Enzymatic Fluoroalkylation using Te-Adenosyl-Telluromethionine Analogs and Late-Stage Diversification of Natural Products Exhibiting Antibacterial Behavior

Project: Research project

Project Details

Description

Project Narrative The proposed work focuses on the design and synthesis of fluoroalkyl group-carrying analogs of S- adenosylmethionine, and their use in performing regio- and stereoselective enzymatic fluoroalkylation. The work provides a novel approach for late stage fluoroalkylation, which enables facile derivatization of a wide range of antibacterial natural products.
StatusActive
Effective start/end date3/15/212/28/23

Funding

  • National Institute of Allergy and Infectious Diseases: $189,000.00

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.