ASTHMA CLINICAL RESEARCH NETWORK

Project: Research project

Project Details

Description

The Data Coordinating Center (DCC) of the Asthma Clinical Research
Network (ACRN) is located in the Department of Health Evaluation
Sciences at Penn State's Hershey Medical Center. There are four specific
goals of the DCC: 1) providing biostatistical leadership in the design,
conduct, and analysis of ACRN protocols and ancillary studies; 2)
providing project management and administrative support for the ACRN -
its investigators, Clinical Center personnel, review committees and
monitoring boards; 3) providing data management and research computing
support for the ACRN; 4) establishing methods for a single DCC to
conduct multiple projects and ancillary studies. The four operational
units within the DCC (Biostatistics, Project Management, Data
Management, and Research Computing) have unique responsibilities and
objectives aimed at obtaining these goals. The DCC has established
systems and procedures which lead and support the ACRN in implementing
well-designed clinical trials and in collecting pristine data sets to
address important issues in asthma treatment and to establish a firm
clinical investigative database from which treatment decisions can be
based and further hypotheses generated. In this application, we propose
to continue fulfilling the specific goals outlined above, investigate
and develop novel biostatistical approaches related to asthma research,
expand administrative responsibilities, and increase data management
module development. In the next funding period, biostatistical methods
will be developed for each of the studies undertaken by the ACRN. In
addition, we propose to develop new biostatistical approaches to indices
of asthma control commonly used in clinical trials. Specific indices
include methacholine challenge, PEFR, and daily measures which may be
predictive of treatment failure. Project management responsibilities
will continue in the next five years with some expansion in the area of
developing and publishing standard operating procedures for managing
Data Coordinating Centers. Particular emphasis Will be placed on
responsibilities associated with conducting multiple protocols. During
the next five years, the data management unit, in conjunction with the
research computing unit, plans to enhance the function of the existing
data management application modules, as well as develop new modules such
as a protocol violations module. These units also plan to develop a
pulmonary function database capturing the electronic transfer of all
spirometry testing data, identify appropriate hardware and software to
electronically scan all data collection forms and reports for storage
and retrieval, and determine the feasibility of distributing additional
data management processes by incorporating more edit checks during first
entry of the data at the Clinical Centers.
StatusFinished
Effective start/end date9/30/938/31/06

Funding

  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute: $157,536.00
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute: $2,050,812.00
  • National Heart, Lung, and Blood Institute: $1,257,068.00
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute: $272,953.00
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute: $228,927.00
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute: $1,142,328.00
  • National Heart, Lung, and Blood Institute

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