Research output per year
Research output per year
Personal profile
Research interests
During mammalian development, hundreds of cell types derived from a single zygote are maintained throughout cell cycles. Deregulation of cell identity is often associated with pathogenesis such as cancer. Despite identical genetic information, cells with distinct identity are controlled by the differential epigenetic landscape. Dr. Zhonghua Gao's research interest is to understand how cell identity is established and maintained via epigenetic mechanisms, particularly how Polycomb group complexes are involved in regulating chromatin structure and gene transcription.
Dr. Gao's lab has established an in vitro neuronal differentiation model using both mouse and human embryonic stem cells. These efforts led to an identification and characterization of novel essential component for a sub-type of PRC1 complex.
The lab is currently continuing to investigate how this regulation controls cell fate determination as well as its involvement in diseases such as cancer and autism.
Dr. Gao is part of the Stem Cell and Regenerative Biology program at Penn State College of Medicine.
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Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway (Nature Communications, (2019), 10, 1, (5649), 10.1038/s41467-019-13542-2)
Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, , Dec 1 2020, In: Nature communications. 11, 1, 3856.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Differentiation and characterization of neural progenitors and neurons from mouse embryonic stem cells
Hanafiah, A., Geng, Z., Wang, Q. & Gao, Z., May 2020, In: Journal of Visualized Experiments. 2020, 159, e61446.Research output: Contribution to journal › Article › peer-review
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Mammalian prc1 complexes: Compositional complexity and diverse molecular mechanisms
Geng, Z. & Gao, Z., Nov 2 2020, In: International journal of molecular sciences. 21, 22, p. 1-18 18 p., 8594.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway
Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, , Dec 1 2019, In: Nature communications. 10, 1, 5649.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
WDR68 is essential for the transcriptional activation of the PRC1-AUTS2 complex and neuronal differentiation of mouse embryonic stem cells
Wang, Q., Geng, Z., Gong, Y., Warren, K., Zheng, H., Imamura, Y. & Gao, Z., Dec 2018, In: Stem Cell Research. 33, p. 206-214 9 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations