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Personal profile

Research interests

Dr. Zissis Chroneos' overall research focuses on understanding how surfactant proteins modulate host defense and inflammation in the lung, with a major current focus on influenza pathogenesis, and host pathogen interactions,innate and adaptive immune responses to bacterial and viral infections.

His laboratory is skilled in acquisition and analysis of respiratory physiology parameters to monitor respiratory gas exchange and lung health, analysis and isolation of immune and structural cells, histopathology, intracellular trafficking of influenza virus and other bacterial pathogens and receptor-mediated signaling.

Dr. Chroneos is known for the 1996 discovery of the surfactant protein A (SP-A) SP-A receptor SP-R210 in macrophages. Current studies in his laboratory focus on understanding the role that SP-R210 isoforms play in macrophage polarization, reprogramming and adaptation to dynamic changes in the local microenvironment.

In 2005, Dr. Chroneos determined the molecular identity of SP-R210 as two isoforms of Myo18A and validated their function in phagocytosis of SP-A-opsonized bacteria in 2011 and subsequently in transgenic mice. SP-R210 isoforms mediate homeostatic and immune functions by tissue macrophages through a cross-talk between SP-R210, GM-CSF, IL-4 and interferon receptors. 

In addition to this work, Dr. Chroneos also has interest in the following research areas:

  • Understanding a new role of SP-A and SP-R210 in iron sequestration by alveolar macrophages and its impact in pulmonary host defense
  • Role of endophilin B2 in epithelial cell regeneration in response to lung injury
  • Mechanisms of alveolar simplification in response to hyperoxic injury

Teaching and educational interests

Dr. Zissis Chroneos is devoted to medical and graduate education. He is a Master Facilitator for Year 1 and 2 problem-based learning courses for medical students.

In addition, he teaches immunology classes in the College of Medicine, including MICRO560 Principles of Immunology, for which he is the course director.

Dr. Chroneos has mentored and directed the research training of undergraduate and graduate students, medical students, postdoctoral and clinical fellows and junior faculty, and has served on multiple doctoral committees for graduate students and mentoring committees for junior faculty.

Education/Academic qualification

Pulmonary Biology and Molecular Biology, Postdoctoral Fellowship, Cincinnati Children's Hospital

19941997

Biochemistry, Postdoctoral Fellowship, Vanderbilt University School of Medicine

19921994

Chemistry, PhD, University of South Carolina

19881992

Biochemical and Biophysical Sciences, BS, University of Houston

19831988

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  • 4 Similar Profiles
Pulmonary Surfactant-Associated Protein A Medicine & Life Sciences
Lung Medicine & Life Sciences
Surface-Active Agents Medicine & Life Sciences
Macrophages Medicine & Life Sciences
Alveolar Macrophages Medicine & Life Sciences
Granulocyte-Macrophage Colony-Stimulating Factor Medicine & Life Sciences
Class A Scavenger Receptors Medicine & Life Sciences
Human Influenza Medicine & Life Sciences

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Projects 2001 2019

Human Influenza
Disease Progression
Comorbidity
Protein Isoforms
Monoclonal Antibodies
Influenza A virus
Antiviral Agents
Lung
Virus Diseases
Activating Transcription Factor 3
Pulmonary Surfactant-Associated Protein A
Phagocytosis
Macrophages
Macrophage Activation
Alveolar Macrophages

Research Output 1987 2019

  • 1801 Citations
  • 23 h-Index
  • 40 Article
  • 3 Review article
  • 1 Editorial

17β-Estradiol affects lung function and inflammation following ozone exposure in a sex-specific manner

Fuentes, N., Nicoleau, M., Cabello, N., Montes, D., Zomorodi, N., Chroneos, Z. C. & Silveyra, P., Nov 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 317, 5, p. L702-L716

Research output: Contribution to journalArticle

Ozone
Estradiol
Pneumonia
Bronchoalveolar Lavage Fluid
Gene Expression
2 Citations (Scopus)

Modulation of the lung inflammatory response to ozone by the estrous cycle

Fuentes, N., Cabello, N., Nicoleau, M., Chroneos, Z. C. & Silveyra, P., Mar 2019, In : Physiological reports. 7, 5, e14026.

Research output: Contribution to journalArticle

Open Access
Estrous Cycle
Ozone
Follicular Phase
Luteal Phase
Bronchoalveolar Lavage Fluid

Resistin directly inhibits bacterial killing in neutrophils

Miller, L., Singbartl, K., Chroneos, Z., Ruiz-Velasco, V., Lang, C. & Bonavia, A., May 30 2019, In : Intensive Care Medicine Experimental. 7, 30

Research output: Contribution to journalArticle

Open Access

Structural and Functional Determinants of Rodent and Human Surfactant Protein A: A Synthesis of Binding and Computational Data

Nalian, A., Umstead, T. M., Yang, C. H., Silveyra, P., Thomas, N. J., Floros, J., McCormack, F. X. & Chroneos, Z. C., Nov 7 2019, In : Frontiers in immunology. 10, 2613.

Research output: Contribution to journalArticle

Open Access
Pulmonary Surfactant-Associated Protein A
Rodentia
Alveolar Macrophages
varespladib methyl
Surface-Active Agents
9 Citations (Scopus)

GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization

Halstead, E. S., Umstead, T. M., Davies, M. L., Kawasawa, Y. I., Silveyra, P., Howyrlak, J., Yang, L., Guo, W., Hu, S., Hewage, E. K. & Chroneos, Z. C., Jan 5 2018, In : Respiratory research. 19, 1, 1 p.

Research output: Contribution to journalArticle

Virus Diseases
Granulocyte-Macrophage Colony-Stimulating Factor
Orthomyxoviridae
Monocytes
Macrophages