Project: Research project

Project Details


The proposed study will examine several possible mechanisms for the
reduced risk of coronary heart disease observed in postmenopausal women
receiving estrogen replacement in a placebo controlled, double-blind,
randomized design. We will compare women receiving estrogen alone to
those receiving placebo and to those receiving estrogen plus progesterone
during the second half of the six month intervention. There is some
evidence that the addition of progesterone will prevent or diminish
estrogen related improvements in lipids and vascular tone. Therefore, the
effects of each treatment regimen on lipid/lipoprotein profile, and
vascular and lipid reactivity to stress will be assessed prior to
treatment as well as after 3 and 6 months of the intervention. This
proposal will fill an important gap in the literature by examining the
effects of hormone replacement on hemodynamic and lipid reactivity to
stress. In addition, we will examine the effects of hormone replacement
therapy on symptoms of depression and anxiety through the use of
structured interviews. Thus, we propose a multidisciplinary study of the
costs and benefits of estrogen replacement on the psychological and
cardiovascular health of postmenopausal women.
Effective start/end date7/1/9511/30/97


  • National Institute of Mental Health
  • National Institute of Mental Health
  • National Institute of Mental Health


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