Alzheimer’s disease shows distinct progressive histological and behavioral hallmarks but its cell-type basis is not clear. Recent human postmortem studies begin to provide compelling rationale thatconstituent cell types bear a non-uniform risk profile, but the underlying cell specific progression ofvulnerabilities remain unknown. Through cross-disciplinary systems biology approaches we will identify thevulnerable subclass of cells in AD, establish cell-type specific AD signatures and further investigate biologicalrelationship between healthy aging and AD pathology.
|Effective start/end date||5/1/21 → 4/30/24|
- National Institute on Aging: $2,194,586.00
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