• 4576 Citations
  • 37 h-Index
1986 …2019
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Research Output 1986 2019

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Article
2019
Motor Neuron Disease
Telemedicine
Respiratory Function Tests
Noninvasive Ventilation
Lung

In memorium: WALTER STOLOV, MD

Robinson, L. R. & Simmons, Z., Jan 1 2019, In : Muscle & nerve. 59, 1, p. 1-2 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis

The ITALSGEN Consortium & The International ALS Genomics Consortium, Apr 1 2019, In : Annals of Neurology. 85, 4, p. 470-481 12 p.

Research output: Contribution to journalArticle

Open Access
Amyotrophic Lateral Sclerosis
Genome-Wide Association Study
Linkage Disequilibrium
Random Allocation
Smoking
Dysarthria
Amyotrophic Lateral Sclerosis
Acoustics
acoustics
Group
2018
2 Citations (Scopus)

Amyotrophic lateral sclerosis–specific quality of life–short form (ALSSQOL-SF): A brief, reliable, and valid version of the ALSSQOL-R

Felgoise, S. H., Feinberg, R., Stephens, H. E., Barkhaus, P., Boylan, K., Caress, J., Clawson, L. L., Elman, L., Goutman, S. A., Mccluskey, L., Russell, J., Tiryaki, E., Weiss, M. & Simmons, Z., Jan 1 2018, (Accepted/In press) In : Muscle and Nerve.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Psychometrics
Statistical Factor Analysis
Quality of Life
Muscles
6 Citations (Scopus)
Dysarthria
Amyotrophic Lateral Sclerosis
Biomechanical Phenomena
speaking
Jaw
5 Citations (Scopus)

Discussing edaravone with the ALS patient: an ethical framework from a U.S. perspective

Yeo, C. J. J. & Simmons, Z., Apr 3 2018, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 19, 3-4, p. 167-172 6 p.

Research output: Contribution to journalArticle

Patient Care Planning
Hope
Beneficence
Drug Costs
United States Food and Drug Administration
1 Citation (Scopus)

Ethical Considerations in Neurogenetic Testing

Su, X. W. & Simmons, Z., Jan 1 2018, In : Seminars in Neurology. 38, 5, p. 505-514 10 p.

Research output: Contribution to journalArticle

Genetic Testing
Beneficence
Nervous System Diseases
Ethics
Physicians
54 Citations (Scopus)

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

ITALSGEN Consortium, Genomic Translation for ALS Care (GTAC) Consortium, ALS Sequencing Consortium, NYGC ALS Consortium, Answer ALS Foundation, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, SLAGEN Consortium, French ALS Consortium & Project MinE ALS Sequencing Consortium, Mar 21 2018, In : Neuron. 97, 6, p. 1268-1283.e6

Research output: Contribution to journalArticle

Kinesin
Genome
Mutation
Genes
Genome-Wide Association Study
1 Citation (Scopus)

Hydration measured by doubly labeled water in ALS and its effects on survival

for the ALS Nutrition-NIPPV Study Group, Apr 3 2018, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 19, 3-4, p. 220-231 12 p.

Research output: Contribution to journalArticle

Drinking
Survival
Water
Body Water
Centers for Medicare and Medicaid Services (U.S.)
1 Citation (Scopus)

Lawful physician-hastened death AAN position statement

Russell, J. A., Epstein, L. G., Bonnie, R. J., Conwit, R., Graf, W. D., Kirschen, M., Kurek, J. A., Larriviere, D. G., Pascuzzi, R. M., Rizzo, M., Sattin, J. A., Simmons, Z., Taylor, L., Tsou, A. & Williams, M. A., Jan 1 2018, In : Neurology. 90, 9, p. 420-422 3 p.

Research output: Contribution to journalArticle

Assisted Suicide
Euthanasia
Neurology
Prescriptions
Physicians

Thank you to our reviewers

Simmons, Z., Dec 1 2018, In : Muscle & Nerve. 58, 6, p. 868-870 3 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

The New York Genome Center ALS Consortium, Jul 13 2018, In : eLife. 7, e37754.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Heterogeneous-Nuclear Ribonucleoprotein Group F-H
Brain
RNA-Binding Proteins
Genes
2017
6 Citations (Scopus)

Acoustic and tongue kinematic vowel space in speakers with and without dysarthria

Lee, J. M., Littlejohn, M. A. & Simmons, Z., Mar 4 2017, In : International Journal of Speech-Language Pathology. 19, 2, p. 195-204 10 p.

Research output: Contribution to journalArticle

Dysarthria
Tongue
Biomechanical Phenomena
Acoustics
Amyotrophic Lateral Sclerosis
2 Citations (Scopus)

Advance care planning for patients with amyotrophic lateral sclerosis

Levi, B., Simmons, Z., Hanna, C., Brothers, A., Lehman, E., Farace, E., Bain, M., Stewart, R. & Green, M., Jul 3 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 5-6, p. 388-396 9 p.

