EPIDEMIOLOGY OF MALE INFERTILITY--CRYPTORCHIDISM

Project: Research project

Description

Cryptorchidism is likely a major cause of male infertility, although there
are no controlled studies of formerly unilateral or bilateral cryptorchid
males. It is not known whether fertility is related to the age of
treatment of cryptorchidism, pretreatment testicular location and
pretreatment size. There is no evidence that orchidopexy effects
subsequent fertility. In spite of the lack of evidence, the current
recommended age to correct cryptorchidism by age 2 is virtually universally
accepted. There is a cohort of 2000 formerly cryptorchid males now 21 years of age or
older who had surgery during childhood at The Children's Hospital of
Pittsburgh between 1955 and 1984. This group is unique because it includes
a large group of patients who had surgery at age 2 or younger so the
relationship to age of treatment can be assessed even among those treated
at very young ages. In this cohort it is estimated that 900 will be
married, able to be contacted and willing to participate in an assessment
of paternity. This project will evaluate these subjects to ascertain: 1. If infertility expressed as paternity is decreased in formerly
unilateral and bilateral cryptorchid. 2. If there is a relationship between the age of treatment pretreatment
testicular location, size, the presence of a biopsy and paternity. External controls will be used for portion one, fertile subjects will serve
as internal controls in portion two. Patient availability has been ascertained to a subset of the population;
2145 subjects of the projected 3750 have been identified from the most
recent 25 years of the 30 year period from 1955 to 1984. The research
investigators are those who have been involved in a very successful
epidemiologic study of former Children's Hospital patients with diabetes
mellitus. A pilot study of 350 medical history records has verified the
availability of subjects and reliability of data. A subset of 25 subjects
have been contacted with initial data collection demonstrating a sampling
of data and reassurance that data can be obtained. This study will, evaluate fertility in cryptorchidism and determine if
treatment of bilateral or unilateral cryptorchidism effects fertility.
StatusFinished
Effective start/end date3/1/929/30/01

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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Cryptorchidism
Male Infertility
Epidemiology
Paternity
Fertility
Spermatozoa
Testosterone
Infertility
Follicle Stimulating Hormone
Therapeutics
Orchiopexy
Medical Records
Hormones
Biopsy