CARDIOVASCULAR RESPONSES TO PARTICULATE AIR POLLUTION

Project: Research project

Project Details

Description

DESCRIPTION: (Adapted from the Investigator's Abstract) The aims of this study
are to evaluate the relationship between air pollution and cardiovascular
diseases and specifically to evaluate parameters which may help to elucidate
biologic mechanisms by which air pollution may result in cardiovascular
disease. Specifically, the study will investigate the relationship between
exposure to criteria air pollutants and cardiac autonomic control measured by
heart rate variability, cardiovascular reactivity, markers of inflammation and
the presence of arrhythmias. The project will also investigate the relationship
between ambient air pollution and validated cardiovascular disease including
sudden cardiac death, myocardial infarction, CHD and stroke. Air pollution data
will be obtained from the US EPA and abstracted into 1, 2, 3 or 6 day mean
exposure levels for the dates prior to the individual participant=s clinical
exams for baseline and exam 4 of the ARIC study. The ARIC study is a biracial
population-based study of cardiovascular disease in 15,792 individuals in four
US communities. The baseline examination of the cohort occurred from 1987-1989,
with annual recontacts and reexaminations every three years. Numerous biologic
measures and health data are obtained at these visits.
StatusFinished
Effective start/end date5/1/004/30/04

Funding

  • National Institute of Environmental Health Sciences: $174,721.00

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