Enzymatic Fluoroalkylation using Te-Adenosyl-Telluromethionine Analogs and Late-Stage Diversification of Natural Products Exhibiting Antibacterial Behavior

Project: Research project

Project Details


Project Narrative The proposed work focuses on the design and synthesis of fluoroalkyl group-carrying analogs of S- adenosylmethionine, and their use in performing regio- and stereoselective enzymatic fluoroalkylation. The work provides a novel approach for late stage fluoroalkylation, which enables facile derivatization of a wide range of antibacterial natural products.
Effective start/end date3/15/212/28/23


  • National Institute of Allergy and Infectious Diseases: $189,000.00


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