AD5 E1B TRANSFORMING GENE AND ESTROGEN-DEPENDENT BREAST TUMOR INDUCTION BY AD9

  • Broach, James (PI)
  • Broach, James (PI)
  • SHENK, THOMAS (PI)
  • SHENK, THOMAS (PI)
  • SHENK, THOMAS (PI)
  • SCHUPBACH, GERTRUD (PI)
  • LEVINE, ARNOLD (PI)
  • SHENK, THOMAS (PI)
  • SHENK, THOMAS (PI)
  • SCHUPBACH, GERTRUD (PI)
  • LEVINE, ARNOLD (PI)
  • SHENK, THOMAS (PI)
  • WIESCHAUS, ERIC (PI)
  • SCHWARZBAUER, JEAN (PI)
  • ZAKIAN, VIRGINIA (PI)

Project: Research project

Project Details

Description

The long term goal of this research proposal is to delineate the
mechanisms by which adenovirus transforming proteins carry out their
functions in lyrically infected human cells, transformed rat cells and
during tumor formation in the rat. The long term objectives fall into two
categories: elucidation of the mechanisms by which the adenovirus type
5 E1B oncoproteins carry out their functions within the infected or
transformed cell; and exploration of the mechanisms underlying the
induction of estrogen-dependent mammary fibroadenomas and fibrosarcomas
by adenovirus type 9. Specific aims include: (1) Delineate the mechanism
by which the adenovirus type 5 E1B-55kDa/E4-34kDa protein complex
controls transport of mRNAs from the nucleus to the cytoplasm of infected
cells. (2) Explore the mechanism by which the adenovirus type 5 E1B-19kDa
oncoprotein blocks the induction of apoptosis by the adenovirus type 5
E1A oncoproteins. (3) Test the role of the adenovirus type 9 E1A
oncoproteins in the induction of mammary tumors and explore the process
of transformation by the adenovirus type 9 E1A and E1B oncogenes. This
proposal is designed to explore the functions of adenovirus oncoproteins.
Analysis of adenovirus gene function has contributed not only to our
understanding of viral growth processes, but it also has provided
important insights to mechanisms underlying cellular gene expression and
growth control, mechanisms directly relevant to our understanding of
oncogenesis in the human.
StatusFinished
Effective start/end date1/1/012/28/07

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