EFFECTS OF EXERCISE ON AIRWAY SIZE AND MUSCLE AFFERENTS

Project: Research project

Project Details

Description

Little is known about the reflex effect on airway caliber of static
muscular contraction. In addition, little is known about the discharge
properties of the group III (ADelta) and IV (C) muscle afferents that are
both stimulated by static contraction and are believed responsible for the
reflex autonomic effects caused by this stimulus. Therefore, the proposed
research will attempt to determine if static contraction of the hindlimb
reflexly dilates the airways. If static contraction does cause reflex
dilation of the airways, then it will be determined whether this dilation
is due to cholinergic withdrawal or to Beta-adrenergic excitation. Also,
the proposed research will attempt to characterize the metabolic and/or
mechanical stimuli that discharge the group III and IV muscle afferents
whose stimulation reflexly evokes the contraction-induced airway dilation.
In all experiments, static contraction will be induced by electrically
stimulating the cut peripheral ends of the L7-S1 ventral roots of
chloralose-anesthetized cats. Changes in airway caliber will be measured
by recording both changes in trachealis muscle tension and changes in total
pulmonary resistance. Changes in afferent input will be measured by
recording changes in single fiber impulse activity from the L7-S1 dorsal
roots. The proposed research may provide new information about the reflex
airway response to static exercise as well as the afferents causing that
response.
StatusFinished
Effective start/end date1/1/901/1/90

Funding

  • National Heart, Lung, and Blood Institute

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