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Research Output 2003 2019

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Article
2019

AMPKα2 knockout enhances tumour inflammation through exacerbated liver injury and energy deprivation-associated AMPKα1 activation

Qiu, S., Liu, T., Piao, C., Wang, Y., Wang, K., Zhou, Y., Cai, L., Zheng, S., Lan, F. & Du, J., Mar 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 3, p. 1687-1697 11 p.

Research output: Contribution to journalArticle

Open Access
Inflammation
AMP-Activated Protein Kinases
Liver
Wounds and Injuries
Neoplasms

Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity

Emrich, S. M., Yoast, R. E., Xin, P., Zhang, X., Pathak, T., Nwokonko, R., Gueguinou, M. F., Subedi, K. P., Zhou, Y., Ambudkar, I. S., Hempel, N., Machaca, K., Gill, D. & Trebak, M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 16, p. 6318-6332 15 p.

Research output: Contribution to journalArticle

Molecules
Chemical activation
Clustered Regularly Interspaced Short Palindromic Repeats
Cell Membrane
Stromal Interaction Molecule 2

The remote allosteric control of Orai channel gating

Zhou, Y., Nwokonko, R. M., Baraniak, J. H., Trebak, M., Lee, K. P. K. & Gill, D., Aug 30 2019, In : PLoS biology. 17, 8, e3000413.

Research output: Contribution to journalArticle

Open Access
Remote control
calcium
Molecules
Cell membranes
Ion Channels
2018
5 Citations (Scopus)
Endoplasmic Reticulum Stress
Lactation
Zinc
Oxidative Stress
Breast
6 Citations (Scopus)

Calcium store refilling and STIM activation in STIM- and Orai-deficient cell lines

Zheng, S., Zhou, L., Ma, G., Zhang, T., Liu, J., Li, J., Nguyen, N. T., Zhang, X., Li, W., Nwokonko, R., Zhou, Y., Zhao, F., Liu, J., Huang, Y., Gill, D. & Wang, Y., Oct 1 2018, In : Pflugers Archiv European Journal of Physiology. 470, 10, p. 1555-1567 13 p.

Research output: Contribution to journalArticle

Oligomerization
Chemical activation
Cells
Calcium
Cell Line
17 Citations (Scopus)

Cross-linking of Orai1 channels by STIM proteins

Zhou, Y., Nwokonko, R. M., Cai, X., Loktionova, N. A., Abdulqadir, R., Xin, P., Niemeyer, B. A., Wang, Y., Trebak, M. & Gill, D., Jan 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 15, p. E3398-E3407

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Cell Membrane
Cluster Analysis
Fluorescence Recovery After Photobleaching
Protein Unfolding
2 Citations (Scopus)

Pore properties of Orai1 calcium channel dimers and their activation by the STIM1 ER calcium sensor

Cai, X., Nwokonko, R. M., Loktionova, N. A., Abdulqadir, R., Baraniak, J. H., Wang, Y., Trebak, M., Zhou, Y. & Gill, D., Jan 1 2018, In : Journal of Biological Chemistry. 293, 33, p. 12962-12974 13 p.

Research output: Contribution to journalArticle

Calcium Channels
Linings
Endoplasmic Reticulum
Dimers
Chemical activation
2017
16 Citations (Scopus)

Mitochondria control store-operated Ca2+ entry through Na+ and redox signals

Ben-Kasus Nissim, T., Zhang, X., Elazar, A., Roy, S., Stolwijk, J. A., Zhou, Y., Motiani, R. K., Gueguinou, M., Hempel, N., Hershfinkel, M., Gill, D., Trebak, M. & Sekler, I., Mar 15 2017, In : EMBO Journal. 36, 6, p. 797-815 19 p.

