• 4700 Citations
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1986 …2019
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Research Output 1986 2019

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Article
2009
22 Citations (Scopus)

Penn State screen exam for the detection of frontal and temporal dysfunction syndromes: Application to ALS

Flaherty, C., Brothers, A., Dearman, B., Eslinger, P. & Simmons, Z., Mar 24 2009, In : Amyotrophic Lateral Sclerosis. 10, 2, p. 107-112 6 p.

Research output: Contribution to journalArticle

Extremities
Reading
Decision Making
Therapeutics
Quality of Life
20 Citations (Scopus)

Problem solving skills predict quality of life and psychological morbidity in ALS caregivers

Murphy, V., Felgoise, S. H., Walsh, S. M. & Simmons, Z., Aug 6 2009, In : Amyotrophic Lateral Sclerosis. 10, 3, p. 147-153 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Caregivers
Quality of Life
Psychology
Morbidity
33 Citations (Scopus)

The SEIQoL-DW for assessing quality of life in ALS: Strengths and limitations

Felgoise, S. H., Stewart, J. L., Bremer, B. A., Walsh, S. M., Bromberg, M. B. & Simmons, Z., Nov 27 2009, In : Amyotrophic Lateral Sclerosis. 10, 5-6, p. 456-462 7 p.

Research output: Contribution to journalArticle

Appointments and Schedules
Quality of Life
Cues
Prospective Studies
2010
60 Citations (Scopus)

Plasma biomarkers associated with ALS and their relationship to iron homeostasis

Mitchell, R. M., Simmons, Z., Beard, J. L., Stephens, H. E. & Connor, J., Jul 1 2010, In : Muscle and Nerve. 42, 1, p. 95-103 9 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Homeostasis
Iron
Biomarkers
Transferrin
12 Citations (Scopus)
Peptidylprolyl Isomerase
Alleles
Phosphorylation
Iron
Alzheimer Disease
22 Citations (Scopus)

Psychological morbidity in ALS: The importance of psychological assessment beyond depression alone

Felgoise, S. H., Chakraborty, B. H., Bond, E., Rodriguez, J., Bremer, B. A., Walsh, S. M., Lai, E. C., McCluskey, L. & Simmons, Z., Jan 1 2010, In : Amyotrophic Lateral Sclerosis. 11, 4, p. 351-358 8 p.

Research output: Contribution to journalArticle

Depression
Psychology
Morbidity
Psychiatry
Outpatients
2011
18 Citations (Scopus)
Advance Care Planning
Decision Support Techniques
Amyotrophic Lateral Sclerosis
Software
Advance Directives
24 Citations (Scopus)

Association of common variants in the human eyes shut ortholog (EYS) with statin-induced myopathy: Evidence for additional functions of EYS

Isackson, P. J., Ochs-Balcom, H. M., Ma, C., Harley, J. B., Peltier, W., Tarnopolsky, M., Sripathi, N., Wortmann, R. L., Simmons, Z., Wilson, J. D., Smith, S. A., Barboi, A., Fine, E., Baer, A., Baker, S., Kaufman, K., Cobb, B., Kilpatrick, J. R. & Vladutiu, G. D., Oct 1 2011, In : Muscle and Nerve. 44, 4, p. 531-538 8 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Muscular Diseases
Agrin
Chromosomes, Human, Pair 6
Genetic Loci
10 Citations (Scopus)

Declines in problem solving and anosognosia in amyotrophic lateral sclerosis: Application of guilford's structure of intellect theory

Flaherty, C., Brothers, A., Yang, C., Svoboda, R. & Simmons, Z., Mar 1 2011, In : Cognitive and Behavioral Neurology. 24, 1, p. 26-34 9 p.

Research output: Contribution to journalArticle

Agnosia
Amyotrophic Lateral Sclerosis
Aptitude
Dementia
Healthy Volunteers
7 Citations (Scopus)

Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues

Hall, E. C., Lee, S., Mairuae, N., Simmons, Z. & Connor, J., Aug 1 2011, In : Neurobiology of Aging. 32, 8, p. 1409-1419 11 p.

