• 4747 Citations
  • 37 h-Index
1986 …2019
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Research Output 1986 2019

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Article
106 Citations (Scopus)

Motor unit number estimation, isometric strength, and electromyographic measures in amyotrophic lateral sclerosis

Bromberg, M. B., Forshew, D. A., Nau, K. L., Bromberg, J., Simmons, Z. & Fries, T. J., Nov 1993, In : Muscle & nerve. 16, 11, p. 1213-1219 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Action Potentials
Motor Neurons
Muscles
Muscle Strength
74 Citations (Scopus)

Methods for estimating the numbers of motor units in human muscles

Doherty, T., Simmons, Z., O'Connell, B., Felice, K. J., Conwit, R., Chan, K. M., Komori, T., Brown, T., Stashuk, D. W. & Brown, W. F., Jan 1 1995, In : Journal of Clinical Neurophysiology. 12, 6, p. 565-584 20 p.

Research output: Contribution to journalArticle

Muscles
51 Citations (Scopus)

Low diagnostic yield of sural nerve biopsy in patients with peripheral neuropathy and primary amyloidosis

Simmons, Z., Blaivas, M., Aguilera, A. J., Feldman, E. L., Bromberg, M. B. & Towfighi, J., Dec 1 1993, In : Journal of the neurological sciences. 120, 1, p. 60-63 4 p.

Research output: Contribution to journalArticle

Sural Nerve
Peripheral Nervous System Diseases
Amyloidosis
Biopsy
Amyloid
117 Citations (Scopus)

Long-term follow-up of patients with chronic inflammatory demyelinating polyradiculoneuropathy, without and with monoclonal gammopathy

Simmons, Z., Albers, J. W., Bromberg, M. B. & Feldman, E. L., Apr 1 1995, In : Brain. 118, 2, p. 359-368 10 p.

Research output: Contribution to journalArticle

Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Paraproteinemias
Monoclonal Gammopathy of Undetermined Significance
47 Citations (Scopus)

Localized hypertrophic neuropathy: Magnetic resonance imaging findings and long-term follow-up

Simmons, Z., Mahadeen, Z. I., Kothari, M. J., Powers, S., Wise, S. & Towfighi, J., Jan 1 1999, In : Muscle and Nerve. 22, 1, p. 28-36 9 p.

Research output: Contribution to journalArticle

Fats
Magnetic Resonance Imaging
Nerve Sheath Neoplasms
Sural Nerve
Magnets
1 Citation (Scopus)

Lawful physician-hastened death AAN position statement

Russell, J. A., Epstein, L. G., Bonnie, R. J., Conwit, R., Graf, W. D., Kirschen, M., Kurek, J. A., Larriviere, D. G., Pascuzzi, R. M., Rizzo, M., Sattin, J. A., Simmons, Z., Taylor, L., Tsou, A. & Williams, M. A., Jan 1 2018, In : Neurology. 90, 9, p. 420-422 3 p.

Research output: Contribution to journalArticle

Assisted Suicide
Euthanasia
Neurology
Prescriptions
Physicians
39 Citations (Scopus)

Isaacs syndrome: A review

Ahmed, A. & Simmons, Z., Jul 1 2015, In : Muscle and Nerve. 52, 1, p. 5-12 8 p.

Research output: Contribution to journalArticle

Isaacs Syndrome
Fasciculation
Peripheral Nerves
Myokymia
Electrodiagnosis

In memorium: WALTER STOLOV, MD

Robinson, L. R. & Simmons, Z., Jan 1 2019, In : Muscle & nerve. 59, 1, p. 1-2 2 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Influence of HFE variants and cellular iron on monocyte chemoattractant protein-1

Mitchell, R. M., Lee, S., Randazzo, W. T., Simmons, Z. & Connor, J., Feb 19 2009, In : Journal of Neuroinflammation. 6, 6.

Research output: Contribution to journalArticle

Chemokine CCL2
Iron
Minocycline
Cytokines
Genotype
92 Citations (Scopus)

Increased incidence of the Hfe mutation in amyotrophic lateral sclerosis and related cellular consequences

Wang, X. S., Lee, S., Simmons, Z., Boyer, P., Scott, K., Liu, W. & Connor, J., Dec 15 2004, In : Journal of the neurological sciences. 227, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Mutation
Incidence
Neuromuscular Diseases
Oxidative Stress
11 Citations (Scopus)

Incorporation of telehealth into a multidisciplinary ALS Clinic: feasibility and acceptability

Geronimo, A., Wright, C., Morris, A., Walsh, S., Snyder, B. & Simmons, Z., Oct 2 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 7-8, p. 555-561 7 p.

