EFFECTS OF ANDROGENS ON THE THYMUS

Project: Research project

Project Details

Description

DESCRIPTION (Adapted from the applicant's abstract): In this application,
it is postulated that the effects of gonadal steroids on immunity are
mediated, at least in part, at the level of the thymus via thymocyte
proliferation and programmed cell death. This proposal examines the role of
androgenic hormones in thymic involution and the development of the immune
repertoire. The four specific aims are to (1) define the cellular targets
for androgen-induced thymocyte apoptosis; (2) define the cellular targets
mediating androgen effects on tissue-specific proliferation; (3) interrupt
intrathymic androgen signaling pathways and examine resulting immune system
composition and function; and (4) define the role of TGF-b in the mediation
of androgen-induced thymic involution.
StatusFinished
Effective start/end date1/1/9012/31/02

Funding

  • NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES: $201,938.00
  • NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
  • NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
  • NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
  • NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
  • NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
  • NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
  • NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
  • NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

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