Crystallographic study of the RNA component of RNase P

Project: Research project

Description

DESCRIPTION (provided by applicant): Ribonuclease P, or RNase P, is the
endonuclease responsible for processing the 5' end of tRNA by cleaving a
precursor and leading to tRNA maturation. RNase P has been identified in all
organisms and cells that need to process tRNA. The phylogenetic and biochemical
analysis of P RNA has now reached the point where structural information is
needed to be able to understand the wealth of information available.
The long range goal of this work is to understand the structure and function of
the RNA component of RNase P, through crystallographic studies. This will
advance, not only our understanding of RNase P, but will also lead to a much
better understanding of other large RNA molecules and will help us understand
better the way RNA molecules fold and add to the emerging structural database
of RNA molecules. It promises to provide new and important structural
information to help fill the void in our knowledge on the structure of these
important molecules.
StatusActive
Effective start/end date2/1/02 → …

Funding

  • National Institutes of Health: $46,584.00
  • National Institutes of Health: $56,308.00
  • National Institutes of Health: $5,500.00

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Ribonuclease P
RNA
Transfer RNA