EXPERIMENTAL TOBACCO CARCINOGENESIS

  • El-Bayoumy, Karam (PI)
  • Prokopczyk, Bogdan (PI)
  • Hecht, Stephen (PI)
  • Silverman, Jerald (PI)
  • Lavoie, Edmond (PI)
  • Haley, Nancy (PI)
  • Rivenson, Abraham S. (PI)
  • Brunnemann, Klaus (PI)
  • Hoffman, Dietrich (PI)

Project: Research project

Description

Tobacco smoking is causally associated with cancer of the lung, upper
aerodigestive tract, pancreas, kidney, and urinary bladder and is
associated with cancer of the liver, uterine cervix and with leukemia.
Involuntary smoking gives rise to some risk of cancer. Tobacco chewing,
especially snuff dipping, is causally associated with cancer of the oral
cavity and pharynx. Tobacco smoke and its particulate matter are
carcinogenic in mice, rats and hamsters. Snuff is tumorigenic in the
oral cavity of rats. It is the overall goal of the Program Project to contribute to an
understanding of the carcinogenicity of tobacco smoke and of smokeless
tobacco and to elucidate the mechanisms involved in the development of
tumors induced by tobacco carcinogenesis. Five projects are proposed.
1. Study of the activation of tobacco-specific nitrosamines (TSNA) in
humans and human risk assessment by measuring adducts of the carcinogenic
TSNA, PAH and aromatic amines with DNA and with globin. 2. Analysis of
tobacco for nitrosamino acids, cigarette smoke analysis for aromatic and
heterocyclic amines and for nitrohydrocarbons, environmental tobacco
smoke analysis for 3-venylpyridine. Cervical mucus will be examined for
alkaloids and TSNA. 7. Study of the carcinogenesis of smokeless tobacco
and betel quid. 10. Study of the mechanisms of the carcinogenic effects
of tobacco smoke carcinogenic effects of tobacco smoke carcinogens in the
oral cavity and esophagus of humans. 5. Development of biomarkers in
smokers for the uptake of benzene.
StatusFinished
Effective start/end date6/15/811/31/97

Funding

  • National Institutes of Health

Fingerprint

Tobacco
Amines
Smoking
Smoke
Smokeless Tobacco
Nitrosamines
Carcinogenesis
Lobeline
Pharyngeal Neoplasms
Cervix Mucus
Tobacco Smoke Pollution
Globins
Particulate Matter
Tobacco Use
Liver Neoplasms
Benzene
Tobacco Products
Uterine Cervical Neoplasms
Cricetinae
Carcinogens