AGE AND CONTROL OF HUMAN SKIN BLOOD FLOW

  • Vgontzas, Alexandros (PI)
  • Ettinger, Steven (PI)
  • Leuenberger, Urs (PI)
  • Lloyd, Thomas (PI)
  • Miller, Barbara (PI)
  • Sinoway, Lawrence (PI)
  • Legro, Richard (PI)
  • Eyster, M. Elaine (PI)
  • Rolls, Barbara Jean (PI)
  • Phelps, David (PI)
  • Floros, Joanna (PI)
  • Boehmer, John (PI)
  • Manni, Andrea (PI)
  • Craig, Timothy (PI)
  • Blosser, Sandralee (PI)
  • McGarrity, Thomas (PI)
  • Ambrose, Anthony (PI)
  • Bixler, Edward (PI)
  • Bascom, Rebecca (PI)
  • Ulbrecht, Jan (PI)
  • Macneill, Colin (PI)
  • Reynolds, Herbert (PI)
  • Dong, Cheng (PI)
  • Cheng, Keith (PI)
  • Giblin, Pamela Hankey (PI)
  • Lee, Peter (PI)
  • Craig, Timothy (PI)
  • Harvey, Harold (PI)
  • Koltun, Walter (PI)
  • Gilchrist, Ian (PI)
  • Ouyang, Ann (PI)
  • Thiboutot, Diane (PI)
  • Ramer, Jeanette (PI)
  • Hartman, Terryl Johnson (PI)
  • Rybka, Witold (PI)
  • Eslinger, Paul (PI)
  • Proctor, David Nathan (PI)
  • Pawelczyk, James Anthony (PI)
  • Klein, Laura (PI)
  • Latash, Mark (PI)
  • Williams, Nancy (PI)
  • Rolls, Barbara Jean (PI)
  • Dodson, William (PI)
  • Han, David (PI)
  • Raja-Khan, Nazia (PI)
  • Lloyd, Thomas (PI)
  • Conroy, David E. (PI)
  • Connor, James (PI)
  • Cui, Jian (PI)
  • Alexander, Lacy Marie (PI)
  • Wilson, Robin (PI)
  • Farace, Elana (PI)
  • Graff, Gavin (PI)
  • Paul, Ian (PI)
  • Flaherty, Claire (PI)
  • Green, Michael (PI)
  • Curry, William (PI)
  • EVARTS (PI)
  • KENNEY, LARRY (PI)
  • KOCH, KENNETH (PI)
  • KULIN, HOWARD (PI)
  • RODICHOK, LAWRENCE (PI)
  • Evans, William (PI)
  • CAMPBELL, WAYNE (PI)
  • DEMERS, LAURENCE (PI)
  • Dunaif, Andrea (PI)
  • Evans, William (PI)
  • KIRWAN, JOHN (PI)
  • MCCABE, PAUL (PI)
  • MILLER, BARBARA (PI)
  • SINOWAY, LAWRENCE (PI)
  • SINOWAY, LAWRENCE (PI)
  • SINOWAY, LAWRENCE (PI)
  • SINOWAY, LAWRENCE (PI)
  • SINOWAY, LAWRENCE (PI)
  • Streufert, Siegfried (PI)
  • ULTMAN, JAMES (PI)
  • KIRCH, DARRELL (PI)
  • KULIN, HOWARD (PI)
  • Evans, William (PI)
  • LEGRO, RICHARD (PI)
  • KENNEY, LARRY (PI)
  • KIRWAN, JOHN (PI)
  • Streufert, Siegfried (PI)
  • ULTMAN, JAMES (PI)
  • Watterberg, Kristi (PI)
  • LATHROP, MARY (PI)
  • MCCABE, PAUL (PI)
  • CAVANAGH, PETER ROBERT (PI)
  • EGGLI, DOUGLAS (PI)
  • GORDON, ROBERT (PI)
  • Smith, Jill (PI)
  • Ahsan, Nasimul (PI)
  • Kris-Etherton, Penny (PI)
  • CAMPBELL, WAYNE (PI)
  • KRAEMER, WILLIAM (PI)
  • Gaumond, Roger (PI)
  • MULFINGER, LORRAINE MAY (PI)
  • CRONIN, ARTHUR (PI)
  • LANOUE, KATHRYN FOLEY (PI)
  • HOLMAN, MICHAEL (PI)
  • Consevage, Michael (PI)
  • Ramirez-Zea, Manuel (PI)
  • Lipton, Allan (PI)
  • RODICHOK, LAWRENCE (PI)
  • DEMERS, LAURENCE (PI)
  • LUCK, JERRY (PI)
  • Gardner, Thomas (PI)
  • Dunaif, Andrea (PI)
  • FINKELSTEIN, JORDAN (PI)
  • VESELL, ELLIOT (PI)
  • FARRELL, PETER (PI)
  • LLOYD, THOMAS (PI)
  • SHOEMAKER, JOEL KEVIN (PI)
  • Ehman, Christopher (PI)
  • SINOWAY, LAWRENCE (PI)
  • RAY, CHESTER (PI)
  • ROLLS, BABARA (PI)
  • HOLTZCLAW, BARBARA (PI)
  • PHELPS, DAVID (PI)
  • SHOEMAKER (PI)
  • KRAEMER, WILLIAM (PI)
  • ROLLS, BABARA (PI)
  • EYSTER (PI)
  • LEUENBERGER, URS (PI)
  • SHOEMAKER, KEVIN (PI)
  • Smith, Jill (PI)
  • LALLOS, CHRISTINE (PI)
  • KOCH, KENNETH (PI)
  • MACLEAN, DAVID (PI)
  • Joshi, Renu (PI)
  • SINOWAY, LAWRENCE (PI)
  • DALEY, JOSEPH (PI)
  • PRITCHARD, THOMAS CHARLES (PI)
  • Khan, Mazhar (PI)
  • WILLIAMS, NANCY IMBODEN (PI)
  • Beard, John Lawrence (PI)
  • MASTRO, ANDREA (PI)
  • Larsson, Lars (PI)
  • Jones, Byron (PI)
  • WILLIAMS, NANCY IMBODEN (PI)
  • LOOMIS, JOSEPH (PI)
  • PAGE, MICHAEL (PI)
  • CORWIN, ELIZABETH (PI)
  • GRANGER, DOUGLAS (PI)
  • AHLUWALIA, NAMAN (PI)
  • Powers, Stephen (PI)
  • SINOWAY, LAWRENCE (PI)
  • MILLER, BARBARA (PI)
  • Craig, Timothy (PI)
  • Craig, Timothy (PI)
  • DONG, CHENG (PI)
  • BARRETT, ANNA (PI)
  • IMADOJEMU, VIRGINIA (PI)
  • LOTT, MARY EJ (PI)
  • EHMANN, CHRISTOPHER (PI)
  • Flood, William (PI)
  • EHMANN, CHRISTOPHER (PI)
  • DAVIS, WALTER (PI)
  • EYSTER, ELAINE (PI)
  • Pu, Min (PI)
  • Reeves, William (PI)
  • Xu, Lihua (PI)
  • LEONG, SHOULING (PI)
  • PALLONE, MICHAEL (PI)
  • PAUL, IAN (PI)
  • SINOWAY, LAWRENCE (PI)
  • AYANNUSI, OLASIMBO (PI)
  • THORNDYKE, LUANNE (PI)
  • SIMMONS, ZACHARY (PI)
  • Birch, Leann (PI)
  • SUSMAN, ELIZABETH (PI)
  • WILLIAMS, NANCY IMBODEN (PI)
  • WEST, SHELIA (PI)
  • ROSALES, FRANCISCO (PI)
  • Proctor, David (PI)
  • Paz, Harold (PI)
  • Yang, Qing (PI)
  • MCNULTY, PATRICK (PI)
  • CRAIG, TIMOTHY JOHN (PI)
  • Erickson, Deborah (PI)
  • Loughran, Thomas Patrick (PI)
  • Galka, Eva (PI)
  • PETIT, MOIRA (PI)
  • WILSON, THAD RAHN (PI)
  • JANICKI, PIOTR (PI)
  • Monahan, Kevin (PI)
  • Thomas, Neal (PI)
  • CONNOR, JAMES (PI)
  • CHUANG, CYNTHIA (PI)
  • BURKS, ERIC (PI)
  • WILLIAMS, NANCY IMBODEN (PI)
  • CHALLIS, JOHN (PI)
  • MILLER, CARLA (PI)
  • DOWNS, DANIELLE SYMONS (PI)
  • RODRIGUES, ISABELLA (PI)
  • MILLER, CARLA (PI)
  • STAUFFER, LORI (PI)
  • SINOWAY, LAWRENCE (PI)
  • CUI, JIAN (PI)
  • TRUSSEL (PI)
  • LEGRO, RICHARD (PI)
  • SIEVERLING, ELIZABETH (PI)
  • Cooney, Robert (PI)
  • CUI, JIAN (PI)
  • CUI, JIAN (PI)
  • PODSKALNY, GERALD PODSKALNY (PI)
  • Singareddy, Ravi (PI)
  • Momen, Afsana (PI)
  • DOWNS, DANIELLE SYMONS (PI)
  • FLORIAN, JOHN (PI)
  • TORGERSON, CAITLIN (PI)
  • PARKER, BETH (PI)
  • FITZGERALD, ERIN (PI)
  • Miraliakbari, Reza (PI)
  • SCOTT, KEVIN (PI)
  • CUI, JIAN (PI)
  • SUBRAMANIAN, THYAGARAJAN (PI)
  • BOUSTRED, MARK (PI)
  • O'BRYAN, THOMAS (PI)
  • MUSCAT, JOSHUA (PI)
  • Paz, Harold (PI)

