CHEMOPREVENTION OF COLON CANCER BY ORGANOSELENIUM

  • El-Bayoumy, Karam (PI)
  • REDDY, BANDARU (PI)
  • Reddy, Bandaru S. (PI)
  • FIALA, EMERICH SILVIO (PI)

Project: Research project

Project Details

Description

Compared to inorganic selenium, synthetic organic selenium
compounds offer greater promise for the chemoprevention of
cancer, in that their chemical structures can be tailored to
provide maximum efficacy with minimal toxicity. To design
more effective organoselenium compounds, it is necessary to
understand their efficacy, mode of action, and structure and
activity relationships. The long term objective of the Collaborative Chemoprevention
Project is to elucidate the role of novel organoselenium
compounds that are less toxic but effective as chemopreventive
agents in colon carcinogenesis. Specifically, the overall project
aims to test p-methoxybenzeneselenol (MBS) and
benzylselenocyanate (BSC), that have been shown to inhibit colon
tumor incidence in animal models, for toxicologic and
pharmacologic properties. It also aims to investigate the
efficacy of various levels of MBS and BSC fed during initiation
and post-initiation phases of colon carcinogenesis induced by a
variety of chemical carcinogens and to identify the mechanism
of action of these organoselenium compounds during the
initiation and post-initiation stages of colon carcinogenesis. In
addition, we propose to determine whether the parent
organoselenium compounds or one of their metabolites are
responsible for their inhibitory activity. It is also proposed to
modify the structures of BSC and MBS in order to enhance their
inhibitory activity and reduce their toxicity and to test the most
active and lease toxic compounds or inhibitors of colon
carcinogenesis. Thus, the data base obtained from the proposed project could
provide the basis for further studies to the rational design of
chemopreventive compounds of greater effectiveness and help to
translate laboratory findings to the human setting.
StatusFinished
Effective start/end date12/31/897/31/02

Funding

  • National Cancer Institute
  • National Cancer Institute
  • National Cancer Institute

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