Research output: Contribution to journalArticle

Serine
Glycogen Synthase Kinase 3
Phosphorylation
Iron
Oxidative Stress
19 Citations (Scopus)

HFE polymorphisms affect cellular glutamate regulation

Mitchell, R. M., Lee, S., Simmons, Z. & Connor, J., Jun 1 2011, In : Neurobiology of Aging. 32, 6, p. 1114-1123 10 p.

Research output: Contribution to journalArticle

Glutamic Acid
Iron
Genotype
Calcium
Cell Line
34 Citations (Scopus)

Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability

Liu, Y., Lee, S., Neely, E., Nandar, W., Moyo, M., Simmons, Z. & Connor, J., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13161-13170 10 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Mutant Proteins
Unfolded Protein Response
Iron
Caspase 3
57 Citations (Scopus)

Palliative care in amyotrophic lateral sclerosis: A review of current international guidelines and initiatives

Bede, P., Oliver, D., Stodart, J., Van Den Berg, L., Simmons, Z., Brannagáin, D. Ó., Borasio, G. D. & Hardiman, O., Apr 1 2011, In : Journal of Neurology, Neurosurgery and Psychiatry. 82, 4, p. 413-418 6 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Palliative Care
Guidelines
Quality of Life
Caregivers
23 Citations (Scopus)

Psychological health in patients with ALS is maintained as physical function declines

Cupp, J., Simmons, Z., Berg, A., Felgoise, S. H., Walsh, S. M. & Stephens, H. E., Jul 1 2011, In : Amyotrophic Lateral Sclerosis. 12, 4, p. 290-296 7 p.

Research output: Contribution to journalArticle

Psychology
Health
Antidepressive Agents
Gastrostomy
Quality of Life
2012
34 Citations (Scopus)

Amyotrophic lateral sclerosis: Time for research on psychological intervention?

Pagnini, F., Simmons, Z., Corbo, M. & Molinari, E., Sep 1 2012, In : Amyotrophic Lateral Sclerosis. 13, 5, p. 416-417 2 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Psychology
Research
Quality of Life
Spirituality
18 Citations (Scopus)

Non-invasive ventilation and gastrostomy may not impact overall quality of life in patients with ALS

Zamietra, K., Lehman, E. B., Felgoise, S. H., Walsh, S. M., Stephens, H. E. & Simmons, Z., Jan 1 2012, In : Amyotrophic Lateral Sclerosis. 13, 1, p. 55-58 4 p.

Research output: Contribution to journalArticle

Noninvasive Ventilation
Gastrostomy
Positive-Pressure Respiration
Quality of Life
Health Status
2013
37 Citations (Scopus)

Biomarker-based predictive models for prognosis in amyotrophic lateral sclerosis

Su, X. W., Simmons, Z., Mitchell, R. M., Kong, L., Stephens, H. E. & Connor, J. R., Dec 2013, In : JAMA neurology. 70, 12, p. 1505-1511 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Cerebrospinal Fluid
Biomarkers
Apoferritins
Hemochromatosis
3 Citations (Scopus)

Frontotemporal degeneration in the patient with amyotrophic lateral sclerosis: Helping the caregiver cope

Houseman, G., Walsh, S., Brothers, A., Lyter, J., Simmons, Z. & Klapper, J., Apr 1 2013, In : Journal of Neuroscience Nursing. 45, 2, p. 96-100 5 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Caregivers
Nurses
Research
6 Citations (Scopus)
Amyotrophic Lateral Sclerosis
Muscles
Genotype
Muscle Proteins
Superoxide Dismutase-1
2014
33 Citations (Scopus)

Estimating daily energy expenditure in individuals with amyotrophic lateral sclerosis

Kasarskis, E. J., Mendiondo, M. S., Matthews, D. E., Mitsumoto, H., Tandan, R., Simmons, Z., Bromberg, M. B. & Kryscio, R. J., Apr 1 2014, In : American Journal of Clinical Nutrition. 99, 4, p. 792-803 12 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Energy Metabolism
Basal Metabolism
Body Composition
Dielectric Spectroscopy
51 Citations (Scopus)

Genetic heterogeneity of amyotrophic lateral sclerosis: Implications for clinical practice and research

