ASTHMA NETWORK DATA COORDINATING CENTER

Project: Research project

Description

Asthma, a disease defined as reversible airway obstruction, afflicts both
genders, all age groups, and all racial/minority groups. The NHLBI is
establishing an Asthma Clinical Research Network (ACRN) and this is a
cooperative agreement application for Penn State University to serve as
the Data Coordinating Center (DCC) for the ACRN. The role of the DCC in
this endeavor is characterized by administrative support, biostatistical
leadership, and data management support for the ACRN. Administrative
support for the ACRN includes facilitating an atmosphere of scientific
collaboration and cooperation between all participating individuals and
institutions; establishing and promoting an effective communication, data
transfer, and reporting structure among the DCC, the Clinical Centers,
and the NHLBI; organizing meetings of the Steering Committee and sub-
committees; overseeing the sub-contract with the laboratory performing
the chemical analysis of blood samples; and coordinating the development
and distribution of the study protocols and Manual of Operations.
Biostatistical leadership for the ACRN includes comparing the merits of
potential experimental designs; proposing optimal experimental designs;
selecting homogeneous study groups and implementing methods to remove
systematic bias; projecting appropriate sample sizes to achieve the
stated clinical objectives; selecting a method of randomization; ensuring
that pharmaceutical formulations or other types of treatment are masked
in a sufficient manner; monitoring quality control of chemical assays;
providing the Steering Committee and External Advisory Committee with
interim and final data summaries and biostatistical analyses; and
collaborating on the presentations at professional meetings and the
submission of manuscripts for publication. Data management support for
the ACRN includes developing a distributed data system for data entry at
the Clinical Centers and transmission to the DCC; providing a system for
subject enrollment, randomization, and data collection; designing the
data collection forms; developing a system for tracking subjects,
compliance, data, and blood specimens; executing procedures for data
security and data quality control, storage, and back-up; and reporting
accrual, adverse events, and subject safety.
StatusFinished
Effective start/end date9/30/938/31/06

Funding

  • National Institutes of Health: $157,536.00
  • National Institutes of Health: $1,257,068.00
  • National Institutes of Health: $1,142,328.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $2,050,812.00
  • National Institutes of Health
  • National Institutes of Health: $713,631.00
  • National Institutes of Health
  • National Institutes of Health: $1,077,438.00
  • National Institutes of Health: $64,656.00
  • National Institutes of Health
  • National Institutes of Health: $228,927.00
  • National Institutes of Health: $272,953.00
  • National Institutes of Health: $54,940.00

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Asthma
Research
National Heart, Lung, and Blood Institute (U.S.)
Advisory Committees
Random Allocation
Quality Control
Research Design
Laboratory Chemicals
Biostatistics
Clinical Trials
Databases
Peak Expiratory Flow Rate
Computer Communication Networks
Minority Groups
Drug Compounding
Methacholine Chloride
Manuscripts
Spirometry
Airway Obstruction
Clinical Protocols