• 4827 Citations
  • 37 h-Index
1986 …2020

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Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

ITALSGEN Consortium, Genomic Translation for ALS Care (GTAC) Consortium, ALS Sequencing Consortium, NYGC ALS Consortium, Answer ALS Foundation, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, SLAGEN Consortium, French ALS Consortium & Project MinE ALS Sequencing Consortium, Mar 21 2018, In : Neuron. 97, 6, p. 1268-1283.e6

Research output: Contribution to journalArticle

80 Scopus citations

H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis

Nandar, W., Neely, E. B., Simmons, Z. & Connor, J., Dec 1 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 12, p. 2413-2426 14 p.

Research output: Contribution to journalArticle

15 Scopus citations
6 Scopus citations

HFE polymorphisms affect cellular glutamate regulation

Mitchell, R. M., Lee, S., Simmons, Z. & Connor, J., Jun 1 2011, In : Neurobiology of Aging. 32, 6, p. 1114-1123 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Histological-MRI correlation in the primary motor cortex of patients with amyotrophic lateral sclerosis

Meadowcroft, M. D., Mutic, N. J., Bigler, D. C., Wang, J. L., Simmons, Z., Connor, J. R. & Yang, Q. X., Mar 1 2015, In : Journal of Magnetic Resonance Imaging. 41, 3, p. 665-675 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Hydration measured by doubly labeled water in ALS and its effects on survival

for the ALS Nutrition-NIPPV Study Group, Apr 3 2018, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 19, 3-4, p. 220-231 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Hypothyroid myopathy with a strikingly elevated serum creatine kinase level

Scott, K. R., Simmons, Z. & Boyer, P. J., Jul 17 2002, In : Muscle and Nerve. 26, 1, p. 141-144 4 p.

Research output: Contribution to journalArticle

54 Scopus citations

Incorporation of telehealth into a multidisciplinary ALS Clinic: feasibility and acceptability

Geronimo, A., Wright, C., Morris, A., Walsh, S., Snyder, B. & Simmons, Z., Oct 2 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 7-8, p. 555-561 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Increased incidence of the Hfe mutation in amyotrophic lateral sclerosis and related cellular consequences

Wang, X. S., Lee, S., Simmons, Z., Boyer, P., Scott, K., Liu, W. & Connor, J., Dec 15 2004, In : Journal of the neurological sciences. 227, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

93 Scopus citations

Influence of HFE variants and cellular iron on monocyte chemoattractant protein-1

Mitchell, R. M., Lee, S., Randazzo, W. T., Simmons, Z. & Connor, J., Feb 19 2009, In : Journal of Neuroinflammation. 6, 6.

Research output: Contribution to journalArticle

27 Scopus citations

In memorium: WALTER STOLOV, MD

Robinson, L. R. & Simmons, Z., Jan 1 2019, In : Muscle & nerve. 59, 1, p. 1-2 2 p.

Research output: Contribution to journalArticle

Isaacs syndrome: A review

Ahmed, A. & Simmons, Z., Jul 1 2015, In : Muscle and Nerve. 52, 1, p. 5-12 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Lawful physician-hastened death AAN position statement

Russell, J. A., Epstein, L. G., Bonnie, R. J., Conwit, R., Graf, W. D., Kirschen, M., Kurek, J. A., Larriviere, D. G., Pascuzzi, R. M., Rizzo, M., Sattin, J. A., Simmons, Z., Taylor, L., Tsou, A. & Williams, M. A., Jan 1 2018, In : Neurology. 90, 9, p. 420-422 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Localized hypertrophic neuropathy: Magnetic resonance imaging findings and long-term follow-up

Simmons, Z., Mahadeen, Z. I., Kothari, M. J., Powers, S., Wise, S. & Towfighi, J., Jan 1 1999, In : Muscle and Nerve. 22, 1, p. 28-36 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Long-term follow-up of patients with chronic inflammatory demyelinating polyradiculoneuropathy, without and with monoclonal gammopathy

Simmons, Z., Albers, J. W., Bromberg, M. B. & Feldman, E. L., Apr 1 1995, In : Brain. 118, 2, p. 359-368 10 p.

Research output: Contribution to journalArticle

118 Scopus citations

Low diagnostic yield of sural nerve biopsy in patients with peripheral neuropathy and primary amyloidosis

Simmons, Z., Blaivas, M., Aguilera, A. J., Feldman, E. L., Bromberg, M. B. & Towfighi, J., Dec 1 1993, In : Journal of the neurological sciences. 120, 1, p. 60-63 4 p.

Research output: Contribution to journalArticle

51 Scopus citations

Methods for estimating the numbers of motor units in human muscles

Doherty, T., Simmons, Z., O'Connell, B., Felice, K. J., Conwit, R., Chan, K. M., Komori, T., Brown, T., Stashuk, D. W. & Brown, W. F., Jan 1 1995, In : Journal of Clinical Neurophysiology. 12, 6, p. 565-584 20 p.