Research output: Contribution to journalArticle

Advance Care Planning
Amyotrophic Lateral Sclerosis
Decision Support Techniques
Terminal Care
Personal Autonomy
Brain-Computer Interfaces
Amyotrophic Lateral Sclerosis
Evoked Potentials
Neurodegenerative Diseases
Alleles
3 Citations (Scopus)

Fixed dynamometry is more sensitive than vital capacity or ALS rating scale

Andres, P. L., Allred, M. P., Stephens, H. E., Proffitt Bunnell, M., Siener, C., Macklin, E. A., Haines, T., English, R. A., Fetterman, K. A., Kasarskis, E. J., Florence, J., Simmons, Z. & Cudkowicz, M. E., Oct 1 2017, In : Muscle and Nerve. 56, 4, p. 710-715 6 p.

Research output: Contribution to journalArticle

Vital Capacity
Amyotrophic Lateral Sclerosis
Extremities
Sample Size
Longitudinal Studies
9 Citations (Scopus)

Incorporation of telehealth into a multidisciplinary ALS Clinic: feasibility and acceptability

Geronimo, A., Wright, C., Morris, A., Walsh, S., Snyder, B. & Simmons, Z., Oct 2 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 7-8, p. 555-561 7 p.

Research output: Contribution to journalArticle

Telemedicine
Caregivers
Health Personnel
Videoconferencing
Quality of Health Care
1 Citation (Scopus)

Right-to-Try Investigational Therapies for Incurable Disorders

Simmons, Z., Oct 1 2017, In : CONTINUUM Lifelong Learning in Neurology. 23, 5, Peripheral Nerve and Motor Neuron Disorders, p. 1451-1457 7 p.

Research output: Contribution to journalArticle

Investigational Therapies
Beneficence
Therapeutics
Compassionate Use Trials
Amyotrophic Lateral Sclerosis
2 Citations (Scopus)

The P300 ‘face’ speller is resistant to cognitive decline in ALS

Geronimo, A. & Simmons, Z., Oct 2 2017, In : Brain-Computer Interfaces. 4, 4, p. 225-235 11 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Bioelectric potentials
Evoked Potentials
Neurodegenerative diseases
Cognition
Frontotemporal Lobar Degeneration
Estrogens
Dementia
Consensus
Extremities
2016
20 Citations (Scopus)

A qualitative study of multidisciplinary ALS clinic use in the United States

Stephens, H. E., Young, J., Felgoise, S. H. & Simmons, Z., Feb 17 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 1-2, p. 55-61 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Form Perception
Standard of Care
Research
Clinical Trials
25 Citations (Scopus)

A randomized trial of mexiletine in ALS

Weiss, M. D., Macklin, E. A., Simmons, Z., Knox, A. S., Greenblatt, D. J., Atassi, N., Graves, M., Parziale, N., Salameh, J. S., Quinn, C., Brown, R. H., Distad, J. B., Trivedi, J., Shefner, J. M., Barohn, R. J., Pestronk, A., Swenson, A. & Cudkowicz, M. E., Apr 19 2016, In : Neurology. 86, 16, p. 1474-1481 8 p.

Research output: Contribution to journalArticle

Mexiletine
Muscle Cramp
Placebos
Vital Capacity
Pharmacokinetics
5 Citations (Scopus)

Compliance with recommendations made in a multidisciplinary ALS clinic

Fullam, T., Stephens, H. E., Felgoise, S. H., Blessinger, J. K., Walsh, S. & Simmons, Z., Feb 17 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 1-2, p. 30-37 8 p.

Research output: Contribution to journalArticle

Compliance
Ambulatory Care
Caregivers
Mental Health
Physiologic Monitoring
1 Citation (Scopus)

Genetic Testing of Presymptomatic Individuals at Risk for Progressive Myopathy

Simmons, Z., Dec 1 2016, In : CONTINUUM Lifelong Learning in Neurology. 22, 6, p. 2006-2011 6 p.

Research output: Contribution to journalArticle

Genetic Testing
Muscular Diseases
Beneficence
Physicians
Inborn Genetic Diseases
13 Citations (Scopus)

Pain in amyotrophic lateral sclerosis: Patient and physician perspectives and practices

Stephens, H. E., Lehman, E., Raheja, D., Yang, C., Walsh, S., Mcarthur, D. B. & Simmons, Z., Feb 17 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 1-2, p. 21-29 9 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Physicians
Pain
Pain Management
Postal Service
11 Citations (Scopus)

Patient-reported problematic symptoms in an ALS treatment trial

Raheja, D., Stephens, H. E., Lehman, E., Walsh, S., Yang, C. & Simmons, Z., May 18 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 3-4, p. 198-205 8 p.