Research output: Contribution to journalArticle

Telemedicine
Caregivers
Health Personnel
Videoconferencing
Quality of Health Care
54 Citations (Scopus)

Hypothyroid myopathy with a strikingly elevated serum creatine kinase level

Scott, K. R., Simmons, Z. & Boyer, P. J., Jul 17 2002, In : Muscle and Nerve. 26, 1, p. 141-144 4 p.

Research output: Contribution to journalArticle

Muscular Diseases
Creatine Kinase
Hypothyroidism
Serum
Myositis
1 Citation (Scopus)

Hydration measured by doubly labeled water in ALS and its effects on survival

for the ALS Nutrition-NIPPV Study Group, Apr 3 2018, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 19, 3-4, p. 220-231 12 p.

Research output: Contribution to journalArticle

Drinking
Survival
Water
Body Water
Centers for Medicare and Medicaid Services (U.S.)
14 Citations (Scopus)

Histological-MRI correlation in the primary motor cortex of patients with amyotrophic lateral sclerosis

Meadowcroft, M. D., Mutic, N. J., Bigler, D. C., Wang, J. L., Simmons, Z., Connor, J. R. & Yang, Q. X., Mar 1 2015, In : Journal of Magnetic Resonance Imaging. 41, 3, p. 665-675 11 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Cortex
Myelin Sheath
Astrocytes
Brain Death
19 Citations (Scopus)

HFE polymorphisms affect cellular glutamate regulation

Mitchell, R. M., Lee, S., Simmons, Z. & Connor, J., Jun 1 2011, In : Neurobiology of Aging. 32, 6, p. 1114-1123 10 p.

Research output: Contribution to journalArticle

Glutamic Acid
Iron
Genotype
Calcium
Cell Line
6 Citations (Scopus)
Amyotrophic Lateral Sclerosis
Muscles
Genotype
Muscle Proteins
Superoxide Dismutase-1
15 Citations (Scopus)

H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis

Nandar, W., Neely, E. B., Simmons, Z. & Connor, J., Dec 1 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 12, p. 2413-2426 14 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Transgenic Mice
Disease Progression
Animal Models
Genotype
70 Citations (Scopus)

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

ITALSGEN Consortium, Genomic Translation for ALS Care (GTAC) Consortium, ALS Sequencing Consortium, NYGC ALS Consortium, Answer ALS Foundation, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, SLAGEN Consortium, French ALS Consortium & Project MinE ALS Sequencing Consortium, Mar 21 2018, In : Neuron. 97, 6, p. 1268-1283.e6

Research output: Contribution to journalArticle

Kinesin
Genome
Mutation
Genes
Genome-Wide Association Study
1 Citation (Scopus)

Genetic Testing of Presymptomatic Individuals at Risk for Progressive Myopathy

Simmons, Z., Dec 1 2016, In : CONTINUUM Lifelong Learning in Neurology. 22, 6, p. 2006-2011 6 p.

Research output: Contribution to journalArticle

Genetic Testing
Muscular Diseases
Beneficence
Physicians
Inborn Genetic Diseases
184 Citations (Scopus)

Genetic risk factors associated with lipid-lowering drug-induced myopathies

Vladutiu, G. D., Simmons, Z., Isackson, P. J., Tarnopolsky, M., Peltier, W. L., Barboi, A. C., Sripathi, N., Wortmann, R. L. & Phillips, P. S., Aug 1 2006, In : Muscle and Nerve. 34, 2, p. 153-162 10 p.

Research output: Contribution to journalArticle

Muscular Diseases
Lipids
Pharmaceutical Preparations
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Muscles
51 Citations (Scopus)

Genetic heterogeneity of amyotrophic lateral sclerosis: Implications for clinical practice and research

Su, X. W., Broach, J., Connor, J., Gerhard, G. S. & Simmons, Z., Jan 1 2014, In : Muscle and Nerve. 49, 6, p. 786-803 18 p.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Amyotrophic Lateral Sclerosis
Research
Clinical Trials
Exome
3 Citations (Scopus)

Frontotemporal degeneration in the patient with amyotrophic lateral sclerosis: Helping the caregiver cope

Houseman, G., Walsh, S., Brothers, A., Lyter, J., Simmons, Z. & Klapper, J., Apr 1 2013, In : Journal of Neuroscience Nursing. 45, 2, p. 96-100 5 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Caregivers
Nurses
Research
4 Citations (Scopus)

Fixed dynamometry is more sensitive than vital capacity or ALS rating scale

Andres, P. L., Allred, M. P., Stephens, H. E., Proffitt Bunnell, M., Siener, C., Macklin, E. A., Haines, T., English, R. A., Fetterman, K. A., Kasarskis, E. J., Florence, J., Simmons, Z. & Cudkowicz, M. E., Oct 2017, In : Muscle and Nerve. 56, 4, p. 710-715 6 p.

