• 898 Citations
  • 14 h-Index
20072019

Research output per year

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Personal profile

Research interests

The main interest of Dr. Yongsoo Kim’s lab is to understand structural and functional organization of the mammalian brain using mice as an animal model. Particularly, Dr. Kim is interested in understanding the neural circuit basis of social behavior and its dysfunction in brain disorders. Social behavior is complex, requiring the integration of multiple sensory modalities, internal state information and memories of prior experience in order to generate highly nuanced responses to diverse environmental scenarios. Impairment of social behavior occurs often in many neurodevelopmental and psychiatric disorders.

Thus, the Kim lab’s goal is to understand how local and brain-wide neural network operate to generate normal social behavior and how such processes are altered in pathological conditions. Toward that goal, Dr. Kim’s lab uses an automated 3D microscopy system called serial two-photon tomography to image whole mouse brains with cellular resolution. Dr. Kim used this imaging method with sophisticated data processing pipeline to systematically analyze target signals in the entire mouse brain. Previously, he used this method to perform cFos-based neural activity mapping, quantitative cell type mapping and brain-wide axonal projection mapping.

Currently, Dr. Kim’s lab is developing three-dimensional digital mouse brain atlases across different ages to establish a bioinformatics solution to register detected signals. Using the digital map, he is working on mapping oxytocin and oxytocin receptor-expressing neurons that play an essential role in generating and regulating social behavior. Moreover, he is also working on generating a detailed three-dimensional structure of microvaculature in the whole mouse brain.

Education/Academic qualification

Postdoctoral Training, Cold Spring Harbor Laboratory

20102015

Visiting Student, University of Oxford

20082010

PhD, Northwestern University

20042010

BS, Seoul National University

19962000

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Research Output

  • 898 Citations
  • 14 h-Index
  • 17 Article
  • 1 Conference contribution
  • 1 Comment/debate
  • 1 Review article

Enhanced and unified anatomical labeling for a common mouse brain atlas

Chon, U., Vanselow, D. J., Cheng, K. C. & Kim, Y., Dec 1 2019, In : Nature communications. 10, 1, 5067.

Research output: Contribution to journalArticle

Open Access
  • ISMORE: An iterative self super-resolution algorithm

    Zhao, C., Son, S., Kim, Y. & Prince, J. L., Jan 1 2019, Simulation and Synthesis in Medical Imaging - 4th International Workshop, SASHIMI 2019, Held in Conjunction with MICCAI 2019, Proceedings. Burgos, N., Gooya, A. & Svoboda, D. (eds.). Springer, p. 130-139 10 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 11827 LNCS).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  • The A30P α-synuclein mutation decreases subventricular zone proliferation

    Zhang, X. M., Anwar, S., Kim, Y., Brown, J., Comte, I., Cai, H., Cai, N. N., Wade-Martins, R. & Szele, F. G., Jul 15 2019, In : Human molecular genetics. 28, 14, p. 2283-2294 12 p., ddz057.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization

    Kelly, S. M., Raudales, R., He, M., Lee, J. H., Kim, Y., Gibb, L. G., Wu, P., Matho, K., Osten, P., Graybiel, A. M. & Huang, Z. J., Jul 25 2018, In : Neuron. 99, 2, p. 345-361.e4

    Research output: Contribution to journalArticle

  • 8 Scopus citations

    Subset of cortical layer 6b neurons selectively innervates higher order thalamic nuclei in mice

    Hoerder-Suabedissen, A., Hayashi, S., Upton, L., Nolan, Z., Casas-Torremocha, D., Grant, E., Viswanathan, S., Kanold, P. O., Clasca, F., Kim, Y. & Molnár, Z., Jan 1 2018, In : Cerebral Cortex. 28, 5, p. 1882-1897 16 p.

    Research output: Contribution to journalArticle

  • 23 Scopus citations

    Prizes

    Junior Faculty Research Scholar Award

    Yongsoo Kim (Recipient), Prasanna Karunanayaka (Recipient) & Judie Ann Howrylak (Recipient), 2017

    Prize: Honorary award

    Korean Government Overseas Scholarship

    Yongsoo Kim (Recipient), 2004

    Prize: Honorary award

    NARSAD Young Investigator Award

    Yongsoo Kim (Recipient), 2013

    Prize: Honorary award