Research output: Contribution to journalArticle

Quality of Life
Aptitude
Fatigue
Ceftriaxone
Mucus
21 Citations (Scopus)
Brain-Computer Interfaces
Brain computer interface
Amyotrophic Lateral Sclerosis
Imagery (Psychotherapy)
Communication
3 Citations (Scopus)

Primary lateral sclerosis and early upper motor neuron disease: Characteristics of a cross-sectional population

Fournier, C. N., Murphy, A., Loci, L., Mitsumoto, H., Lomen-Hoerth, C., Kisanuki, Y., Simmons, Z., Maragakis, N. J., McVey, A. L., Al-Lahham, T., Heiman-Patterson, T. D., Andrews, J., McDonnell, E., Cudkowicz, M. & Atassi, N., Jan 1 2016, In : Journal of Clinical Neuromuscular Disease. 17, 3, p. 99-105 7 p.

Research output: Contribution to journalArticle

Motor Neuron Disease
Amyotrophic Lateral Sclerosis
Electromyography
Population
Hereditary Spastic Paraplegia
15 Citations (Scopus)

Prospective exploratory muscle biopsy, imaging, and functional assessment in patients with late-onset Pompe disease treated with alglucosidase alfa: The EMBASSY Study

van der Ploeg, A., Carlier, P. G., Carlier, R. Y., Kissel, J. T., Schoser, B., Wenninger, S., Pestronk, A., Barohn, R. J., Dimachkie, M. M., Goker-Alpan, O., Mozaffar, T., Pena, L. D. M., Simmons, Z., Straub, V., Guglieri, M., Young, P., Boentert, M., Baudin, P. Y., Wens, S., Shafi, R. & 2 others, Bjartmar, C. & Thurberg, B. L., Sep 1 2016, In : Molecular Genetics and Metabolism. 119, 1-2, p. 115-123 9 p.

Research output: Contribution to journalArticle

Functional assessment
Glycogen Storage Disease Type II
Enzyme Replacement Therapy
Biopsy
Glycogen
6 Citations (Scopus)

Statins accelerate disease progression and shorten survival in SOD1G93A mice

Su, X. W., Nandar, W., Neely, E. B., Simmons, Z. & Connor, J., Aug 1 2016, In : Muscle and Nerve. 54, 2, p. 284-291 8 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Disease Progression
coenzyme Q10
Simvastatin
Amyotrophic Lateral Sclerosis
7 Citations (Scopus)

The role of mental health and self-efficacy in the pain experience of patients with amyotrophic lateral sclerosis

Stephens, H. E., Lehman, E., Raheja, D., Yang, C., Walsh, S. & Simmons, Z., May 18 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 3-4, p. 206-212 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Self Efficacy
Mental Health
Pain
Depression
12 Citations (Scopus)

Verbal communication impacts quality of life in patients with amyotrophic lateral sclerosis

Felgoise, S. H., Zaccheo, V., Duff, J. & Simmons, Z., May 18 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 3-4, p. 179-183 5 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Aptitude
Communication
Quality of Life
Analysis of Variance
2015
10 Citations (Scopus)

Acceptance of brain-computer interfaces in amyotrophic lateral sclerosis

Geronimo, A., Stephens, H. E., Schiff, S. & Simmons, Z., Jun 1 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 3-4, p. 258-264 7 p.

Research output: Contribution to journalArticle

Brain-Computer Interfaces
Amyotrophic Lateral Sclerosis
Computer Systems
Biomedical Engineering
Self-Help Devices
1 Citation (Scopus)

Adaptive endoplasmic reticulum stress alters cellular responses to the extracellular milieu

Liu, Y., Neely, E., Simmons, Z. & Connor, J., May 1 2015, In : Journal of Neuroscience Research. 93, 5, p. 766-776 11 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Apoptosis
Cell Survival
Motor Neurons
Pathologic Processes
13 Citations (Scopus)

Histological-MRI correlation in the primary motor cortex of patients with amyotrophic lateral sclerosis

Meadowcroft, M., Mutic, N. J., Bigler, D. C., Wang, J., Simmons, Z., Connor, J. & Yang, Q., Mar 1 2015, In : Journal of Magnetic Resonance Imaging. 41, 3, p. 665-675 11 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Cortex
Myelin Sheath
Astrocytes
Brain Death
38 Citations (Scopus)

Isaacs syndrome: A review

Ahmed, A. & Simmons, Z., Jul 1 2015, In : Muscle and Nerve. 52, 1, p. 5-12 8 p.