Research output: Contribution to journalArticle

Mitochondria
Inventory control
Oxidation-Reduction
Cell membranes
Ion Channels
2016
11 Citations (Scopus)

Molecular mechanisms underlying inhibition of STIM1-Orai1-mediated Ca2+ entry induced by 2-aminoethoxydiphenyl borate

Wei, M., Zhou, Y., Sun, A., Ma, G., He, L., Zhou, L., Zhang, S., Liu, J., Zhang, S. L., Gill, D. & Wang, Y., Nov 1 2016, In : Pflugers Archiv European Journal of Physiology. 468, 11-12, p. 2061-2074 14 p.

Research output: Contribution to journalArticle

Drug Design
2-aminoethoxydiphenyl borate
Homeostasis
Chemical activation
Pharmaceutical Preparations
38 Citations (Scopus)

The Orai1 store-operated calcium channel functions as a hexamer

Cai, X., Zhou, Y., Nwokonko, R. M., Loktionova, N. A., Wang, X., Xin, P., Trebak, M., Wang, Y. & Gill, D. L., Dec 9 2016, In : Journal of Biological Chemistry. 291, 50, p. 25764-25775 12 p.

Research output: Contribution to journalArticle

Calcium Channels
Dimers
Clustered Regularly Interspaced Short Palindromic Repeats
Biotinylation
Ions
33 Citations (Scopus)

The STIM1-binding site nexus remotely controls Orai1 channel gating

Zhou, Y., Cai, X., Loktionova, N. A., Wang, X., Nwokonko, R. M., Wang, X., Wang, Y., Rothberg, B. S., Trebak, M. & Gill, D., Dec 8 2016, In : Nature communications. 7, 13725.

Research output: Contribution to journalArticle

helices
Binding Sites
porosity
mutations
Mutation
2015
52 Citations (Scopus)

Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU

Santhanam, S., Rajan, S., Hoffman, N. E., Zhang, X., Guo, S., Kolesar, J. E., Hines, K. J., Ragheb, J., Jog, N. R., Caricchio, R., Baba, Y., Zhou, Y., Kaufman, B. A., Cheung, J. Y., Kurosaki, T., Gill, D. & Madesh, M., Mar 3 2015, In : Science signaling. 8, 366, p. ra23

Research output: Contribution to journalArticle

Metabolism
Endoplasmic Reticulum
Mitochondria
Lymphocytes
Genes
34 Citations (Scopus)

STIM1 dimers undergo unimolecular coupling to activate Orai1 channels

Zhou, Y., Wang, X., Wang, X., Loktionova, N. A., Cai, X., Nwokonko, R. M., Vrana, E., Wang, Y., Rothberg, B. S. & Gill, D., Sep 24 2015, In : Nature communications. 6, 8395.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Dimers
endoplasmic reticulum
dimers
mutations
2014
89 Citations (Scopus)

Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site

Wang, X., Wang, Y., Zhou, Y., Hendron, E., Mancarella, S., Andrake, M. D., Rothberg, B. S., Soboloff, J. & Gill, D. L., Feb 4 2014, In : Nature communications. 5, 3183.

Research output: Contribution to journalArticle

Leucine
Endoplasmic Reticulum
Chemical activation
endoplasmic reticulum
leucine
18 Citations (Scopus)

Potent functional uncoupling between STIM1 and Orai1 by dimeric 2-aminodiphenyl borinate analogs

Hendron, E., Wang, X., Zhou, Y., Cai, X., Goto, J. I., Mikoshiba, K., Baba, Y., Kurosaki, T., Wang, Y. & Gill, D., Jan 1 2014, In : Cell Calcium. 56, 6, p. 482-492 11 p.

Research output: Contribution to journalArticle

2-aminodiphenyl
DPB162-AE
Inhibitory Concentration 50
Pharmacology
Proteins
2013
160 Citations (Scopus)

MTOR regulates lysosomal ATP-sensitive two-pore Na+ channels to adapt to metabolic state

Cang, C., Zhou, Y., Navarro, B., Seo, Y. J., Aranda, K., Shi, L., Battaglia-Hsu, S., Nissim, I., Clapham, D. E. & Ren, D., Feb 14 2013, In : Cell. 152, 4, p. 778-790 13 p.

