FACTORS AFFECTING CALORIC REGULATION IN FEEDING

Project: Research project

Project Details

Description

The proposed experiments will investigate the regulation of food
intake in humans. Two hypotheses will be tested. The first is
that the regulation of the intake of dietary fat differs from that
of carbohydrate. The second hypothesis is that the regulation of
these nutrients differs between normal weight non-dieting
subjects, and obese and normal weight dieters. These hypotheses
will be tested in a series of experiments that systematically
introduce variable which increasingly approximate normal feeding
situations. The following experiments are proposed: 1)
Differences in the time course of the inhibitory effects of fats
and carbohydrates on subsequent ingestion will be determined in a
highly controlled test in which the preload and subsequent test
meal are similar. 2) The degree to which subjects detect and
compensate for varying levels of fat and carbohydrate will be
determined by systematically varying the number of calories in
fixed volume preloads with similar sensory properties. The test
meal will again be similar to the preload. 3) The regulation
following different levels of fat and carbohydrate in preloads will
then be assessed in more natural situations, in which the test meal
following the preload provides a choice of luncheon foods.
Twenty-five day studies in a residential laboratory will extend
these findings to determine the long-term adjustments in response
to alterations in calories from fats or carbohydrates in a normal
lunch. This progression of studies from the highly controlled to
the more natural feeding situation will allow us to determine how
factors such as variety, palatability, and differences in the
physiological management of nutrients contribute to control of
food intake. Differences in response to nutrient and caloric
manipulations between obese subjects and normal weight dieters
and non-dieters will allow suggestions for rational treatments of
obesity.
StatusFinished
Effective start/end date8/1/877/31/88

Funding

  • NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

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