• 4700 Citations
  • 37 h-Index
1986 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1986 2019

Filter
Article
Article
67 Citations (Scopus)

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

ITALSGEN Consortium, Genomic Translation for ALS Care (GTAC) Consortium, ALS Sequencing Consortium, NYGC ALS Consortium, Answer ALS Foundation, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, SLAGEN Consortium, French ALS Consortium & Project MinE ALS Sequencing Consortium, Mar 21 2018, In : Neuron. 97, 6, p. 1268-1283.e6

Research output: Contribution to journalArticle

Kinesin
Genome
Mutation
Genes
Genome-Wide Association Study
15 Citations (Scopus)

H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis

Nandar, W., Neely, E. B., Simmons, Z. & Connor, J., Dec 1 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 12, p. 2413-2426 14 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Transgenic Mice
Disease Progression
Animal Models
Genotype
6 Citations (Scopus)
Amyotrophic Lateral Sclerosis
Muscles
Genotype
Muscle Proteins
Superoxide Dismutase-1
19 Citations (Scopus)

HFE polymorphisms affect cellular glutamate regulation

Mitchell, R. M., Lee, S., Simmons, Z. & Connor, J., Jun 1 2011, In : Neurobiology of Aging. 32, 6, p. 1114-1123 10 p.

Research output: Contribution to journalArticle

Glutamic Acid
Iron
Genotype
Calcium
Cell Line
13 Citations (Scopus)

Histological-MRI correlation in the primary motor cortex of patients with amyotrophic lateral sclerosis

Meadowcroft, M. D., Mutic, N. J., Bigler, D. C., Wang, J. L., Simmons, Z., Connor, J. R. & Yang, Q. X., Mar 1 2015, In : Journal of Magnetic Resonance Imaging. 41, 3, p. 665-675 11 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Cortex
Myelin Sheath
Astrocytes
Brain Death
1 Citation (Scopus)

Hydration measured by doubly labeled water in ALS and its effects on survival

for the ALS Nutrition-NIPPV Study Group, Apr 3 2018, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 19, 3-4, p. 220-231 12 p.

Research output: Contribution to journalArticle

Drinking
Survival
Water
Body Water
Centers for Medicare and Medicaid Services (U.S.)
54 Citations (Scopus)

Hypothyroid myopathy with a strikingly elevated serum creatine kinase level

Scott, K. R., Simmons, Z. & Boyer, P. J., Jul 17 2002, In : Muscle and Nerve. 26, 1, p. 141-144 4 p.

Research output: Contribution to journalArticle

Muscular Diseases
Creatine Kinase
Hypothyroidism
Serum
Myositis
11 Citations (Scopus)

Incorporation of telehealth into a multidisciplinary ALS Clinic: feasibility and acceptability

Geronimo, A., Wright, C., Morris, A., Walsh, S., Snyder, B. & Simmons, Z., Oct 2 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 7-8, p. 555-561 7 p.

Research output: Contribution to journalArticle

Telemedicine
Caregivers
Health Personnel
Videoconferencing
Quality of Health Care
92 Citations (Scopus)

Increased incidence of the Hfe mutation in amyotrophic lateral sclerosis and related cellular consequences

Wang, X. S., Lee, S., Simmons, Z., Boyer, P., Scott, K., Liu, W. & Connor, J., Dec 15 2004, In : Journal of the neurological sciences. 227, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Mutation
Incidence
Neuromuscular Diseases
Oxidative Stress
27 Citations (Scopus)

Influence of HFE variants and cellular iron on monocyte chemoattractant protein-1

Mitchell, R. M., Lee, S., Randazzo, W. T., Simmons, Z. & Connor, J., Feb 19 2009, In : Journal of Neuroinflammation. 6, 6.

Research output: Contribution to journalArticle

Chemokine CCL2
Iron
Minocycline
Cytokines
Genotype

In memorium: WALTER STOLOV, MD

Robinson, L. R. & Simmons, Z., Jan 1 2019, In : Muscle & nerve. 59, 1, p. 1-2 2 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Isaacs syndrome: A review

Ahmed, A. & Simmons, Z., Jul 1 2015, In : Muscle and Nerve. 52, 1, p. 5-12 8 p.