Research output: Contribution to journalArticle

Nutrients
Adenosine Triphosphate
Sirolimus
Ion Channels
Food
2012
231 Citations (Scopus)

TPC proteins are phosphoinositide- Activated sodium-selective ion channels in endosomes and lysosomes

Wang, X., Zhang, X., Dong, X. P., Samie, M., Li, X., Cheng, X., Goschka, A., Shen, D., Zhou, Y., Harlow, J., Zhu, M. X., Clapham, D. E., Ren, D. & Xu, H., Oct 12 2012, In : Cell. 151, 2, p. 372-383 12 p.

Research output: Contribution to journalArticle

Sodium Channels
Endosomes
Phosphatidylinositols
Lysosomes
Ion Channels
2011
31 Citations (Scopus)

The role of calcium release activated calcium channels in osteoclast differentiation

Zhou, Y., Lewis, T. L., Robinson, L. J., Brundage, K. M., Schafer, R., Martin, K. H., Blair, H. C., Soboloff, J. & Barnett, J. B., Apr 1 2011, In : Journal of Cellular Physiology. 226, 4, p. 1082-1089 8 p.

Research output: Contribution to journalArticle

Osteoclasts
Calcium Channels
Calcium
Cytokines
Calcium Release Activated Calcium Channels
15 Citations (Scopus)

WT1/EGR1-mediated control of STIM1 expression and function in cancer cells

Ritchie, M. F., Zhou, Y. & Soboloff, J., Jun 1 2011, In : Frontiers in Bioscience. 16, 7, p. 2402-2415 14 p.

Research output: Contribution to journalArticle

Wilms Tumor
Tumors
Cells
Growth
Neoplasms
2010
35 Citations (Scopus)

Wilms tumor suppressor 1 (WT1) and early growth response 1 (EGR1) are regulators of STIM1 expression

Ritchie, M. F., Yue, C., Zhou, Y., Houghton, P. J. & Soboloff, J., Apr 2 2010, In : Journal of Biological Chemistry. 285, 14, p. 10591-10596 6 p.

Research output: Contribution to journalArticle

Wilms Tumor
Tumors
Growth
Response Elements
Calcium
2009
91 Citations (Scopus)

STIM protein coupling in the activation of Orai channels

Wang, Y., Deng, X., Zhou, Y., Hendron, E., Mancarella, S., Ritchie, M. F., Tang, X. D., Baba, Y., Kurosaki, T., Mori, Y., Soboloff, J. & Gill, D., May 5 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 18, p. 7391-7396 6 p.

Research output: Contribution to journalArticle

Borates
Cell Membrane
Endoplasmic Reticulum
Proteins
Cytosol
68 Citations (Scopus)

The short N-terminal domains of STIM1 and STIM2 control the activation kinetics of Orai1 channels

Zhou, Y., Mancarella, S., Wang, Y., Yue, C., Ritchie, M., Gill, D. & Soboloff, J., Jul 17 2009, In : Journal of Biological Chemistry. 284, 29, p. 19164-19168 5 p.

Research output: Contribution to journalArticle

Chemical activation
Amino Acids
Kinetics
HEK293 Cells
Sequence Homology
10 Citations (Scopus)

UVA-induced calcium oscillations in rat mast cells

Zhou, Y. D., Fang, X. F. & Cui, Z. J., Jan 2009, In : Cell Calcium. 45, 1, p. 18-28 11 p.

Research output: Contribution to journalArticle

Calcium Signaling
Mast Cells
tetrandrine
NADPH Oxidase
Calcium Channel Blockers
2003
15 Citations (Scopus)

A physiological role for protoporphyrin IX photodynamic action in the rat Harderian gland?

Cui, Z. J., Zhou, Y., Satoh, Y. & Habara, Y., Oct 1 2003, In : Acta Physiologica Scandinavica. 179, 2, p. 149-154 6 p.

Research output: Contribution to journalArticle

Harderian Gland
Light
Photosensitizing Agents
Fura-2
Carbachol