Research output: Contribution to journalArticle

Isaacs Syndrome
Fasciculation
Peripheral Nerves
Myokymia
Electrodiagnosis
10 Citations (Scopus)

Multidisciplinary ALS clinics in the USA: A comparison of those who attend and those who do not

Stephens, H. E., Felgoise, S., Young, J. & Simmons, Z., Jun 1 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 3-4, p. 196-201 6 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Social Problems
Quality of Life
Nutritionists
Home Care Services
17 Citations (Scopus)

Patient-Perceived Outcomes and Quality of Life in ALS

Simmons, Z., Apr 1 2015, In : Neurotherapeutics. 12, 2, p. 394-402 9 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Quality of Life
Patient Care
Health
Outcome Assessment (Health Care)
11 Citations (Scopus)

Relationship of creatine kinase to body composition, disease state, and longevity in ALS

Gibson, S. B., Kasarskis, E. J., Hu, N., Pulst, S. M., Mendiondo, M. S., Matthews, D. E., Mitsumoto, H., Tandan, R., Simmons, Z., Kryscio, R. J. & Bromberg, M. B., Nov 27 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 7-8, p. 473-477 5 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Creatine Kinase
Body Composition
Fasciculation
Dielectric Spectroscopy
15 Citations (Scopus)

Serum ferritin is elevated in amyotrophic lateral sclerosis patients

Su, X. W., Clardy, S. L., Stephens, H. E., Simmons, Z. & Connor, J., Mar 1 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 1-2, p. 102-107 6 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Ferritins
Serum
Survival
Iron
16 Citations (Scopus)

The potential of psychological interventions to improve quality of life and mood in muscle disorders

Graham, C. D., Simmons, Z., Stuart, S. R. & Rose, M. R., Jul 1 2015, In : Muscle and Nerve. 52, 1, p. 131-136 6 p.

Research output: Contribution to journalArticle

Muscular Diseases
Quality of Life
Psychology
Acceptance and Commitment Therapy
Cognitive Therapy
2014
31 Citations (Scopus)

Estimating daily energy expenditure in individuals with amyotrophic lateral sclerosis

Kasarskis, E. J., Mendiondo, M. S., Matthews, D. E., Mitsumoto, H., Tandan, R., Simmons, Z., Bromberg, M. B. & Kryscio, R. J., Apr 1 2014, In : American Journal of Clinical Nutrition. 99, 4, p. 792-803 12 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Energy Metabolism
Basal Metabolism
Body Composition
Dielectric Spectroscopy
50 Citations (Scopus)

Genetic heterogeneity of amyotrophic lateral sclerosis: Implications for clinical practice and research

Su, X. W., Broach, J., Connor, J., Gerhard, G. S. & Simmons, Z., Jan 1 2014, In : Muscle and Nerve. 49, 6, p. 786-803 18 p.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Amyotrophic Lateral Sclerosis
Research
Clinical Trials
Exome
13 Citations (Scopus)

H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis

Nandar, W., Neely, E. B., Simmons, Z. & Connor, J., Dec 1 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 12, p. 2413-2426 14 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Transgenic Mice
Disease Progression
Animal Models
Genotype
88 Citations (Scopus)

Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: A multi-stage, randomised, double-blind, placebo-controlled trial

Ceftriaxone Study Investigators, Nov 1 2014, In : The Lancet Neurology. 13, 11, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

Ceftriaxone
Amyotrophic Lateral Sclerosis
Placebos
Safety
Central Venous Catheters
2013
37 Citations (Scopus)

Biomarker-based predictive models for prognosis in amyotrophic lateral sclerosis

Su, X. W., Simmons, Z., Mitchell, R. M., Kong, L., Stephens, H. E. & Connor, J., Jan 1 2013, In : JAMA Neurology. 70, 12, p. 1505-1511 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Cerebrospinal Fluid
Biomarkers
Apoferritins
Hemochromatosis
3 Citations (Scopus)

Frontotemporal degeneration in the patient with amyotrophic lateral sclerosis: Helping the caregiver cope

Houseman, G., Walsh, S., Brothers, A., Lyter, J., Simmons, Z. & Klapper, J., Apr 1 2013, In : Journal of Neuroscience Nursing. 45, 2, p. 96-100 5 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Caregivers
Nurses
Research
6 Citations (Scopus)

H63D HFE polymorphisms are associated with increased disease duration and decreased muscle superoxide dismutase-1 expression in amyotrophic lateral sclerosis patients

Su, X. W., Lee, S., Mitchell, R. M., Stephens, H. E., Simmons, Z. & Connor, J., Aug 1 2013, In : Muscle and Nerve. 48, 2, p. 242-246 5 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Muscles
Genotype
Muscle Proteins
Superoxide Dismutase-1
2012
32 Citations (Scopus)

Amyotrophic lateral sclerosis: Time for research on psychological intervention?

Pagnini, F., Simmons, Z., Corbo, M. & Molinari, E., Sep 1 2012, In : Amyotrophic Lateral Sclerosis. 13, 5, p. 416-417 2 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Psychology
Research
Quality of Life
Spirituality