Research output: Contribution to journalArticle

Isaacs Syndrome
Fasciculation
Peripheral Nerves
Myokymia
Electrodiagnosis
1 Citation (Scopus)

Lawful physician-hastened death AAN position statement

Russell, J. A., Epstein, L. G., Bonnie, R. J., Conwit, R., Graf, W. D., Kirschen, M., Kurek, J. A., Larriviere, D. G., Pascuzzi, R. M., Rizzo, M., Sattin, J. A., Simmons, Z., Taylor, L., Tsou, A. & Williams, M. A., Jan 1 2018, In : Neurology. 90, 9, p. 420-422 3 p.

Research output: Contribution to journalArticle

Assisted Suicide
Euthanasia
Neurology
Prescriptions
Physicians
47 Citations (Scopus)

Localized hypertrophic neuropathy: Magnetic resonance imaging findings and long-term follow-up

Simmons, Z., Mahadeen, Z. I., Kothari, M. J., Powers, S., Wise, S. & Towfighi, J., Jan 1 1999, In : Muscle and Nerve. 22, 1, p. 28-36 9 p.

Research output: Contribution to journalArticle

Fats
Magnetic Resonance Imaging
Nerve Sheath Neoplasms
Sural Nerve
Magnets
116 Citations (Scopus)

Long-term follow-up of patients with chronic inflammatory demyelinating polyradiculoneuropathy, without and with monoclonal gammopathy

Simmons, Z., Albers, J. W., Bromberg, M. B. & Feldman, E. L., Apr 1 1995, In : Brain. 118, 2, p. 359-368 10 p.

Research output: Contribution to journalArticle

Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Paraproteinemias
Monoclonal Gammopathy of Undetermined Significance
51 Citations (Scopus)

Low diagnostic yield of sural nerve biopsy in patients with peripheral neuropathy and primary amyloidosis

Simmons, Z., Blaivas, M., Aguilera, A. J., Feldman, E. L., Bromberg, M. B. & Towfighi, J., Dec 1 1993, In : Journal of the neurological sciences. 120, 1, p. 60-63 4 p.

Research output: Contribution to journalArticle

Sural Nerve
Peripheral Nervous System Diseases
Amyloidosis
Biopsy
Amyloid
74 Citations (Scopus)

Methods for estimating the numbers of motor units in human muscles

Doherty, T., Simmons, Z., O'Connell, B., Felice, K. J., Conwit, R., Chan, K. M., Komori, T., Brown, T., Stashuk, D. W. & Brown, W. F., Jan 1 1995, In : Journal of Clinical Neurophysiology. 12, 6, p. 565-584 20 p.

Research output: Contribution to journalArticle

Muscles
105 Citations (Scopus)

Motor unit number estimation, isometric strength, and electromyographic measures in amyotrophic lateral sclerosis

Bromberg, M. B., Forshew, D. A., Nau, K. L., Bromberg, J., Simmons, Z. & Fries, T. J., Nov 1993, In : Muscle & nerve. 16, 11, p. 1213-1219 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Action Potentials
Motor Neurons
Muscles
Muscle Strength
10 Citations (Scopus)

Multidisciplinary ALS clinics in the USA: A comparison of those who attend and those who do not

Stephens, H. E., Felgoise, S., Young, J. & Simmons, Z., Jun 1 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 3-4, p. 196-201 6 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Social Problems
Quality of Life
Nutritionists
Home Care Services
33 Citations (Scopus)

Muscle biopsy in the evaluation of patients with modestly elevated creatine kinase levels

Simmons, Z., Peterlin, B. L., Boyer, P. J. & Towfighi, J., Feb 1 2003, In : Muscle and Nerve. 27, 2, p. 242-244 3 p.

Research output: Contribution to journalArticle

Creatine Kinase
Biopsy
Muscles
Neurologic Examination
Serum
34 Citations (Scopus)

Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability

Liu, Y., Lee, S., Neely, E., Nandar, W., Moyo, M., Simmons, Z. & Connor, J., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13161-13170 10 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Mutant Proteins
Unfolded Protein Response
Iron
Caspase 3
18 Citations (Scopus)

Non-invasive ventilation and gastrostomy may not impact overall quality of life in patients with ALS

Zamietra, K., Lehman, E. B., Felgoise, S. H., Walsh, S. M., Stephens, H. E. & Simmons, Z., Jan 1 2012, In : Amyotrophic Lateral Sclerosis. 13, 1, p. 55-58 4 p.

