Projects per year
Personal profile
Research interests
During mammalian development, hundreds of cell types derived from a single zygote are maintained throughout cell cycles. Deregulation of cell identity is often associated with pathogenesis such as cancer. Despite identical genetic information, cells with distinct identity are controlled by the differential epigenetic landscape. Dr. Zhonghua Gao's research interest is to understand how cell identity is established and maintained via epigenetic mechanisms, particularly how Polycomb group complexes are involved in regulating chromatin structure and gene transcription.
Dr. Gao's lab has established an in vitro neuronal differentiation model using both mouse and human embryonic stem cells. These efforts led to an identification and characterization of novel essential component for a sub-type of PRC1 complex.
The lab is currently continuing to investigate how this regulation controls cell fate determination as well as its involvement in diseases such as cancer and autism.
Dr. Gao is part of the Stem Cell and Regenerative Biology program at Penn State College of Medicine.
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Projects
- 2 Finished
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Epigenetic regulation of cell identity by PRC1 complexes
National Institute of General Medical Sciences
8/1/19 → 7/31/22
Project: Research project
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Regulation of ES Cell Cardiac Differentiation by PRC1 Complexes
1/1/17 → 12/31/19
Project: Research project
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Bmi1 Regulates Wnt Signaling in Hematopoietic Stem and Progenitor Cells
Yu, H., Gao, R., Chen, S., Liu, X., Wang, Q., Cai, W., Vemula, S., Fahey, A. C., Henley, D., Kobayashi, M., Liu, S. Z., Qian, Z., Kapur, R., Broxmeyer, H. E., Gao, Z., Xi, R. & Liu, Y., Dec 2021, In: Stem Cell Reviews and Reports. 17, 6, p. 2304-2313 10 p.Research output: Contribution to journal › Article › peer-review
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Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway (Nature Communications, (2019), 10, 1, (5649), 10.1038/s41467-019-13542-2)
Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N., & 12 others , Dec 1 2020, In: Nature communications. 11, 1, 3856.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Differentiation and characterization of neural progenitors and neurons from mouse embryonic stem cells
Hanafiah, A., Geng, Z., Wang, Q. & Gao, Z., May 2020, In: Journal of Visualized Experiments. 2020, 159, e61446.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Mammalian prc1 complexes: Compositional complexity and diverse molecular mechanisms
Geng, Z. & Gao, Z., Nov 2 2020, In: International journal of molecular sciences. 21, 22, p. 1-18 18 p., 8594.Research output: Contribution to journal › Review article › peer-review
Open Access14 Scopus citations -
Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway
Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N., & 12 others , Dec 1 2019, In: Nature communications. 10, 1, 5649.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations