EXPERIMENTAL TOBACCO CARCINOGENESIS

  • El-Bayoumy, Karam (PI)
  • Hoffman, Dietrich (PI)
  • HECHT, STEPHEN (PI)
  • LAVOIE, EDMOND (PI)
  • BRUNNEMANN, KLAUS (PI)
  • Prokopczyk, Bogdan (PI)
  • HALEY, NANCY (PI)
  • SILVERMAN, JERALD (PI)
  • Rivenson, Abraham (PI)

Project: Research project

Project Details

Description

The established causal relationship of tabacco usage and several types of cancer
and the continuation of cigarette smoking by 54 million Americans mandate that
the studies on the mechanisms underlying tobacco carcinogenesis be continued and
that the biological properties of new smoking products be monitored. The
identification of compounds and processes involved in tobacco carcinogenesis
contributes directly to the understanding of chemical and environmental
carcinogenesis per se. The proposed program will elucidate the formation and
mechanism of action of organ-specific tobacco carcinogens, such as the
N'-nitrosamines which derive from alkaloids and from certain agricultural
formulations used on tobacco crops. It will also identify tobacco-specific
nitrosamines and their role in oral cancer of tabacco chewers and snuff users by
chemical analytical studies and by bioassays in Syrian golden hamsters. The
program will also include chemical identification of mutagenic nitropolynuclear
aromatic hydrocarbons in cigarette smoke and assessment of their potential as
carcinogens in small rodents.
Identification of the active cocarcinogenic components of the neutral and weakly
acidic subfractions of tobacco smoke condensate will focus on chemical
classification and on determination of their relative activity in a newly
developed short-term screening test on mouse skin epithelium. Mutagenic flavor
compounds in the smoke of low yield cigarettes will be assessed chemically, as
well as biologically. Bioassays will be initiated to study the effects of the
major nicotine metabolites on bladder cancer induction in rats.
StatusFinished
Effective start/end date6/1/855/31/86

Funding

  • National Cancer Institute

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