Su, X. W., Broach, J., Connor, J., Gerhard, G. S. & Simmons, Z., Jan 1 2014, In : Muscle and Nerve. 49, 6, p. 786-803 18 p.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Amyotrophic Lateral Sclerosis
Research
Clinical Trials
Exome
15 Citations (Scopus)

H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis

Nandar, W., Neely, E. B., Simmons, Z. & Connor, J., Dec 1 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 12, p. 2413-2426 14 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Transgenic Mice
Disease Progression
Animal Models
Genotype
93 Citations (Scopus)

Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: A multi-stage, randomised, double-blind, placebo-controlled trial

Ceftriaxone Study Investigators, Nov 1 2014, In : The Lancet Neurology. 13, 11, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

Ceftriaxone
Amyotrophic Lateral Sclerosis
Placebos
Safety
Central Venous Catheters
2015
10 Citations (Scopus)

Acceptance of brain-computer interfaces in amyotrophic lateral sclerosis

Geronimo, A., Stephens, H. E., Schiff, S. & Simmons, Z., Jun 1 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 3-4, p. 258-264 7 p.

Research output: Contribution to journalArticle

Brain-Computer Interfaces
Amyotrophic Lateral Sclerosis
Computer Systems
Biomedical Engineering
Self-Help Devices
2 Citations (Scopus)

Adaptive endoplasmic reticulum stress alters cellular responses to the extracellular milieu

Liu, Y., Neely, E., Simmons, Z. & Connor, J., May 1 2015, In : Journal of Neuroscience Research. 93, 5, p. 766-776 11 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Apoptosis
Cell Survival
Motor Neurons
Pathologic Processes
13 Citations (Scopus)

Histological-MRI correlation in the primary motor cortex of patients with amyotrophic lateral sclerosis

Meadowcroft, M. D., Mutic, N. J., Bigler, D. C., Wang, J. L., Simmons, Z., Connor, J. R. & Yang, Q. X., Mar 1 2015, In : Journal of Magnetic Resonance Imaging. 41, 3, p. 665-675 11 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Cortex
Myelin Sheath
Astrocytes
Brain Death
38 Citations (Scopus)

Isaacs syndrome: A review

Ahmed, A. & Simmons, Z., Jul 1 2015, In : Muscle and Nerve. 52, 1, p. 5-12 8 p.

Research output: Contribution to journalArticle

Isaacs Syndrome
Fasciculation
Peripheral Nerves
Myokymia
Electrodiagnosis
10 Citations (Scopus)

Multidisciplinary ALS clinics in the USA: A comparison of those who attend and those who do not

Stephens, H. E., Felgoise, S., Young, J. & Simmons, Z., Jun 1 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 3-4, p. 196-201 6 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Social Problems
Quality of Life
Nutritionists
Home Care Services
17 Citations (Scopus)

Patient-Perceived Outcomes and Quality of Life in ALS

Simmons, Z., Apr 1 2015, In : Neurotherapeutics. 12, 2, p. 394-402 9 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Quality of Life
Patient Care
Health
Outcome Assessment (Health Care)
12 Citations (Scopus)

Relationship of creatine kinase to body composition, disease state, and longevity in ALS

Gibson, S. B., Kasarskis, E. J., Hu, N., Pulst, S. M., Mendiondo, M. S., Matthews, D. E., Mitsumoto, H., Tandan, R., Simmons, Z., Kryscio, R. J. & Bromberg, M. B., Nov 27 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 7-8, p. 473-477 5 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Creatine Kinase
Body Composition
Fasciculation
Dielectric Spectroscopy
15 Citations (Scopus)

Serum ferritin is elevated in amyotrophic lateral sclerosis patients

Su, X. W., Clardy, S. L., Stephens, H. E., Simmons, Z. & Connor, J., Mar 1 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 1-2, p. 102-107 6 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Ferritins
Serum
Survival
Iron
17 Citations (Scopus)

The potential of psychological interventions to improve quality of life and mood in muscle disorders

Graham, C. D., Simmons, Z., Stuart, S. R. & Rose, M. R., Jul 1 2015, In : Muscle and Nerve. 52, 1, p. 131-136 6 p.