Research output: Contribution to journalArticle

Vital Capacity
Amyotrophic Lateral Sclerosis
Extremities
Sample Size
Longitudinal Studies
12 Citations (Scopus)

Familial clustering of muscular and cardiac involvement in myotonic dystrophy type 1

Groh, W. J., Lowe, M. R., Simmons, Z., Bhakta, D. & Pascuzzi, R. M., Jun 1 2005, In : Muscle and Nerve. 31, 6, p. 719-724 6 p.

Research output: Contribution to journalArticle

Myotonic Dystrophy
Thymine
Cluster Analysis
Siblings
Cytosine
33 Citations (Scopus)

Factors supporting quality of life over time for individuals with amyotrophic lateral sclerosis: The role of positive self-perception and religiosity

Bremer, B. A., Simone, A. L., Walsh, S., Simmons, Z. & Felgoise, S. H., Jan 1 2004, In : Annals of Behavioral Medicine. 28, 2, p. 119-125 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Self Concept
Quality of Life
Health
Neuromuscular Diseases
7 Citations (Scopus)

Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues

Hall, E. C., Lee, S., Mairuae, N., Simmons, Z. & Connor, J., Aug 1 2011, In : Neurobiology of Aging. 32, 8, p. 1409-1419 11 p.

Research output: Contribution to journalArticle

Serine
Glycogen Synthase Kinase 3
Phosphorylation
Iron
Oxidative Stress
176 Citations (Scopus)

Expansion of the myotonic dystrophy CTG repeat reduces expression of the flanking DMAHP gene

Thornton, C. A., Wymer, J. P., Simmons, Z., McClain, C. & Moxley, R. T., Aug 14 1997, In : Nature Genetics. 16, 4, p. 407-409 3 p.

Research output: Contribution to journalArticle

Myotonic Dystrophy
Genes
Muscles
Trinucleotide Repeat Expansion
Trinucleotide Repeats
Brain-Computer Interfaces
Amyotrophic Lateral Sclerosis
Evoked Potentials
Neurodegenerative Diseases
Alleles
Motor Neuron Disease
Telemedicine
Respiratory Function Tests
Noninvasive Ventilation
Lung
1 Citation (Scopus)

Ethical Considerations in Neurogenetic Testing

Su, X. W. & Simmons, Z., Jan 1 2018, In : Seminars in Neurology. 38, 5, p. 505-514 10 p.

Research output: Contribution to journalArticle

Genetic Testing
Beneficence
Nervous System Diseases
Ethics
Physicians
33 Citations (Scopus)

Estimating daily energy expenditure in individuals with amyotrophic lateral sclerosis

Kasarskis, E. J., Mendiondo, M. S., Matthews, D. E., Mitsumoto, H., Tandan, R., Simmons, Z., Bromberg, M. B. & Kryscio, R. J., Apr 1 2014, In : American Journal of Clinical Nutrition. 99, 4, p. 792-803 12 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Energy Metabolism
Basal Metabolism
Body Composition
Dielectric Spectroscopy
49 Citations (Scopus)

Emotional perception deficits in amyotrophic lateral sclerosis

Zimmerman, E. K., Eslinger, P. J., Simmons, Z. & Barrett, A. M., Jun 1 2007, In : Cognitive and Behavioral Neurology. 20, 2, p. 79-82 4 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Dementia
Depression
Facial Expression
Emotions

EMG-PRO

Jaradeh, S., Ahmad, B. K., Simmons, Z., Felice, K. J., Poole, R. M. & Jaros, L., Jan 1 1996, In : Journal of Clinical Neurophysiology. 13, 1, p. 98-99 2 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Electrodiagnostic studies: Are they useful in clinical practice?

Kothari, M. J., Blakeslee, M. A., Reichwein, R., Simmons, Z. & Logigian, E. L., Dec 1998, In : Archives of Physical Medicine and Rehabilitation. 79, 12, p. 1510-1511 2 p.

