CMV RETINITIS RETREATMENT TRIAL

  • Rolls, Barbara Jean (PI)
  • Johns, Michael (PI)
  • MILLER, EDWARD (PI)
  • WOLFE, JOHN (PI)
  • WOLFE, JOHN (PI)
  • ROSS, RICHARD (PI)
  • BECKER, LEWIS (PI)
  • FISCHMAN, MARIAN (PI)
  • CHARACHE, SAMUEL (PI)
  • MCKUSICH, VICTOR (PI)
  • Moser, Hugo (PI)
  • TUNE, LARRY (PI)
  • DONEHOWER, ROSS (PI)
  • DRACHMAN, DANIEL (PI)
  • FOLSTEIN, SUSAN (PI)
  • LADENSON, PAUL (PI)
  • AVERSANO, THOMAS (PI)
  • Caballero, Benjamin (PI)
  • FEINBURG, JUDITH (PI)
  • FLEXNER, CHARLES (PI)
  • FLEXNER, CHARLES (PI)
  • LIETMAN, PAUL (PI)
  • ROSENFELD, BRIAN (PI)
  • ROWINSKY, ERIC (PI)
  • ELMAN, MICHAEL (PI)
  • Cornblath, David (PI)
  • DOBS, ADRIAN (PI)
  • FLEXNER, CHARLES (PI)
  • GARDNER, TIMOTHY (PI)
  • GROCHOW, LOUISE (PI)
  • JABS, DOUGLAS (PI)
  • PETTY, BREBT (PI)
  • PETTY, BRENT (PI)
  • SAUDEK, CHRISOTPHER (PI)
  • Sherman, Steven (PI)
  • Valle, David (PI)
  • WALKER, GORDON (PI)
  • WAND, GARY (PI)
  • CARBONE, KATHRYN (PI)
  • CRUM, ROSA (PI)
  • HALLER, KAREN (PI)
  • JOHNSON, MARY (PI)
  • LEVINE, DAVID (PI)
  • KRENZISCHEK, DINA (PI)
  • LOGAN, PHYLLIS (PI)
  • MCKHANN, GUY (PI)
  • NOLAN, MARIE (PI)
  • OWENS, SHARON (PI)
  • PHOON, COLIN (PI)
  • RACUSEN, LORRAINE (PI)
  • RACUSE, LORRAINE (PI)
  • ROBEY-WILLIAMS, CATHERINE (PI)
  • WAINSTOCK, JEAN (PI)
  • PORTER, REGINA (PI)
  • SAUDEK, CHRISTOPHER (PI)
  • MOSES, HAMILTON (PI)
  • PEARLSON, GODFREY (PI)
  • Hanley, Daniel (PI)
  • JABS, DOUGLAS (PI)
  • LESSER, RONALD (PI)
  • RAVICH, WILLIAM (PI)
  • CHAISSON, RICHARD (PI)
  • Frost, James (PI)
  • GELBACH, DANIEL (PI)
  • DOOLEY, WILLIAM (PI)
  • FELDMAN, ARTHUR (PI)
  • GOTTLIEB, SIDNEY (PI)
  • MATEO, OFELIA (PI)
  • GOULD, MARIE (PI)
  • BAKER (PI)
  • EVANS, CHRISTINE (PI)
  • SHANTY, JOYCE (PI)
  • SULMASY, DANIEL (PI)
  • KWITEROVICH, PETER (PI)
  • HUNGERFORD, DAVID (PI)
  • McIvor, Michael (PI)
  • JENKINS, MARK (PI)
  • STILLMAN, FRANCES (PI)
  • WHELTON, ANDREW (PI)
  • GEORGOPOULOS, ANGELIKI (PI)
  • Gerstenblith, Gary (PI)
  • CHARACHE, SAMUEL (PI)
  • GRIFFITH, LAWRENCE (PI)
  • HENDRIX, THOMAS (PI)
  • MOSER, HUGH (PI)
  • ELMAN, MICHAEL (PI)
  • MCARTHUR, JUSTIN (PI)
  • LIETMAN, PAUL (PI)
  • AVERSANO, THOMAS (PI)
  • Fisher, Robert (PI)
  • GORDON, GARY (PI)
  • MCKUSICH, VICTOR (PI)
  • PETRI, MICHELLE (PI)
  • Rood, Richard (PI)
  • SZABA, GEORGE (PI)
  • FROST, JOHN (PI)
  • WALKER, GORDON (PI)
  • BAYLIN, STEPHEN (PI)
  • FOLSTEIN, MARSHAL (PI)
  • COOKE, ROBERT (PI)
  • PYERITZ, REED (PI)
  • SAPIR, DANIEL (PI)
  • WALKER, MACKENZIE (PI)
  • WHELTON, PAUL (PI)
  • WIGLEY, FREDERICK (PI)
  • BRINKER, JEFFREY (PI)
  • GADACZ, THOMAS (PI)
  • Gerstenblith, Gary (PI)
  • HERLONG, FRANKLIN (PI)
  • JANKEL, WILLIAM (PI)
  • Migeon, Claude (PI)
  • REID, PHILIP (PI)
  • PLATIA, EDWARD (PI)
  • MIROWSKI, MICHEL (PI)
  • MOWER, MARTIN (PI)
  • SHAPIRO, THERESA (PI)
  • SUMMER, WARREN (PI)
  • WALSER, MACKENZIE (PI)
  • BAYLIN, STEPHEN (PI)
  • BENDER, WALTER (PI)
  • BURROW, CHRISTOPHER (PI)
  • LEVINE, MICHAEL (PI)
  • Villar, Jose (PI)