Research output: Contribution to journalArticle

Muscular Diseases
Quality of Life
Psychology
Acceptance and Commitment Therapy
Cognitive Therapy
2016
23 Citations (Scopus)

A qualitative study of multidisciplinary ALS clinic use in the United States

Stephens, H. E., Young, J., Felgoise, S. H. & Simmons, Z., Feb 17 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 1-2, p. 55-61 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Form Perception
Standard of Care
Research
Clinical Trials
27 Citations (Scopus)

A randomized trial of mexiletine in ALS

Weiss, M. D., Macklin, E. A., Simmons, Z., Knox, A. S., Greenblatt, D. J., Atassi, N., Graves, M., Parziale, N., Salameh, J. S., Quinn, C., Brown, R. H., Distad, J. B., Trivedi, J., Shefner, J. M., Barohn, R. J., Pestronk, A., Swenson, A. & Cudkowicz, M. E., Apr 19 2016, In : Neurology. 86, 16, p. 1474-1481 8 p.

Research output: Contribution to journalArticle

Mexiletine
Muscle Cramp
Placebos
Vital Capacity
Pharmacokinetics
5 Citations (Scopus)

Compliance with recommendations made in a multidisciplinary ALS clinic

Fullam, T., Stephens, H. E., Felgoise, S. H., Blessinger, J. K., Walsh, S. & Simmons, Z., Feb 17 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 1-2, p. 30-37 8 p.

Research output: Contribution to journalArticle

Compliance
Ambulatory Care
Caregivers
Mental Health
Physiologic Monitoring
1 Citation (Scopus)

Genetic Testing of Presymptomatic Individuals at Risk for Progressive Myopathy

Simmons, Z., Dec 1 2016, In : CONTINUUM Lifelong Learning in Neurology. 22, 6, p. 2006-2011 6 p.

Research output: Contribution to journalArticle

Genetic Testing
Muscular Diseases
Beneficence
Physicians
Inborn Genetic Diseases
14 Citations (Scopus)

Pain in amyotrophic lateral sclerosis: Patient and physician perspectives and practices

Stephens, H. E., Lehman, E., Raheja, D., Yang, C., Walsh, S., Mcarthur, D. B. & Simmons, Z., Feb 17 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 1-2, p. 21-29 9 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Physicians
Pain
Pain Management
Postal Service
11 Citations (Scopus)

Patient-reported problematic symptoms in an ALS treatment trial

Raheja, D., Stephens, H. E., Lehman, E., Walsh, S., Yang, C. & Simmons, Z., May 18 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 3-4, p. 198-205 8 p.

Research output: Contribution to journalArticle

Quality of Life
Aptitude
Fatigue
Ceftriaxone
Mucus
25 Citations (Scopus)
Brain-Computer Interfaces
Brain computer interface
Amyotrophic Lateral Sclerosis
Imagery (Psychotherapy)
Communication
3 Citations (Scopus)

Primary lateral sclerosis and early upper motor neuron disease: Characteristics of a cross-sectional population

Fournier, C. N., Murphy, A., Loci, L., Mitsumoto, H., Lomen-Hoerth, C., Kisanuki, Y., Simmons, Z., Maragakis, N. J., McVey, A. L., Al-Lahham, T., Heiman-Patterson, T. D., Andrews, J., McDonnell, E., Cudkowicz, M. & Atassi, N., Jan 1 2016, In : Journal of Clinical Neuromuscular Disease. 17, 3, p. 99-105 7 p.

Research output: Contribution to journalArticle

Motor Neuron Disease
Amyotrophic Lateral Sclerosis
Electromyography
Population
Hereditary Spastic Paraplegia
17 Citations (Scopus)

Prospective exploratory muscle biopsy, imaging, and functional assessment in patients with late-onset Pompe disease treated with alglucosidase alfa: The EMBASSY Study

van der Ploeg, A., Carlier, P. G., Carlier, R. Y., Kissel, J. T., Schoser, B., Wenninger, S., Pestronk, A., Barohn, R. J., Dimachkie, M. M., Goker-Alpan, O., Mozaffar, T., Pena, L. D. M., Simmons, Z., Straub, V., Guglieri, M., Young, P., Boentert, M., Baudin, P. Y., Wens, S., Shafi, R. & 2 others, Bjartmar, C. & Thurberg, B. L., Sep 1 2016, In : Molecular Genetics and Metabolism. 119, 1-2, p. 115-123 9 p.

