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Research Output 1999 2019

  • 2549 Citations
  • 19 h-Index
  • 22 Article
Article
45 Citations (Scopus)

2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97)

Bursavich, M. G., Parker, D. P., Willardsen, J. A., Gao, Z., Davis, T., Ostanin, K., Robinson, R., Peterson, A., Cimbora, D. M., Zhu, J. F. & Richards, B., Mar 1 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 5, p. 1677-1679 3 p.

Research output: Contribution to journalArticle

Thiazoles
NF-kappa B
Enzyme Inhibitors
Ubiquitin
Proteolysis
81 Citations (Scopus)

A dimeric Smac/Diablo peptide directly relieves caspase-3 inhibition by XIAP: Dynamic and cooperative regulation of XIAP by Smac/Diablo

Gao, Z., Tian, Y., Wang, J., Yin, Q., Wu, H., Li, Y. M. & Jiang, X., Oct 19 2007, In : Journal of Biological Chemistry. 282, 42, p. 30718-30727 10 p.

Research output: Contribution to journalArticle

Effector Caspases
Caspase 3
Caspase 9
Peptides
Caspases
23 Citations (Scopus)

Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3 H -quinazolin-6-yl)methylprop-2- ynylamino]- N -(3-pyridylmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide phosphoribosyltransferase (Nampt)

Lockman, J. W., Murphy, B. R., Zigar, D. F., Judd, W. R., Slattum, P. M., Gao, Z. H., Ostanin, K., Green, J., McKinnon, R., Terry-Lorenzo, R. T., Fleischer, T. C., Boniface, J. J., Shenderovich, M. & Willardsen, J. A., Dec 23 2010, In : Journal of Medicinal Chemistry. 53, 24, p. 8734-8746 13 p.

Research output: Contribution to journalArticle

Nicotinamide Phosphoribosyltransferase
Cytotoxins
CB 30865
benzamide
105 Citations (Scopus)

An AUTS2-Polycomb complex activates gene expression in the CNS

Gao, Z., Lee, P., Stafford, J. M., Schimmelmann, M. V., Schaefer, A. & Reinberg, D., Dec 18 2014, In : Nature. 516, 7531, p. 349-354 6 p.

Research output: Contribution to journalArticle

Polycomb Repressive Complex 1
Autistic Disorder
Central Nervous System
Gene Expression
Polycomb-Group Proteins
465 Citations (Scopus)

Apoptotic and autophagic cell death induced by histone deacetylase inhibitors

Shao, Y., Gao, Z., Marks, P. A. & Jiang, X., Dec 28 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 52, p. 18030-18035 6 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Autophagy
Caspases
Cell Death
Butyrates
54 Citations (Scopus)

A Wnt-CKIε-Rap1 Pathway Regulates Gastrulation by Modulating SIPA1L1, a Rap GTPase Activating Protein

Tsai, I. C., Amack, J. D., Gao, Z. H., Band, V., Yost, H. J. & Virshup, D. M., Mar 1 2007, In : Developmental Cell. 12, 3, p. 335-347 13 p.

Research output: Contribution to journalArticle

Casein Kinase I
GTPase-Activating Proteins
Gastrulation
Catenins
Morphogenesis
3 Citations (Scopus)

Calcineurin B- and calmodulin-binding preferences identified with phage- displayed peptide libraries

Gao, Z. & Zhong, G., Mar 4 1999, In : Gene. 228, 1-2, p. 51-59 9 p.

Research output: Contribution to journalArticle

Peptide Library
Calcineurin
Calmodulin
Bacteriophages
Peptides
175 Citations (Scopus)

Casein kinase I phosphorylates and destabilizes the β-catenin degradation complex

Gao, Z., Seeling, J. M., Hill, V., Yochum, A. & Virshup, D. M., Feb 5 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 3, p. 1182-1187 6 p.

Research output: Contribution to journalArticle

Casein Kinase I
Catenins
Protein Phosphatase 2
Xenopus
Wnt Signaling Pathway
42 Citations (Scopus)

Chemical Proteomics Identifies Nampt as the Target of CB30865, An Orphan Cytotoxic Compound

Fleischer, T. C., Murphy, B. R., Flick, J. S., Terry-Lorenzo, R. T., Gao, Z. H., Davis, T., McKinnon, R., Ostanin, K., Willardsen, J. A. & Boniface, J. J., Jun 25 2010, In : Chemistry and Biology. 17, 6, p. 659-664 6 p.

Research output: Contribution to journalArticle

Nicotinamide Phosphoribosyltransferase
Proteomics
NAD
Enzymes
Chemical Phenomena
62 Citations (Scopus)

Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis

Gao, Z., Shao, Y. & Jiang, X., Dec 1 2005, In : Journal of Biological Chemistry. 280, 46, p. 38271-38275 5 p.

Research output: Contribution to journalArticle

Caspase 2
Apoptosis
Proteins
Cytochromes c
Mitochondria
24 Citations (Scopus)

Identification of casein kinase I substrates by in vitro expression cloning screening

Gao, Z. H., Metherall, J. & Virshup, D. M., Feb 16 2000, In : Biochemical and Biophysical Research Communications. 268, 2, p. 562-566 5 p.

