• Eslinger, Paul (PI)
  • Laird, Cermak (PI)
  • Alexander, Michael (PI)
  • O'Connor, Margaret (PI)
  • Milberg, William (PI)
  • Bauer, Russell (PI)
  • Gabrieli, John D E (PI)
  • Cermak, Laird (PI)
  • Verfaellie, Mieke (PI)

Project: Research project


This program proposal seeks support for a Memory Disorders Research
Center which is dedicated to the study of the information-
processing deficits underlying memory disturbances of individuals
suffering brain injury or disease. These investigations will
utilize contemporary research techniques and instrumentation to
explore the on-line processing impairments of amnesic patients.
This will permit greater understanding of the memory process and
will provide a basis for differential assessment and therapy.
Toward this end, four independent, yet interrelated projects are
proposed. The first (Issues) focuses on unresolved issues of
amnesia including an analysis of the relative contributions of
episodic and semantic memory to implicit priming; compilation and
organizational aspects of procedural learning; reconstruction and
familiarity as aspects of contextual learning and, finally, factors
underlying remote memory disturbances. The second component (Case
Studies) seeks to describe unique individual cases of amnesia both
from a clinical and issue-driven experimental point of view.
Alcoholic Korsakoff, post-encephalitic, anoxic, bilateral temporal,
retrosplenial and selective stroke patients will be assessed for
their dissociative memorial abilities and disabilities. The third
component (Neuroanatomy) explores the neuroanatomy of amnesia using
neuro-imaging techniques such as MRI and CAT scans. This will
culminate in a greater understanding of the neural systems
underlying memory and information processing. The fourth component
(Assessment and Therapy) will develop an assessment battery to
permit the differential diagnosis of amnesic patients along many
of the dimensions explored in the Issues Component of this
proposal. This assessment will then provide a basis for
therapeutic attempts with some of these amnesic individuals. The
entire Center will be administered, organized and monitored through
the development of a Core administration depicted in the fifth, and
final component of this program project. This will include
administrative assistance, secretarial support, consults and
educational opportunities. The entire program will thus bring
together research from otherwise diverse, and often disparate,
areas of investigation to explore the behavioral, cognitive and
neural underpinnings of amnesia.
Effective start/end date4/1/892/28/05


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


Memory Disorders
Automatic Data Processing
Long-Term Memory
Brain Diseases
Brain Injuries
Differential Diagnosis
Research Design
Magnetic Resonance Imaging