EXERCISE FOR ELDERLY PERIPHERAL REVASCULARIZED PATIENTS

Project: Research project

Project Details

Description

DESCRIPTION (adapted from Investigator's abstract): Peripheral arterial
occlusive disease (PAOD) patients with critical limb-threatening ischemia have
improved peripheral circulation following infrainguinal revascularization.
Despite this hemodynamic benefit, little change in functional tatus occurs, and
many patients have residual ambulatory dysfunction. The lack of functional
improvement in revascularized patients may be due to muscle wasting, myopathy,
and extreme physical deconditioning secondary to their pre-existing critical
limb-threatening ischemia. Therefore, the investigators hypothesize that a
program of aerobic exercise training is necessary to optimize ambulation,
free-living daily physical activity, and health-related quality of life through
the mechanisms of improved muscle structure and function, walking economy,
cardiopulmonary function, and further gains in peripheral circulation. This
randomized controlled clinical trial comparing an exercise group undergoing a
program of graded treadmill walking, and a delayed entry non-exercise control
group will address the following two aims: (1) to determine whether a 6-month
exercise rehabilitation program will improve claudication distances,
free-living daily physical activity, and health-related quality of life of
older, revascularized patients with PAOD, and (2) to determine whether the
primary mechanisms by which exercise rehabilitation affects the above
functional outcomes are through alterations in muscle structure and function,
walking economy, peripheral circulation, and cardiopulmonary function. Eighty
PAOD patients will be randomized into either the exercise group (n=40) or the
delayed entry non-exercise control group (n=40) three to six months following
successful lower extremity arterial bypass. The 6-month exercise program will
consist of graded treadmill walking 3 times per week with progressive
increments in exercise duration from 15 to 40 minutes, and progressive
increments in exercise intensity from 50 to 80 percent of exercise capacity.
The overall intent is that this study will demonstrate that exercise
rehabilitation is an important adjuvant to revascularization surgery to achieve
clinically meaningful gains in ambulation, free-living daily physical activity,
and quality of life in PAOD patients with critical limb-threatening ischemia.
StatusFinished
Effective start/end date7/1/006/30/01

Funding

  • National Institute on Aging: $154,125.00

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