Research output: Contribution to journalArticle

Casein Kinase I
Cloning
Desmoglein 2
Organism Cloning
Screening
82 Citations (Scopus)

L3MBTL2 Protein Acts in Concert with PcG Protein-Mediated Monoubiquitination of H2A to Establish a Repressive Chromatin Structure

Trojer, P., Cao, A. R., Gao, Z., Li, Y., Zhang, J., Xu, X., Li, G., Losson, R., Erdjument-Bromage, H., Tempst, P., Farnham, P. J. & Reinberg, D., May 20 2011, In : Molecular cell. 42, 4, p. 438-450 13 p.

Research output: Contribution to journalArticle

Lysine
Chromatin
Polycomb Repressive Complex 1
Histone Code
RNA Interference

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, Sun, Y., Wong, T. N., Link, D. C., Liu, Y., Boswell, H. S., Mayo, L. D., Huang, G., Kapur, R., Yoder, M. C., Broxmeyer, H. E., Gao, Z. & Liu, Y., Dec 1 2019, In : Nature communications. 10, 1, 5649.

Research output: Contribution to journalArticle

Open Access
hematopoiesis
Hematopoiesis
Hematopoietic Stem Cells
Epigenomics
mutations
455 Citations (Scopus)

NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN

Wang, X., Trotman, L. C., Koppie, T., Alimonti, A., Chen, Z., Gao, Z., Wang, J., Erdjument-Bromage, H., Tempst, P., Cordon-Cardo, C., Pandolfi, P. P. & Jiang, X., Jan 12 2007, In : Cell. 128, 1, p. 129-139 11 p.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Tumors
Neoplasms
Proteins
224 Citations (Scopus)

Nuclear entry of the circadian regulator MPER1 is controlled by mammalian casein kinase I ε

Vielhaber, E., Eide, E., Rivers, A., Gao, Z. & Virshup, D. M., Jul 1 2000, In : Molecular and cellular biology. 20, 13, p. 4888-4899 12 p.

Research output: Contribution to journalArticle

Casein Kinase I
Drosophila
Nuclear Localization Signals
HEK293 Cells
Nuclear Proteins
419 Citations (Scopus)

PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes

Gao, Z., Zhang, J., Bonasio, R., Strino, F., Sawai, A., Parisi, F., Kluger, Y. & Reinberg, D., Feb 10 2012, In : Molecular cell. 45, 3, p. 344-356 13 p.

Research output: Contribution to journalArticle

Embryoid Bodies
Embryonic Stem Cells
Ligases
Ubiquitin
Proteomics
63 Citations (Scopus)

Processing of autophagic protein LC3 by the 20S proteasome

Gao, Z., Gammoh, N., Wong, P. M., Erdjument-Bromage, H., Tempst, P. & Jiang, X., Jan 1 2010, In : Autophagy. 6, 1, p. 126-137 12 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Proteins
Autophagy
Proteolysis
28 Citations (Scopus)

Regulation of Kir Channels by Intracellular pH and Extracellular K+: Mechanisms of Coupling

Dahlmann, A., Li, M., Gao, Z. H., McGarrigle, D., Sackin, H. & Palmer, L. G., Apr 1 2004, In : Journal of General Physiology. 123, 4, p. 441-454 14 p.

Research output: Contribution to journalArticle

Ions
Cations
Inwardly Rectifying Potassium Channel
Amino Acid Substitution
Xenopus
33 Citations (Scopus)

Stimulation of ATG12-ATG5 conjugation by ribonucleic acid

Shao, Y., Gao, Z., Feldman, T. & Jiang, X., Jan 1 2007, In : Autophagy. 3, 1, p. 10-16 7 p.

Research output: Contribution to journalArticle

RNA
Light
Ribosomes
Microtubule-Associated Proteins
Autophagy
131 Citations (Scopus)

The program for processing newly synthesized histones H3.1 and H4

Campos, E. I., Fillingham, J., Li, G., Zheng, H., Voigt, P., Kuo, W. H. W., Seepany, H., Gao, Z., Day, L. A., Greenblatt, J. F. & Reinberg, D., Nov 1 2010, In : Nature Structural and Molecular Biology. 17, 11, p. 1343-1351 9 p.

Research output: Contribution to journalArticle

Histones
Post Translational Protein Processing
Histone Chaperones
Karyopherins
Holoenzymes
21 Citations (Scopus)

There is communication between all four Ca2+-bindings sites of calcineurin B

Gallagher, S. C., Gao, Z. H., Li, S., Dyer, R. B., Trewhella, J. & Klee, C. B., Oct 9 2001, In : Biochemistry. 40, 40, p. 12094-12102 9 p.

Research output: Contribution to journalArticle

Calcineurin
Binding Sites
Fourier transforms
Mutation
Dialysis
2 Citations (Scopus)

WDR68 is essential for the transcriptional activation of the PRC1-AUTS2 complex and neuronal differentiation of mouse embryonic stem cells

Wang, Q., Geng, Z., Gong, Y., Warren, K., Zheng, H., Imamura, Y. & Gao, Z., Dec 2018, In : Stem Cell Research. 33, p. 206-214 9 p.

Research output: Contribution to journalArticle

Open Access
Autistic Disorder
Transcriptional Activation
Polycomb Repressive Complex 1
Genes
Mouse Embryonic Stem Cells