Research output: Contribution to journalArticle

Neural Conduction
Physicians
Nervous System Diseases
Research Personnel

Electrodiagnostic findings in a patient with waardenburg syndrome

Ahmed, A. & Simmons, Z., Sep 1 2009, In : Journal of Clinical Neuromuscular Disease. 11, 1, p. 54-56 3 p.

Research output: Contribution to journalArticle

Waardenburg Syndrome
Polyneuropathies
Neural Conduction
Biopsy
Waardenburg syndrome type 2
293 Citations (Scopus)

Electrocardiographic abnormalities and sudden death in myotonic dystrophy type 1

Groh, W. J., Groh, M. R., Saha, C., Kincaid, J. C., Simmons, Z., Ciafaloni, E., Pourmand, R., Otten, R. F., Bhakta, D., Nair, G. V., Marashdeh, M. M., Zipes, D. P. & Pascuzzi, R. M., Jun 19 2008, In : New England Journal of Medicine. 358, 25, p. 2688-2697 10 p.

Research output: Contribution to journalArticle

Myotonic Dystrophy
Sudden Death
Electrocardiography
Tachycardia
Confidence Intervals
42 Citations (Scopus)

Dysphagia in elderly men with myasthenia gravis

Kluin, K. J., Bromberg, M. B., Feldman, E. L. & Simmons, Z., Jun 1996, In : Journal of the neurological sciences. 138, 1-2, p. 49-52 4 p.

Research output: Contribution to journalArticle

Myasthenia Gravis
Deglutition
Deglutition Disorders
Aptitude
Pyriform Sinus
19 Citations (Scopus)

Duplication within the SEPT9 gene associated with a founder effect in North American families with hereditary neuralgic amyotrophy

Landsverk, M. L., Ruzzo, E. K., Mefford, H. C., Buysse, K., Buchan, J. G., Eichler, E. E., Petty, E. M., Peterson, E. A., Knutzen, D. M., Barnett, K., Farlow, M. R., Caress, J., Parry, G. J., Quan, D., Gardner, K. L., Hong, M., Simmons, Z., Bird, T. D., Chance, P. F. & Hannibal, M. C., Apr 1 2009, In : Human molecular genetics. 18, 7, p. 1200-1208 9 p.

Research output: Contribution to journalArticle

Brachial Plexus Neuritis
Founder Effect
Exons
Genes
Pedigree
6 Citations (Scopus)

Discussing edaravone with the ALS patient: an ethical framework from a U.S. perspective

Yeo, C. J. J. & Simmons, Z., Apr 3 2018, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 19, 3-4, p. 167-172 6 p.

Research output: Contribution to journalArticle

Patient Care Planning
Hope
Beneficence
Drug Costs
United States Food and Drug Administration
44 Citations (Scopus)

Differential expression of genes in amyotrophic lateral sclerosis revealed by profiling the post mortem cortex

Wang, X. S., Simmons, Z., Liu, W., Boyer, P. & Connor, J., Dec 1 2006, In : Amyotrophic Lateral Sclerosis. 7, 4, p. 201-216 16 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Gene Expression
Genes
Apoptosis
Ubiquitination
15 Citations (Scopus)

Dichotomy between clinical findings and MR abnormalities in pontine infarction

Biller, J., Adams, H. P., Dunn, V., Simmons, Z. & Jacoby, C. G., Sep 24 1986, In : Journal of Computer Assisted Tomography. 10, 3, p. 379-385 7 p.

Research output: Contribution to journalArticle

Infarction
Magnetic Resonance Spectroscopy
Nervous System
Magnetic Resonance Imaging
10 Citations (Scopus)

Declines in problem solving and anosognosia in amyotrophic lateral sclerosis: Application of guilford's structure of intellect theory

Flaherty, C., Brothers, A., Yang, C., Svoboda, R. & Simmons, Z., Mar 1 2011, In : Cognitive and Behavioral Neurology. 24, 1, p. 26-34 9 p.

Research output: Contribution to journalArticle

Agnosia
Amyotrophic Lateral Sclerosis
Aptitude
Dementia
Healthy Volunteers
5 Citations (Scopus)

Compliance with recommendations made in a multidisciplinary ALS clinic

Fullam, T., Stephens, H. E., Felgoise, S. H., Blessinger, J. K., Walsh, S. & Simmons, Z., Feb 17 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 1-2, p. 30-37 8 p.