Research output: Contribution to journalArticle

Noninvasive Ventilation
Gastrostomy
Positive-Pressure Respiration
Quality of Life
Health Status
14 Citations (Scopus)

Pain in amyotrophic lateral sclerosis: Patient and physician perspectives and practices

Stephens, H. E., Lehman, E., Raheja, D., Yang, C., Walsh, S., Mcarthur, D. B. & Simmons, Z., Feb 17 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 1-2, p. 21-29 9 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Physicians
Pain
Pain Management
Postal Service
15 Citations (Scopus)

Painless compressive cervical myelopathy with false localizing sensory findings

Simmons, Z., Biller Md, J., Beck Md, D. W. & Keyes Md, W., Jan 1 1986, In : Spine. 11, 9, p. 869-872 4 p.

Research output: Contribution to journalArticle

Spinal Cord Compression
Myelography
Thorax
Tomography
Pain
57 Citations (Scopus)

Palliative care in amyotrophic lateral sclerosis: A review of current international guidelines and initiatives

Bede, P., Oliver, D., Stodart, J., Van Den Berg, L., Simmons, Z., Brannagáin, D. Ó., Borasio, G. D. & Hardiman, O., Apr 1 2011, In : Journal of Neurology, Neurosurgery and Psychiatry. 82, 4, p. 413-418 6 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Palliative Care
Guidelines
Quality of Life
Caregivers
9 Citations (Scopus)

Parotid gland injections of botulinum toxin A are effective in treating sialorrhea in amyotrophic lateral sclerosis

Scott, K. R., Kothari, M. J., Venkatesh, Y. S., Murphy, T. & Simmons, Z., Dec 1 2005, In : Journal of Clinical Neuromuscular Disease. 7, 2, p. 62-65 4 p.

Research output: Contribution to journalArticle

Sialorrhea
Type A Botulinum Toxins
Parotid Gland
Amyotrophic Lateral Sclerosis
Injections
17 Citations (Scopus)

Patient-Perceived Outcomes and Quality of Life in ALS

Simmons, Z., Apr 1 2015, In : Neurotherapeutics. 12, 2, p. 394-402 9 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Quality of Life
Patient Care
Health
Outcome Assessment (Health Care)
11 Citations (Scopus)

Patient-reported problematic symptoms in an ALS treatment trial

Raheja, D., Stephens, H. E., Lehman, E., Walsh, S., Yang, C. & Simmons, Z., May 18 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 3-4, p. 198-205 8 p.

Research output: Contribution to journalArticle

Quality of Life
Aptitude
Fatigue
Ceftriaxone
Mucus
22 Citations (Scopus)

Penn State screen exam for the detection of frontal and temporal dysfunction syndromes: Application to ALS

Flaherty, C., Brothers, A., Dearman, B., Eslinger, P. & Simmons, Z., Mar 24 2009, In : Amyotrophic Lateral Sclerosis. 10, 2, p. 107-112 6 p.

Research output: Contribution to journalArticle

Extremities
Reading
Decision Making
Therapeutics
Quality of Life
25 Citations (Scopus)
Brain-Computer Interfaces
Brain computer interface
Amyotrophic Lateral Sclerosis
Imagery (Psychotherapy)
Communication
60 Citations (Scopus)

Plasma biomarkers associated with ALS and their relationship to iron homeostasis

Mitchell, R. M., Simmons, Z., Beard, J. L., Stephens, H. E. & Connor, J. R., Jul 1 2010, In : Muscle and Nerve. 42, 1, p. 95-103 9 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Homeostasis
Iron
Biomarkers
Transferrin
38 Citations (Scopus)

Polyneuropathy associated with IgA monoclonal gammopathy of undetermined significance

Simmons, Z., Bromberg, M. B., Feldman, E. L. & Blaivas, M., Jan 1993, In : Muscle & nerve. 16, 1, p. 77-83 7 p.

