Project: Research project

Project Details


DESCRIPTION (provide by applicant): This application seeks support for the
first meeting ever to be held on Multiple Hereditary Exostoses (MHE), a human
syndrome affecting formation of growth plate tumors. MHE is a debilitating
disorder characterized by benign, bony malformations throughout life, and in a
percentage of cases, overt malignancy. They propose to bring together a group
of physicians and scientists to discuss every aspect of this disease, from
clinical presentation and current treatments, to molecular genetics,
biochemistry, and potential therapeutic strategies. This initial meeting will
be small and by invitation only so that the leading researchers in the field
can get to know one another, establish collaborations, and collectively plan
how they can best further the attack on this disease. They also plan to invite
several representatives of the MHE Coalition, a nonprofit, grassroots
organization representing more than 400 families affected by MHE, to attend the
entire conference and provide information back to their members. In addition,
they will hold two workshops open to the public, summarizing the current
understanding of MHE and prospects for the future.

The two organizers, Scott Selleck, M.D., Ph.D., and Jeff Esko, Ph.D. are both
actively involved in understanding the molecular basis of MHE and serve on the
scientific board of advisors for the MHE coalition. Dr. Selleck, the PI, was
recently appointed Director of Molecular Genetics at the Arizona Cancer Center,
the University of Arizona. Dr. Esko, co PI, is a world renowned expert on
glycosaminoglycan synthesis and function, and is currently Professor of Cell
and Molecular Medicine at the University of California, San Diego Medical
School. The Arizona Cancer Center, an NCI designated comprehensive cancer
center, has agreed to serve as the conference site, providing meeting rooms,
facilities, and will sponsor the opening night dinner.

The sessions planned include: 1) Clinical presentation of MHE, 2) medical
genetics, 3) biochemistry 4) bone development and repair, 5) MHE models and two
workshops, Issues in living with the disease and Therapeutic horizons. They
have selected speakers from the researchers in the fields in order to educate
elements of the clinical and research community, and foster collaborations
across discipline boundaries.
Effective start/end date6/14/026/13/03


  • National Institute of Arthritis and Musculoskeletal and Skin Diseases: $20,001.00


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