Projects per year
Personal profile
Research interests
Dr. Zissis Chroneos' overall research focuses on understanding how surfactant proteins modulate host defense and inflammation in the lung, with a major current focus on influenza pathogenesis, and host pathogen interactions,innate and adaptive immune responses to bacterial and viral infections.
His laboratory is skilled in acquisition and analysis of respiratory physiology parameters to monitor respiratory gas exchange and lung health, analysis and isolation of immune and structural cells, histopathology, intracellular trafficking of influenza virus and other bacterial pathogens and receptor-mediated signaling.
Dr. Chroneos is known for the 1996 discovery of the surfactant protein A (SP-A) SP-A receptor SP-R210 in macrophages. Current studies in his laboratory focus on understanding the role that SP-R210 isoforms play in macrophage polarization, reprogramming and adaptation to dynamic changes in the local microenvironment.
In 2005, Dr. Chroneos determined the molecular identity of SP-R210 as two isoforms of Myo18A and validated their function in phagocytosis of SP-A-opsonized bacteria in 2011 and subsequently in transgenic mice. SP-R210 isoforms mediate homeostatic and immune functions by tissue macrophages through a cross-talk between SP-R210, GM-CSF, IL-4 and interferon receptors.
In addition to this work, Dr. Chroneos also has interest in the following research areas:
- Understanding a new role of SP-A and SP-R210 in iron sequestration by alveolar macrophages and its impact in pulmonary host defense
- Role of endophilin B2 in epithelial cell regeneration in response to lung injury
- Mechanisms of alveolar simplification in response to hyperoxic injury
Teaching and educational interests
Dr. Zissis Chroneos is devoted to medical and graduate education. He is a Master Facilitator for Year 1 and 2 problem-based learning courses for medical students.
In addition, he teaches immunology classes in the College of Medicine, including MICRO560 Principles of Immunology, for which he is the course director.
Dr. Chroneos has mentored and directed the research training of undergraduate and graduate students, medical students, postdoctoral and clinical fellows and junior faculty, and has served on multiple doctoral committees for graduate students and mentoring committees for junior faculty.
Education/Academic qualification
Pulmonary Biology and Molecular Biology, Postdoctoral Fellowship, Cincinnati Children's Hospital
1994 → 1997
Biochemistry, Postdoctoral Fellowship, Vanderbilt University School of Medicine
1992 → 1994
Chemistry, PhD, University of South Carolina
1988 → 1992
Biochemical and Biophysical Sciences, BS, University of Houston
1983 → 1988
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Projects
- 3 Finished
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Novel therapeutic monoclonal antibody targeting SP-R210 isoforms to prevent influenza disease progression and expedite resolution of comorbidities
Chroneos, Z. & AGRAWAL, A.
U.S. Department of Health and Human Services
8/23/18 → 7/31/20
Project: Research project
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Regulation of the lung antiviral inflammatory response
National Heart, Lung, and Blood Institute
9/4/15 → 8/31/17
Project: Research project
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SP-A Receptor Modulation of Macrophage Phagocytosis
Chroneos, Z. & CHRONEOS, Z. C.
National Heart, Lung, and Blood Institute
7/1/01 → 5/31/07
Project: Research project
Research output
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Cytokine Panels and Pediatric Acute Respiratory Distress Syndrome: A Translational Investigation∗
McKeone, D. J., Mathewson, M., Dalal, P. G., Spear, D., Umstead, T. M., Hicks, S. D., Chroneos, Z. C., Wang, M., Thomas, N. J. & Halstead, E. S., 2020, (Accepted/In press) In: Pediatric Critical Care Medicine. p. E1084-E1093Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Lower respiratory tract delivery, airway clearance, and preclinical efficacy of inhaled GM-CSF in a postinfluenza pneumococcal pneumonia model
Umstead, T. M., Hewage, E. K., Mathewson, M., Beaudoin, S., Chroneos, Z. C., Wang, M. & Halstead, E. S., Apr 2020, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 318, 4, p. L571-L579Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
17β-Estradiol affects lung function and inflammation following ozone exposure in a sex-specific manner
Fuentes, N., Nicoleau, M., Cabello, N., Montes, D., Zomorodi, N., Chroneos, Z. C. & Silveyra, P., Jan 1 2019, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 317, 5, p. L702-L716Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Modulation of the lung inflammatory response to ozone by the estrous cycle
Fuentes, N., Cabello, N., Nicoleau, M., Chroneos, Z. C. & Silveyra, P., Mar 2019, In: Physiological reports. 7, 5, e14026.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Resistin directly inhibits bacterial killing in neutrophils
Miller, L., Singbartl, K., Chroneos, Z., Ruiz-Velasco, V., Lang, C. & Bonavia, A., May 30 2019, In: Intensive Care Medicine Experimental. 7, 30Research output: Contribution to journal › Article › peer-review
Open Access