FELINE MODEL OF AIDS-DEMENTIA COMPLEX--NEUROPATHOGENESIS

  • Dorn, Lorah D. (PI)
  • Lee, Peter (PI)
  • Dorn, Lorah D. (PI)
  • Greene, Douglas (PI)
  • Fricker, F. (PI)
  • Davis, Holly (PI)
  • Broznski, Beverly (PI)
  • Johnson, Linda (PI)
  • Ulatmann, Michelle (PI)
  • Karasic, Raymond (PI)
  • McElderry, Craig (PI)
  • Post, Christopher (PI)
  • Blatt, Steven (PI)
  • Siegel, Selma (PI)
  • Chan, Kenney (PI)
  • Isaacman, Daniel (PI)
  • Gordon, Harold (PI)
  • Needleman, Herbert (PI)
  • Wing, Rena (PI)
  • Swartz, Mindy (PI)
  • Apalsh, A.N.N. (PI)
  • Kolmen, Barbara (PI)
  • Phebus, Carol K. (PI)
  • Mirro, Joseph (PI)
  • Michaels, Richard (PI)
  • Gill, Thomas (PI)
  • Khan, Nadeem (PI)
  • Brozanski, Beverly (PI)
  • Breck, Jane (PI)
  • Apalsch, A.N.N. (PI)
  • Supance, John (PI)
  • Mulvihill, John (PI)
  • Gilmour, Carol (PI)
  • Del Rosario, Fernando (PI)
  • Motoyama, Etsuro (PI)
  • Knine, Hnin (PI)
  • Fingold, David (PI)
  • Proujansky, R.O.Y. (PI)
  • Cohen, Bernard (PI)
  • Christianopoulos, Kriston (PI)
  • Starzl, Thomas (PI)
  • Steele, Mark (PI)
  • Oliver, Thomas (PI)
  • Donaldson, William (PI)
  • Drash, Allan L. (PI)
  • Lucero, Marisha (PI)
  • Bell, Michael (PI)
  • Puczynski, Sandra (PI)
  • Faro, Albert (PI)
  • Blatt, Julie (PI)
  • Wollman, Michael (PI)
  • Albright, Leland (PI)
  • Del Rosario, J. (PI)
  • Scher, Mark (PI)
  • Zuberbuhler, James (PI)
  • Hoberman, Alejandro (PI)
  • Orenstein, David (PI)
  • Skoner, David (PI)
  • Fireman, Philip (PI)
  • Sukanich, Aurapin (PI)
  • Barranger, John (PI)
  • Orenstein, Susan (PI)
  • Arslanian, Silva (PI)
  • Wald, Ellen (PI)
  • Feldman Witchel, Selma (PI)
  • Foley, Thomas P. (PI)
  • Green, Micheal (PI)
  • Casselbrant, Margaretha (PI)
  • Fischer, Donald (PI)
  • Hofkosh, Dena (PI)
  • Reis, Evelyn (PI)
  • Beerman, Lee (PI)
  • Kaye, Walter (PI)
  • Wiener, Eugene (PI)
  • Venkataraman, Shekhar (PI)
  • Jakacki, Regina (PI)
  • Kovacs, Maria (PI)
  • Martin, Judy (PI)
  • Adelson, P. David (PI)
  • Marazita, Mary (PI)
  • Dilorenzo, Carlo (PI)
  • Becker, Dorothy J. (PI)
  • Sindhi, Rakesh K. (PI)
  • Campbell, Thomas F. (PI)
  • Perlmutter, David (PI)
  • Mitchell, Thomas (PI)
  • Koehler, Maria (PI)
  • Beers, Sue (PI)
  • Schneck, Francis (PI)
  • Goldstein, Nira (PI)
  • Erbey, John (PI)
  • Winnie, Glenna (PI)
  • Paradise, Jack (PI)
  • Pilewski, Joseph (PI)
  • Painter, Michael (PI)
  • Mandel, Ellen (PI)
  • Skoner, David (PI)
  • Arjmand, Ellis (PI)
  • Barranger, John (PI)
  • McMahon, Deborah (PI)
  • Pierce, Mary Clyde (PI)
  • Kuller, Lewis (PI)
  • Goodpaster, Bret H. (PI)
  • Jakicic, John (PI)
  • Ahmann, Andrew (PI)
  • Roth, Kimberly (PI)
  • Gold, Melanie (PI)
  • Pilewski, Joseph Mark (PI)
  • Kelley, David (PI)
  • Helgeson, Vicki (PI)
  • Saps, Miguel (PI)
  • Riddler, Sharon (PI)
  • Maldoon, Matthew (PI)
  • Ritchey, Arthur (PI)
  • Gallagher, Kara (PI)
  • Marcus, Marsha (PI)
  • Charron-Prochownik, Denise Cecile (PI)
  • Arslanian, Silva (PI)
  • Tersak, Jean Marie (PI)
  • Goyal, Rakesh (PI)
  • Harpavat, Manisha (PI)
  • Rajakumar, Kumaravel (PI)
  • Feldman Witchel, Selma (PI)
  • Berger, Rachel (PI)
  • Orenstein, David (PI)
  • Gungor, Neslihan (PI)
  • Casselbrant, Margaretha (PI)
  • Zimmer, Michelle (PI)
  • Blank, Cheryl (PI)
  • Bacha, Fida (PI)
  • Libman, Ingrid (PI)
  • Webber, Stephanie (PI)
  • Daviss, W. Burleson (PI)
  • Finder, Jonathan (PI)
  • Hickey, Robert (PI)
  • Gondor, Magdalen (PI)
  • Chakravarti, Aravinda (PI)
  • Kurland, Geoffrey (PI)
  • Finegold, David (PI)
  • Finegold, David (PI)

Project: Research project

Description

Phase I research will involve participation in a currently-funded five-year
project titled Feline Neurotropic Retroviruses (NIH, NINDS, NS28510) which
has the overall goal of developing an animal model of the neurologic
abnormalities associated with the human immunodeficiency virus (HIV)
infection. Neurotropic feline retroviruses are being isolated and
molecularly cloned to be characterized viral genetically, in vitro, and
ultimately inoculated into specific pathogen free cats. Neuropathology
will be the focus of this Special Emphasis Research Career Award (SERCA)
concentrating on the following Specific Aims: 1)Characterization of retrovirus-associated morphologic lesions within the
nervous system in both naturally-occurring and experimentally-infected
cats, 2)Correlation of clinical neurological deficits with the characterized
morphologic lesions within the nervous system of retrovirus-infected cats, 3)Identification of the target cells within the nervous system of
retrovirus-infected cats, and 4)Correlation of in situ cytokine production with the characterized
morphologic lesions within the nervous system of retrovirus-infected cats. Phase I studies will involve the following techniques, light, electron, and
confocal microscopy, immunohistochemistry and in situ hybridization,
morphometry and tomography. It is anticipated that Phase II research will
utilize the acquired expertise and results obtained from Specific Aims 1
and 2 to focus and extend investigations relating to Specific Aims 3 and 4
above.
StatusFinished
Effective start/end date10/1/7411/30/09

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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Sex Differentiation
Gonadotropin-Releasing Hormone
Cryptorchidism
Orchiopexy
Sexual Development
Male Infertility
Leuprolide
Epidemiology
Turner Syndrome
Bone Density
Retroviridae
Hormones
Molecular Biology
Paternity
Growth Hormone
Semen Analysis
Adrenarche
Gonadotropins
Testosterone
Testis