Research output: Contribution to journalArticle

Monoclonal Gammopathy of Undetermined Significance
Polyneuropathies
Immunoglobulin A
Immunoglobulin M
Immunoglobulin G
142 Citations (Scopus)

Presentation and initial clinical course in patients with chronic inflammatory demyelinating polyradiculoneuropathy: Comparison of patients without and with monoclonal gammopathy

Simmons, Z., Albers, J. W., Bromberg, M. B. & Feldman, E. L., Nov 1993, In : Neurology. 43, 11, p. 2202-2209 8 p.

Research output: Contribution to journalArticle

Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Paraproteinemias
Monoclonal Gammopathy of Undetermined Significance
Immunoglobulin A
Immunoglobulin M
3 Citations (Scopus)

Primary lateral sclerosis and early upper motor neuron disease: Characteristics of a cross-sectional population

Fournier, C. N., Murphy, A., Loci, L., Mitsumoto, H., Lomen-Hoerth, C., Kisanuki, Y., Simmons, Z., Maragakis, N. J., McVey, A. L., Al-Lahham, T., Heiman-Patterson, T. D., Andrews, J., McDonnell, E., Cudkowicz, M. & Atassi, N., Jan 1 2016, In : Journal of Clinical Neuromuscular Disease. 17, 3, p. 99-105 7 p.

Research output: Contribution to journalArticle

Motor Neuron Disease
Amyotrophic Lateral Sclerosis
Electromyography
Population
Hereditary Spastic Paraplegia
20 Citations (Scopus)

Problem solving skills predict quality of life and psychological morbidity in ALS caregivers

Murphy, V., Felgoise, S. H., Walsh, S. M. & Simmons, Z., Aug 6 2009, In : Amyotrophic Lateral Sclerosis. 10, 3, p. 147-153 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Caregivers
Quality of Life
Psychology
Morbidity
12 Citations (Scopus)
Peptidylprolyl Isomerase
Alleles
Phosphorylation
Iron
Alzheimer Disease
17 Citations (Scopus)

Prospective exploratory muscle biopsy, imaging, and functional assessment in patients with late-onset Pompe disease treated with alglucosidase alfa: The EMBASSY Study

van der Ploeg, A., Carlier, P. G., Carlier, R. Y., Kissel, J. T., Schoser, B., Wenninger, S., Pestronk, A., Barohn, R. J., Dimachkie, M. M., Goker-Alpan, O., Mozaffar, T., Pena, L. D. M., Simmons, Z., Straub, V., Guglieri, M., Young, P., Boentert, M., Baudin, P. Y., Wens, S., Shafi, R. & 2 others, Bjartmar, C. & Thurberg, B. L., Sep 1 2016, In : Molecular Genetics and Metabolism. 119, 1-2, p. 115-123 9 p.

Research output: Contribution to journalArticle

Functional assessment
Glycogen Storage Disease Type II
Enzyme Replacement Therapy
Biopsy
Glycogen
23 Citations (Scopus)

Psychological health in patients with ALS is maintained as physical function declines

Cupp, J., Simmons, Z., Berg, A., Felgoise, S. H., Walsh, S. M. & Stephens, H. E., Jul 1 2011, In : Amyotrophic Lateral Sclerosis. 12, 4, p. 290-296 7 p.

Research output: Contribution to journalArticle

Psychology
Health
Antidepressive Agents
Gastrostomy
Quality of Life
22 Citations (Scopus)

Psychological morbidity in ALS: The importance of psychological assessment beyond depression alone

Felgoise, S. H., Chakraborty, B. H., Bond, E., Rodriguez, J., Bremer, B. A., Walsh, S. M., Lai, E. C., McCluskey, L. & Simmons, Z., Jan 1 2010, In : Amyotrophic Lateral Sclerosis. 11, 4, p. 351-358 8 p.

Research output: Contribution to journalArticle

Depression
Psychology
Morbidity
Psychiatry
Outpatients
183 Citations (Scopus)

Quality of life in ALS depends on factors other than strength and physical function

Simmons, Z., Bremer, B. A., Robbins, R. A., Walsh, S. M. & Fischer, S., Jan 1 2000, In : Neurology. 55, 3, p. 388-392 5 p.

