zhang, W., Cai, L. & Zhao, C., Aug 31 2009, In : Experimental and Molecular Medicine. 41, 8, p. 538-547 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Surface electrocardiogram and action potential in mice lacking urea transporter UT-B

Meng, Y., Zhao, C., Zhang, X., Zhao, H., Guo, L., Lü, B., Zhao, X. & Yang, B., May 1 2009, In : Science in China, Series C: Life Sciences. 52, 5, p. 474-478 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices

Zhou, M., Xu, G., Xie, M., Zhang, X., Schools, G. P., Ma, L., Kimelberg, H. K. & Chen, H., Jul 1 2009, In : Journal of Neuroscience. 29, 26, p. 8551-8564 14 p.

Research output: Contribution to journalArticle

114 Scopus citations

Protective effect of total arasolides of aralia elata (Miq) seem on cardiomyopathy in rats with early stage diabetes and its mechanism

Xi, S. G., Zhang, X., Zhang, W. J., Wei, Z. R. & Zhao, C. Y., Mar 28 2008, In : Journal of Jilin University Medicine Edition. 34, 2, p. 209-213 5 p.

Research output: Contribution to journalArticle

2006

Effects of exogenous phosphatidic acid on calcium current of ventricular myocytes

Zhang, W. J., Ge, J. Y., Zhao, C. Y., Zhang, X. X., Zhan, S. & Zhong, G. G., May 1 2006, In : Journal of Jilin University Medicine Edition. 32, 3, p. 422-424 3 p.

Research output: Contribution to journalArticle

Effects of lysophosphatidic acid on arrhythmia in acute myocardial infarction rats

Zhang, X., Zhao, C. Y., Zhang, H., Wang, H., Sun, Y. Q. & Zhong, G. G., May 1 2006, In : Journal of Jilin University Medicine Edition. 32, 3, p. 407-409 3 p.

Research output: Contribution to journalArticle