Project: Research project

Project Details

Description

Nutritional therapy of the nephrotic syndrome - We have found that a very
low protein diet, supplemented by essential amino acids, may induce long-
term remission of the nephrotic syndrome, even when it is caused by
diabetes or by focal segmental glomerulosclerosis (disorders in which the
nephrotic syndrome rarely remits spontaneously), provided that treatment
is started before renal function has deteriorated severely. The mechanism
of this surprising result remains to be determined by study of additional
patients.

Use of ketoconazole to slow progression of chronic renal failure - A
randomized cross-over study of ketoconazole (to suppress cortisol
production) plus low-dose prednisone (to prevent anterior pituitary
escape) in patients with progressive chronic renal failure of various
types has been completed. In diabetic nephropathy, glomerular disease, and
interstitial nephritis, rate of decline of glomerular filtration rate
slowed significantly; in polycystic kidney disease, rate of decline
accelerated. Side effects or toxicity caused drug withdrawal in 20% of
patients.

Survival on dialysis of patients treated with a supplemented very low
protein diet before dialysis - Extending our previously published finding
that patients so treated generally enter dialysis with normal serum
albumin levels, in contrast to the national experience, we determined the
survival on dialysis of 46 such patients. During the first two years,
survival on dialysis was markedly improved, compared with the national
experience, correcting for age, sex, and diagnosis. Whether this was
because these patients had higher serum albumin levels during dialysis
could not be determined.

Use of dehydroepiandrosterone to slow progression of chronic renal failure
- Based on our unpublished finding that progression is negatively
correlated with serum DHEA-S concentration, we hypothesized that DHEA
supplementation may slow progression. Accordingly, a randomized, double-
blind crossover study of sequential glomerular filtration rates in
patients with all types of chronic renal failure given either a placebo or
enough DHEA to raise serum DHEA-S level to about 12 ug/ml has been
started.

Renal production of nitric oxide as a determinant of progression - We have
reported in abstract form that progression is positively correlated with
the 24 excretion rate of nitrate (the stable end-product of nitric
oxide). We have developed a method to determine renal (as opposed to
systemic) production of nitrate, based on measuring nitrate and chloride
clearances and glomerular filtration rate before and after an oral load of
NaNO 3. We plan to extend these measurements and to determine whether the
source of renal NO production is inducible to nitric oxide synthase (as
opposed to constitutive NOS) by repeating these measurements after giving
a nearly specific inhibitor of iNOS (aminoguanidine).
StatusFinished
Effective start/end date1/1/0111/30/96

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