DETECTION AND CONTROL OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS AND EMERGING VIRAL DISEASES OF SWINE

Project: Research project

Project Details

Description

The porcine respiratory disease complex [PRDC] is an economically important disease syndrome of swine.The porcine reproductiveand respiratory disease syndrome virus [PRRSV] is the leading infectious cause of economic loss and mortality in swine production. However, other swine respiratory viruses such as porcine circovirus strain 2 [PCV2] and swine influenza virus [SIV] are important coinfecting agents which exacerbate the clinical effects of PRDC. Effective vaccines against PRRSV are an unmet and urgent industry need. Similarly, vaccineswhich can help producers to differentiate between vaccinated and infected animals [DIVA capabilities] are important for monitoring vaccine compliance and eventual disease eradication. By studying the mechanisms of immune evasion and coinfectionof PRRSV and PCV2 we will obtain the fundamental knowledge required to develop improved vaccines and diagnostic tools. We expect to develop effective vaccines that will direct host antibody responses to the most protective antigenic epitopes. We will also develop user-friendly diagnostic tools with DIVA capabilities. Therefore, the primary impact of this project is in contributing to the understanding of viral immunity and in translating basic research findings into practical applications which are of direct benefit to the swine industry.

StatusFinished
Effective start/end date9/15/119/30/19

Funding

  • National Science Foundation: $455,192.00

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