If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Dr. Zissis Chroneos' overall research focuses on understanding how surfactant proteins modulate host defense and inflammation in the lung, with a major current focus on influenza pathogenesis, and host pathogen interactions,innate and adaptive immune responses to bacterial and viral infections.

His laboratory is skilled in acquisition and analysis of respiratory physiology parameters to monitor respiratory gas exchange and lung health, analysis and isolation of immune and structural cells, histopathology, intracellular trafficking of influenza virus and other bacterial pathogens and receptor-mediated signaling.

Dr. Chroneos is known for the 1996 discovery of the surfactant protein A (SP-A) SP-A receptor SP-R210 in macrophages. Current studies in his laboratory focus on understanding the role that SP-R210 isoforms play in macrophage polarization, reprogramming and adaptation to dynamic changes in the local microenvironment.

In 2005, Dr. Chroneos determined the molecular identity of SP-R210 as two isoforms of Myo18A and validated their function in phagocytosis of SP-A-opsonized bacteria in 2011 and subsequently in transgenic mice. SP-R210 isoforms mediate homeostatic and immune functions by tissue macrophages through a cross-talk between SP-R210, GM-CSF, IL-4 and interferon receptors. 

In addition to this work, Dr. Chroneos also has interest in the following research areas:

  • Understanding a new role of SP-A and SP-R210 in iron sequestration by alveolar macrophages and its impact in pulmonary host defense
  • Role of endophilin B2 in epithelial cell regeneration in response to lung injury
  • Mechanisms of alveolar simplification in response to hyperoxic injury

Teaching and educational interests

Dr. Zissis Chroneos is devoted to medical and graduate education. He is a Master Facilitator for Year 1 and 2 problem-based learning courses for medical students.

In addition, he teaches immunology classes in the College of Medicine, including MICRO560 Principles of Immunology, for which he is the course director.

Dr. Chroneos has mentored and directed the research training of undergraduate and graduate students, medical students, postdoctoral and clinical fellows and junior faculty, and has served on multiple doctoral committees for graduate students and mentoring committees for junior faculty.

Education/Academic qualification

Pulmonary Biology and Molecular Biology, Postdoctoral Fellowship, Cincinnati Children's Hospital


Biochemistry, Postdoctoral Fellowship, Vanderbilt University School of Medicine


Chemistry, PhD, University of South Carolina


Biochemical and Biophysical Sciences, BS, University of Houston


Fingerprint Dive into the research topics where Zissis Chroneos is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.


  • Research Output

    • 1832 Citations
    • 23 h-Index
    • 40 Article
    • 3 Review article
    • 1 Editorial

    17β-Estradiol affects lung function and inflammation following ozone exposure in a sex-specific manner

    Fuentes, N., Nicoleau, M., Cabello, N., Montes, D., Zomorodi, N., Chroneos, Z. C. & Silveyra, P., Nov 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 317, 5, p. L702-L716

    Research output: Contribution to journalArticle

  • Modulation of the lung inflammatory response to ozone by the estrous cycle

    Fuentes, N., Cabello, N., Nicoleau, M., Chroneos, Z. C. & Silveyra, P., Mar 2019, In : Physiological reports. 7, 5, e14026.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Scopus citations

    Resistin directly inhibits bacterial killing in neutrophils

    Miller, L., Singbartl, K., Chroneos, Z., Ruiz-Velasco, V., Lang, C. & Bonavia, A., May 30 2019, In : Intensive Care Medicine Experimental. 7, 30

    Research output: Contribution to journalArticle

    Open Access

    Structural and Functional Determinants of Rodent and Human Surfactant Protein A: A Synthesis of Binding and Computational Data

    Nalian, A., Umstead, T. M., Yang, C. H., Silveyra, P., Thomas, N. J., Floros, J., McCormack, F. X. & Chroneos, Z. C., Nov 7 2019, In : Frontiers in immunology. 10, 2613.

    Research output: Contribution to journalArticle

    Open Access
  • GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization

    Halstead, E. S., Umstead, T. M., Davies, M. L., Kawasawa, Y. I., Silveyra, P., Howyrlak, J., Yang, L., Guo, W., Hu, S., Hewage, E. K. & Chroneos, Z. C., Jan 5 2018, In : Respiratory research. 19, 1, 1 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations