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Personal profile

Research interests

During mammalian development, hundreds of cell types derived from a single zygote are maintained throughout cell cycles. Deregulation of cell identity is often associated with pathogenesis such as cancer. Despite identical genetic information, cells with distinct identity are controlled by the differential epigenetic landscape. Dr. Zhonghua Gao's research interest is to understand how cell identity is established and maintained via epigenetic mechanisms, particularly how Polycomb group complexes are involved in regulating chromatin structure and gene transcription.

Dr. Gao's lab has established an in vitro neuronal differentiation model using both mouse and human embryonic stem cells. These efforts led to an identification and characterization of novel essential component for a sub-type of PRC1 complex.

The lab is currently continuing to investigate how this regulation controls cell fate determination as well as its involvement in diseases such as cancer and autism.

Dr. Gao is part of the Stem Cell and Regenerative Biology program at Penn State College of Medicine.

 

Fingerprint Dive into the research topics where Zhonghua Gao is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Casein Kinase I Medicine & Life Sciences
Ubiquitin Medicine & Life Sciences
Polycomb Repressive Complex 1 Medicine & Life Sciences
Nicotinamide Phosphoribosyltransferase Medicine & Life Sciences
Proteins Medicine & Life Sciences
Calcineurin Medicine & Life Sciences
Autistic Disorder Medicine & Life Sciences
Chromatin Medicine & Life Sciences

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Research Output 1999 2018

  • 2447 Citations
  • 19 h-Index
  • 21 Article
1 Citation (Scopus)

WDR68 is essential for the transcriptional activation of the PRC1-AUTS2 complex and neuronal differentiation of mouse embryonic stem cells

Wang, Q., Geng, Z., Gong, Y., Warren, K., Zheng, H., Imamura, Y. & Gao, Z., Dec 1 2018, In : Stem Cell Research. 33, p. 206-214 9 p.

Research output: Contribution to journalArticle

Open Access
Autistic Disorder
Transcriptional Activation
Polycomb Repressive Complex 1
Genes
Mouse Embryonic Stem Cells
99 Citations (Scopus)

An AUTS2-Polycomb complex activates gene expression in the CNS

Gao, Z., Lee, P., Stafford, J. M., Schimmelmann, M. V., Schaefer, A. & Reinberg, D., Dec 18 2014, In : Nature. 516, 7531, p. 349-354 6 p.

Research output: Contribution to journalArticle

Polycomb Repressive Complex 1
Autistic Disorder
Central Nervous System
Gene Expression
Polycomb-Group Proteins
392 Citations (Scopus)

PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes

Gao, Z., Zhang, J., Bonasio, R., Strino, F., Sawai, A., Parisi, F., Kluger, Y. & Reinberg, D., Feb 10 2012, In : Molecular cell. 45, 3, p. 344-356 13 p.

Research output: Contribution to journalArticle

Embryoid Bodies
Embryonic Stem Cells
Ligases
Ubiquitin
Proteomics
82 Citations (Scopus)

L3MBTL2 Protein Acts in Concert with PcG Protein-Mediated Monoubiquitination of H2A to Establish a Repressive Chromatin Structure

Trojer, P., Cao, A. R., Gao, Z., Li, Y., Zhang, J., Xu, X., Li, G., Losson, R., Erdjument-Bromage, H., Tempst, P., Farnham, P. J. & Reinberg, D., May 20 2011, In : Molecular cell. 42, 4, p. 438-450 13 p.

Research output: Contribution to journalArticle

Lysine
Chromatin
Polycomb Repressive Complex 1
Histone Code
RNA Interference
44 Citations (Scopus)

2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97)

Bursavich, M. G., Parker, D. P., Willardsen, J. A., Gao, Z., Davis, T., Ostanin, K., Robinson, R., Peterson, A., Cimbora, D. M., Zhu, J. F. & Richards, B., Mar 1 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 5, p. 1677-1679 3 p.

Research output: Contribution to journalArticle

Thiazoles
NF-kappa B
Enzyme Inhibitors
Ubiquitin
Proteolysis