Research output: Contribution to journalArticle

74 Scopus citations

Motor unit number estimation, isometric strength, and electromyographic measures in amyotrophic lateral sclerosis

Bromberg, M. B., Forshew, D. A., Nau, K. L., Bromberg, J., Simmons, Z. & Fries, T. J., Nov 1993, In : Muscle & nerve. 16, 11, p. 1213-1219 7 p.

Research output: Contribution to journalArticle

106 Scopus citations

Multidisciplinary ALS clinics in the USA: A comparison of those who attend and those who do not

Stephens, H. E., Felgoise, S., Young, J. & Simmons, Z., Jun 1 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 3-4, p. 196-201 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Muscle biopsy in the evaluation of patients with modestly elevated creatine kinase levels

Simmons, Z., Peterlin, B. L., Boyer, P. J. & Towfighi, J., Feb 1 2003, In : Muscle and Nerve. 27, 2, p. 242-244 3 p.

Research output: Contribution to journalArticle

34 Scopus citations

Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability

Liu, Y., Lee, S. Y., Neely, E., Nandar, W., Moyo, M., Simmons, Z. & Connor, J. R., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13161-13170 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Non-invasive ventilation and gastrostomy may not impact overall quality of life in patients with ALS

Zamietra, K., Lehman, E. B., Felgoise, S. H., Walsh, S. M., Stephens, H. E. & Simmons, Z., Jan 1 2012, In : Amyotrophic Lateral Sclerosis. 13, 1, p. 55-58 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Pain in amyotrophic lateral sclerosis: Patient and physician perspectives and practices

Stephens, H. E., Lehman, E., Raheja, D., Yang, C., Walsh, S., Mcarthur, D. B. & Simmons, Z., Feb 17 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 1-2, p. 21-29 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Painless compressive cervical myelopathy with false localizing sensory findings

Simmons, Z., Biller Md, J., Beck Md, D. W. & Keyes Md, W., Jan 1 1986, In : Spine. 11, 9, p. 869-872 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Palliative care in amyotrophic lateral sclerosis: A review of current international guidelines and initiatives

Bede, P., Oliver, D., Stodart, J., Van Den Berg, L., Simmons, Z., Brannagáin, D. Ó., Borasio, G. D. & Hardiman, O., Apr 1 2011, In : Journal of Neurology, Neurosurgery and Psychiatry. 82, 4, p. 413-418 6 p.

Research output: Contribution to journalArticle

58 Scopus citations

Parotid gland injections of botulinum toxin A are effective in treating sialorrhea in amyotrophic lateral sclerosis

Scott, K. R., Kothari, M. J., Venkatesh, Y. S., Murphy, T. & Simmons, Z., Dec 1 2005, In : Journal of Clinical Neuromuscular Disease. 7, 2, p. 62-65 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Patient-Perceived Outcomes and Quality of Life in ALS

Simmons, Z., Apr 1 2015, In : Neurotherapeutics. 12, 2, p. 394-402 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Patient-reported problematic symptoms in an ALS treatment trial

Raheja, D., Stephens, H. E., Lehman, E., Walsh, S., Yang, C. & Simmons, Z., May 18 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 3-4, p. 198-205 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Penn State screen exam for the detection of frontal and temporal dysfunction syndromes: Application to ALS

Flaherty, C., Brothers, A., Dearman, B., Eslinger, P. & Simmons, Z., Mar 24 2009, In : Amyotrophic Lateral Sclerosis. 10, 2, p. 107-112 6 p.

Research output: Contribution to journalArticle

22 Scopus citations
27 Scopus citations

Plasma biomarkers associated with ALS and their relationship to iron homeostasis

Mitchell, R. M., Simmons, Z., Beard, J. L., Stephens, H. E. & Connor, J. R., Jul 1 2010, In : Muscle and Nerve. 42, 1, p. 95-103 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

Polyneuropathy associated with IgA monoclonal gammopathy of undetermined significance

Simmons, Z., Bromberg, M. B., Feldman, E. L. & Blaivas, M., Jan 1993, In : Muscle & nerve. 16, 1, p. 77-83 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

The NYGC ALS Consortium, Oct 29 2019, In : Cell Reports. 29, 5, p. 1164-1177.e5

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Presentation and initial clinical course in patients with chronic inflammatory demyelinating polyradiculoneuropathy: Comparison of patients without and with monoclonal gammopathy

Simmons, Z., Albers, J. W., Bromberg, M. B. & Feldman, E. L., Nov 1993, In : Neurology. 43, 11, p. 2202-2209 8 p.