Research output: Contribution to journalArticle

Functional assessment
Glycogen Storage Disease Type II
Enzyme Replacement Therapy
Biopsy
Glycogen
6 Citations (Scopus)

Statins accelerate disease progression and shorten survival in SOD1G93A mice

Su, X. W., Nandar, W., Neely, E. B., Simmons, Z. & Connor, J. R., Aug 1 2016, In : Muscle and Nerve. 54, 2, p. 284-291 8 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Disease Progression
coenzyme Q10
Simvastatin
Amyotrophic Lateral Sclerosis
7 Citations (Scopus)

The role of mental health and self-efficacy in the pain experience of patients with amyotrophic lateral sclerosis

Stephens, H. E., Lehman, E., Raheja, D., Yang, C., Walsh, S. & Simmons, Z., May 18 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 3-4, p. 206-212 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Self Efficacy
Mental Health
Pain
Depression
13 Citations (Scopus)

Verbal communication impacts quality of life in patients with amyotrophic lateral sclerosis

Felgoise, S. H., Zaccheo, V., Duff, J. & Simmons, Z., May 18 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 3-4, p. 179-183 5 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Aptitude
Communication
Quality of Life
Analysis of Variance
2017
7 Citations (Scopus)

Acoustic and tongue kinematic vowel space in speakers with and without dysarthria

Lee, J. M., Littlejohn, M. A. & Simmons, Z., Mar 4 2017, In : International Journal of Speech-Language Pathology. 19, 2, p. 195-204 10 p.

Research output: Contribution to journalArticle

Dysarthria
Tongue
Biomechanical Phenomena
Acoustics
Amyotrophic Lateral Sclerosis
2 Citations (Scopus)

Advance care planning for patients with amyotrophic lateral sclerosis

Levi, B., Simmons, Z., Hanna, C., Brothers, A., Lehman, E., Farace, E., Bain, M., Stewart, R. & Green, M., Jul 3 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 5-6, p. 388-396 9 p.

Research output: Contribution to journalArticle

Advance Care Planning
Amyotrophic Lateral Sclerosis
Decision Support Techniques
Terminal Care
Personal Autonomy
Brain-Computer Interfaces
Amyotrophic Lateral Sclerosis
Evoked Potentials
Neurodegenerative Diseases
Alleles
4 Citations (Scopus)

Fixed dynamometry is more sensitive than vital capacity or ALS rating scale

Andres, P. L., Allred, M. P., Stephens, H. E., Proffitt Bunnell, M., Siener, C., Macklin, E. A., Haines, T., English, R. A., Fetterman, K. A., Kasarskis, E. J., Florence, J., Simmons, Z. & Cudkowicz, M. E., Oct 1 2017, In : Muscle and Nerve. 56, 4, p. 710-715 6 p.

Research output: Contribution to journalArticle

Vital Capacity
Amyotrophic Lateral Sclerosis
Extremities
Sample Size
Longitudinal Studies
11 Citations (Scopus)

Incorporation of telehealth into a multidisciplinary ALS Clinic: feasibility and acceptability

Geronimo, A., Wright, C., Morris, A., Walsh, S., Snyder, B. & Simmons, Z., Oct 2 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 7-8, p. 555-561 7 p.

Research output: Contribution to journalArticle

Telemedicine
Caregivers
Health Personnel
Videoconferencing
Quality of Health Care
1 Citation (Scopus)

Right-to-Try Investigational Therapies for Incurable Disorders

Simmons, Z., Oct 1 2017, In : CONTINUUM Lifelong Learning in Neurology. 23, 5, Peripheral Nerve and Motor Neuron Disorders, p. 1451-1457 7 p.

Research output: Contribution to journalArticle

Investigational Therapies
Beneficence
Therapeutics
Compassionate Use Trials
Amyotrophic Lateral Sclerosis