Research output: Contribution to journalArticle

Quality of Life
Sickness Impact Profile
Psychology
157 Citations (Scopus)

Quality of life in ALS is maintained as physical function declines

Robbins, R. A., Simmons, Z., Bremer, B. A., Walsh, S. M. & Fischer, S., Feb 27 2001, In : Neurology. 56, 4, p. 442-444 3 p.

Research output: Contribution to journalArticle

Quality of Life
Spirituality
Analysis of Variance
Multivariate Analysis
Cross-Sectional Studies
12 Citations (Scopus)

Relationship of creatine kinase to body composition, disease state, and longevity in ALS

Gibson, S. B., Kasarskis, E. J., Hu, N., Pulst, S. M., Mendiondo, M. S., Matthews, D. E., Mitsumoto, H., Tandan, R., Simmons, Z., Kryscio, R. J. & Bromberg, M. B., Nov 27 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 7-8, p. 473-477 5 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Creatine Kinase
Body Composition
Fasciculation
Dielectric Spectroscopy
101 Citations (Scopus)

Relationships between clinical symptom severity scales and nerve conduction measures in carpal tunnel syndrome

You, H., Simmons, Z., Freivalds, A., Kothari, M. J. & Naidu, S. H., 1999, In : Muscle and Nerve. 22, 4, p. 497-501 5 p.

Research output: Contribution to journalArticle

Carpal Tunnel Syndrome
Neural Conduction
Median Nerve
Wounds and Injuries
Hand
17 Citations (Scopus)

Relative stability of a minimal CTG repeat expansion in a large kindred with myotonic dystrophy

Simmons, Z., Thornton, C. A., Seltzer, W. K. & Sue Richards, C., Jan 1 1998, In : Neurology. 50, 5, p. 1501-1504 4 p.

Research output: Contribution to journalArticle

Trinucleotide Repeat Expansion
Myotonic Dystrophy
Mutation
Population
35 Citations (Scopus)

Religiousness is related to quality of life in patients with ALS

Walsh, S. M., Bremer, B. A., Felgoise, S. H. & Simmons, Z., May 13 2003, In : Neurology. 60, 9, p. 1527-1529 3 p.

Research output: Contribution to journalArticle

Quality of Life
34 Citations (Scopus)

Reproducibility of motor unit number estimation in individual subjects

Simmons, Z., Epstein, D. K., Borg, B., Mauger, D. T., Kothari, M. J. & Shefner, J. M., Apr 10 2001, In : Muscle and Nerve. 24, 4, p. 467-473 7 p.

Research output: Contribution to journalArticle

Motor Neuron Disease
Longitudinal Studies
Software
30 Citations (Scopus)
Respiratory System Abnormalities
Survival
Amyotrophic Lateral Sclerosis
Vital Capacity
Dyspnea
1 Citation (Scopus)

Right-to-Try Investigational Therapies for Incurable Disorders

Simmons, Z., Oct 1 2017, In : CONTINUUM Lifelong Learning in Neurology. 23, 5, Peripheral Nerve and Motor Neuron Disorders, p. 1451-1457 7 p.

Research output: Contribution to journalArticle

Investigational Therapies
Beneficence
Therapeutics
Compassionate Use Trials
Amyotrophic Lateral Sclerosis
93 Citations (Scopus)

Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: A multi-stage, randomised, double-blind, placebo-controlled trial

Ceftriaxone Study Investigators, Nov 1 2014, In : The Lancet Neurology. 13, 11, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

Ceftriaxone
Amyotrophic Lateral Sclerosis
Placebos
Safety
Central Venous Catheters
1 Citation (Scopus)

Selection design phase II trial of high dosages of tamoxifen and creatine in amyotrophic lateral sclerosis

Babu, S., Macklin, E. A., Jackson, K. E., Simpson, E., Mahoney, K., Yu, H., Walker, J., Simmons, Z., David, W. S., Barkhaus, P. E., Simionescu, L., Dimachkie, M. M., Pestronk, A., Salameh, J. S., Weiss, M. D., Brooks, B. R., Schoenfeld, D., Shefner, J., Aggarwal, S., Cudkowicz, M. E. & 1 others, Atassi, N., Jan 1 2019, (Accepted/In press) In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration.

Research output: Contribution to journalArticle

Creatine
Amyotrophic Lateral Sclerosis
Tamoxifen
Placebos
Vital Capacity