A NEW IN VIVO HUMAN VAGINAL XENOGRAFT MODEL

  • Christensen, Neil (PI)
  • KREIDER, JOHN (PI)
  • HOWETT, MARY KATHERINE (PI)
  • CHRISTENSEN, NEIL (PI)
  • Wigdahl, Brian (PI)
  • HOWETT, MARY (PI)
  • NORRIS, STEVEN (PI)
  • WYRICK, PRISCILLA (PI)
  • MALAMUD, DANIEL (PI)
  • HEYNER, SUSAN (PI)
  • KREIDER, JOHN (PI)
  • Wigdahl, Brian (PI)
  • HOWETT, MARY (PI)
  • NORRIS, STEVEN (PI)
  • WYRICK, PRISCILLA (PI)
  • MALAMUD, DANIEL (PI)
  • HEYNER, SUSAN (PI)
  • Wigdahl, Brian (PI)
  • NORRIS, STEVEN (PI)
  • WYRICK, PRISCILLA (PI)
  • MALAMUD, DANIEL (PI)
  • HEYNER, SUSAN (PI)
  • CHRISTENSEN, NEIL (PI)
  • HOWETT, MARY KATHERINE (PI)

Project: Research project

Project Details

Description

Model systems for microbicide evaluations are inadequate. In vitro tests
can provide support for drug efficacy but cannot reproduce the complex
vaginal environment. The vaginas of experimental animals are poorly
characterized and do not provide a sufficient representation of the human
counterpart. In this project, we will modify our human xenograft system so
that grafts of human vagina can be used for microbicide evaluation. The
Specific Aims of the study are as follows:

1. Define the Composition of human Vaginal Xenografts

2. Determine Human Vaginal Xenografts Responsiveness to Sex Steroids

3. Test the Susceptibility of Human Vaginal Xenografts to Primary
infections with Selected Pathogens

4. Determine the Effectiveness and Toxicity of Selected Microbicides on
Pathogens in Human Vaginal Xenografts.
StatusFinished
Effective start/end date1/1/017/31/05

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