• Vrana, Kent (PI)
  • Wood, Frank (PI)
  • Ferris, Mark (PI)
  • Jones, Sara Raulerson (PI)
  • Booze, Rosemarie (PI)
  • Howlett, Allyn (PI)
  • Dworkin, Steven (PI)
  • Porrino, L. (PI)
  • Davies, Huw M. (PI)
  • Deadwyler, Samuel A. (PI)
  • Roberts, David Charles Stephen (PI)
  • Morton, Kathryn (PI)
  • Hemby, Scott Edwards (PI)
  • Beveridge, Thomas J.R. (PI)
  • Childers, Steven (PI)
  • Nader, M. (PI)
  • Bennett, Barbara (PI)
  • Porrino, Linda J. (PI)
  • Deadwyler, Samuel A. (PI)
  • Roberts, David Charles Stephen (PI)
  • Davies, Huw (PI)
  • Morgan, Drake (PI)
  • Smith, James (PI)

Project: Research project


Substance abuse is a severely debilitating disorder that results in
significant liabilities for an orderly society. These include not only the
individual and the personal consequences resulting from such abuse, but
also secondary effects such as the illegal activities related to
procurement, as well as decreased productivity that follows an individual's
loss of control to compulsive drug use. Although significant advances in
treatment have been accomplished, there is still a great deal to understand
and implement. The effective and efficient treatment and prevention of
substance abuse could be assisted with further knowledge of the basic
biological mechanisms underlying these processes. It has become
increasingly to be similar in complexity. One of the major goals of the
Center for the Neurobiological Investigation of Drug Abuse is to provide an
environment for scientific interactions to occur between NIDA funded
investigators. The broad range of research expertise on drug abuse issues
in the Center spans from the basic molecular mechanisms of drug action, to
the consequences of drug abuse in humans. The research areas involved
include: receptor coupling mechanisms; receptor binding; patch clamp
techniques; neurochemistry; neuroendocrinology; behavioral neurophysiology;
microdialysis; behavioral pharmacology; medication development and
assessment; and positron emission tomography. This expertise in drug abuse
research will be applied to targeted Projects dealing with contemporary
issues to be realized through Core supported laboratories, permitting new
directions and levels of collaboration that would not otherwise be
possible. Training in neurobiological methods applied to the investigation
of drug abuse will occur at both the predoctoral and postdoctoral levels.
The Center will also serve as a resource to the public by providing
information concerning the basic mechanisms of the actions of abused
substances. The establishment of this Center will permit a comprehensive
research, training and service environment focused on collaborative
investigations of neurobiological mechanisms of drug abuse.
Effective start/end date9/30/912/29/20


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


Substance-Related Disorders
Street Drugs
Pharmaceutical Preparations
Opiate Alkaloids
Gene Expression
Self Administration
Recombinant DNA
Research Personnel
Imprinting (Psychology)