• 675 Citations
  • 18 h-Index
20082018
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Personal profile

Research interests

Dr. Zheng-Ming Ding’s NIH-funded research is focused on elucidating neurobiological mechanisms underlying the development of substance use disorders, including nicotine and alcohol.

Dr. Ding utilizes behavioral paradigms to characterize various behavioral effects of drugs of abuse related to motivation and reward. Neurochemical, molecular biological and chemogenetic techniques are employed to investigate the involvement of neurotransmitter systems, intracellular proteins and neuro-circuits in mediating the effects of drugs of abuse.

His major project studies the involvement of cotinine, the major metabolite of nicotine, in the development of nicotine reinforcement. This project characterizes the rewarding and reinforcing effects of cotinine and neurochemical mechanisms underlying these effects in rats. The interactions between nicotine and cotinine in producing reinforcement is also investigated. Results from this project will provide evidence implicating cotinine as a major factor contributing to nicotine addiction and identify cotinine as a target for future development of smoking cessation medications.

Dr. Ding’s second project studies the role of prefrontal cortex in alcohol reinforcement and drinking. This project investigates the glutamate neurotransmission and neuro-circuits within and from the prefrontal cortex in the development of alcohol reinforcement and high alcohol drinking.

His third project examines a potential association between the development of Alzheimer’s disease-like pathological changes and the development of nicotine addiction. This project characterizes nicotine reward-related behaviors in a transgenic rat model of Alzheimer’s disease and seeks to associate these behavioral changes with Alzheimer’s-specific protein changes in the brain.

Fingerprint Dive into the research topics where Zheng-Ming Ding is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 18 Similar Profiles
Ventral Tegmental Area Medicine & Life Sciences
Rats Chemical Compounds
Ethanol Medicine & Life Sciences
Alcohols Medicine & Life Sciences
Alcohol Drinking Medicine & Life Sciences
Nucleus Accumbens Medicine & Life Sciences
Gene expression Chemical Compounds
Wistar Rats Medicine & Life Sciences

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Research Output 2008 2018

  • 675 Citations
  • 18 h-Index
  • 29 Article
6 Citations (Scopus)

Gene expression changes in the ventral hippocampus and medial prefrontal cortex of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking

McClintick, J. N., McBride, W. J., Bell, R. L., Ding, Z-M., Liu, Y., Xuei, X. & Edenberg, H. J., May 1 2018, In : Alcohol. 68, p. 37-47 11 p.

Research output: Contribution to journalArticle

Prefrontal Cortex
Gene expression
Alcohol Drinking
Rats
Hippocampus
2 Citations (Scopus)

Reduced Levels of mGlu2 Receptors within the Prelimbic Cortex Are Not Associated with Elevated Glutamate Transmission or High Alcohol Drinking

Ding, Z-M., Ingraham, C. M., Hauser, S. R., Lasek, A. W., Bell, R. L. & McBride, W. J., Nov 1 2017, In : Alcoholism: Clinical and Experimental Research. 41, 11, p. 1896-1906 11 p.

Research output: Contribution to journalArticle

Alcohol Drinking
Rats
Glutamic Acid
Wistar Rats
Alcohols
5 Citations (Scopus)
Dopamine Agents
Ventral Tegmental Area
Metabotropic Glutamate Receptors
Alcohol Drinking
Dopamine
15 Citations (Scopus)
Periaqueductal Gray
GABA-A Receptors
Neuropeptides
Ion Channels
Gene expression
25 Citations (Scopus)

Gene expression changes in serotonin, GABA-A receptors, neuropeptides and ion channels in the dorsal raphe nucleus of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking

McClintick, J. N., McBride, W. J., Bell, R. L., Ding, Z. M., Liu, Y., Xuei, X. & Edenberg, H. J., Feb 2015, In : Pharmacology Biochemistry and Behavior. 129, p. 87-96 10 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Neuropeptides
Binge Drinking
Ion Channels
Gene expression