Research output: Contribution to journalArticle

Compliance
Ambulatory Care
Caregivers
Mental Health
Physiologic Monitoring
155 Citations (Scopus)

Clinical delineation and localization to chromosome 9p13.3-p12 of a unique dominant disorder in four families: Hereditary inclusion body myopathy, paget disease of bone, and frontotemporal dementia

Kovach, M. J., Waggoner, B., Leal, S. M., Gelber, D., Khardori, R., Levenstien, M. A., Shanks, C. A., Gregg, G., Al-Lozi, M. T., Miller, T., Rakowicz, W., Lopate, G., Florence, J., Glosser, G., Simmons, Z., Morris, J. C., Whyte, M. P., Pestronk, A. & Kimonis, V. E., Jan 1 2001, In : Molecular Genetics and Metabolism. 74, 4, p. 458-475 18 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Frontotemporal Dementia
Chromosomes
Chromosomes, Human, Pair 9
Bone
64 Citations (Scopus)

Chronic inflammatory demyelinating polyradiculoneuropathy in children: II. Long-term follow-up, with comparison to adults

Simmons, Z., Wald, J. J. & Albers, J. W., Dec 12 1997, In : Muscle and Nerve. 20, 12, p. 1569-1575 7 p.

Research output: Contribution to journalArticle

Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Intravenous Immunoglobulins
Plasma Exchange
Guillain-Barre Syndrome
Prednisone
61 Citations (Scopus)
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Cerebrospinal Fluid Proteins
Cranial Nerve Diseases
Clinical Studies
Gait
74 Citations (Scopus)

Cerebellar infarction: Comparison of computed tomography and magnetic resonance imaging

Simmons, Z., Biller, J., Adams, H. P., Dunn, V. & Jacoby, C. G., Mar 1986, In : Annals of Neurology. 19, 3, p. 291-293 3 p.

Research output: Contribution to journalArticle

Infarction
Tomography
Magnetic Resonance Imaging
Arteries
Brain Stem Infarctions
18 Citations (Scopus)

Case‐of‐the‐month: Perineuritis presenting as mononeuritis multiplex

Simmons, Z., Albers, J. W. & Sima, A. A. F., May 1992, In : Muscle & nerve. 15, 5, p. 630-635 6 p.

Research output: Contribution to journalArticle

Mononeuropathies
Sural Nerve
Plasma Exchange
Prednisone
Vascular Diseases
37 Citations (Scopus)

Biomarker-based predictive models for prognosis in amyotrophic lateral sclerosis

Su, X. W., Simmons, Z., Mitchell, R. M., Kong, L., Stephens, H. E. & Connor, J. R., Dec 2013, In : JAMA neurology. 70, 12, p. 1505-1511 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Cerebrospinal Fluid
Biomarkers
Apoferritins
Hemochromatosis
86 Citations (Scopus)

A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis

Chiò, A., Schymick, J. C., Restagno, G., Scholz, S. W., Lombardo, F., Lai, S. L., Mora, G., Fung, H. C., Britton, A., Arepalli, S., Gibbs, J. R., Nalls, M., Berger, S., Kwee, L. C., Oddone, E. Z., Ding, J., Crews, C., Rafferty, I., Washecka, N., Hernandez, D. & 48 others, Ferrucci, L., Bandinelli, S., Guralnik, J., Macciardi, F., Torri, F., Lupoli, S., Chanock, S. J., Thomas, G., Hunter, D. J., Gieger, C., Wichmann, H. E., Calvo, A., Mutani, R., Battistini, S., Giannini, F., Caponnetto, C., Mancardi, G. L., La Bella, V., Valentino, F., Monsurrò, M. R., Tedeschi, G., Marinou, K., Sabatelli, M., Conte, A., Mandrioli, J., Sola, P., Salvi, F., Bartolomei, I., Siciliano, G., Carlesi, C., Orrell, R. W., Talbot, K., Simmons, Z., Connor, J., Pioro, E. P., Dunkley, T., Stephan, D. A., Kasperaviciute, D., Fisher, E. M., Jabonka, S., Sendtner, M., Beck, M., Bruijn, L., Rothstein, J., Schmidt, S., Singleton, A., Hardy, J. & Traynor, B. J., Apr 20 2009, In : Human molecular genetics. 18, 8, p. 1524-1532 9 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Amyotrophic Lateral Sclerosis
Single Nucleotide Polymorphism
Odds Ratio
Nerve Degeneration