Research output: Contribution to journalArticle

143 Scopus citations

Primary lateral sclerosis: Consensus diagnostic criteria

Turner, M. R., Barohn, R. J., Corcia, P., Fink, J. K., Harms, M. B., Kiernan, M. C., Ravits, J., Silani, V., Simmons, Z., Statland, J., Van Den Berg, L. H. & Mitsumoto, H., Jan 1 2020, (Accepted/In press) In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticle

Open Access

Primary lateral sclerosis and early upper motor neuron disease: Characteristics of a cross-sectional population

Fournier, C. N., Murphy, A., Loci, L., Mitsumoto, H., Lomen-Hoerth, C., Kisanuki, Y., Simmons, Z., Maragakis, N. J., McVey, A. L., Al-Lahham, T., Heiman-Patterson, T. D., Andrews, J., McDonnell, E., Cudkowicz, M. & Atassi, N., Jan 1 2016, In : Journal of Clinical Neuromuscular Disease. 17, 3, p. 99-105 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Problem solving skills predict quality of life and psychological morbidity in ALS caregivers

Murphy, V., Felgoise, S. H., Walsh, S. M. & Simmons, Z., Aug 6 2009, In : Amyotrophic Lateral Sclerosis. 10, 3, p. 147-153 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
12 Scopus citations

Prospective exploratory muscle biopsy, imaging, and functional assessment in patients with late-onset Pompe disease treated with alglucosidase alfa: The EMBASSY Study

van der Ploeg, A., Carlier, P. G., Carlier, R. Y., Kissel, J. T., Schoser, B., Wenninger, S., Pestronk, A., Barohn, R. J., Dimachkie, M. M., Goker-Alpan, O., Mozaffar, T., Pena, L. D. M., Simmons, Z., Straub, V., Guglieri, M., Young, P., Boentert, M., Baudin, P. Y., Wens, S., Shafi, R. & 2 others, Bjartmar, C. & Thurberg, B. L., Sep 1 2016, In : Molecular Genetics and Metabolism. 119, 1-2, p. 115-123 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Psychological health in patients with ALS is maintained as physical function declines

Cupp, J., Simmons, Z., Berg, A., Felgoise, S. H., Walsh, S. M. & Stephens, H. E., Jul 1 2011, In : Amyotrophic Lateral Sclerosis. 12, 4, p. 290-296 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Psychological morbidity in ALS: The importance of psychological assessment beyond depression alone

Felgoise, S. H., Chakraborty, B. H., Bond, E., Rodriguez, J., Bremer, B. A., Walsh, S. M., Lai, E. C., McCluskey, L. & Simmons, Z., Aug 2010, In : Amyotrophic Lateral Sclerosis. 11, 4, p. 351-358 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Quality of life in ALS depends on factors other than strength and physical function

Simmons, Z., Bremer, B. A., Robbins, R. A., Walsh, S. M. & Fischer, S., Jan 1 2000, In : Neurology. 55, 3, p. 388-392 5 p.

Research output: Contribution to journalArticle

184 Scopus citations

Quality of life in ALS is maintained as physical function declines

Robbins, R. A., Simmons, Z., Bremer, B. A., Walsh, S. M. & Fischer, S., Feb 27 2001, In : Neurology. 56, 4, p. 442-444 3 p.

Research output: Contribution to journalArticle

159 Scopus citations

Relationship of creatine kinase to body composition, disease state, and longevity in ALS

Gibson, S. B., Kasarskis, E. J., Hu, N., Pulst, S. M., Mendiondo, M. S., Matthews, D. E., Mitsumoto, H., Tandan, R., Simmons, Z., Kryscio, R. J. & Bromberg, M. B., Nov 27 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 7-8, p. 473-477 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Relationships between clinical symptom severity scales and nerve conduction measures in carpal tunnel syndrome

You, H., Simmons, Z., Freivalds, A., Kothari, M. J. & Naidu, S. H., 1999, In : Muscle and Nerve. 22, 4, p. 497-501 5 p.

Research output: Contribution to journalArticle

101 Scopus citations

Relative stability of a minimal CTG repeat expansion in a large kindred with myotonic dystrophy

Simmons, Z., Thornton, C. A., Seltzer, W. K. & Sue Richards, C., May 1998, In : Neurology. 50, 5, p. 1501-1504 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Religiousness is related to quality of life in patients with ALS

Walsh, S. M., Bremer, B. A., Felgoise, S. H. & Simmons, Z., May 13 2003, In : Neurology. 60, 9, p. 1527-1529 3 p.

Research output: Contribution to journalArticle

35 Scopus citations

Reproducibility of motor unit number estimation in individual subjects

Simmons, Z., Epstein, D. K., Borg, B., Mauger, D. T., Kothari, M. J. & Shefner, J. M., Apr 10 2001, In : Muscle and Nerve. 24, 4, p. 467-473 7 p.

Research output: Contribution to journalArticle

34 Scopus citations
31 Scopus citations

Right-to-Try Investigational Therapies for Incurable Disorders

Simmons, Z., Oct 1 2017, In : CONTINUUM Lifelong Learning in Neurology. 23, 5, Peripheral Nerve and Motor Neuron Disorders, p. 1451-1457 7 p.

Research output: Contribution to journalArticle

1 Scopus citations