Project: Research project

Project Details

Description

The cutaneous circulation plays an integral role in human
thermoregulation. There are intrinsic age-related changes in the dermal
matrix, in the cutaneous vessels and in autonomic control of blood flow,
any or all of which may alter the cutaneous vascular response to local
and whole-body thermal stresses. Studies performed under previous NIH
funding demonstrated that during heat stress the increase in skin blood
flow (SkBF) and skin vascular conductance per degree Centigrade increment
in body temperature is markedly attenuated in healthy active men and
women over the age of 55, when compared to 20-30 year -old subjects.
This decrement appears to be due to peripheral rather than central (e.g.,
hypothalamic) age-related changes. However, many questions remain about
aging and control of skin blood flow. The human SkBF response to
elevated body temperature is unique in that there is a well developed
active sympathetic vasodilator system as well as an adrenergic
vasoconstrictor system. Under any given set of environmental influences,
the balance between these two competing systems determines the net SkBF,
yet it is not known which vasoconstrictor influences and thus allows for
the study of the active vasodilator system in the absence of constrictor
effects - provides a tool with which to examine the mechanisms underlying
the effects of intrinsic aging on SkBF. In addition, interventions aimed
at increasing thermally-induced vasodilation in older subjects have not
been examined. Therefore the scope of this project is to systematically
study the effects of age on the control of human skin blood flow, and the
mechanisms underlying the age-related changes.
StatusFinished
Effective start/end date1/1/015/31/11

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